This video segment introduces and describes the Reed-Sternberg cell, a key diagnostic feature in certain lymphomas. It begins by visually referencing the cell's appearance, comparing it to an 'owl' looking directly at the viewer. The video then details the morphological characteristics of the Reed-Sternberg cell: it's a large cell, typically with two nuclei (or a bilobed nucleus), each containing a prominent eosinophilic nucleolus, surrounded by a clear halo of cytoplasm. The cell is identified as a neoplastic cell originating from a B cell, specifically one that failed to undergo hypermutation to express its antibodies within the germinal center of a lymph node. Immunophenotypically, Reed-Sternberg cells are characterized as CD15 positive and CD30 positive. The video also mentions that when these cells are observed against a background of other B cells, they can create a 'moth-eaten' appearance, a term used by pathologists. Finally, it notes that Reed-Sternberg cells are more commonly found in the mixed cellularity subtype of Hodgkin's disease. The segment concludes with a call to action, encouraging viewers to like the video, leave comments, subscribe, and follow on social media.

Medicosis Perfectionalis

The old "I" that's looking at you, the Reed-Sternberg cell, is the topic of today's video. So let's get started.

[Music]

The Reed-Sternberg cell is a large cell with two nuclei. Each nucleus has a prominent eosinophilic nucleolus. Around the nuclei is a halo of clear cytoplasm, just like the hole directly looking at you.

There is a Reed-Sternberg cell is a neoplastic cell derived from the B cell. Where is the B cell? In the germinal center of the lymph node. As you know, these cells that didn't undergo hypermutation to express their antibodies are the R-S cells. Multinucleated or could be bi-lobed nucleus. Our cells are CD15 positive and CD30 positive. When you see the R-S cell on a background of B cells, it gives you the moth-eaten appearance. Creative pathologist, whoo-hoo!

Okay, R-S cells are more easily found in the mixed cellularity subtype of Hodgkin's disease. So, what do you think? Did you like this video? Please give it a like. Let me know in the comments what you think. And don't forget to subscribe and follow me on Facebook. Thank you so much. Until next time, be safe, stay happy, and study hard.

Reed-Sternberg Cell | Owl 🦉-Eye Appearance | Hodgkin’s Lymphoma

the old I that's looking at you the read
Sternberg cell is the topic of today's
video so let's get started
[Music]
the reed Sternberg cell is a large cell
with two nuclei each nucleus has a
prominent AOC Nephila nucleolus around
the nuclei is a halo of clear cytoplasm
just like the hole directly looking at
you there is turmeric cell is a new
plastic cell derived from the B cell
where is the B cell in the germinal
center of the lymph node as you know
these cells that didn't undergo
hypermutation to express their
antibodies are the RSL's multinucleated
or could be by lobe nucleus our cells
are C D 15 positive and C D 30 positive
when you see the RSL on a background of
B cell it gives you the moth-eaten
appearance creative pathologist whoo-hoo
okay our cells are more easily found in
the mixed cellularity subtype of
Hodgkin's disease so what do you think
did you like this video please give it a
like let me know in the comments what do
you think and don't forget to subscribe
and follow me on Facebook thank you so
much until next time be safe stay happy
and study hard

Get Our Mobile App

Reed-Sternberg Cell | Owl 🦉-Eye Appearance | Hodgkin’s Lymphoma

Transcription