Grave's Disease and How to Reverse It - Dr Trevor Bachmeyer

So, here's what I'm going to do today. I'm going to solve Graves disease. I'm going to do it for free. I'm going to give you line by line every answer from the beginning to the end. Explain what Graves disease is.

And like I said, I'm going to do it all for free because like I, I'm at the point right now today where I'm about ready to say up yours to the entire medical world and everybody in it because the whole point is that we should be all working together. But too many toddlers are making reaction videos of me because they're like, "I don't like what he's saying." It's they've crossed the line. He's marketing this cockeyed. She looks like Peter Pedigrew from Harry Potter, lady. I'm like, "Really? Of all people, you should be going, 'Maybe I could learn from this guy,' but you're too busy with your fragile little ego looking like a boy deciding what you should wear on your penis." I just don't know what to say. I just don't.

It's a bizarre thought to me because at 52 years old, if I was a 22 or 23-year-old med student, the first thing I would be doing is looking for the person solving all the problems, not throwing hate. But this is a weird world we're living. Hey, you do you, boo. And before somebody goes, "You shouldn't be a rant. You shouldn't let them get to you." Don't. I'm making a comment. Do you know why? 'Cause it's my show.

You know what's absolutely insane is that right now as we speak, millions of people are walking around with a disease that a doctor, I got to get my chair more comfortable. That a doctor, slide it over here. Maybe that's better. There we go. All right. So, that that some doctor who graduated medical school told them they're going to have for the rest of their life. A disease that their doctor told them was genetic. Genetic. Graves is not genetic, by the way. I'll prove it. A disease that their doctors told them required to either poison their thyroid, burn it with radiation, or even worse, surgically remove it because it's catastrophic.

Listen, this is going to sound crazy, but just stick with me 'cause I'm going to change everything you think you know about autoimmune disease, and I'll just solve Graves disease. It's not a thyroid problem. It never was. Never want. That's not an opinion either. That is just basic biology that everybody should understand, especially if they've gone to med school. Let me ask you a fundamental question, okay? Just watch. What is Graves disease? Really? Most people, especially doctors, 99% of doctors, in fact, I've never heard a doctor say otherwise except me, will tell you that it's an autoimmune thyroid condition, and they'll say your immune system is attacking your thyroid gland and that it's some very neatly packaged diagnosis. It's freaking wrong. It's freaking wrong.

Here's what Graves is actually at the biological level. It's a systemic inflammatory cascade originating from the breakdown. Follow me. From the breakdown in immune tolerance that manifests as a thyroid-targeted antibody production. Period. Let me break it down in a way that actually makes sense. So you guys actually know this. Your immune system has this wicked feature. It's called immune tolerance. It's the ability to distinguish between self and other, like self and non-self, right? This is maintained by a population of T cells called regulatory T cells. T-regs. I talk about these all the time. These are your immune system's peacekeepers. Their entire job is to prevent their immune system, yours, from beating you to death.

Here's the thing, and this is critical. T-regs don't work by themselves, and they don't work all isolated. They're like security guards in an airport. You can't have a guard securing the entire terminal. You need all of them working in concert all over the place. So, when we look at Graves patients, research by Tor in 2002 that is published in the Journal of Immunology revealed something absolutely critical. Follow me on this. Graves patients don't have thyroid-specific immune problems. They have a global regulatory T-cell dysfunction. Their T-regs aren't working properly across the entire immune system. Okay?

So, that being said, then that makes this the entire foundation. Agreed? Because this is where you need to start looking instead of just the issue with modern medicine is it's unwilling to admit that it's wrong because everybody's got their dick tied in a knot or their boobs tied up trying to get on somebody's case or trying to complain about it or trying to discredit somebody else because they want to be right. It's not about being right. It's about looking at biology and solving the problem. I come out here for free. I don't none of you guys pay me. None of you. And my marketing here, I'll help you. You ready? I'm going to market to you right now. You ready? Buckle up. This is going to be it's going to be rough.

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The only person I've ever marketed for on this show ever, I think, has been I think has been Bedros Keuilian. I said, "You want to build a monster business? You need to hire him." Period. He will, if you listen to what he says, he will make you he'll put a he'll put a B in front of that illionaire. I promise.

So, look, you got to understand, if you if just that being said, if you fix the thyroid, but you don't fix the T-reg function, remember what I said, it's a systemic global T-reg problem. It's not a thyroid problem. But if you fix the thyroid, but don't fix the immune issue, you've fixed precisely squat. You've turned off an alarm on a building, excuse me, on a building that's still on fire.

So, how about we look at what triggers the T-reg, the breakdown instead, because this is where it gets a little wild. So, the immune system is very intelligent. It's like I almost said the Pentagon, but I think that's an oxymoron. So, I before you guys get mad, stop it. Just let me talk. It's a very organized operation. You've got you've got immune soldiers, T-C cells, B cells, macrophages, but the problem is who's commanding those soldiers? Who's telling them where to go, when to fight, when to stand down? That is something called your neuroimmune axis. Your nervous system and your immune system are married, like they are hardwired together, baby. When your nervous system is in sympathetic overdrive, so that's your fight, flight, or freeze system, your immune regulation goes tits up.

So here's there's more. When your gut bacteria are compromised, your immune tolerances collapse. It's like a house of cards. They're just a disaster. So Graves is what happens when I'll explain. I three metabolic three fundamental metabolic biological failures. But I need to get a little more specific on this one. Complete failure simultaneously. Three of them. You've got a neural immune regulation issue. That's shot. Your intestinal barrier integrity totally compromised. And your metabolic efficiency is tanked. So we've got systemic inflammation, insulin resistance, and an energy problem. This is why I'm trying to tell you the cause of all disease is the same. The presentations are different. But this isn't a thyroid. And please, just listen to me. Which is why you aren't seeing a reduction in disease. Do you know that over the last 60 years that the incidence of Graves disease have gone through the roof? How can it be genetics if that's the case? Oh, I'll prove it. I'm going to piss off all the doctors, all the med students, all the little science nerds because I'm just as nerdy. I just look a lot cooler than you.

This isn't a thyroid disease. It's a metabolic, neurological, immunological crisis that just happens to show itself and express itself through your thyroid. The thyroid is just the messenger that's being shot because nobody's being attentive to what the message actually is. So, look, let's look at what happens when Graves disease takes over your entire biology. Okay, this is important. Like, really talk about it, not the surface-level stuff that your imbecile doctor and your med student buddy told you. Okay, listen to me. This is so important. And I know I'm dogging on people just 'cause I'm really irritated today. But the other side of the equation is because I think it's about time that the medical people were held accountable, not them trying to hold other people accountable to their idiotic dogmatic nonsense that has provided nothing.

So when antibodies start binding to your TSH receptor, that's thyroid-stimulating hormone receptor, you're not just getting increased thyroid hormone. That's the problem. You're triggering this cascading systemic catastrophe. Your entire biology gives you the finger. Your thyroid pumps out T3 and T4. These aren't just energy hormones. I saw that on a commercial the other day. That is pharmaceutical marketing language designed to oversimplify. These are the ultimate control system of cellular metabolism for you ready for this? Every single cell in your body. All of them. It's not that you have some cells that respond and some that don't.

So, here's what happens. T3 comes into the cell, enters the nucleus of your cell. It binds to the thyroid hormone receptors. When you have excess T3, which is what happens in Graves, you're essentially telling every cell in your body to speed up, not optimize, not do better. Hit the fun flipper, full throttle, stomp it into the floor, the gas pedal. Okay, this is really a big deal because your mitochondria, those the nuclear reactors, the powerhouses of your cells, have thyroid hormone receptors in them. So when T3 is high, you're asking your mitochondria to produce more ATP. But here's the issue with that. If your mitochondrial function is already compromised by inflammation and nutrient deficiency, which it is if you've got Graves, just to be clear, which it is, you can't actually produce more ATP efficiently. So you know what happens? Metabolic chaos. Your cells are running at like 4 million% capacity when they can only produce about a 100% output. The gap between demand and supply becomes reactive oxygen species, free radicals, and oxidative stress is exploding through your system like this fire tearing through a warehouse.

Meanwhile, your cardiovascular system is going nuts. T3 increases what are called beta-adrenergic receptors and it increases their sensitivity. So basically, it makes your cells more responsive to something you don't want them more responsive to in this moment, adrenaline. So now your heart, your tachycardic, so your heart's racing, your blood pressure is through the roof, and your blood vessels are constricted. But here's what most people don't understand. This isn't just uncomfortable for somebody with Graves. This is creating a state of chronic sympathetic activation. Your nervous system thinks it's under threat 24/7, 365. And when your nervous system is in that state, listen to me, your parasympathetic nervous system, the rest and digest, the one that's supposed to calm your butt down, the one that controls your immune regulation, digestion, healing, yeah, it's completely suppressed. How can you function? Your GI tract, gastrointestinal tract, starts shutting down. You know why Graves patients, by the way, have insanely horrific digestion? It's not the thyroid hormone directly. It's that the thyroid hormone is keeping your nervous system in fight or flight, which literally diverts blood away from your digestive system.

Your intestinal barriers start breaking down. So, when your gut isn't getting the proper blood flow and you're in sympathetic overdrive, the tight junctions, the connections between your intestinal walls become permeable. This is what we call leaky gut, but it's a real thing. Just before somebody, "Oh, it's psychological." No, it's real. It's absolutely critical actually to understanding how Graves works. And I explained it on my post, but I'll explain it here. There's research by Visser in 2012 in Nature Reviews Endocrinology showed that thyroid hormone resistance, which is what happens when your cells can't respond properly to thyroid hormone. Remember insulin resistance, same thing, right? Your cells can't. The problem isn't the hormone, the problem is the cell that needs to respond, the receptor on the cell. That's what I need you guys to understand. So this is what happens, right? You can't become thyroid resistant. So your cells don't respond properly to thyroid hormone. Is actually this is what he found though. Found it was a protective mechanism when your mitochondria are dysfunctional. It's doing it to save your butt. So let me translate what this means. Your body is literally trying to protect itself from excess thyroid hormone because your cells can't handle the metabolic demand. It's not a that's not a disease. That's your body going, "Please, can you can somebody pay attention to me? Can you listen to the signal? Can you help me?" But we're so busy taking medications and running this indoctrinated mindset about what health really is that we think it's an absent if it's not FDA approved or it doesn't have a rubber stamp on it from some knucklehead medical doctor or that it doesn't come from a box in your pharmaceutical aisle that the problem it doesn't exist or it's a voodoo foofy answer. That's not even accurate. Grandma knew more about healthcare than most of the doctors right now. Look at what I and you know I'm right. You know why? And if you go my grandparents died when they were 50. My grandparents lived into their 90s, mid to late 90s. My mom is going to be probably 100 years old. Why? 'Cause my mom's a badass. She doesn't take a lot of junk. She takes care of herself. She walks all the time. My mom is 83 and she's kicking butt and taking names. My mom's awesome. Hey, but there's a reason because she takes care of her system. It's not genetics. My dad passed away 14 years ago because he didn't take care of his biology. You have to understand epigenetics versus genetics. What are you doing to your system? You guys, please listen to me. I don't come out here for me. I come out here 'cause I whether you get it or not. This is real genuine tough love because I love you enough to tell you the truth. So you guys should be spreading this to everybody. Like I I should your job honestly. You want to know what your job is listening to me? I don't care if the 5,000, 10,000, 20,000, 100,000 people listen to this. Your job is to get one person. Each of you guys call it one more. So my what's my preacher Josh How calls it? One more. Get one more person to subscribe to my channel. Why? Yes. I don't care about the money. I care that people get this information. Get why you get them to subscribe so they actually see the stuff that comes out or turn on some notification if it exists. I have no idea. But something send them to my Instagram. Send them to my Rumble. You guys, I'm going to set up a newsletter just so you have information. And you know what the marketing is going to be? You ready? You ready? It's going to be a link to Elite Biogenics. Oh, no. Marketing my own company. That's not why I'm doing it. And it's going to be an email to work with me. And that's it. God, the catastrophe of me marketing to you guys. You know how many ads I've run for either one of my companies? Zero. Before you say, "I get your Facebook ads." Those are for a free webinar. And I've got people that show up to that friggin webinar who've never bought anything from me. They've been coming for 3 months. They've never bought anything. They use all my [ __ ] for free. So save it. And I show up. I started it on Super Bowl weekend last year and there was nobody in my call and I did the entire thing anyway and I have never missed. That's not true. I missed one. I missed one because I didn't have a choice 'cause I was in the hospital so I didn't have a choice. I never miss because I care enough to not miss about you, not me. So understand and now I get 200, 300 people at the call every Sunday at 4:00 Central. So if you want to come, just come. The link is in my Instagram. You want me to put it in my YouTube? I'll put it on my YouTube. Just show up. Do I think you should buy something? Yeah, I think you I only have one product. The Black Card or buying from Elite. I don't care if you do or you don't though. But I'm saying that's it. But do I think you should? Yeah, because you get somebody. You know what the Black Card is? Just you know, before you're like, "I don't even know what that is." You get access to my live Q&A call every Monday. You get access to the VIP community where you actually get to ask me questions and I'll solve your freaking health problem for real. You don't have to wait 2 years to get an MRI, right? And you can actually interact with me and you get my protocol library that actually works. So, you decide what you want to do with it. I just give you the I lay it out for you to play it out, right? Your body's trying to protect you from the problem so you don't trash yourselves even more. You know that your biology is smarter than you, right? Like it knows what it's doing. Smarter than your conscious mind.

And look at So, here's what happens neurologically. This is a big deal because I just had a Graves patient. I just talked to this lady and we just started working. And if you go, let's track her. Let's make sure it works. Don't even listen. You guys pop Advil knowing full well that white piece of paper says you're going to die when you take it. My dad died of NSAIDs, so let's save it before you go, "I need proof." No, you want a guarantee? I ain't going to give you one 'cause where's the guarantee you're going to give me that you're actually going to do every single thing I give you? You're not.

So look at neurologically your prefrontal cortex, okay? The part of your brain that does rational thinking, emotional regulation, executive function, right? It's bathed in excess catecholamines. Catecholamines are like adrenaline, noradrenaline. You know what that does, by the way, just so you know what that does? It shuts down your prefrontal cortex and hyperactivates your amygdala. You know what your amygdala is? That's your fear center. So now listen, you're not just dealing, this is why it's a big deal. You're not just dealing with a physical illness. You're dealing with anxiety that is absolutely real because your brain chemistry is altered, genuinely altered. You're experiencing panic attacks that medicine classifies, these imbecile medical doctors classify as psychiatric symptoms when they're actually they're not psychiatric. They're actually a direct result of a biological cascade initiated by the TSH receptor antibodies. That's not psychiatric. I have no sympathy. I think psychiatrists are full of [ __ ] anyway, but that's a whole other conversation. This is why Graves patients almost always invariably develop anxiety disorders. It's not in their head. It's called biochemistry.

Listen, here's I'll blow your mind. You ready? Your thyroid gland, it's like the size of a really small butterfly. Weighs about 20 grams. It's one of the smallest organs in your body. But the TSH receptor, the target in Graves disease, exists in at least 30 different tissues throughout all this, baby. Your entire body. Yeah, I know. Wait, what? Yeah, that's right. Your immune system isn't just attacking your thyroid in Graves disease. It's potentially attacking TSH receptors, orbital fibroblasts, which is why Graves patients develop something called exophthalmos, the eye, the bulgy eyes, the eye protrusion. And don't get mad if you have that. Trying to help you. This isn't just cosmetic. It orbital inflammation can cause a whole lot of bad things. One of them is vision loss and the other one is blindness. It's attacking TSH receptors on your skin fibroblasts, which is why Graves dermopathy, that thickened skin, usually on the shins. Like you have to understand, look at how it's presenting, right? Look at how it's presenting. It's attacking TSH receptors on your adipose tissue, your fat cells. TSH receptors regulate fat metabolism and energy expenditure. It's attacking TSH receptors in your bone. TSH receptors on osteoblasts directly regulate bone formation. This is why Graves patients have accelerated bone loss and increased fracture risk. It's attacking the TSH receptors in your skeletal muscle. It's affecting muscle protein synthesis, which is why Graves patients experience muscle weakness and muscle wasting. I could do this all day. It's hitting cardiovascular tissue, affecting heart rate, contractility, ejection fraction, vascular function, and most importantly, just so you know, it's attacking TSH receptors on your immune cells themselves. TSH receptors exist on T-cells and B cells. Remember, I went over this, right? Macrophages, but T-cells and B cells. So when you have antibodies to the TSH receptor, now do you see where I'm going with this? Because it it becomes this feedback loop. You're making this loop where the immune dysregulation becomes self-perpetuating because it's causing the problem and attacking the problem to make more of the problem. And by the way, this is documented very clearly. Ree Smith 2010 published in the Journal of Clinical Investigation. Go. I'm going all out on these research studies. Look them up yourself by the way. Google PubMed. They demonstrated that TSH receptor expression extends far beyond thyroid and antibody binding creates multi-systemic pathology. It's everywhere, baby.

So, Graves isn't just a thyroid problem. It is a multi-system autoimmune disease that happens to have the thyroid in its sights and its primary target because the thyroid has the highest concentration of TSH receptors, but the disease extends throughout your entire body. Yes, I did use the finger guns. Don't worry, you'll get over it. But this is what's even more critical. The actual damage in Graves isn't just from the antibodies. It's from the inflammatory cytokines produced by the immune cells attacking those receptors. So IL6, TNF alpha, IL flooding the hell out of your system. These aren't just inflammatory markers that you see on a blood test. By the way, you got to start looking at your biology different. I'm trying to give you the lesson. These are signaling molecules that affect your blood-brain barrier integrity, your intestinal barrier integrity, your mitochondrial function, your insulin signaling, and your thyroid hormone metabolism itself in all your peripheral tissue. This is a very ugly vicious cycle. The inflammation caused by the immune attack increases intestinal permeability, which increases bacterial lipopolysaccharide translocation. So it dumps into your bloodstream the gram-negative fragments, which triggers more immune activation, which produces more inflammatory cytokines. That's why Graves is often called an autoimmune disease. That's a misnomer. It's an absolute misnomer. It's not that your immune system is broken and attacking you randomly. It's that your immune system is responding to an actual threat. Usually some combination of molecular mimicry where a pathogen shares epitopes with your TSH receptor, dysbiosis where pathogenic bacteria are triggering constant immune activation, intestinal barrier breakdown, allowing bacterial antigens into systemic circulation, right? LPS, chronic infections like Epstein-Barr, by the way, like crazy, or nutritional deficiencies. This is what I talked about with the mitochondria, inflammation, nutritional deficiencies 100% of the time, which compromises all of these compromise immune regulation. Your immune system, to be honest, you guys, is doing exactly what it's supposed to do. It's responding to a threat. The problem is that the threat is creating collateral damage across everything, all organ systems, your whole system.

I'm going to hit you with something that's going to piss off every doctor, every med student, and everyone that's ignorant still making reaction videos about me. Graves is not genetic. Not even close. I'll prove it. And before you flip out, yes, there are genetic predispositions, but genetic predisposition is not the same as genetic determination, is it? Yes, this is critical. There are Look, there I'll just I'll lay it out. There are specific HLA alleles, right off of the right HLA alleles, particularly I'll even tell you what they are, HLA-DR3 and HLA-DQ2, that increase ability to Graves. If you have those alleles, your risk is elevated. But elevated risk isn't destiny. Human beings have proved that since we've been on this planet. Here's what most medical schools get wrong. They, and I took a lot of genetics, just so you know, so I know what I'm talking about. They teach that genetics loads the gun, but environment pulls the trigger. Nope. Genetics loads the gun, but environment pulls the trigger, aims it, and pulls it again, and aims it, pulls it again, aims it, pulls it again. The expression of autoimmune disease is determined by epigenetics. How your environment and stress, your train wreck diet, chronic infections, lifestyle choices are controlling which genes get turned on and which ones get turned off.

Pullman did a study in 1992 on identical twins. Just so you know, these are people with identical genetics, perfectly across the board. What they found was absolutely revealing. If one twin had Graves disease, the other twin only had it about 50% of the time. So that means your genetics are literally a You ever take statistics? It's like a coin flip. Your environment is what determines which side the damn coin lands on. And more recently, even we can even go more just go up the calendar a little bit. Tor 2005 in the Journal of Immunology showed that Graves disease involves multiple genetic loci and that the penetrance, that means the likelihood of having the gene leads to disease, is surprisingly low.

Here's what really breaks the genetic narrative though. This is what I was talking about earlier. Graves disease rates have increased exponentially in the last 60 years. Your genetics haven't changed in the 60 years. Don't tell me they have. No, they haven't. But your environment sure the hell hasn't it, baby. Your environment is a train wreck. What's changed in the past six decades? Let's take a look. Let's see. The food supply has become industrialized, stripped of nutrients, and filled with inflammatory seed oils and refined carbohydrates. Stress levels have skyrocketed with the constant stimulation of digital technology. Even this thing I'm on right now. Sleep patterns are disrupted by artificial light, constant connectivity. You just never turn it off. Antibiotic use is ridiculous. It's destroyed your microbiome through repeated courses for minor infections that probably were viral and would have been self-resolving anyway. You guys jump on antibiotics when you hear a loud noise. "Oh, it hurt my feelings. I need antibiotics." Like, you guys are weird. Chronic infections have multiplied through exposure to modern pathogens and reactivation of latent viruses like Epstein-Barr, for example. Nutrient density has plummeted as food has become incredibly processed. It's disgusting. You don't need 80 ingredients for a loaf of bread. My wife makes bread. It's got four ingredients. I could eat the bread all the time. There's no such thing as a gluten problem or celiac issues. Those are because you're eating crap. I can go over those too line by line if you want and prove it. Your light exposure has become completely unnatural, light at night, which suppresses melatonin. And life. So you sit on your butt all the time. You desk jobs and playing video games and staring at your phone. I watched a lady walk across the parking lot right in front of our car yesterday when we were at jiu-jitsu. This big fat tank of a woman on her phone totally disregarding the car and then just shot my wife a look. I'm like, "Are you kidding? You wouldn't be able to get out of the way of the vehicle even if you tried."

If Graves were genetic, listen to me. If Graves were genetic, we'd expect it to be relatively stable in the population. Instead, it's going through the roof. It's skyrocketing. And by the way, in women particularly, it's increasing in men, but in women, huh? The genetic version of Graves, let me explain. Here's what it looks like. You have the HLA Darth Ail. So you'll probably get Graves sometime in your life. That's a presumptive close in sales, by the way, which are most medical doctors. I need to sell you to believe that the poison that I'm going to give you and the [ __ ] I'm going to tell you is actually real. I am not trying to sell you anything. I'm not not at all. But here's what we actually this is what I actually see clinically with real patients. This is what I see. You have the HLA-DR3 allele, but you'll only get Graves if you have at the same time dysbiosis, intestinal permeability, chronic Epstein-Barr infection, iodine excess, selenium deficiency, massive nutrient deficiency, and chronic stress that's tearing your system apart. That's called epigenetics. That's the environment that overrides genetics. And here's the most important part. If your environment caused the disease, your environment can solve the disease. You can't change your genes. No, you cannot. But you can change your microbiome, restore the intestinal barrier, you can resolve chronic infections, you can restore nutrient status, you can reduce inflammatory states in your body all day long. And when you do those things, the genetic predisposition becomes completely irrelevant. The gene is loaded, but the environment no longer pulls the friggin trigger.

That just makes me crazy. Look at the nervous system. It's the most overlooked system in Graves disease, and it's absolutely critical to understanding even how this disease actually develops. Let me explain the neuroimmune axis in a way that actually just makes sense so you get it. Okay, your autonomic nervous system has two branches. Sympathetic, which is fight, flight, or freeze, and parasympathetic, which is your rest and digest. Remember, I told you this already. So, the vagus nerve, really long, longest in the body, is this two-way communication highway between your brain and your immune system. It's not just carrying signals one direction, right? It's this constant dialogue where inflammation flows continuously both directions. When your vagus nerve is functioning correctly, it's sending a signal to immune cells. "Hey, we're safe. You can relax. You don't need to be on high alert. Put the guns back in their holsters." This signal is carried through vagal neurons that release acetylcholine, which binds the alpha-7 nicotinic acetylcholine receptor. Yeah, you know where I'm going with this thing, but it's not what you want to use in the way you think. So, just listen. It binds this receptor on macrophages and immune cells. It's called the cholinergic anti-inflammatory pathway, and it's fundamental to immune homeostasis. When this pathway is working, your immune system remains regulated. T-regs are functioning. Inflammatory response is proportional and adequate and running the way it's supposed to. It's very controlled.

But when the vagal tone is low, which happens with chronic stress, poor sleep, infections, dysbiosis, this anti-inflammatory signal is weak or absent altogether and the system goes haywire. Tracy in 2002 in Nature showed that vagal stimulation directly suppresses TNF production. This is a fundamental biological principle. Your nervous system controls your immune response. It's not an option. It's not like you can decide not to use it. It's hardwired into your physiology.

So in Graves disease, what the frack is happening? The antibodies are binding to TSH receptors. I told you this already, which is creating an inflammatory cascade. But what allowed those antibodies to be created in the first place? A breakdown in immune regulation, and that breakdown in immune regulation is directly linked to low vagus tone, which is linked to chronic sympathetic activation. Oh, the Graves patient is literally in this state of chronic fight or flight or freeze. Their amygdala, remember what I told you, the fear center, the threat detection is hyperactive. Prefrontal cortex is turned off. The vagus nerve is barely firing. It's weak. This creates the self-perpetuating cycle. Low vagal tone, poor immune regulation, immune dysregulation, TSH receptor antibodies, excessive thyroid hormone, increased sympathetic activation, and even lower vagus tone. It just goes in this ugly circle. The thyroid hormone is making the sympathetic overdrive worse, which is making the immune dysregulation worse, which is causing more antibody production. Mic drop.

But here's what's critical. The initial trigger was neurological. The initial breakdown in immune tolerance wasn't due to the thyroid hormone. It was due to the autonomic dysfunction that preceded it. This is why Graves patients report their disease started during a period of massive stress, after an infection, or after some crazy major life event. You know what these all are? I'll help you. Vagal tone suppressors. Trace it back to what it is. But nobody's looking for the cause. They call it idiopathic. That means "we're idiots and we don't know what caused it." I'll never say that.

So when you treat the thyroid hormone, whether with beta-blockers, anti-thyroid drugs, radioactive iodine, or surgery, you're not addressing the vagal tone. You're not restoring immune regulation. You're just turning down the volume on the end product. It's not doing anything. It's not helping at all. Meanwhile, the underlying autonomic dysfunction persists and gets worse. I got to drink some coffee. Listen, it doesn't even make sense to me.

Look at your GI tract, okay? Your intestines are like ground zero for autoimmune disease all the time. This is where Graves really gets interesting from a mechanistic standpoint. Follow me. The intestinal tract has a single layer of epithelial cells, just one cell thick. It separates your bloodstream from the nasty contents of your gut. No, it's not clean. It's gross. If that barrier breaks down, pathogens and bacterial antigens get into your systemic circulation and trigger immune activation. This is called intestinal permeability, leaky gut. It's the foundation of you ready for this? Every single autoimmune disease. What maintains the the intestinal barrier integrity? You ready? Tight junction proteins, specifically claudins, occludin, which are held together by zonula occludens proteins, Z1 being the most important one. I guess it really doesn't matter. These proteins form seals between adjacent epithelial cells. What regulates these tight protein junctions? Thyroid hormone, zonulin, the composition of your gut microbiome, and your autonomic nervous system. Do you see how this works? And which one I said first?

Here's where it gets really wild for Graves. Patients with Graves disease show significantly increased intestinal permeability compared to healthy controls, documented by Visser in 2011 in Archives of Internal Medicine. But here's a critical question that doctors never ask. This is why you need to ask me questions. I try my best to answer everybody, but I get about 10,000 emails at least a day. Did the Graves disease cause the intestinal permeability or did the intestinal permeability cause the Graves disease? The answer is both. Yeah, you weren't expecting that, right? You were okay. Wait, which one is it, Dr. T? Okay, it's in a vicious cycle. But the intestinal permeability problem usually comes first, easily 90, 95% of the time. Here's why. Your microbiome is responsible for maintaining tight junction integrity through short-chain fatty acid production, specifically butyrate. Your beneficial bacteria ferment dietary fiber. They produce these essential metabolites. They're also educating your immune system through antigen presentation to your gut-associated lymphoid tissue, competing with pathogenic bacteria for resources and producing neuroendocrine signaling molecules that affect your brain and your immune system. Watch. So when your gut like when your microbiome is dysbiotic, when you've had repeated antibiotic courses, screws you up, man. When you've eaten a diet high in processed foods, no fiber, when you're chronically strung out of your mind, your beneficial bacteria flip you off and die. Okay? They're replaced by gram-negative pathogens for the most part. Now, gram-negative bacteria have lipopolysaccharides in their cell wall. LPS is an extremely powerful immune stimulant for a reason. I won't get into it, but it very much. It binds to TLR4, Toll-like receptor 4 receptors on your intestinal epithelial cells and your macrophages. Remember T-cells, B-cells, macrophages. Picking up what I'm putting down. So when your intestinal barrier is compromised, this LPS translocates into your bloodstream. Your immune system detects this as a massive existential threat, like me to the medical industrial complex. This is called metabolic endotoxemia, and it is documented very well. Cani 2007 in Diabetes showed that chronic lipopolysaccharide translocation creates a state of chronic low-grade inflammation that is distinct from acute inflammation. It's constant. It's absolutely relentless and it's extremely damaging. Your immune system is now in constant activation mode. Your T-regs are being overwhelmed trying to manage this constant inflammatory signal. Meanwhile, your dysbiotic gut microbiome is also producing metabolites that suppress T-reg differentiation. Specifically, reduced butyrate production means reduced HDAC inhibition, which means reduced FOX P3 expression, which means fewer T-regs being generated. That's it. So, your peacekeepers don't have the army. So, now in your dysbiotic state, you've also got pathogenic bacteria that express antigens that are structurally, follow me, this is mimicry, structurally similar to TSH receptor. This is molecular mimicry. Your immune system makes antibodies to these bacterial antigens, right? And those antibodies cross-react with your TSH receptor. Learner, this is documented really well. Learner 2015, Frontiers in Immunology, they identified specific bacterial antigens that cross-react with thyroid peroxidase and thyroglobulin. So watch, here's I'll give you the sequence just so you have it. Let me lay it out. This is the sequence. Dysbiosis, intestinal barrier breakdown, then lipopolysaccharide translocation migrates into the bloodstream, chronic immune activation, reduced T-reg differentiation, molecular mimicry with pathogenic bacteria, TSH receptor antibodies, Graves disease. The thyroid isn't the problem. It is the last domino to fall in a line of dominoes that started falling in your gut.

Your endocrine system is a disaster. And it's this wonderful piece of equipment that keeps you it keeps you alive in ways you can't even comprehend. In Graves disease, the entire thing is shredded. Let's start with the HPA axis, the hypothalamic-pituitary-adrenal axis. This is your control system. This for stress response, right? It coordinates your entire hormonal response to threats and challenges, etc. So when you're stressed out, which modern men and women are, either acute stress or chronic stress, whatever it is, your hypothalamus, your hypothalamus releases CRH, which stimulates your pituitary to release ACTH, which stimulates your adrenals to release the one thing you don't want them to do in this particular moment in time, which is cortisol. Cortisol is your anti-inflammatory hormone, and at the right levels, essential for immune regulation and T-reg function. But here's the thing. If you're chronically strung out, and Graves patients are 100%, whether they realize it or not, just so you know, your cortisol levels become dysregulated. You might see high cortisol early in the day, but then rapid depletion, flattened cortisol curves throughout the day, so it just becomes neutral, or you get this nocturnal cortisol elevation that trashes your sleep. When cortisol is dysregulated, your immune system regulation goes crazy. T-regs can't function properly without adequate cortisol signaling in any case, not even just Graves. Remember this. And just so you know, this is demonstrated a 2011 in Brain Behavior and Immunity. Prove this.

Meanwhile, your thyroid hormone is creating additional endocrine chaos throughout your entire system. Thyroid hormone affects sex hormone metabolism. It regulates sex hormone-binding globulin, SHBG. When thyroid hormone is reg is elevated, SHBG increases, which reduces free estrogen and free testosterone. But here's what's crucial. Estrogen actually plays a role in T-reg differentiation. It also affects your insulin sensitivity. Thyroid hormone increases insulin receptor sensitivity at the cellular level, but only if your mitochondria are functioning properly. If they're not, which they usually aren't in Graves patients, I've never seen them function properly, you get paradoxical insulin resistance despite high thyroid hormone. It affects your appetite hormones, leptin and ghrelin. Thyroid hormone affects these signals, which affects your metabolic rate, which affects your energy balance, which affects your immune function. So now you have chronic non-stop infections. And here's something absolutely critical that almost never gets discussed in medical school. The relationship between thyroid hormone, estrogen, and autoimmune disease. It ticks me off, man. 'Cause they're creating a bunch of drug pushers, pharmaceutical reps that have a very expensive education that taught them two things: Jack and [ __ ] and Jack left town. I am here to help you 'cause I love you. The end.

There is a reason autoimmune diseases are about 10 times more common in women than in men. And it's not because women are genetically weaker, before somebody misreads what I said. It's because estrogen is an immune enhancer. Estrogen, you follow me on this one. Estrogen upregulates B-cell activation and antibody production. This is actually immunologically correct. It's preparing a woman's immune system for a pregnancy where she'll need to tolerate a semi-allergenic fetus while still maintaining immune competence. You want the basic English? It tolerates a parasite. Don't get grossed out. That's just the way it is. It's a foreign body that your body's Oh, I got to make sure it's If you don't understand how wickedly smart your biology is yet, then I've taught you nothing. You need to look at what God built, man. We did not come from a big bang. But here's the thing with estrogen also upregulates T-reg differentiation. So the immune enhancement is balanced by immune tolerance. Okay. The problem in Graves is that this balance has been disrupted. When here's what happens in the dis the dysbiotic microbiome can't process estrogen properly. So the estrobolome, the the collection of bacteria that manage estrogen metabolism, is extremely compromised. Hold on. But this leads to where was I? The estrogen metabolism, right? It's compromised. So, this is going to this is going to lead to estrogen recirculation and elevated circulating estrogen. Elevated estrogen. Follow me on this. Combined with dysregulated thyroid hormone creates maximal B-cell activation and antibody production. That's not what you want right now. This is documented by the documented by the way. Pione 2013 Autoimmunity Reviews. They showed that estrogen levels correlate with autoimmune disease severity in women.

So in Graves disease in women, you have a triple hit. This is the problem. A dysregulated HPA axis leading to low cortisol and impaired T-reg function, dysbiotic microbiome leading to estrogen dysmetabolism and high estrogen, which is what I just talked about, driving B-cell activation, and elevated thyroid hormone further amplifying your immune activation. This is why women are hit so much harder. When I see men and I see women with this, it you're not even in the same league. Which is why I also say women are so much tougher than men. They get hit so much harder by Graves disease. Their endocrine system is being attacked from every possible angle all at the same time.

Look at Graves in your immune system. Okay, so let's this is the actual let me let me go over the actual immune failure in Graves disease because this is where biology gets to me fascinating. Your immune system has B cells and T cells. B cells make antibodies. T cells coordinate the immune response and kill infected cells. Okay, so now you understand the difference. In Graves disease, you have pathogenic B cells that are making antibodies against your TSH receptor. But here's the critical question. Why didn't your T-regs kill these B cells? T-regs are supposed to suppress self-reactive B cells before they become a problem, right? Thymus, the education, the boot camp. The answer is that your T-reg function is compromised at a fundamental level. Watch this. T-regs are created in your thymus through a process that requires involution being balanced with new T-reg generation. So IL2 signaling, I've talked I did I talked about this really hard the other day. IL2 signaling, which depends on proper nutrient status, which means if you're eating like an [ __ ] you're causing a lot of problems. You're setting yourself up for failure if you have a genetic predisposition. Okay. TGF-beta signaling, which requires a healthy microbiome, your gut, and proper vitamin D and TCR stimulation by dendritic cells presenting antigen with proper co-stimulation. Now in Graves disease patients, what we see is that T-regs are either numerically reduced or functionally impaired. Usually, it's both. Tor 2003, the Journal of Clinical Endocrinology and Metabolism showed that Graves patients have reduced numbers of CD4 and CD25 T-regs and that their T-regs have impaired suppressive capacity even when they're there. This is the lynchpin. This is like that's you get this right. This is the key. This is where the disease actually originates. What causes the T-reg dysfunction? Chronic inflammation. So when you're chron, this is so important to get, when you're chronically inflamed from dysbiosis, from lipopolysaccharide translocation into your bloodstream, from chronic infection. Your immune system is in full throttle activation mode 24/7. In this state, T-regs can't differentiate properly. It's not possible. You need a calm immune environment for T-regs to develop and function. I've talked about this before. Nutrient deficiency. Okay, T-regs require vitamins A, D, and E for proper function. They're they require adequate zinc. They

Require adequate selenium. Most Graves patients are deficient in almost all of these. This isn't accidental. The disbiotic state and intestinal permeability prevents proper nutrient absorption. That's the problem.

Look at the disbiotic microbiome. Specific commensal specific bacteria produce metabolites that differentiate T-regs to produce butyrate. When these bacteria are depleted, T-reg differentiation tanks. Adarashi in 2013 in Immunity proved this entire concept.

Look at chronic infection. What did I mention? Epstein Barr virus. It's present in almost a high percentage, 85% plus, of Graves patients. EBV infects B cells and drives autoreactive B cell proliferation, makes more of them. This is a direct driver of TSH receptor antibody production.

Intestinal barrier dysfunction. When your intestinal barrier is compromised, you get constant immune activation from microbial products. This prevents all proper T-reg differentiation.

Once this T-reg dysfunction is established, what happens? Okay, so look, your CD4 helper cells aren't being properly regulated. Specifically, the TH7, I talked about this, TH1, TH2, TH7. Your specifically your TH7 cells, which produce IL17, are proliferating unchecked. They've got no limiter. TH7 cells, pro-inflammatory cells that drive antibody production. They produce IL17, IL6, and my favorite, TNF alpha, for the win. Your TH1 cells, which produce IFN gamma, also activated. Your B cells are activated by these T-helper cells and start producing antibodies against your TSH receptor.

When these antibodies bind to the TSH receptor, they activate the classical complement pathway. Your complement system, which is part of your innate immune system, floods in and creates C3A, C5A, which are powerful inflammatory mediators. These bring in neutrophils and macrophages which release TNF alpha and IL6 which drives B cell activation even further and a whole bunch more antibody production. It's a positive feedback loop. It's a problem. This is this ugly cycle I keep telling you about. The antibodies create the inflammation which drives more B cell activation which creates more antibodies. The only way to break this loop is to restore immune tolerance by restoring T-reg function. Man, am I tired of being right.

Look, current treatment is a disaster for this. The three, I'll give you three, three main medical treatments that I see and I'll be honest about what they do and what they don't do.

Beta blockers. Okay. Your doctor prescribed a beta blocker, usually propranolol, to manage heart rate and reduce anxiety, which I explained why it's happening right through the roof. Okay. Makes sense on the surface because it addresses the sympathetic overdrive symptoms. The problem is that beta blockers are only treating the sympathetic overdrive symptom. How are they treating the disease? Just how are they treating the disease? That's saying my brakes are squeaking. Turn up the radio. It got rid of the squeaking brakes because you can't hear them.

And more problematically, just, you know, the beta blockers are making the disease worse. Here's why. Beta blockers suppress your parasympathetic activation. Your parasympathetic nervous system is responsible for immune regulation. When you block sympathetic signaling, you're actually supposed to allow parasympathetic signaling to come back online. But that's not what happens with a beta blocker. You're creating a state of artificial parasympathetic suppression on top of your already suppressed parasympathetic tone. Right? Vagal tone is trashed. You know what this does? It worsens immune dysregulation because you're removing the anti-inflammatory signal from that vagus nerve.

It does more. Beta blockers impair your ability to exercise. Further worsens mitochondrial function and immune regulation. Exercise, just so you know, is crucial for immune tolerance development. Critical by blocking your cardiovascular response because it can't. This is why people in the Olympics that do all kinds of events, they get tested for beta blockers. Oh, I don't know if you knew that or not. But here's the problem. If you're blocking the cardiovascular response, you're preventing this essential adaptation. The only reason I brought up the Olympic thing is because it's going on right now. Can't believe they ran out of condoms. Huh? I think that's made up. But here, more importantly, and if you don't know what I'm talking about, don't worry about it. Let it go.

Propranolol has a side effect that almost nobody talks about. You ready? This is my favorite one because it makes me laugh. When you hear this, you're going to go, "What the f?" It impairs thyroid hormone conversion from T4 to T3 in peripheral tissues. Make it make sense. It's proven, by the way. It inhibits 5DS, the enzyme that converts T4 to T3. So, while you're taking this to manage Graves, you're creating an artificial hypothyroid state in your peripheral tissues. Now, it's actually beneficial short-term because it reduces some of the thyroid hormone effects. Long-term, it's worsening your metabolic function and your cellular bioenergetics. Beta blockers also cause weight gain, fatigue, erectile dysfunction, depression, exercise intolerance, and worsening insulin sensitivity. There's a whole pile of problems. All of these side effects are making your metabolic state worse and your immune dysregulation persist unaddressed.

Antithyroid drugs, okay, these are bad. PTU. These drugs work by inhibiting thyroid peroxidase, the enzyme required for thyroid hormone synthesis. They reduce thyroid hormone production. Okay, so this is you look at cholesterol drugs and they reduce your ability to produce cholesterol, which is what pretty much everything in your body is based on. Got it? It's making a lab number look good. You seeing the similarities here? Same with metformin. Makes a lab number look good. It doesn't solve the insulin resistance. It just makes your HbA1c look better. What about your HOMA? So, look at this. Sounds reasonable. The antithyroid drugs sound reasonable. Here's the problem. They don't address the immune dysregulation whatsoever. Your immune system is still cranking out TSH receptor antibodies. Your T-regs are still dysfunctional. Your microbiome is still disbiotic. Your intestinal barrier is still full of holes. All you're doing is turning down the volume on the end product.

And here's where, listen, here's where it gets genuinely dangerous. PTU causes agranulocytosis, the near complete loss of white blood cells. Now, this doesn't happen in everybody, but it happens in about half a percent of patients. I'm not willing to take that risk when this is solvable because when it happens, it's catastrophic. You're essentially immunosuppressed and can die from the sniffles. PTU is hepatotoxic. Acute liver failure from PTU requiring a transplant. PTU causes hypothyroidism when your dosing is right, which is opposite of what you had before. Hypothyroidism is inflammatory. It worsens your metabolic state and your mitochondrial function. It puts you at autoimmune risk because now you're creating a pro-inflammatory state which worsens the conditions that allow autoimmune disease to develop in the first, in the first place.

Sometimes when I talk about this stuff and I think anybody ever saying anything about peptides or supplements, provided they're decent, like I don't know, some of these shills, these soccer moms selling stuff out of their basement, going, "And all you medical doctors and you med students and all you scientists pushing chemistry [ __ ] is wrong with you, man? You guys are hurting people. You damn well know it too. And if you don't, you're just as ignorant as Big Pharma."

Here, here's the critical part about PTU. If you stop it, the Graves disease comes ripping back. The relapse rate after stopping PTU is about 50% at year one. Why? Let's see. Because you never treated the actual disease. You suppress the symptom. How is that a, how is that managing? Wait, it is. It's managed decline. Go figure. This stuff gets me so mad.

How about radioactive iodine ablation? Oh, this is fun. This is where it gets really problematic. Your doctor gives you radioactive iodine, concentrates right here. This is where your thyroid is. Hits you right here. It destroys your thyroid tissue. Congratulations. You've destroyed the target organ of the autoimmune response. Cool. Now, what happens? Okay. First, you immediately become hypothyroid because you no longer have a functioning thyroid. So, now you need thyroid replacement therapy for life. Managed decline, baby.

But here's what's critical. The autoimmune disease doesn't go away. Hey, your immune system still has dysregulated T-regs because you didn't solve the problem. Your microbiome is still disbiotic. Your intestinal barrier is still filled with holes. It's still permeable. Your inflammatory state is still unabated. So, what does your immune system attack next? Some patients develop autoimmune responses against other tissues or Graves ophthalmopathy after RAI even if they didn't have it before. The orbital inflammation continues, gets worse because the immune dysregulation is still there.

Here it gets even better. Radioactive iodine causes immediate post-ablation thyroiditis and flare of Graves symptoms as the thyroid is destroyed and the thyroid antigens are dumped into circulation. So you get an immediate worsening before improvement. Don't worry, it'll get worse, but we'll manage that with some more drugs. And here, most importantly, listen, the thyroid replacement therapy you'll need for life is a crude approximation of your actual physiological dose that your own thyroid produces. You're replacing a dynamic, self-regulating system with a fixed dose of synthetic hormone. This creates its own problems within the thyroid hormone issue because you get thyroid hormone resistance, inadequate conversion of T4 to T3. You with me so far?

How about a unified problem with all three approaches? None of them actually address the actual disease. They treat the symptom while leaving the disease intact. All three approaches assume the thyroid is the problem. I've already proven that it's not. The thyroid is not the problem. The immune dysregulation is the problem. Dysbiosis is the problem. Intestinal permeability is the freaking problem. Mitochondrial dysfunction is the freaking problem. Listening to what I tell you is not the problem. Listening to what every medical shill has to tell you is the problem. Listening to med students and PhDs and medical doctors who have no interest in actually helping you because they're so inflated with their ego. That's the problem. I'm not selling you anything. So until you address the real problems I just talked about, the disease persists even after you've removed the target organ or suppressed its function. It's been proven.

Listen, Graves is reversible. And this is going to make a bunch of doctors and med students really pissed off. Good. Completely reversible. Not manageable or treatable or whatever it is you want to cover it up with and go, "reversible." And I'm not saying this because I'm some optimist because I'm a grumpy old man. I'm saying it, and I'm not giving you false hope either. The problem isn't with what I give you, you guys. The problem is with what you do with it. I'm saying this because it's supported by the biology and data and everything about how a human being works.

So let me explain the pathway to recovery by understanding how the disease is even developed. Okay. So Graves disease develops through, I'm going to run this sequence, and I did this on my post because I want you to understand it. It's really important. It develops through the following sequence. So there's this initial insult that disrupts vagal tone and your autonomic balance. So infection, traumatic event, whatever. Low vagal tone prevents T-reg differentiation and maturation. Now your microbiome becomes disbiotic from disregulated immune signaling. Dysbiosis causes intestinal barrier breakdown. Intestinal barrier breakdown causes lipopolysaccharide translocation. It dumps into your bloodstream. Lipopolysaccharide translocation drives chronic immune activation. Chronic immune activation prevents T-reg function. Without T-regs, pathogenic B cells, which I just explained in this podcast, proliferate. These B cells make TSH receptor antibodies. Now those TSH receptor antibodies activate your thyroid causing Graves disease. Each step is a consequence of the previous step, which means if you reverse the pathway, you reverse the disease.

By the way, the reversal pathway requires systematic restoration of autonomic balance, vagal tone through stress reduction, sleep, breathing practices, cold, vagal tone exercises, a bunch of things. When you restore, and I'll just put, listen, I'm going to put the research if you guys go, "Your research isn't really research." You're right. Absolutely. You know what it is? It's given in a way that I can actually give it to you without running into all kinds of problems of censorship. Do you ever think of that? I'm out here trying to help you and giving you stuff that, according to the world, you shouldn't be able to give that to somebody. Dr. Trevor, are you out of your mind? Giving somebody the answer is not something you can do. Holy [ __ ] that better piss you off as much as it pisses me off.

When you restore vagal tone, you reactivate the cholinergic anti-inflammatory pathway. Your immune system receives the signal that it's safe. Okay. I, there's a whole bunch of things to go through that I don't need to go through them. They're going to be on a list. I want to, but I really want to go inside and hang out with my wife. But throughout the entire process that's done with everything, CoQ10, carnitine, peptides, N-acetylcysteine, curcumin, there's so many things. As you go through all this thing, and I don't worry, I'll give it to you. It's all free. I'm not asking you for any money. Your TSH receptor antibodies should be declining throughout this entire thing. And as you restore immune tolerance, as you reduce systemic inflammation, as you restore T-regs, the antibody production slows and eventually stops.

Just by the way, I talk about Mia because she's my personal executive assistant. Let me explain something. She came to me with thyroid problems, massive, 12 years, I believe. I have to, might be misspeaking. It was a long time where the doctor told her, a medical doctor told her that she was going to die if she wasn't on thyroid medication. She's not on a [ __ ] thing anymore. Yeah, I'm gritty and angry today because I'm tired of people throwing stones at me who live in a glass house who couldn't save their mama if they needed to because they drugged them into death. She is crushing it right now. Her husband, we're going to solve that. She's got a great family. She's part of my black card, plus being a badass assistant, plus being a great friend, plus being the moderator. You guys got to understand, man. I do the real thing because I give a [ __ ] about people. You guys need to, I'm not doing this for me. I don't need to do this. I could literally disappear for the rest of my life and my wife and my kids and I would be fine. I don't need any more money. I don't care if people know who I am. I'm a grumpy, gritty 52-year-old doctor who adores his wife and adores his family. I do this for you guys, period. Which on the flip, I would expect from you that you share this and share me with everybody and you go market my channel to everyone so you can be responsible for helping other people instead of some stupid pharmaceutical ad that they spend billions of dollars getting on Super Bowl.

Look, when the TSH receptor, I'll even give you the numbers so you actually understand. When those receptor antibody titers drop below 1.75, that is pretty much guaranteeing clinical remission. But we're not done. When they hit zero, you have immunological recovery. So, as your immune system stops attacking your thyroid and the inflammatory cascade stops and thyroid levels normalize, your TSH normalizes, T4 and T3 normalize, the need for antithyroid drugs disappears. So, you don't need, sure as hell don't need an RAI. You don't need surgery. You need to just live your life. Your thyroid's working. This is supported by so many studies showing that TSH receptor antibody negativity predicts remission. Tor 2005 showed that patients who achieve antibody negativity have a remission rate of well over 80%. Sign me up if I have that problem.

Here's the most important part. The entire process is reversible because every step addressing the biological dysfunction that caused the disease, that's what it's doing. You're not suppressing a symptom. You're actually reversing the damn pathophysiology. Look at the bacteria that was disbiotic become eubiotic again. The intestinal epithelium that was permeable becomes tight again. The immune cells that were dysregulated and going crazy become tolerant again. Remember immune tolerance, immune surveillance, they're all interconnected. Mitochondria that was dysfunctional becomes functional again and it's not running at this over state that's causing your biology to go against you. This is how biology works. Just so you know, biology is reversible. You show it every day. Every time you get a paper cut, you reverse your biology. You need to think of it that way. Here's because biology is reversible, that means Graves disease is reversible.

And I'll even give you this, and I wasn't even going to. Here's where the magic happens. This is on the, this is on the research study that I give you, which I, I have to say it that way before you guys flip out. It's not really like that. I, listen, it's on mice and I don't know, pygmy aardvarks or something. I'm here to help you. Like I want to put the word "dumbass" after that so bad. I just did, in case you didn't get that. Listen, there are six components to this outside, and I'll give you all the supplements, all the dietary stuff. I, it'll all be on that list, okay? But six components that work on six different nodes, for lack of a better explanation, of the Graves autoimmune cascade. So watch this is for a kangaroo.

Thymosin alpha 1 increases T-reg population directly. By the way, Mod C restores ATP and suppresses that TH17 problem that's going on. BPC157 heals the intestinal barrier, prevents the LPS-mediated dendritic cell activation, so it's not spilling into your bloodstream anymore, causing that immune response, which causes the inflammatory problem, which causes a whole host of issues. SS31 suppresses mitochondrial reactive oxygen species. It prevents inflammasome activation, right? Repairs cardiolipin holes, right? KPV suppresses pro-inflammatory cytokines and promotes T-regs. And I can't say this one. Alpha 7 nicotinic receptor. Alpha 7 nicotinic acetylcholine receptor agonism. This thing suppresses dendritic cell TLR toll-like receptor activation and promotes T-regs. But follow me on this. Here's the result. Reduced, watch. I'll just, I'll walk you through it. I'll walk you through this whole damn thing. I want you to understand this.

Reduced dendritic cell activation, BPC157 and the alpha 7 nicotinic acetylcholine receptor agonism, and SS31. You get reduced TH17 differentiation, Mod C, KPV, and again, that alpha 7 nicotinic acetylcholine receptor agonism. You get increased T-reg population, Thymosin alpha 1, Mod C, KPV. You get suppressed autoreactive B cell survival. You get reduced TS1. You get reduced TSI antibody production, and you end up with a resolution of Graves disease. I don't know what you want me to say other than I solved the disease for free. How much money am I asking you guys for, for crying out loud? How much am I asking you for? If you will, you ask for this money to help me. Yeah, but I just helped you here for free.

Listen, here's what we've established. Graves is not a thyroid disease. It's a systemic disease of immune dysregulation, neurological dysfunction, dysbiosis, mitochondrial failure, metabolic chaos, intestinal permeability problems, which happens to express itself through your thyroid. It's not genetic, it's epigenetic. Your environment created it, which means your environment can also solve it. Graves is treated through three very failing approaches: beta blockers, antithyroid drugs, and radioactive iodine. And none of them address the damn disease. And all of them have catastrophic side effects. Graves disease is completely reversible. It does this through systematic restoration of autonomic balance, immune tolerance, microbiome health, nutrition, big time, rest, mitochondrial function, intestinal integrity, metabolic sensitivity. This is the future of medicine. It's not managing chronic disease forever with medications that have worse side effects than the damn disease. It's actually reversing the disease by addressing the friggin biological roots.

You guys, information is everywhere on this if you dig for it enough without listening to some yuts that wants you not to buy into it. The science supports this. I don't get anything from this. It's not like I went, "I want all the credit." I don't give a [ __ ]. Just stop stealing my stuff. And case studies everywhere demonstrate this. What's lacking, I said this before and I said it on my post, is actually a damn medical system that's willing to acknowledge that it's been wrong. You don't need permission to be healthy or your doctor to believe that this is valuable to how to implement. You don't need a damn doctor to tell you this is okay. You don't need my permission or anybody else's. "I better go check with my doctor." Then do. And they're just going to give you the same dumb things. You just need to understand your biology and then align your choice with it. You know what that is? Power. Tony Robbins. Personal power. That's the revolution.

I've said this before. Graves disease is just the beginning, by the way. Anyway, I hope you got something out of this. I got to go. Never miss.