Designing detoxification protocols that work with Quicksilver Scientific

[Music] Welcome, welcome everyone to this special webinar event, in collaboration with Quicksilver Scientific and FullScript. I'm Amy Regan from FullScript, and I'm so glad that you joined us today.

A few housekeeping notes: Please place all questions you have in the Q&A box for a chance for them to be answered at the end of the presentation. This webinar is being recorded, and the recording will be sent via email to all attendees and registrants, as well as available to watch at FullScript Webinars in a couple of days. There is a copy of the presentation slides in the handouts section for you to enjoy.

It is my pleasure to introduce today's speaker, Dr. Matt Ready. Dr. Ready has over 20 years of health care experience in naturopathic and functional medicine. Dr. Ready earned a bachelor's degree in biology from the University of Colorado, with an emphasis on chemistry and biochemistry. He went on to naturopathic medicinal school at the National University of Natural Medicine in Portland, Oregon, where he focused on complex digestive issues, environmental toxicity, and immune system dysregulation. He was a professor of Foundational Sciences at Southwest Acupuncture College in Colorado and has a thriving naturopathic and functional medicine practice, Ready Natural Medicine, since 2002. Dr. Ready has been partnering with Quicksilver Scientific as a clinical and educational consultant since 2014.

Dr. Ready, welcome.

Thank you so much. I appreciate it. Happy to be here.

All right, so we are going to be diving right in here, I guess. So thanks everybody for joining us. Um, we're going to be talking today, um, about the Quicksilver Detox Difference. And my hope, as you leave this, is that you really have an idea of how to create protocols for detoxification that will really work for your patients. I want to cover a few different topics, um, in the next 45 minutes or so. I want to briefly look at what toxicity is. Then I want to spend a little bit of time on the principles, or the mechanisms, excuse me, of detoxification. We're going to look at the Quicksilver Scientific detox principles and the framework to kind of think through detoxification, and then we—I'm going to leave you with a few cases just to kind of highlight how you can utilize these principles. So let's look then at toxicity.

So, you know, when we talk about toxicity, I think we have to understand two very important pieces: Number one, that we have to have some sort of exposure. I think everyone already probably understands that, you know, whether it's going to be these different chemicals in our food, whether it's heavy metals, you know, the things that we spray on our mattresses, you know, flame retardant and things—you know, we've got some level of exposure to these toxins that we need to eliminate. But the burden actually then also builds when we—that exposure exceeds our body's ability to manage the exposure. So the biotransformational capacity that all of our cells have is exceeded, um, by this toxin exposure, and that's really what's going to lead to the symptoms and the toxic burden, um, that we all can experience. And symptoms really are challenging to figure out from this sometimes because it mimics so many things. You're going to have mitochondrial issues, immune dysregulation, a lot of neurologic symptoms can occur; it can even lead to cardiovascular issues, GI issues, and then one I think that we're really starting to see more and more these days is the disruption of our endocrine system. So we've got to address both issues when we're talking about a successful detoxification program. We have to identify the toxin exposure; figure out what it is, that source; we need to minimize or eliminate that source. But then we also need to, in the same time, increase the body's ability to transform, process, and then eliminate those toxins. So that's really what we're going to be focusing on here today is our body's ability to transform, process, and eliminate these toxins.

So let's look at how our bodies are designed to manage exposure to these toxins. So a lot of this you may be familiar with, but I really—my goal here is to link everything together in a step-by-step way so that you can think through this very easily. So we know that there are really three broad phases of detoxification: We've gotten phase one, which is activation; phase two, which is conjugation or mobilization; and then phase three is the filtration, transport, and excretion. You know, when I was in school and when I just gotten out of school, we didn't really have a full understanding of all three of these phases. We were really just starting to understand phase one and phase two, and so a lot of the detoxification protocols, uh, you know, that were originally created were very heavy on the understanding of phase one and phase two—again, very important—but you need to link it then with phase three, and I think that is really where some of Quicksilver's protocols really shine, and I think you'll get the most benefit. So all three need to be synced up together.

So let's look at each one of those phases and kind of what's involved. So phase one is the activation phase, and so this is really an oxidative process where it's using the cytochrome P450 system, and it's going to prepare toxins for conjugation. Now, not all toxins require phase one. So, for example, heavy metals like mercury or cadmium really don't need phase one; they are ready to go right into phase two. But other toxins are not ready to go through phase two, so they need to be activated. And really what we're talking about here is taking a toxin and making it a little bit more toxic, creating this free radical aspect of the toxin, and so that we can then move it through phase two, which is conjugation. And here is where these toxins become more water-soluble; they become more recognizable by the various transporters so they can actually be moved out of the cell. Um, we use—this is where we use our glutathione, for example. We can also sulfate things, or sulfation as part of conjugation. Um, glycine is used; other amino acids, taurine, methylation—this is all part of the conjugation, phase two process. When we have reduced activity of phase two, which can be seen very easily in really toxic people, you start—you know, not being able to take these highly reactive free radical toxins from phase one, and they're stuck; they're not able to fully move through the entire process. So we really need to upregulate a lot of phase two when we generate these free radicals. And then that leads us to phase three, the filtration and transportation part of our detoxification system. So we're using various transport proteins here—the MRPs, the OATs, the MCTs—these are organic ion transporters that are within the membranes of cells that move these toxins out. And we have a lot of these, you know, the main place we see these is going to be in our liver, but they can be in other cells as well. Kidneys have quite a few, so do the intestines. And the way to think about these, this aspect, is these transporters deliver and carry these toxins away from the cells.

So if we look at it in a picture, for those of you who are visual learners, you know, we've got here our cell membrane, and within the cell we're going to have phase one and phase two: so the oxidative activation and then moving through phase two with the conjugation. When then we can carry the toxin through, out through the liver, through the other transporters, into the small intestine where it can be moved through the stool. There are other toxins that are moved through the kidneys and out through the urine. So all of these phases need to be synced up. We can also think about it in the microcosm, so more of a cellular function being phase one and phase two, and then more of the macrocosm, which is going to be, you know, moving things through the liver and through the kidneys. So when we understand all three of those different phases, then we can work on using various nutrients, herbs, etc., to enhance these processes. And so this is where Quicksilver—we've developed our principles of detoxification, and there's four main principles of detoxification: We're going to have a push principle, and there's two aspects of that we'll cover here in just a minute in more detail. We've got our catch principle; we also have membranes; and then the remove obstacles principle. So let's look at each one of these four principles in more detail and give you an idea of how to interact with each one of these.

Principle number one: the push principle. And specifically, we're going to be focusing on the drainage part here. So the drainage is—if we look back to our drawing of the microcosm and macrocosm—the drainage principle is really focusing more on the level of the macrocosm. So we're going to be using things that are going to support the movement of the toxins from the liver—specifically, we're talking about bile flow here—and we're also focusing on the kidneys and the ability of the kidneys to mobilize toxins through the—into the urine. We're also talking about circulation really as well. So you'll see things here that actively increase our body's ability to circulate the blood and move the blood. So once we have these aspects supported in the drainage working, that's really where we're going to go next then is looking at more of the inside the cell aspects. But let's focus first here on the ability of moving toxins in the drainage piece, opening up these pathways out of our body. And we're going to zoom in then specifically into part of the liver here. This is going to be a hepatocyte, and the hepatocytes on one side are going to be fed by blood. So the blood's going to be carrying toxins into—you know, into the liver cell; it's going to be bringing them in to the liver; those toxins are going to be moved into the liver, and they're going to move out then through the bile. So let's not focus too much on some of the cellular functions; let's focus more here on phase three with the bile and the bile canaliculi, which is what's carrying the bile that the cell is making away. And the point here—and we're going to come back to this slide in just a minute—but the point here is that we're—we have this motion through this directionality from the blood through the liver and then primarily draining out the other side with the bile. What we see happen for many patients is that the hepatocyte is not able to drain properly. So if we look here at the bile canaliculi, you're going to see that these transporters here—red was probably not the best choice, I apologize—you'll see that the transporters here are actually not all inside the bile—the—the membrane of the cell. We actually pull away some of these transporters, um, and protect them because the toxin buildup within the hepatocyte can damage them. So we wall those off, and we hope that the cell is going to survive, and we're going to move the toxins, um, you know, back—actually what happens is you start having these toxins move back out of the cell into the blood because the drainage aspect from the cell is not working properly. So you—it's you preserve the cell hopefully by keeping these toxins out, um, but in as a result people don't clear these toxins, and they stay in the—in this—in the blood. So we have, instead of this directionality moving from left to right, from the blood all the way through into the bile, we actually have it kicking back into the blood, um, and you're not clearing these toxins. So these are just showing that these transporters that should be moving toxins in now switch and move toxins away from the cell. The kidneys have very similar transporters. So when we're talking about drainage, uh, we also need to support the microtubular—you know, the tubular function, um, within the—within the kidneys as well. So the transporters that we saw in the liver are also inside the kidneys as well, and we would be—we also have to talk about lymph when we're talking about drainage. So lymph is also circulating these toxins around, moving them through, um, and out of the body as well. So we need to keep the lymph—the lymphatic flow going, and bile flow and lymph are very closely related in how they move toxins.

So when we look at things that can support the drainage, we're going to be focused on, like I said before, moving bile and creating more bile. And in herbal medicine, that's going to be cholagogue or bitter herbs. So, for example, you've got dandelion, gentian, myrrh, solidago—these are all herbs traditionally used to, number one, stimulate the creation of bile, and number two, transport bile out—you know, move it. We can also want things that are going to support the kidneys; these are going to be things like aralia, ferulic acid, juniper, dandelion as well—all help with the drainage and the diuretic and the movement through the kidneys. And then, you know, we're talking about blood flow here too, right? We're carrying these toxins; things have to be moving. And this is where we can use things like dong quai or hawthorn, GCO—all things that can improve circulation, uh, you know, of the blood. So really this is our drainage protocol. You know, Quicksilver has products that have these herbs in it, like our Bitter X formula is these four herbs. We have a kidney care product which has, you know, these nutrients in it, these herbs in it as well. And then all kinds of different circulatory products, like our performance cardio, for example, would have these herbs in it.

So the other piece in the push then is going to be our cellular support. So cellular push is going to be focused more here in the—in the cellular phase one and phase two detoxification here, and then we're going to link that then to the drainage. So not only do you—you want to think of things that are going to upregulate the inside—the phase one and phase two—that has to be coupled together then with the drainage. And so here's our hepatocyte picture again. So we again talk about our movement from the blood through the cell of the toxins into the bile. And if you look here at the inside of the cell, we've got phase one taking a toxin, making it more active, making it red. You'll see, uh, you know, here's our red toxin right there, uh, that's going to be then conjugated here and then moved out into the bile through the transporters. Nrf2 is what turns on all of these phase one and phase two enzymes; that's a genetic transcription factor that's going to increase their function. And not only do we have activation of phase one and phase two, we're bringing in phosphatidylcholine, um, which is going to fluidize the bile, um, and really make sure that everything is flowing out. And you'll notice here that all of the transporters are nicely embedded, transporting these toxins out of the cell into the bile, and there's our directionality from left to right. So what do we want to use to increase phase one and phase two and link it together with the drainage? Well, we're going to want to use things that are going to, number one, stimulate the bile flow, like we talked about before. G—got our bitter herbs that we talked about earlier. We've got our phosphatidylcholine, which is going to fluidize the bile. We can also then use things that are going to support mast cell—the mast cell activation that can happen during detoxification, as well as any kind of immune dysregulation. So these are going to be things like DIM and quercetin and luteolin. And then we can also then upregulate that Nrf2—again, remember that's the cellular transcription factor that's going to turn on phase one and phase two. So we're going to use DIM and quercetin, luteolin, and alpha lipoic acid is a powerful Nrf2 upregulator. So all of these together are going to—not only is really going to sync up phase one, phase two, and phase three for detoxification, and this is all a part of Quicksilver Scientific's Liver Support formula, which will do everything that we've just talked about. It's a really amazing formula for that. We can also add glutathiones. Remember, glutathione is a major part of that phase two, the conjugation, and the—part of the problem with toxicity is that people are often very low in glutathione or burn through it very quickly and can't regenerate it fast enough to keep the toxic load clear, moving through, um, particularly when there's heavy metals going on, but it can be other toxins as well. And so adding in extra glutathione can be extremely helpful, and you really need to have the reduced liposomal glutathione for that.

So here is just a summary of everything that we talked about with our cellular function: We've got Nrf2 upregulators like alpha lipoic acid, luteolin, and DIM. You know, AMPK—we didn't—we're not going to cover that too much today, but that's an aspect of detoxification that happens when you're in a more fasted state, when the cell is actually going through autophagy and clearing away old mitochondria and toxins that way. So we can upregulate Nrf2; that's all part of a cellular push concept. And then glutathione builders using things like liposomal glutathione; you can also use NAC and other other things that can build—build glutathione. So just a couple of papers here as well, looking at aspects of detoxification using DIM, using AMPK activation as well.

All right, so let's then—so that's our push, our push principle—so supporting both the drainage and supporting the cellular aspects of detoxification. So our second principle is the catch principle. So this is going to be toxin binding and excretion. So if we've—what we're focusing on here then is going to be our intestinal clearance of these toxins. So as we move these toxins out of the cell through the liver into the GI system, we don't want to reabsorb these toxins; we want to make sure they are bound up properly so they can be carried out—out of the body. And that's where a good binding principle needs to be addressed. And so there's a lot of different binders out there, um, and different binders have different jobs as far as their ability and their affinity for different toxins. So we can use things like charcoal, um, we can use things like bentonite clay, zeolite, functionalized silica. This is a product Quicksilver uses called IMD, which is basically a silica—silica with all these, what are called thiol functional groups. And if you look here at—this is a drawing of silica, and all around it here are these thiols—these sulfur-containing functional groups—those are metal binders, like mercury and cadmium—very good binding of heavy metals with functionalized silica or IMD. Um, we can also have chitin; chitin is a very great binder to many toxins. So, you know, really having something that has as many of these binding agents available—Quicksilver has the Ultra Binder, which has all of these added to it, and each one—and it's important because different toxins have different affinities, so you want as the biggest, most broad binder as you possibly can. So that one's pretty straightforward: bind the toxins.

So then our third principle is membranes. Now, membranes, you know, were really made famous, um, with Bruce Lipton's work, talking about the communication between the inside the cell and the outside of the cell through the cellular membrane. And remember, membranes extend—not only are they not only outside of the cell, but they also extend into the cell with the organelles. So all the organelles, from our mitochondria to the endoplasmic reticulum, the membrane around the nucleus—all have very similar properties; they're basically built by phosphatidylcholine, these phospholipids, and their role is in transport and movement in and out of the cell, as well as communication between the outside and the inside. So we really need strong, healthy membranes, and we know that a lot of different toxins, for example, like cadmium, are very damaging to cellular membranes. And when you lose those—that integrity of the cells, when you lose the integrity of the membranes, you lose a lot of the communication. So supporting that is extremely important. And if we go back to our hepatocyte, I want to bring your attention—I'm going to switch colors here—we can use a little brighter one here—I want to bring your attention to phosphatidylcholine. So not only does phosphatidylcholine build the membranes, but it's a major ingredient in the bile. So if—when we're talking about drainage, when we're talking about coupling phase one, phase two, and phase three, we need phosphatidylcholine in that as well, and that's all going to be, um, you know, important to support here. So when we're talking about other aspects of membranes, we talked already here about phosphatidylcholine, um, we can look at taurine is another really important nutrient, very great antioxidant. Astaxanthin's—that beautiful red pigment we see found in a lot of—in some various seaweeds—very, very useful at building cell membranes. Vitamin E, strong antioxidant for cell membranes, and then omega-3 fatty acids are also important here too. MembraneMend is the Quicksilver product that has all of these added to it, uh, and you can use these individually as well. Pure PC is also available, which is just phosphatidylcholine. And there's just some drawings here showing the transport and movement of in and out of the cells. So healthy cell membranes mean healthy cells.

All right, and that leads us to our fourth principle: removing obstacles. So this is actually where a lot of the art, I think, of detoxification is really going to come in because different people have different obstacles that are in the way of them detoxing. So you—you can use—do all the three things that we just talked about with the push and the catch and helping with membranes, but if these obstacles are present, it's going to be a much harder process to deliver these results that you want. So let's look at the first of these obstacles, and these are microbial obstacles: active and latent infections. So when we have a chronic infection, that's going to generate chronic inflammation, and the chronic inflammation depresses detoxification, leading to more toxicity. When you have more toxicity now, you go—and you've actually dysregulated the immune system; you've switched over from a more balanced Th1 to Th2 communication, and now you've increased the Th2, which means you're not getting on top of the infection and clearing it. So there's an immune dysfunction; you've got this chronic infection, chronic inflammation, and the cycle continues, and it can be a very challenging situation that we find ourselves in. So these are going to be your patients with active—you know, with Lyme, it could have gut infections, um, you know, any kind of a parasitic type issue—anything that's not getting fully resolved can lead to very challenging detoxification. Here's a couple of papers talking about the direct relationship between some viruses like RSV and how it downregulates the Nrf2, so you actually slow down that cellular detoxification. Here's an enterovirus, uh, that does the same thing in this paper. So what do we use then to improve our body's ability to handle these infections? Well, all types of herbs are used—you know, to do this, uh, for example, artemisinin. Artemisinin is really great at getting rid of parasitic infections; it's—it's been shown to improve, uh, the balance in GI infections as well, um, so also Japanese knotweed can be used, uh, for example, or cat's claw. Cat's claw is one of my favorite ones for viral issues; if you've got like Epstein-Barr, some of these latent viruses, cat's claw can be very useful. Cryptolepis, wonderful herb in the tickborne illness space. So using cryptolepis, and then Quicksilver does have, um, a product—our CryptoComax has these added together—all these together, uh, in order to support you in clearing away some of these latent infections.

Another obstacle that people have, and this can—is that inflammation that we—that I showed you—you know, inflammation could be from an infection, but it could be from something else; maybe it could be from a traumatic brain injury, um, it could also be from a food poisoning type of a thing, maybe toxin in a food—whether it's—maybe not necessarily bacterial but other other things as well. Uh, this is a paper we talk about all the time here at Quicksilver, um, which is really demonstrates this problem that we tend to have with, um, various toxic agents. And so the title of this paper is, "Concurrent inflammation is a determinant of the susceptibility to toxicity from these xenobiotic agents." So basically, if we break this down, we can say, okay, now we have—we have a toxic agent...

Here, with um, that's a xenobiotic agent. How toxic is it? Is a direct result of how much inflammation somebody has. So, so the more inflammation people have, they're more susceptible to the toxicity from that xenobiotic agent. And so an example of a xenobiotic agent is going to be LPS, or lipopolysaccharide, coming from Gram-negative bacteria. And so what we're—what this graph is showing is these times of increased susceptibility from LPS. And so if you have a GI disturbance, or or have alcohol—increased alcohol—all of that, uh, these types of uh exposures are going to increase our susceptibility to uh LPS. And so we really need to work with, number one, clearing away the LPS in this case, right? But we also need to work with the concurrent inflammation, um, as well. And so how do we calm the system? How do we reduce inflammation? And this is where we're going to use things like kumin Basia. You can use full and broad-spectrum hemp with the CBD and the various phytocannabinoids. GABA and alanine—wonderful for calming the brain and the overactive um inflammation in the brain. Certain herbs like skullcap or passionflower, chamomile, very useful as well, helping people sleep, uh, if needed, that can help reduce inflammation. Vitamin C, DIM, curcumin, luden—all have an effect in calming, uh, calming the inflammatory process.

Our final remove obstacle is going to be energy creation, or low energy; so improving energy creation. So this is a paper that looked at how uh toxic uh methylmercury was—uh, in these are in actually these *C. elegans*, which are these little worms that they were studying. But basically they, uh, they measured the amount of NAD, so the the mitochondrial output, um, of these *C. elegans*. And in the when they didn't have any um mercury—so this is showing the mercury here, uh, or no mer—no, excuse me, they they were not treated with NAD um and mercury. And as the mercury levels went up, you'll see, uh, the level of mercury go up, you'll see, um, that this—the mitochondrial function decreased dramatically. But when they gave them NAD, that the mitochondrial function actually stabilized, um, and we see the same thing here, um, the actual number of mitochondria—a very similar thing happened. So the more NAD that they had, in—in the second uh study aspect of the study—the more mitochondria they actually retained. The mercury did not damage their mitochondria as much when they had actually had NAD available, um, and this—and on the right here they're showing how the actual NAD levels that were measured when they didn't have NAD uh given to them—their NAD levels just dropped, you know, as you would expect. But when they did have NAD given to them, they actually made more NAD. So that's very useful to know—when we actually have a toxic state and we keep the mitochondria functioning and we keep providing the building blocks to that—can allow the function, it can build more on its own and can stay on top of things much more readily instead of just getting depleted. Uh, and so here this is showing mitochondria that's functioning properly here on the left, and then this is showing a mitochondria that's getting damaged on the right and not able to generate the ATP. And when we—so here's what we're talking about is NAD creation, mitochondrial function. So we can use things like NMN, we can use CoQ10, PQQ, resveratrol, we can use various vitamin compounds like a multivitamin or B complex, um, and we can also use different herbs, um, adrenal herbs, etc. Multi-mineral—minerals are needed here as well.

So very quickly, I just wanted to address um the importance of bioavailability. So everything that we've just talked about really works best if you can actually get it into the body, right? And in the context of supplements, you know, some of the delivery systems that we use—the the traditional things of capsules and powders and even tinctures and tablets—really are limited in their ability to get absorbed. And some things are much easier to absorb than others. You know, for example, vitamin C you might be able to absorb a little bit easier, but glutathione you can't really absorb at all, or something like curcumin—very, very challenging to absorb. And so, you know, especially if you've got patients with with GI issues, if you've got a lot of gut inflammation, you're really limiting your absorption. So that's why if we can deliver it in a way that gets—bypasses our gut and delivers these compounds directly into the blood—blood supply, we actually can get the results that we're looking for. And this is really where the Quicksilver delivery system comes in with our liposomes and our nanoemulsions. So a liposome, um, is slightly different than a nanoemulsion. A liposome is going to be a lipid bilayer. So what we're showing you here is this is B here, this is a liposome. You've got a lipid bilayer—phospholipid bilayer—and inside that bilayer is a water core where we've dissolved things like glutathione or vitamin C—water-soluble compounds. If we're talking about about a nanoemulsion, we're talking about a single uh uh layer of phospholipids, and inside that is going to be fat-soluble compounds like vitamin D and uh CBDs and any—any a lot of the herbs as well—the compounds found in in various herbal uh extractions are going to be fat-soluble. So you're going to use a nanoemulsion here. So what Quicksilver does then is we make these nanoemulsions and liposomes, um, and we make them very small—we actually make them nanosized. Now nanosized particles are really nothing to fear; they're just means really small, um, and they're going to get absorbed directly, um, into uh the mucous membranes of the mouth, right into the blood supply. And that's because they are made—Quicksilver makes them extremely small. And so in order for you to actually absorb them through the oral cavity, they need to be small unilamellar particles or vesicles, and they need to be under 100 nanometers in size. If they're not under 100 nanometers in size, they're not going to get absorbed through the oral cavity and the upper part of the GI; they're going to go into the into the gut and have to get absorbed uh pretty much the way any kind of supplement, you know, powder or or tincture or tablet would. So you want to make these particles small, and that's really the brilliance of the chemistry um that that Quicksilver provides. So it's this balance between these phospholipids, various emulsifiers and different ingredients that creates this very stable—these stable products. And you can tell the size very easily just by looking. And so what we see here, um, are going to be uh five different CBD products, and they're all marketed as liposomal products. But what I want to point your attention to is that the Quicksilver one, if you'll notice, is here—this one on the far right. You can see directly through the product here; it's transparent. So you can see the uh the bottle shot through the product. If you look at these other products, they're all going to be cloudy and thick, and that's because the particles are larger than the wavelengths of light. So there—the light is reflecting back as a cloudy product. If it goes right through, you're going to—you see through it. So a quick way to tell if it's under 100 nanometers in size is if you can see through it. And this graph is just demonstrating the same thing as far as absorption goes—the smaller the particle, which is going from left to right here, uh, the higher the absorption uh of these—of the compounds. And we measure—not only can you look at it, you know, see that it's transparent, but we actually have laser sizers at Quicksilver. So here's our distribution—this is our glutathione here, and you can see the distribution um in nanometers, um, and you—you—you want to see these peaks here, um, be under 100, um, and that's the distribution—very tight distribution—versus our competitors here, you'll see a much wider distribution, um, and starting really small, or the smallest is going to be, you know, around 50; it can go all the way up past a thousand nanometers within, you know, a mean here going to be of of 300. So that's going to be your cloudier um product—products—and not absorbable. And the reason we want these products to be so absorbable is because we want to get them in the body quickly and activate things all together. We don't want to wait for one thing to get absorbed easily while another thing's going to take two or three hours to get absorbed and get to therapeutic doses. And what we call that is biosynchronous activation, which is a delivery—which is really the end result of these uh compounds all being delivered at the same time—you're activating everything all together. And that's going to mobilize the bile flow, the push part with the Nrf2 upregulation, um, it's going to support the membranes—everything happening all at once. So you can deliver what you need quickly and effectively.

So here's just a breakdown of the things we talked about, um, in one document, uh, from uh our PUSH principle—catch membranes and removing obstacles—and the various things that can support them. So let's look really quickly here at a couple of case examples, and then we'll get to some of your questions. So the first example here is going to be a 52-year-old male who, with high blood pressure, uh, overweight, and having anxiety. And so in order to really improve this particular patient, we focused a lot on his circulation due to the hypertension and then in the cellular push. And so that's going to be the the drainage piece in the cellular uh push part because of the the weight issue, um, I wanted to support him with NMN. So we supported his blood sugar regulation, we supported his autophagy, um, as well as upregulating some of the detoxification pathways with the Nrf2 upregulation that the—some of these same compounds deliver. And we added in a catch with the UltraBinder, which is the charcoal and clay and zeolite. And then for the anxiety and removing the inflammation—because remember, you can't really detox well if if you don't uh calm down the brain and get the anxiety under control. And so that's where we used a broad-spectrum—or excuse me, a full-spectrum—uh CBD product—a hemp CBD uh formula. Had another woman who, um, had weight gain, fatigue, and a lot of brain fog. And so we did um our our LiverSauce, which is really going to be those bitter herbs as well as the Nrf2 upregulators, um, here, um, and then we did the UltraBinder. So this is our PUSH catch liver detox. So our our LiverSauce focus is here; our UltraBinder focuses here. We added in some extra glutathione for her; she did have a parasite that we identified, so got her on some artemisinin. And then for her energy, started her on our NAD Platinum product, which has got the uh NMN, uh the CoQ10, resveratrol, PQQ, um, as well as the B complex. So is a mold patient—I know a lot of you probably work with mold patients. So working in the Quicksilver world with mold—again, you're going to see—we supported the both aspects of drainage and cellular push. So we've got the LiverSauce, the bitters, and the Nrf2 upregulators. We added in the kidney support—our KidneyCare—really make sure the kidneys were draining properly. We put in the glutathione, and we did the UltraBinder. So we've got the charcoal, the chitin—definitely for the mold, uh, the mycotoxin binding as well as the charcoal—we'll do that as well. Really wanted to get in the uh membrane support here as well. So we've got our MembraneMend, which is all of these at uh support here; we had the NAD Platinum uh with the low energy because we re—you know, with mold there's definitely a mitochondrial impairment going on, so we needed to get that going. And then we added in some adaptogen herbs to keep the adrenals strong as well. And then our last case here—this is a—was an autism case—so neuroinflammation case—you know, when with autistic patients, that's really the biggest driver is just—brain is on fire—and they have very, very backed-up detoxification channels here. So we—here you can see—support with the drainage um and the cellular push with our LiverSauce. We've got our UltraBinder, and then this particular formula is—we have one called CBD Synergies AX, which is a combination of the uh full-spectrum uh CBD along with GABA and these herbs—wonderful for calming the brain, uh, and and really very useful in autistic cases as well. All right, I feel like I cruised through that really fast, but um, really wanted to cover all that, um, so my hope here is that everyone really has a good sense then of those four—those four different principles. And if you can put all those together, you're going to have a successful detoxification. So thank you guys. Wow, wow, wow. Thank you so much, Dr. Ready. Oh my goodness, so much to absorb. Yeah, yeah, it's a lot. So excellent. Anyone with questions, please put them in the Q&A box, and uh we can see if we have time to answer them.

First off, um, Con is asking, is LiverSauce enough for someone with—without a gallbladder? Yeah, great question. So remember the gallbladder is the storage of bile; the liver is what makes the bile. So you're—when someone loses their gallbladder, it's a really good indicator that they are not making very good quality bile. And so that builds up over time, and then they tend to lose their gallbladder—the creation of stones and, you know, obstruction and that kind of thing. So LiverSauce will definitely uh be useful in the creation and the movement of bile, um, because of those bitter herbs and the phosphocholine that's in there, um, so yes, absolutely—can be used in patients without a gallbladder. But you probably want to go a little slower at first, make sure that, um, they're able to—well, they just don't have that store of bile anymore, right? Their bile is just dripping into the intestine kind of consistently, uh, without that store in the gallbladder. So you're going to—everything's going to be a little slower, I guess, is my point there. Excellent. Rachel is wondering what would—um, what would—have you chose to support with NAC instead of glutathione? Do you ever use both at the same time? Um, I rarely use NAC, um, because of Quicksilver liposomal glutathione, um, you know, the reason in the past that that was really recommended was because you can't give someone glutathione in a capsule; you digest it—you break it apart. I mean, glutathione is only three amino acids, um, and NAC is going to be one of those amino acids—the cysteine. So you will build glutathione from NAC; it's useful in that context, um, but in really chronically ill people, why not just give them straight glutathione? Minimize their need to synthesize it on their own—provide it right to them, um, and since it is in a liposomal delivery and it's going to actually get absorbed as glutathione, uh, and will be able to be um utilized that way. So, um, you know, I would say just to answer that question—a lot of toxicity, chronic issues—go right to—to glutathione. If you have someone that's—they're generally pretty healthy and you just want to support kind of their own ability to create it, you could use some NAC. Excellent. Robby is wondering how long do the liposomal products last once opened? So yeah, great question. They aren't—they will eventually, you know, degrade a bit, um, particularly the—you know, we're just talking about glutathione—glutathione really should be used within a month of opening it, um—we—other products, you know, you're probably wanting it to be used definitely within a couple of months, um, just to get optimal potency from them. I mean, it's likely that they'll be generally stable for a while, but, you know, we can't guarantee, you know, potency, um—I mean, there is some of the products we have do have expiration dates; some of them are are newer, so we actually haven't established some of that yet, and they're—they're working on building that data, which—which takes a little bit of time, um, but, um, you know, they're—they're not fragile enough that they're going to break down within like, you know, a week or even a month after opening them generally, um, but if you're really want to get the optimal use of them, yeah, you know, use them, you know, reg—you know, regularly fairly quickly. Yeah, excellent. Uh, Lindsay is wondering what is a—what's good for a lead detox specifically? Yeah. So lead, you know, lead's very slow to come out, so you're—you're still supporting everything that we talked about, um, with, you know, opening up those pathways, moving, you know, upregulating those enzymes, um—kidneys really need support with lead, and, you know, we—we use our liposomal EDTA. So EDTA is going to be the binder for lead; it's going to be—it's a very specific binder and going to hold on to it and clear it out, um, so but it will clear it out really through the kidneys. So if you're using EDTA specifically for lead, make sure that you have the kidney support on board as well. Excellent. Carly is wondering what are your thoughts on using the BitterX in addition to the bitters already in the LiverSauce? Are there additional bitters necessary in cases, and if so, which ones? Yeah, so that's a good—that's right, because the BitterX is the same herbs that are in LiverSauce, um, and—but remember there's no Nrf2 upregulation with, you know, just the um bitters, um—the people that are really uh nauseous or have some really slow digestive function, extra bitters can be extremely beneficial there, and you can definitely use them together. Uh, you know, the LiverSauce is usually used a couple of times a day, and you could intersperse BitterX kind of other times, and I found it beneficial kind of ongoingly, you know, people just have a little bit of bitters—maybe one or two pumps—maybe up to four—in between their doses of the LiverSauce if needed, um, so yeah, you can definitely use them together; uh, you don't have to, but some people might find help from that. Excellent. Yeah, um, how do you recommend tailoring protocols for really sensitive patients? So really sensitive people need a lot of the drainage support. So that first principle that we—that I talked about—opening up those pathways—is really needed, so you don't really want to push a lot of that Nrf2 uh movement right away with those really sensitive people. One of the thing I think where we ran into problems, especially in the past with detoxification protocols, was upregulating a lot of these processes cellularly, and there wasn't any support for getting them moving out. And so people felt terrible, you know, when we talked about that being herxheimer reactions or different things like that, and I think it was often just overwhelm of our—of our drainage pathways. And so sensitive people, you really just want to start slow; you want to get the drainage pathways open first; uh, that's where the BitterX would come in, where the LI—where the KidneyCare would come in; um, you might even just use like V—you know, some extra vitamin C in those cases. We have a protocol called the PreTox protocol, which is designed for these sensitive people to really get the drainage pathways open first and then move them into more of the PUSH catch protocol, um, where you do stimulate more—focus detoxification, um, and the other thing that you can do if really sensitive people is go just a little slower. You may not do—you know, if a dose—if you might like to do—you might recommend like two teaspoons a day of everything—maybe you just do it one or even a half—you know, just—you can just go a little bit slower, um, and I don't want people to be afraid of like LiverSauce or NF—Nrf2 upregulation—you don't have to be—but in really sensitive people, maybe wait a month or two before you bring in a lot of that. Excellent. Let's see here—is—is your approach to mercury detox the same as the lead detox you just mentioned? Um, are you using EDTA as well? So lead—um, lead will bind—mercury will bind to EDTA well, but mercury really doesn't have a huge affinity for EDTA. And so with binding mercury, you're really using the IMD or that functionalized silica product I was talking about, um, because mercury is very reactive to thiol—the sulfur-containing functional groups. And so you need that in—you know, available to bind mercury. So when you're doing a push, you know, mercury's going to be coming through uh into the bile; it's going to be bound to glutathione—conjugated glutathione—into the gut, and then it can bind right there to the IMD, um, and then that will hold on to it and clear it out. So uh you really don't need to do the drastic chelation protocols and other things like that when you understand how to link up these parts of detoxification and especially the binder piece with um this—this thiol binding that uh we can do to mercury. Excellent. And how long do you use the detox products for? Timing is really tricky because, um, everybody needs different amounts. And I think one thing I would say to that is remember our bodies are always doing some level of detoxification. And when—so there's a—there's a general need to support kind of continuous everyday detox, and then there's chunks of time where we can really focus on a detox and like do a detox, you know, kind of a thing. And those sorts of chunks of time, I think, are going to be between anywhere from 30 to maybe 90 days, depending on what's going on—sometimes longer, um, but I think if we can, you know, definitely focus initially on a 30- to 60-day kind of detox and then run with certain things ongoingly—that's really where we get the most lasting effects for our patients. So things like, you know, our Advanced PUSH catch protocol for a month or two and then moving them more into just maybe a little bit of bitters and, you know, PC or something—just to—as an example—just to kind of keep things moving along ongoingly, um, because it's a toxic world we live in; we have to be able to manage these things on an ongoing basis. And how do you approach detox with um an elevated liver function test? So there's a reason the liver enzymes are elevated—something's inflaming the liver—something's, you know, impeding its function. So you're—depending on how significant the uh liver inflammation is, you may need to first calm that down, um, you know, my go-to for that would be milk thistle and probably pure PC or MembraneMend—something just to really heal the liver, um, and then start moving and getting the bile moving. I—you know, the—there's no—you just don't want to overwhelm our already inflamed liver; you need to calm that down first. But there's a reason it got inflamed in the first place—again, remember, detoxing protocols have to eliminate the source of the toxin first, and then we have to upregulate the mechanism. So if it's something like too much alcohol, well, you got to stop drinking obviously, right? And you got to then heal the liver, or, you know, identify the source, remove the source, and then heal the liver and then go from there. Excellent. All right, let's do one more question. Um, Gordon is wondering, with chronic patients, do you start the whole protocol at once or do you layer them in—to monitor progress—and then start the—or—or start them all at once? Yeah, um, that's going to really be patient by patient, um, but really uh sensitive people, yeah, you may layer things in one at a time. But, you know, Dr. Shade always says there's two pitfalls that people have in doing detoxification: number one is going uh too fast too soon, but the other is going too slow for too long. And so if you're starting with, you know, one product and then doing that for a week and then doing another one for a week—another one—you know, you end up just taking forever, and you really don't need to do that. I mean, we have tried to create our protocols in a way that gradually increases the dosing, so you can uh uh see what happens. But—and you can always reduce the amount that you're doing as well. So whether it's like a teaspoon, maybe you do a half, but you're still using everything all together, and then you're building from there. So, you know, it's easy to be too conservative and too slow, um, I think we don't want to—we just don't want to do that. So don't be afraid of it, but be—be wise, and, you know, listen to your patients. But I guess my—

I wouldn't still go one at a time if if if I don't think you need to. Excellent, well, great advice. Well, I want to say thank you so much to everyone who attended today, and thank you also to Dr. Ready for this great presentation.

Everyone, take a lookout in their email with a link to view this recording, as well as a special offer from Quicksilver Scientific over the next couple of days. Anyone who has any additional questions can send them over to me at Amy amy.rean.rg-n@fullscript.dcom.

I hope everyone enjoyed the presentation. And any final thoughts for us, Dr. Ready? Not to put you on the spot.

Um, no, I don't think so. Thank you so much for having me. I really appreciate it. It's fun to do these, and um, yeah, I—oh, I guess I could say I'm available through Quicksilver for consultations on any kind of product, protocols, questions with patients, things like that. So if if that is something you're interested in, um, you can reach out to Quicksilver to get on my schedule for that.

So excellent. Thank you so much, every—everyone have a great—everyone. Bye. [Music] [Music]