REPLAY - Webinar - Psychological & psychiatric disorders: Hormone therapies.

So as you know, it is, um, we're going to talk about psychological disorders and the hormone therapies, the beneficial effects of hormone therapies on psychiatric disease and psychiatric and psychological disorders. And, um, we are, I have a guest today, and we're going to start by interviewing the guest. And the guest is, uh, let me see if I can go on with my presentation. The guest we have here is Ascanio. Um, Ascanio, I'm going to stop sharing my screen so we can see you better. And, um, Ascanio Polymeni is a good friend. He's one of the Italian pioneers of anti-aging medicine and hormone therapies. And he has something in common with me, is that he always plays the guinea pig for his treatments. Meaning that if he starts a treatment, he will try it on himself. I think that's what you told me, Ascanio. And this is a golden rule I apply very often, is that when I start a treatment, I always try to know what it is. And the best way to know how it is, is to do the treatment. Ascanio, I know you're in, um, you will be afterwards in a hurry, so it is better that, um, interviewing the, now, Ascanio, can you tell us something more about, uh, your, um, work in neurosteroids? Neurosteroids are little compounds you have in the brain that are produced by the brain and that have psychological effects and also physical. Can you tell something more, especially about the psychological effects of neurosteroids and what they are exactly?

Uh, first, first, thanks for this invitation. Thanks to the people that are listening. Uh, our discussion on our lecture, one of the main focus of interest is the aspects are in general of hormones on the brain. So we know that the nervous system is closed, interacts, uh, with the immune system, with the endocrine system, and vice versa. Two, we need to see to this, uh, area, uh, in the same network. Of course, hormones, uh, whole lot. So hormones have effects on the network, was mentioned, and can are involved in a lot of disorders, psychological disorders, neurochemical disorders, or psychiatric disorders. So we know that the imbalancement of lots of hormones are closely related to depletion, anxiety, and also schizophrenia, and so on. My interest, uh, is male, uh, mainly focused on the fair, the aspects of steroids that you know are the hormones that are produced from cholesterol by the adrenal glands and by gonads, mainly, but also by the nervous system.

The effects of steroids on the brain. And can you tell something more about these effects? For example, I know that DHEA is a neurosteroid. I know that pregnenolone is a neurosteroid. Can you tell some of the effects that they can do? An example, for example, the steroids are two kinds of, uh, non-genomic tapes, which means, uh, direct or in diversifying neural transmission, which means they improve the release of the production or inhibit the catabolization of neurotransmitters like serotonin, acetylcholine, dopamine, GABA, and so on. This depends, but also by the hormones. For example, the first hormone that we have decided also because he's the grandmother of steroids, he's a pregnant. Pregnant accepts a biphasic aspect on GABA, that is, uh, the neural transmission of relaxing. The same together, we know that the benzodiazepines, uh, act on on GABA, and some hormones can have an agonistic action on GABA, like progesterone, or the main one, of the most important progesterone metabolites, that is all of the amyloid, allopregnanolone, is involved in a lot of anxiety disease. The rest from progesterone, I believe. And the progesterone and these metabolized essence, anagonistic effects on GABA, which means, uh, more relaxation. They improve, uh, red, decrease, uh, can have a positive benefit on sleep and so on, like a benzodiazepine. Two, in some kind of disease, when we check deficiencies of progesterone, we think for example, in premenstrual signs from all premium pose, when we have often deficiency or progesterone, instead of using benzodiazepines, we can use these hormones that act on relaxing.

So Ascanio, you would use, um, progesterone, uh, also for men, so they to have this, uh, relaxing effect? Yes, we can. As you know, progesterone can be used also in men for anti-androgenic effect, and could counteract the negative effects of our diet, the other testosterone or prostate glands. But this is another area. But also men, insomniac men, we can use safely progesterone, uh, often combined in low doses with other supplements, and not hormonal supplements, that, uh, sleep, like cynine, like glycine, melatonin, adenosine, and so on. Yeah.

So what would be a good dose of progesterone you would give to a man and a good dose for a woman, for example? But for more women, depends also by the age and menopause. We use one at the, uh, two. Also, we know that one of the main compliance and menopause is insomnia. Insomnia, not, not necessarily related to hot flashes, is one of the main problems in the premier post women. In in this case, we use, uh, sublingual progesterone that, as you know, acts, uh, fast, very fast, alone or combined with other supplements. The dose in these cases is around 100, 150 to 200 milligrams. For men, it's much less, because around 25, 50 is okay.

And what is the doses, for example, not only you would give to, for, for, um, for men and for women in general? What is the aboriginal drills you give? But it depends by the different factor. I, I don't know the exact reason, but we saw a more respect in man sleeping using the same doses. We need, we need to, to, to know also the interaction of of the hormones with the neurochemistry, that is probably different in receptor sensitivity in women, in men. So I prefer to use less doses of men. Also, they are overweight, for example. There is not a reason. I saw more legendary, more or less using the same doses of contrast than women. Yes, this is a personal experience. I don't know what is your personal experience about this, this, uh, possibility to use different doses, gender, gender dependent doses. Probably is a difference at the sensitivity of, uh, neurochemistry. You, you are also an expert in what is called hormesis, or the, to have a better balance in order that you have to have a certain stress. By having a stress, short stress, people live longer and feel better.

Can you tell more about this? So is intermittent fasting helping that? Yes, yes, this is another of my, my special research. And we, we can find a connection, uh, between the hormonal treatment and the aspects of the lifestyle changes on improving the aging process. And we know that low doses of stress, except the positive affair. This is the automatic aspect that is dose dependent. This is also for drugs. So if you use low doses for drugs, you can have positive aspects. Then you can have a lot of side effects, increasing the doses. You say, what said, parasail saw a lot of years ago, though venom, which means that increases the dose of the drug or supplements of the normal, we can, we can have a lot of side effects or menses, means that low doses of stress or message comes from greed or now, which means stress, tension. Low doses of stress acts like a vaccination, stimulates the cells to produce a lot of anti-inflammatory and antioxidant enzymes. Not also, but the cells in this case, especially the cells of the brain, of the muscle, under positive stress of fasting, for example, of aerobic activity, really is some neurotrophic. Among these, we are studying, brain derived neurotrophic factor, brain, the light and resource factor. Is an aerostrapping that is close to the relation to mood, improves mood, improves, uh, well-being, and accepts through the enhancements of dendrites overgrowth, the memory of the course. But bring the labels and entropy factor accepts also a peripheral positive effect, improving sensitivity to leptin, to insulin, decreasing implementing that, as you know, is a low-grade inflammation, is the mother of all diseases.

And, uh, you said also that DHEA can stimulate this brain derived neurotrophic factor and mimicking this sense, the short-term stress positively? Yes, we know that they should check among among the hormones that I prescribe, and I think also you this year is one of the most quoted by the patients, especially women. I think that we have a great prescription of DHEA or worldwide. This means that the realist works, especially on well-being, on energy, on memory, especially in women, and especially in other parts of women and premenopause, menopause, post-menopause period. We know that that DHEA accepts a lot of positive effects. You know everything in the brain, excess, mainly effects on, as you know, dopamine, excess, also a GABA antagonistic action, stimulates an MDA. But now there are new studies that bind the, uh, the that bind the administration of DHEA and the positive benefits of this year with the efforts that we find with fasting, with cold therapy, and physical activity, that are the main aspect of the positive bad effect of masses on aging. This is the release of brain derived neurotrophic factor. If you go on PubMed and write the DHEA and the brain derived neurotrophic factor, you find very intelligent studies about the efforts of the DHEA and and especially we, if we combine DHEA with, uh, a change in our lifestyle, which means intermittent physical activities, but of these, of these, uh, special aspects of romances on aging, we can speak, I think, next, because it is a very interesting area. So that demonstration of BCA could accept its positive effect on aging also through the release of brain derived neurotrophic factor, that is actually considered worldwide one of the main neurotrophic involved in successful aging. Very interesting.

Um, now, um, can you, is brain derived neurotrophic factor available or not? Or is you have to stimulate its release? Or is it awesome? We, we need to stimulate because, uh, the atmosphere at the brain, the brain derived neurotrophic factor is easily catabolized. We don't have as a treatment, but we can stimulate through hormones. We can use with disaster, for example, homeopathic brain derived neurotrophic factor, is a nice medication, homeopathic BDNF, that is produced by a German famous German homeopathic, uh, brand. And in general, we can improve the release of BDNF using, uh, combining hormonal treatment and and and and chronopassing or integrating automatic, integrative automatic, uh, strategy. This is a new, new ad of research.

Let's go over back to, um, let's say more classical hormones like the female hormones and testosterone. What is your experience? Because I think you give all the hormones. What is your, um, experience, uh, in treating the woman with depressive feelings, men with depressive feelings, with those sex hormones? Did you, do you have some examples where you were amazed, or you find their, their thoughts? We can speak about two kinds of women that, uh, have a, uh, psychological compliance. The first group is young, young women. And we, we find great success in treating premature premenstrual syndrome in these ladies with progesterone and metabolites of progesterone. We that could be combined also with supplements that modulate serotonin release and production. I remember you, this is very important, that the premenstrual syndrome that is recognized in UK, in USA, but not only, not, not, for example, in Italy. Premenstrual syndrome is a, in a typical mood disorder that is inserted, of course, as, uh, actually known, the identifier, the mood disorder is inserted in a DSM-4, that is the bible of psychiatry. The only drugs that we can use, I'm speaking about drugs in these, in this disease, in this particular disease of young women, are the SSRIs, like a serotonin paradoxine, cycle, and so on. And we have a lot of studies, very intensive, that have proved that the SSRIs accept, not only a diverse action on serotonin, in inhibition of a particular, very particular serotonin, but accept in various effects on anxiety through the release of neurosteroids, in particular, uh, allopregnanolone. So the neurosteroid could be the final attempt of the positive benefit of SSRIs on premenstrual syndrome. The same, we can say for in menopause and premenopause. We know that the, the deficiency, first in premenopausal women, of progesterone, and then also of, uh, estrogen and the testosterone, uh, creates an impressive dampening of neurotransmission production. Because progesterone is an activator of GABA, estrogen is the perfect antidepressant because, uh, activates serotonin and dopamine, and also dopamine. And the pathogen is the strongest dopamine activator. So it's clear that depression and or insomnia or mood disorder in general, anxiety, of course, all sorts of flashes, but this is typical of menopause. These psychological disorders improve very well, in an impressive way, without using drugs. But you know that a lot of SSRIs often are used in treating menopause, menopause disorders. I, I think that we can do this in women that cannot take hormones, but it's crazy to use, uh, uh, psycho drugs portraying mood disorders that are closer than related to hormonal imbalance. Yes.

Did you know also that SSRIs, those antidepressants, also increase quite clearly the testosterone in women and in men? So that's one of the other effects why they work. But, um, so what is your opinion? If you have a person who's depressed, would you give first hormones or we get first antidepressant drugs? This is, this is a, this is a smart question. I think you have a very young brain to do this question. [Laughter] Great. Well, you know, probably my answer, but I want to know your answer. It's clear that, uh, if we check the hormones, we check the hormone in some diseases like that, that's classically related to hormonal imbalancement or hormonal deficiencies, like postpartum depression, for example. This is another, another interesting disease that a lot of women know very well, and premenstrual syndrome, or menopause. And for men, in andropause, would be great before to test the level of hormones. But is normal, and to treat first the, the compliance with hormones. In a second step, so we can use also antidepressants. Depends also the severity of the disease, because we have a mixture of factors in the promotion of depression. Depression is not a normal, normal aspect. Depression is related to stress, is related to environmental, uh, situations, like, uh, if we think to lockdown, this, uh, through e-associate, depression is a, is a, is a multi, multi-faceted, uh, uh, disease. But in this typical situation, we have a great improvement of the compliance using the purple myths of hormones. This is for women, and also for women, also for men in non-drupals. We have a great improvement using testosterone, testosterone, using a combination of DHEA and, uh, pregnenolone in men. We have an improvement of the, the self-esteem, there we have an improvement, well-being, we have been improving our sexual roles, and, uh, without using drugs. I think that in this situation, uh, it's better to start with hormones. If we don't have, we don't see, uh, great results, so we can switch to through drugs. That, but the most doctors do the contrary. Yeah.

So, um, are there many doctors like you working in Italy with hormone therapies? Or a few? Sorry about, are there many doctors in Italy working in the hormone therapies? Or, yeah, in Italy, situation, you are speaking in Italy? Yeah, Italy. What is the situation? If a patient in Italy wants to go to a doctor, is he will he find busy a doctor? Sorry, sorry. But in this moment, your voice looks like a mess. You don't hear me well. In Italy, in Italy, we don't have a lot of doctors because we don't have too many schools. But I, I think 150, not more, of doctors use hormones in anti-aging, mainly, mainly, of course, gynecologists. Gynecologists, a lot of gynecologists are using now, uh, bioidentical hormones and pastors alone, especially through vaginal routes, and the especially DHEA. This is, uh, in Italy, this is the specialization that uses, uh, hormones also bioidentical. And we have a progress in the use of hormones in this area, thanks to the school of, uh, uh, endocrinology, gynecology, doctrinology of the prosody. They are very focused in the use of bioidentical hormones in this area. Less in other specializations, much less. But I think that it's growing, it's growing. Okay, good.

Um, I think we're, we're finished now, Ascanio, because you have to leave. It's almost 8:30, so I don't want to put you on the stress. I really thank you for being there. Um, you have given a bit the energy from Italy. Very good. Thank you. And I hope that you will continue with your work on earth terrorists and homogeneous and and all those things. Thank you. See you. Thank you, Terry. Thank you. Bye-bye. Bye-bye. Bye-bye. Bye-bye. Bye-bye. Bye-bye. Thank you. Thank you.

Um, so, um, if you can take out your video now and, uh, on release. Okay, good. And perfect. Okay. Um, let me now, um, take full control and, um, I'm going to talk about actually my experience with psychological disorders and psychiatry. And, um, I must tell you, it's not a real secret, but I have started medicine actually as a psychiatrist. I, I started as an assistant psychiatrist. And when I saw so many hormone deficiencies among the people with psychiatric diseases, I must say that I, um, [Music] said I'm not in the right place. In an institute of psychiatry, I think I have to go into endocrinology, which is a family tradition since about four generations from father to son. And I have also a sister works in endocrinology. So basically, I had more success with hormone therapies to treat psychological disorders, much more than the psychotropic drugs that often decrease the hormones. So, this is, um, I would say, a very special overview seminar of a model on psychological disorders and psychiatric disorders and the beneficial effects of hormone therapy. That is very close to my heart because I'm really fascinated about solving acrylic depression, anxiety, autism, and paranoia, schizophrenia, and all those different disorders. So let me show you some of the slides. So basically, um, the model I have, uh, constitute for physicians is a model on a whole session of two hours on anxiety and hormone treatments. Then there are two talks about two hours, two hours and a half on depression with all the main hormones that you see here that really work with a lot of studies, but a lot of practical information, exactly what you should be careful when you have such a problem. So the stress also disorders, distress, actually hormone treatments are probably most efficient working is to resist the stress much better when you're on the hormone therapy. But there are different stores of stress disorder, so that is investigated. We'll have a talk on autism, schizophrenia, very in detail. Uh, there's a lot of information, exactly two talks, one on autism and one of schizophrenia, with always the practical tips, how to do it, how quick people improve, and things like that. You have all the information. And then there's a session on patient cases, and there are other sessions that are will be later added on nutritional and nutrition and lifestyle and diet to improve acne, mood disorders, and psychiatric disorders. So let me give you some, uh, of the information I give. And for example, in the first session on anxiety disorders, uh, we will see that there's a frequency considered four percent, but that's four percent of people have a severe form of anxiety disorder. But all of us, including me, we probably have some minor forms of anxiety that are worth to be treated by hormone therapy. For example, if I stop for two days my growth hormone treatment, I start having little anxiety all over the time. I'm not very anxious now. So of course, I'm taking growth hormone. But so every hormone can help you, or many of those hormones can help you to decrease anxiety much better than drugs. Benzodiazepines have also been linked to a higher mortality, more cancer, more Alzheimer's. So that, that sort of calming pill doesn't have side effects that you don't have with the hormones if you give the adequate amount. And, um, so in Western Europe and North America, there are a lot of people suffer from anxiety. So in the countries that are richer, I would say it's more anxiety. And in the European Union, more than 60 million people have anxiety disorder. So it's really something that is worth doing. But that 60, those 60 million that we're talking about, European Union, that's just the top of the iceberg. And we know what what happened with the COVID. There's so many more people anxious. And what happened with the Ukraine war, especially in Europe, there's more people being anxious. We feel also the anxiety of Ukraine people. And so we're, we're, um, really, uh, supporting them. But, but, but on the distance, which is maybe not as sufficient. And so, to give an idea how important is to treat anxiety disorders, because the severe anxiety disorder that has done a psychiatric disorder, actually is linked to five times more, uh, suicide death in women before the age of 45, and seven times more suicide than in men. So, so something has to be done about. And giving just drugs that treat the consequence and not the cause of an anxiety disorder, um, because hormone deficiencies can cause of, uh, anxiety disorder. Well, treating only the consequences, maybe not that satisfying for a physician. And so, what are the five major hormone deficiencies behind anxiety? Well, important anxiety, especially growth hormone and low IGF-1, low growth, that's probably, uh, that sort of deficiency gives the greatest anxiety. It gives a dramatic anxiety, uh, that goes into panic attacks easily. And low testosterone, men and women, is probably the second, uh, deficiency to give important anxiety, uh, in both genders, not only men. Oxytocin also, but low oxytocin is more on anxiety, uh, when you're in social interaction with people, when you meet people, when you're afraid of meeting people, that sort of anxiety can be overcome with oxytocin. So low oxytocin gives that sort of social anxiety. Low progesterone, we talked about the premenstrual syndrome with Dr. Ascanio Polymeni of Italy. And progesterone has really a calming effect on the anxiety of the premenstrual syndrome. But it also has a calming effect in men. If men take it, they generally say that my shoulders and my neck are more relaxed when I take it, and I sleep better with it in a relaxed condition. And, uh, so then there's melatonin. Melatonin taken at night, uh, also decreases anxiety quite a lot. So these are the major hormone deficiencies that actually give anxiety. And when you give the treatment, you overcome anxiety quite well.

So let's look at some of the information. Growth hormone supplementation, uh, on anxiety. Where is growth hormone produced? Well, growth hormone produces this tiny little gland that is called the pituitary gland. And in the anterior part, it is made. And this hormone, it can be supplemented. And it gives actually, probably the most, the strongest anxiety effect possible with hormone therapy. And and it really makes you calm and cool without losing your concentration, like benzodiazepines do. You, you really are relaxed. The body and you see what is essential in your life. I even became much more spiritual when I started to take growth hormone because I was free of those parasitic anxieties that I had. And, and, and because I'm relaxed, I could see everything once more essential. And, uh, so it really helps me, uh, to make good decisions and, uh, just to feel good. That alone is already a major effect. And so it gives you deep inner peace and it promotes spirituality more than any other hormone. I can talk a lot about spirituality, but I must say, I have to say thank you to this treatment because it really helped me on see what really matters in life. And then we have, um, what sort of typical anxiety do people have when they have growth hormone deficiency? And this sort of information I see for every hormone deficiency because, um, I have the advantage of having also a lot of deficiencies. I have to correct myself, but also having those generous patients that come to me and that I, I help and, and I see the difference. So growth hormone, when you're lowering growth hormone, you have, um, compared to growth hormone sufficient adult, you have the impression that the world is a fearful place because you have the level of a dwarf, actually, of growth hormone, if you're really very severely deficient in growth hormone, and, and, and in a big body. And so that gives a lot of anxious thoughts and feelings. Uh, you, um, and without any reason, you just feel anxious and you don't know why. That's typical for growth hormone deficiency. And, um, so that gives you anxious thoughts that are in feelings that are during day and night. And you have a tendency then, if you're growth hormone deficient and you're not treated, to dramatize, dramatically, you find everything's dramatic and, and get outbursts of anxiety. But that's not very pleasant for your environment, basically. You, if you're growth hormone deficient, you cannot do anything about it. You need to get a treatment. If you don't do that, then you're helpless against this dramatization. Um, and so social phobia patients that that are afraid of mixing with people. And basically, what you see here is that, um, they have a 23% lower growth hormone level after stimulation by clonidine. And panic disorder patients that have a more severe form of anxiety, they have a 61% increase of serum growth hormone. So more than two and a half times lower growth hormone levels. So no wonder that they have panic attacks. And so, um, also when I, I, uh, teach about growth hormone and I teach about anxiety disorders, I also give tips that are important to do and to respect. Um, you first must and measure the most efficient product when there's growth hormone deficiency, and that is growth hormone itself, the identical growth hormone, not a growth hormone secretagogue, nor a growth hormone peptide that is a fraction of the molecule. You need the real thing, the growth hormone. And the, it's more efficient to decrease inside. The second tip is that you don't need a lot to decrease anxiety. 0.05 milligrams to 0.1 milligram is often sufficient to decrease most of the anxiety and, and improve psychologically. So it's, also better tolerated. You don't get adrenal inhibition, etc. So, um, low doses are sufficient with growth hormone. And then you should absolutely avoid alcohol at least five days a week, if not more, because alcohol decreases by 70 to 75% the growth hormone you will make in the night and also neutralizes the treatment. So it's almost, uh, no, not useful to take, um, growth hormone if you drink every day, two glasses of alcohol, for example. You will neutralize much of the efficacy. And, um, so, so, so basically, very important to, to know all the little fine tuning you should do when you have an anxiety disorder or depressive disorder. It's not always the same sort of tips you have, or you have autism, etc.

Now I wanted also to talk about testosterone supplementation, uh, in many women who have anxiety. Of course, I'm talking about supplementing people who have hormone deficiencies. I'm not talking about giving a hormone treatment to a person who has no deficiency because it will not work. Hormone therapies work to decrease anxiety and to improve psychological disorders if the person has low levels. They don't have to be catastrophically low, but they have to be inadequate levels, insufficient levels. So when you give testosterone to, to men, but also to women, they become determined. They know what they want. They know they can do this, and they will do it because they have the power to do it. So growth hormone gives them power and self-assurance. And so no wonder that that improves depression in men. It also gives them courage, exactly what a person who has depression often is lacking. So testosterone can reverse that demand. And actually, it is often testosterone is even more spectacular in women. So I've written a book for testosterone. I think it can really interest you because it has all the information, all information on prostate cancer, prostate hypertrophy, or you can reverse that or treat it also with testosterone, and, and some other things. Um, how to treat the testosterone deficiency when it's mild or moderate or severe, how to correct imbalances when you make they make too much estrogens out of it. So you really have a lot of information in it. If you want a book that overviews all the materials, all the study preferences, and mainly all the practical information and pictures, you have it in this book. So you, um, I really, um, would give you, um, for, I would advise you to, to have this book. You really have the information. So let's look at women. When women have a testosterone deficiency, they have a mild to important anxiety during the day. They especially hesitate a lot. They cannot take decisions easily. Very difficult for them to take decisions. When a woman is testosterone deficient, she also worries a lot. And there's a lack of courage and of daring. They don't dare to do things. And, um, um, and so there's a whole series of way of of treating all these different type of anxieties that a woman can have with discussion. And I can tell you, it's really efficient to make women impressively better for the anxiety with an adequate dose of testosterone. But there's a little tip is that never give, uh, as a physician that starts to a woman without giving female hormones. There must be a balance between the two.

What about oxytocin supplementation on anxiety? Well, oxytocin is produced actually by the hypothalamus. And the hypothalamus actually provides oxytocin and is then released in the pituitary gland somewhere below. But it's made in the hypothalamus. And when a woman has anxiety due to oxytocin deficiency, but also it's the case for men, she is anxious or he is anxious, or that can be mildly or severe. It's social interactions. I know this well because, um, if I don't have oxytocin, I'm more anxious in social interaction. I, I don't want to go to parties or have difficulty taking into contact. You would maybe use to be surprised, but yes, it is much more difficult. You're more afraid. And once I'm, I'm there, it's okay. But, um, when I'm not there, I can have tendency to isolate myself if I don't take oxytocin. So you have a fear of encountering, of also showing emotions. People have low oxytocin, they have an anxiety, but they also don't want to expose emotions. They don't even know their emotions often. So blocked are their emotions. It's called philophobia. And this anxiety in social interaction is really fear of people. Typically makes people shy. I was a kid, very shy. I can tell you, I'm not so shy anymore. So I can reassure you, but, um, it's easier with oxytocin now. So I also, um, you feel disturbed by people. You don't want to meet people because they disturb you. And they feel aggressed easily when you're low in oxytocin. And, and then you're much more lonely because you don't want to see people. You get lonely. And so it's a lonely anxiety with oxytocin. Um, so I, it's really something you need to treat in your patients because we're here to work together. We're here to live together. We're here to love each other. And without oxytocin, it's much harder to do. So, and so the loneliness of nothing. And to see how oxytocin can decrease anxiety, we note that when you put cold pain stress on the arm, for example, you put a cold pack on the arm, that's a painful act, and that creates anxiety in young adults. And when you give them before intravenous oxytocin, uh, it, uh, the anxiety three minutes after such a test is much less. So it's significantly decreased anxiety. If you feel better, you feel less anxious. So even with cold pain, it's okay. So you, when you hear, you see the anxiety and this is the pain session, you see with placebo, you somewhere help, but the oxytocin, it's much better, it's more significant. I wrote a book on oxytocin. And it's probably my favorite or one of my favorite books because I told also my story and a bit my family story, my slogan, and how it changed my life actually for the better. Um, and I, for example, um, I was a little bit shy or have difficulties meeting people. I had to, I wanted to buy a horse for my, uh, girl, my eldest daughter. And, um, I went, uh, to buy. And we saw several horses. And I talked with everybody, which didn't happen very easily with people who were selling. The people who were there, um, I even talked with the horses much easier. I was not afraid of nothing socially. So it really, uh, was for me, marvelous, actually, experience. I have good souvenirs about them. And so if you want this book, you can also download it. You can click on this and you will see how to, to get it. It's a book that is also good for general public, very easy to read, but a lot of information, how to do things, how where it works, etc. I don't think there's another book like this with so much information on oxytocin. And, um, so there's a session on other hormone deficiencies and their effect on anxiety. And these five other hormone deficiencies that can create anxiety are both thyroid, can be linked to anxiety, especially in the morning. More you don't want to get out of the bed. You're afraid of getting out from bed. That's typical for hyperthyroidism. Low estrogens can also give a moderate form of anxiety. Low cortisol also, too, because you don't have the punch to face things. Low DHEA, especially in women, and, uh, low pregnenolone are linked to more anxiety. And so I talk in this session a lot about all these hormone deficiencies. And let me just show you one thing. Um, what about autoimmune thyroiditis? You've probably all heard about Hashimoto's disease of the thyroid. There's a sort of inflammation of the thyroid gland where the body makes antibodies that actually destroys the thyroid gland. Well, this situation can sometimes be linked with so-called normal levels of hormones, but it's always linked with a lot of psychological disorders and physical disorders. Um, so there's high cholesterol, more, uh, atherosclerosis in those people, more cancer also. But look at Hashimoto's thyroiditis and anxiety. There's more neuroticism, there's more obsessive-compulsive disorder, and there's nine times more panic attacks in people with Hashimoto's thyroiditis. So it's not an instant disease, you need to treat it. And I have models that explain how to treat all thyroid dysfunctions, including Hashimoto's thyroiditis. You need to give supplements of nutrients, you need to improve the food, the supplements, nutrients is selenium, vitamin D, inositol, myosin, or stone, and, and you need to give thyroid hormones and much other things. You possibly need to give also adrenal hormones to decrease this autoimmune thyroiditis. Otherwise, the person, if a patient keeps on having this disease, has nine times more panic attacks, obsessive-compulsive disorder means that the person is worrying all the time. How many people around you don't worry all the time? Maybe you also. So you probably might have an autoimmune thyroiditis and you probably need to have a treatment so that your psychological disorder, if you can call that, gets better. And so also something is very important is that we live now in the COVID era. And too much thyroid can give also anxiety. And people who were before treated with thyroid hormones, some of those were since they had the COVID or had the vaccine of the COVID, they have developed a very bizarre form. They have a sort of, they have anxiety, they are feel nervous, irritable, aggressive, inner feeling of trembling, tachycardia, actually developed thyroid overdose. And when you have that, you have to stop two days, and then, uh, you decrease the dose of thyroid because this is hyperthyroidism. Strangely, these patients at the same time feel cold, have cold hands, cold feet, have slow Achilles reflex, which are consequences, accurate, of hypothyroidism. So they have both hyper and hypothyroid, hyperthyroidism in the head, the heart, the trunk, but extremities, they are hypothyroid. How do you do it? Well, you need to compromise. That compromise is taking less thyroid hormones. Um, you have to get rid of the hypothyroidism because some of those patients saw they lost all their muscles, you get thin, thin skin, for example, because they had too much thyroid that they were eaten up by that. And very bizarre, when you loaded those, they had warmer extremities, felt better. But this is since we have the COVID, there are much more hormone imbalances. There's often low cortisol, there's other low thyroid, but also more even often times this. Listen, so doctors need to know that and sometimes they have to compromise and take lower thyroid hormones, so to avoid the symptoms of excess thyroid in their patients. Now, one of the reasons they get excessively thyroid is that they get extended too much direct in moments of stress because they are cortisol deficient. So if you correct the cortisol deficiency, you stabilize. There's not too quick conversion of the weak T4 into the very potent thyroid hormone T3. And that is okay. So you probably need to treat the cortisol deficiency in these patients first.

So depressive disorders, what are the digital effects of hormone therapy? Well, there's also frequency following the World Health Organization is that it's very near that of anxiety disorders, although it's a little bit higher. There are 5% of adults suffer from depression, and all the adults 5.7%, so more frequent all the past. And in the world, 200 million people are estimating having depression. But that's more a severe form of depression. How many of us don't have from time to time depressive females? They are more women are affected by depression than men. But still, when it's men, it's very painful. They seem to be not doing well at the job and become childless. So, so, um, also the risk of suicide is even much higher than with anxiety disorders. Look at these figures. Women, 16 times more risk of suicide death before the age of 45 if they have depressive disorder. Imagine when a person has a depression, it's in certain sense an emergency. 13 times more risk of suicide this before age of 45 in men. That's two to three times more than with anxiety disorders. And depressive disorders also gives more disease like more abdominal obesity, more breast cancer, about three times more breast cancer depressed women. And, and overall mortality almost doubled after one year in depressed patients. They die from other causes than just suicide. And so we could really question of the fact that is depressive disorder not due to among the faces or aggravated by hormone deficiency? Certainly, it's, I can tell you out of experience. I have much more experience as a doctor prescribing hormones to treat, uh, depression than a psychiatric institute with all those psychotropic drugs. And, and I'm not against psychiatrists, but some of my best friends are psychiatrists, and they do their best. They're, um, there are generous people, they're really good people. Um, but I think they should learn more about hormones because with hormones, that better efficacy. There's one antidepressant, and, and you will see that their type of therapy works better. I had once a psychiatrist that I didn't know, he sent me 34 patients. He said, and I didn't know. And he said, I sent you 34 patients, and they all got better. And those 34 patients were my worst patients, patients I, I had refractory depression or infractory psychiatrist. And you all helped them to do better. That was amazing. So at least five symptoms of nine must be present. Uh, these are the criteria of the American Psychiatric Association. And you need to have a depressive mood, a loss of interest or pleasure, an increase or decrease in weight, so sleeping too much or less, being agitated or tired, tired or feeling guilty or worthless, or having reduced capacity to think it over, and having thoughts of dying or suicide. When you look at all those symptoms that are can characterize depression, you find them all as symptoms of hormone deficiencies, typical symptoms of hormonal deficiency. So, um, I really believe out of experience with hormone treatments that the first treatment of depression, but also of other psychiatrists, it should be hormone treatment. It is not enough for all patients. Some for some, it is really enough and makes major breakthrough. Some need is so multi-factor that all the factors have to be treated. The essential factor in order to have success is treating the hormone deficiencies behind the psychological disorder. So to see all the glands that help and make hormones against depression with thyroid gland and all these hormones are low often in various types of depression, estradiol, no testosterone, high estradiol gives cannot skip depression in men, low cortisol, low DHEA, pituitary gland, low growth hormone, and low oxytocin. They all can provide all these, the deficient provide depression, and that is refractory, actually, to antidepressant treatment because it's caused by the hormone deficiencies. And so what is the best treatment for depress? Is it non-bioidentical antidepressants? I wouldn't say so. You can use them for a short time, but lifelong, no. Lifelong hormone therapies, yes. So bioidentical hormones, in my experience, work better, and it's efficient, it's safer, you don't have side effects if you give the correct dose, and it treats the cause of many of those depressions.

So let's look at thyroid. What target does for depression? Here's a hypothyroid patient, typically with swollen face, lower small lower eyelids, and look, it doesn't look happy. And typically, if she, she has been hypothyroid, she will have depression. And she wakes up with the dyes at the morning, she wants to stay in her bed because the world looks, let's say, wow, makes her anxious and not, not want to get out of bed. Also, typically a person who slows down is in the morning, not in good mood, grumpy upon a way, irritable, having a heavy head because the head is really heavy, it's full of mixed edema accumulated during the night. She also feels worse in the morning and at inactivity and at rest. So she feels better when moving, actually, and, and feels better in evening and activity, typically. So those patients don't feel bad all the time. They feel worse in the morning, and as measures, the more they move, the better they feel. And then the evening, often they feel good and they want to go to bed because they have that good feeling. And for example, here, what is the present rate of one with subclinical hypothyroidism? So subclinical hypothyroidism means that a patient has a high TSH above the upper reference range, and the risk in the lab test looks normal. Well, the risk of, um, is is about three times higher. Autoimmune thyroiditis when you have antibodies against the thyroid is three times higher. And when over the hypothyroidism is also low thyroid hormone, the low blow resistance range limit of the reference range, eight times more clinical hyper, uh, depression, and clinical hypothyroidis, very frequent depression when there's thyroid dysfunction. And in Hashimoto's thyroiditis with those antibodies, there's one and a half to nine times more depression depending on the study. And there's, and the, the severity of the hypothyroidism and 40 more deaths by suicide. [Music] So it's not a healthy situation. So the mechanism that leads to depression, uh, in hypothyroid, there's a lot of mechanism. In one of those mechanisms, it's just simple, there's an accumulation in the head of waste products called, you see how small this patient is, it's also smaller inside, around in the brain, in all other tissues. So this mixed edema compresses the brain tissue. You cannot feel good when there's compression in your head. And so in direction, before long treatment doesn't work well because this study I did on patients who were on T4, and I later put them on T3 and T4 combination, but 60% of those patients taking thyroxine, those that was normally should have helped, were still depressed. And so a second mechanism is that thyroid hormone are the most potent hormone to accelerate the blood flow through the brain. So in hyperthyroid, this is decreasing brain blood flow. And this can be in, in this study of Scheinberg in 1950, very old study, 38% decrease in brain blood flow. And there was also more cerebrovascular resistance, and there was 27% less oxygen and glucose consumption compared to normal. So you don't have a good blood supply, don't have enough oxygen in the brain. And, and so what can thyroid hormonal treatment do for depression? Well, in patients with Hashimoto's thyroiditis, and you, you see here that, um, faced with autoimmune thyroiditis, they received thyroxine treatment for more than a year, which is not the most efficient treatment, but anyway, compared to patients who did not receive T4, there was actually one third less risk of depression in the patients who received thyroxine. So these have normally patients have normal values of T3 and T4 and TSH, but they had autoimmune antibodies that were damaging their thyroid gland. And the result is, uh, if they are treated with thyroxine, they are better, less risk of depression. And what can thyroid treatment do for refractory depression? So what is refractory depression? That's a depression that doesn't respond to traditional antidepressants. Well, those patients with this form of resistant refractory depression, and this is from a meta-analysis of six studies, uh, they have actually, uh, 1.6 to 3.4 times more subclinical hypothyroidism. So some degree of low thyroid function. And patients with antidepressant treatment resistant depression actually have 10 times more subclinical hypothyroidism. So 52% of these patients compared to what was expected, 5% in general population, 52% have subclinical hypothyroidism, means that the TSH is above the upper reference rate. So it's already a degree of hypothyroidism. So, um, there are studies that showed the efficacy of thyroid hormone on refractory depression. And these are all placebo-controlled trials I'm shown. So there are more studies, and it shows that actually, um, when you give T3 plus antidepressant, T3 is the most potent thyroid hormone, you significant decrease.

Depression in those refractory depressions. And so you have a whole series of studies where it worked in. And those are the most valuable studies, or double-blind, placebo-controlled trials. There's even one from 2013, so it's not all older studies, some are new, are relatively recent.

So now, the second most important treatment against depression is actually, um, estrogens together with progesterone. I never give estrogens alone in women, even if they have a hysterectomy, always with progesterone. And so it helps for depression, very importantly, in women who are oxygen deficient, not if they have enough resources. And so I consider this as the second most efficient treatment against hormone treatment against depression. And for example, you see this woman in estrogen deficiency. Women have two to three and a half times easier depression, uh, in, in this 2015 study. And here is 18 percent of earth direct woman half depression in this study. At least in 56 percent of young, middle-aged hepatitis women have depression. But an older person, if they have some form of hypothyroidism, it's worse. So there's more depression. 75 percent of all the hepatitis women have episodes of major depression, not the small depression, major depression. So in general, you have to consider three to four times easier depression. We saw another study where in overt hyperthyroidism, it was eight times higher. Yeah.

So this is a slide that should be in the third function. So let's look at estrogen therapy. And one of the most amazing therapies is the efficacy of association therapy to decrease postnatal depression. You see that postpartum depression, 70 percent of women in postpartum have postpartum depression. So that's quite high. One in six women have postpartum depression. And it increases above the age of 35, almost doubles. And there's, if you are have a high university degree, uh, you're, uh, also involved almost three times more risk than people with lower education. And so postnatal depression, what is that exactly? That's the depression in six months after the liver, in the postnatal period, in the past pattern. So in the six months of the liver of the baby, the main cause in my experience is insufficient estrogen levels during the postnatal period. So when you hear a deficiency, you hear there's a treatment.

And, um, so what happens is this gives an overview of actually what happens before pregnancy. You have a normal menstrual cycle with normal estrogen levels. This is the level of estrogen. So you see a peak, pre-ovulatory peak, and then you have higher levels in the second phase of the menstrual cycle. When you go into a pregnancy, you have much higher levels of estrogens and progesterone. So that's all fine, a lot of compounds fighting off depression. But at the delivery, there's a crash, a severe drop in estrogen, progesterone levels. It's almost zero. And that can cause postpartum depression. Of course, it's too big a change in a woman. And so in postpartum depression, there are two times lower serum estradiol levels. Levels are already low in women in the perspective, but it's almost zero, half of the level in women who are depressed. Uh, exactly. Levels below the low reference range of menopausal women here. And so they are also two and a half times lower serum serotonin levels. Then, and the lower the serum estradiol levels are, the more there's postnatal depression, depressive symptoms. So it's really a relationship. Undoubtedly, the cause of the postpartum depression is at least partially, if not totally, caused by low levels of estrogens. There are other studies showing the relationship and also the improvement when you give estradiol treatment of personalized suppression. So here's a treatment with transdermal estradiol and oral dydrogesterone. That's difficult. And you see here three months of transdermal and then three months of cyclical dydrogesterone. And you see it increased about 40 percent the depression scores on the edible postnatal depression.

And then testosterone treatment. Let's look at another type of treatment, testosterone treatment for women, which refractory depression. You've done all your best as a physician and you have no success. Uh, women stay suppressed. You give hormones, you give everything, but you forgot to give high dose of testosterone. And those women remain collapsed with small doses of testosterone, remain collapsed with female hormones, remain collapsed, and they are no good to do anything. Extreme depression that responds to nothing, a real mental collapse. Some women have had that. Age 40, something happened or nothing happened, but they felt no energy anymore and they dropped severely. And you give treatment, they still feel tired and depressed. Nothing can be done about five to 20 years of collapse. And you, as a physician, are the magician. You can change that situation. You can change that by providing testosterone injections, one per month during two to four months. You can have a dress without this collapse. One woman could become prime minister, an iron lady like we've found in UK, fighting spirit. She gets with it. I'm really amazed how this treatment can help women to become brilliant women. Women should always become brilliant. She, that's her destiny. For men too. But I must say, it's also destiny of women. Women don't take their destiny. They're just a shadow of themselves. Woman, you need to shine with who you are. And testosterone counts. Women don't do that without them. The assumption. So you can give intramuscular injections. And there are those. You can even give it every two days. But in general, it's once a day, once per month, 50 to maximum 150 milligrams per month. Frequency once per month is generally, but it can be in smaller amounts quicker. But you need to avoid masculinity because with these levels go higher at higher levels. So you can get finasteride. And that's an oral progesterone derivative that blocks conversion of the safe testosterone into the dihydrotestosterone that provides masculinization, facial hair, hair loss, and things like that. So you don't want to do that in your patient. But the dose can be relatively high. Give high dose of this. And but it always works well if you are able to balance well the finasteride correctly. And you don't have frowns with the finasteride that you can have if you only get finasteride anymore. You may never get finasteride without testosterone, also not in men. But it can be some gentle regression.

So DHEA treatment, can that help against depression? This is the double-blind, placebo-controlled trial where men and women with dysthymia. So dysthymia is actually, um, a mild degree of, um, depression. It's not severe. Uh, and can be, um, quickly improved. There's a positive event happening. So it's, it's not constantly low in this person. You can have this sort of dysthymia, this low mood, and placebo can, 20 percent can be improved. In this study, those who took DHEA for six weeks, and the first three weeks, they received 90 milligrams. That was investigated after two weeks of 90 milligrams per day of DHEA. There was a 60 percent of patients improved symptoms. That most significantly improved were the lack of feelings, the sort of emotional numbness, the loss of energy, the lack of motivation. All improved with 90 milligrams. The vitae is a slow-working substance. But if you give a higher amount, you have a quicker effect. You can have within three weeks much more effect because 90 milligrams is an overdose normally. And inability to cope also improved. They were less sad and worth less, also with that dietary conversation. So it's significantly improved depressive feelings.

Now let's look at stress disorder. We made a survey among all our patients years ago. What is your major complaint? And they could list five complaints. The major complaint was fatigue. Where they came from? That was the reason why they came to consult here. It wasn't the status. The second complaint was no resistance to stress. And we didn't suggest the psychological. We just let them write down what they wanted. Just ask them to make it short. So and the third was depression. So imagine psychologically corresponding are really top of the concerns of patients coming to the consultation for hormonal therapy. What is this stress? Distress is an excessive stress that is not the positive stress. We're talking with Dr. Escanyon. Many, then you need short positive stress to improve and live long. Well, de-stress increases mortality. If you have here, um, patients with post-traumatic stress disorder, they have a trans heart transplant. And they have a sort of post-traumatic stress disorder. Well, if they have that after transplant, get 14 times more mortality. Imagine three years after heart transplant. So people who can have a post-traumatic stress disorder don't benefit much from their transplanted heart. And hormone deficiencies can increase stressful feelings and likelihood of post-traumatic stress disorder. So when we look here at the hormone deficiency that can make you also irritable. It's one of the consequences of being stressed over, too much stress. Who is all fish? The number one hormone when you're deficient in that hormone, you're very likely to be irritable. Often growth hormone deficiency too. Lack of proton is more irritable. Progesterone deficiency, it's also a hormone. Normally it calms you down. Don't have enough, get more irritable. Look at this womanly premenstrual syndrome. By lacking progesterone, they're quite irritable. Often their husband has to run away as he sees my wife has to get her premenstrual syndrome. They're more killing happening in the premenstrual period. So be careful. And as a physician, treat the progesterone deficiency. Melatonin deficiency. If you don't have enough, you can also be more irritable. And then there are excesses. Too much estrogen can make you irritable. Too much testosterone too makes you impatient. Cortisol excess can also make you irritable. And melatonin excess also because of melatonin test can decrease cortisol levels and become irritable because of low cortisol levels. The worst irritability by hormone excess, estrogen excess that creates this nervousness and irritability of the premenstrual syndrome.

Let's have a close look at what cortisol deficiency can do for those distressed disorders. Typically, when this cortisol deficiency, the patient feels overwhelmed by working stress. Everything is too much. Anywhere, any stress is too much. When you hear that from your patient, you know the patient has likely cortisol deficiency. And you know what to do. You need to correct the cortisol deficiency with DHEA. We'll talk about this in the model more deeply. And so burnout, post-traumatic stress disorder is linked to low cortisol levels. You see a metabolism of what hydrocortisone can do for post-traumatic stress disorder. And hydrocortisone significantly decreases these, uh, post-traumatic stress disorder symptoms. And it also increased the incidence of post-traumatic stress disorder significantly by minus 15 percent. And it also works especially in prevention. If you have a surgery, for example, that can create a post-traumatic stressor, start at the surgery. Cortisol, start before even before the surgery. And then you will see there will be less likelihood of post-traumatic stress disorder. So cortisol treatment, when you give it during cardiac surgery, uh, you have less light need for norepinephrine. So need to intervene by the anesthesiologist to save the life of the patient. And in intensive care, it shortens the duration they need to stay in the intensive care unit because they recover better. And during follow-up, there's less stress symptoms, typically due to the hydrocortisone. And there's a better quality of life. So really, hydrocortisone is something that decreases stress symptoms. And it's the hormone number one to do that. And if you want to know how to treat with hormones, I have the hormone handbook that really gives you the keys to safe hormone therapies, how to do it, and how to solve therapy problems. If you don't want to buy a smaller book or less expensive book, it's the patient hormone handbook. And you can order here. I think if you work with hormonal treatments or if you're a patient, you buy the patient book. These are the most essential books you can buy because you have all the important information you need to know to be able to go through.

Now I have done talks about autism, very detailed. I won't go into detail here. We cannot do all the things. I think people were more concerned by anxiety and depression. If you want to have more information, just register for the model on psychological disorders. But here, let me give you some information. What hormone deficiencies may increase autism? Oxytocin deficiency, thyroid deficiency, horizontally. Oxytocin deficiency is probably the number one. And some kids can even be solved by oxytocin alone. I don't think the best approach is just one hormone treatment. I believe several hormone treatments is the better approach to solve autism. And also good food and, um, some psychotherapy. So low growth hormone, low melatonin also can favor autism. And one excess testosterone has been considered of increasing of this. This may be one of the reasons why boys are four times more affected by autism than girls. And just to, to know, just look at a boy, for example, who has autism. Look at him. What do you see? There's a lack of facial flesh, lack of emotional expression, divergent eye gaze, your voice to look into your eyes, yes, one lower eyelids, no smile. Those are all physical signs of hormonal deficiencies. The lack of facial flesh is lack of oxytocin. Lack of emotional expression, lack of oxytocin. Divergent eye gaze, lack of oxytocin. Swollen lower eyelids, low thyroid. No smile is also lack of oxytocin. But there are more signs. So I look into details with pictures, uh, in the model.

So let's look at oxytocin deficiency and autism. And you see here, for example, autistic boys compared to control boys, let's say healthy boys, have significantly lower serum oxytocin levels. And also have high levels of the C-terminal extended peptides of oxytocin. So oxytocin is lower, but other forms of oxytocin where it's linked to amino acids and less efficient or higher yeast have unusable oxytocin levels. And so there's a greater ratio of those C-terminal extended peptides compared to the oxytocin. And that gives deficits in oxytocin peptide processing. And that they reflect. So they are not able to work well with oxytocin, these autistic boys. And we give an oxytocin treatment. This is the case of Sarah, a girl of three years that was considered autistic. She wasn't, um, never spoke at three years. When I got her first here, she said five years. Hyperkinetic, no attention, affection given to the young brother, considered a low IQ of 75. And the solution was to give her very small amounts of oxytocin, sublingual, three international units per day, one-eighth of a tablet of 10 units. And, and she was much better. When she came back here, she was very hyperkinetic, didn't look me into the eyes because she had stopped the treatment regularly. There was a sort of supply problem. They didn't have oxytocin enough. And, and, and then she came back into her autism. She was obviously diagnosed. And also your brother as autistic. And then they, we had an official paper saying they were not as dizzy. But that was when she, they were taking both oxytocin.

So also another deficiency can promote or placement is cortisol. And I want to make you realize that it can't start in the pregnancy. Mothers who have a low serum cortisol during the pregnancy, half actually later in their five-year-old born children, they were significantly more autism spectrum disorder among the boys, not the girls. So low cortisol level in the mother, it's not good during the pregnancy. A low cortisol level in the mother during pregnancy also gives more vomiting, more nausea. So women with nausea often have cortisol deficiency. It gives also the melasma that they have on the face. So you can spot that. You don't even have to check the blood. You just look at the physical signs. You already have an idea if the patient has a low cortisol that can give to a child an autistic drug carer child more of this month. And the treatment is then of course to give during, and it's safe, hydrocortisone, vitamin cortisol with small doses of DHEA, not too much.

What about schizophrenia? I also have abundant information on that, uh, how you can deal with it. And I think again here that, um, hormone treatments are as important as psychotropic drugs to help these patients. I think they need some psychotropic drugs. The problem we have with schizophrenia is that these patients refuse the treatment. You can do fantastic treatments and they don't take it, or they take it a while and then throw it away when they're better. So this real problem of their sort of opposing act, opposing, um, thoughts and action against any medical treatment, especially hormone treatment. So oxytocin deficiency is probably, um, the most severe deficiency in schizophrenia. Growth hormone deficiency too. These are the two most important ones that contribute to schizophrenia or psychosis. Thyroid deficiency also can help you can promote this sort of schizophrenia. Cortisol DHEA deficiency, melatonin deficiency, estrogen, and progesterone deficiency. Progesterone in men, there's a suspicion there. 50 percent lower levels of progesterone in schizophrenia in men. And testosterone deficiency in men can also promote schizophrenia. And so the corresponding correction of these deficiencies with the hormones helps.

Let's look at growth hormone deficiency. And when you look at a person with schizophrenia, like here, he's actually talking to a tree that is here. They have difficulties to prioritize. They have a lack of inner peace and anxieties. They have a bone dense back, typical of low growth hormone. You have a tense body during the day. And so when you look at the chronic schizophrenic men that don't drink, don't take any psychotropic drug, you see there could be a healthy event. There's significantly lower growth hormone levels at night, during between 10 p.m. and 8 a.m. So the whole night, the growth hormone is mainly secreted at night. And they don't really have an internal growth hormone peak. And most of the growth hormone is created at night in form of a peak, when 75 percent of growth hormone is thus produced. And that is absent in those men with schizophrenia.

Can DHEA treatment help? Among all those treatments, well, here's DHEA treatment that was added to antipsychotic drugs as a driven therapy and decreased the negative symptoms. What are the negative symptoms in schizophrenia patients? Don't do some things like they don't socialize. That's a negative symptom. So if there's a lower incidence of negative symptoms, that means that they're socializing, that they're doing activities they didn't do before. And also decreased the extrapyramidal symptoms. We know that you have those abnormal involuntary movements of hands and maybe other limbs due to the psychotropic medication. That is decreased by DHEA. And so I also have a section on psychological disorders where we see patient practice, patient cases, very, very interactive model. And I think everything will be out this week or for Monday or Tuesday, next Tuesday latest. And let me give you some information about my next events before we go to questions. Is that, um, on Saturday in the United States, through webinar, um, in the conference of H.R.T. Bioidentical Hormone Replacement Therapy Conference of the F.R.M. in San Diego, I'm giving at 1 p.m. Pacific Time a conference of two hours. I think it's really fascinating on the how hormone treatments improved the physical appearance and physical signs of deficiency. And, um, in July, I will do for Access Lab a live webinar. In August, um, for Pharmaceutica will be the congress in Buenos Aires for the pharmacy VIP congress, also live webinar. In September, um, I will give a webinar for the A4M on longevity. I will give a talk in a conference live in Madrid, uh, in, and September, beginning of October, there's also a workshop. So also longevity, reversing physical aging, detecting physical aging of hormone deficiency. And then there will be also in October, um, another longevity webinar. We'll have probably a very prominent person in longevity talking. And, uh, we'll also have in November Longevidade Congress, Sao Paulo, Brazil. That will be a very interesting also a whole workshop on logistics. And also workshop on what's the A4 Congress in December. So very exciting information. A lot is around longevity. There's new information. There's fascinating information of what hormone therapies can do. Also my medical education. We have this program, evidence-based postgraduate program, that you should really subscribe. You have all the information how to treat COVID infections, on fatigue, on thyroid hormones, on cortisol, on the hormone consultation. If you really start normal there, you should really get this model, hormone consultation. You will see it's very practical. Gives you all the good information you need to know to go through with a lot of pictures, very interesting, etc. So there are a lot of, you can go over. Just go on to the website, get that information. But I especially say, hormone consultation, pure beginner. Even if you're advanced, there's a lot of information you never knew that is in here that helps you. This is the model, and I'm presenting here, psychological psychiatric disorder. And we have five models that are available in Spanish. And I really thank Jennifer. Jennifer is doing all the work of translation. She's really great. And she did a fantastic job. So in Español, it is also. You have a special offer if you buy these books here. That's the book on oxytocin. That's the book on testosterone therapy. Period. Gentlemen. And that's also an advance with a lot of pictures on physical signs, more than 650 pictures of hormone deficiency and hormone excess. It's really, really in for. If you want to purchase, just click here. And, um, I want to thank all these partners that has helped us. Success Lab, Laboratory, NE LIMS, Login Data, Fourth House, Napa Tech University, Compounding Pharmacy. And I'm missing some of those. Thousand later. And they all are, are really doing great work. And then I want to let, um, enjoy present themselves. But I'm closing the music. I will give some commentaries on this so that we can do it. So initially, it's one of the best partners I all had up to here. And they are, um, very reliable distributors. They work in true whole Europe, especially Western Europe. And they are have done a fantastic job. Going to see if I can put the music bit lower or stop again, um, because they are really doing some of the best projects I know. And they are doing also some short congresses that are really interesting for doctors, etc. So the high quality projects, they're also friendly people. These are the countries they're really active. And more than 30 years, they're actually in a whole party about that. And, and so they're really, um, people working, I would say, Western Europe. Um, I really recommend this firm. Um, I'm very grateful. They always have helped us. They're positive people. Like you once, they have a whole academy of trained physicians. And you know the nutrients, etc. So you have a reliable partner who doesn't want to sell you just a bad product. They just want to sell me the best products. And I'm always happy to present them and to give an opportunity to present them here on this webinar. Now, um, next slide, then, um, is, uh, these are all the social networks where you can follow me and and the work we do. I work also with other physicians that are, I'm very ritual to be able to work. You have the YouTube where there's a lot of conferences, short interviews, or longer interviews on, and not only on me, there are other doctors also interviewed that are very, very interested. In Facebook, etc. And if you want to contact more personally, office@hertdog.eu is the email. And that's where you can buy books, training programs, there, talkmedicalschool.com. So please contact us. Now we're going to the questions. And I'm going to stop sharing my screen so you will see me. And I have here a list of question and answer that I will answer. And we cannot stay too long because the interpreters. So we have about 20 minutes. Um, okay, somebody's not understanding English, but there's a French and then says, okay, question and answer. What is the right value of progesterone in plasma for men and for women? Well, the right value in women depends if she's before the menopause, she has a menstrual cycle. You check the progesterone the 21st day of the 28-day cycle. So about seven days, one week before the menstruation, you have a peak level of progesterone. And that level should be between eight and, uh, 18 nanograms per milliliter. Sometimes lower values are accepted. Ideal would be around 13, 15 nanograms per milliliter. In men, it's about one nanogram per milliliter, not more. And in men, the progesterone is made by the adrenal glands. Namely, do you recommend the application of progesterone to treat benign prostate hypertrophy? Yes, I surely recommend that. You can give an oral form like 100 milligrams progesterone in the case of benign prostate hypertrophy. But also, um, I, um, give suppositories of, uh, just like 100 milligrams, suppositories of per 100 milligrams per session, suppository. And I, um, can add ethinyl, 300 milligrams, which is sort of antiseptic preparation that also is helpful to decrease benign prostate hypertrophy because benign hypertrophy is partially reversible, if not totally. What are the signs of progesterone or pregnenolone over treatment in men? In men, when you give progesterone and give too much progesterone, they can have, uh, adrenal deficiency symptoms. They have low blood pressure because progesterone and aldosterone receptors can lower blood pressure and a dizziness in the head. And then, and we can also be more depressed because it decreases estradiol levels sometimes too much. So you can have some sort of depression and lightheadedness. So never take a really, never take progesterone or progesterone as a man in the morning because then you would have this heavy head that you can have. It was pregnant. The only side effect I had when I tried it was, um, at 300 milligrams, which is a huge dose, was actually an oily skin. So it converted too much into androgens, testosterone, and I, and my skin got more oily. So that was the only sign. Otherwise, pregnenolone doesn't have too much, uh, easy overdose signs because the normal dose that you give a pregnenolone in the morning, first thing, is 50 to 100 milligrams. So, uh, with that, you generally don't have any physical sign of overdose or psychological sign. You just have a better short-term memory. That's all. So don't forget that when pregnenolone is given, always provide the, um, first thing in the morning because then it starts working for the day and you'll have a better short-term memory for the day. Then the question here, do you have any request from Melanie? You have any recommendations for hormone treatment of an intellectually impaired, mental age about 18 months, 37-year-old woman, only attacks people premenstrually? Yeah, well, if she attacks one premenstrually, you provide progesterone from the 15th to the 20th, from the 16th to the 26th day of the menstrual cycle, normal cycle. Provide about something like 12 days of progesterone in the evening. And she will be much more friendly. Now, how can you improve? And I cannot make a promise, but that's what I would try. I would also try to improve her intellectual properties. Unfortunately, if she has an age, 37, the mental age of about 18 months, you won't be able to improve to a normal age because of the damage done. But basically, I would give thyroid hormones and I would give growth hormone, IGF-1. And she will probably have age 7 or age 10, probably, if, if you have the money to pay her treatment. Then Frank here, speaking about intermittent fasting, how many hours, for example, 16 hours, and how many times a week? Intermittent fasting is, you don't need during a certain time, and that gives a rest to your body and your intestines and makes you that you can have less disease, less cancer, less heart disease, lower cholesterol, less obesity, and also live longer. In animals, they can live longer with intermittent fasting than they can live with a low-calorie diet. With a low-calorie diet, you live about 20 percent longer duration of mice. In my studies, it is 35 percent longer when there's intermittent fasting. So it's important to do it well. And basically, the animal studies have been done differently than humans. And the animals are fasted two days per week, no eating, and then they can eat what they want the other days. Um, so in humans, what we do is we do, you eat two meals and not three meals a day. And they should be close enough to each other. So you have 16 hours fast. So you eat, for example, in the morning and it's in lunch, and maybe two hours later, but not later, not more than that. So you have 16 hours of fasting in eight hours waiting. That's what you can do. So basically, it's easier to remind that you just do two meals a day and that they should be follow each other. More or maybe a snack more can be taken, but there should be one meal that you don't take. And that's the best way to do it. You can, of course, do a whole day of fasting. I do actually, um, I eat one meal a day two days a week when I can. And that helps me to recover from the two days. I sometimes eat three meals, but so on the average, I eat two meals. And that's a good form of intermittent fasting. Um, the treatment of ID, 37-year-old with premenstrual associates seem to be polar also. So do I want to use? And I do want one. What can you do for bipolar disorder? Bipolar disorder, that's a disorder where you have a manic phase where they're very nervous and euphoric and very agitated. And then you have a depressive phase where they're not doing much and they're sad and feel bad. That is the hormone deficiency behind there. That is mostly low thyroid function, especially what is called the rapid cycling bipolar disorder where more than five times per year and up to 50 times a year you have ups and downs of the mood. And, um, that responds well to thyroid therapy. And there's a lot of thyroid deficiency, like 10 times more thyroid deficiencies in people with bipolar disorder. So you, you should provide thyroid hormones. And I think it's the same woman that we're talking about with a low IQ. I think the thyroid hormones will really improve that and make more regular her, um, mood. What supplements do you use that modulate serotonin? Actually, I don't focus so much on serotonin. I focus on hormones that improve depression. But for example, thyroid hormones increase serotonin levels. But if serotonin levels are too high, in some people, it's divided. They decrease the serotonin. There are some studies showing that a Russian study. So basically, I provide a precursor of serotonin called 5-hydroxytryptophan. That's the immediate precursor to serotonin. I prescribe that for in two reasons. The 5-HTP either to decrease appetite. So I give, for example, not more than 25 milligrams in the morning and 12.5 milligrams at lunch and 12.5 milligrams in the afternoon to decrease appetite. Or I give it at night to sleep better. I think myself, regularly, not always. I change with tryptophan. I use 5-HTP to before bedtime and then convert in the night to serotonin and then from serotonin to melatonin four hours later. So I can sleep the four last hours of the sleep better. They give them 50 to 100 milligrams. Okay. We also saw that estrogens, um, also improve serotonin levels. So you can really improve serotonin levels by hormones. There's a person asking if there's a replay. Yes, there's a replay. If you don't have to go away, because you have some other things, you can always view this later on. And then Monica here says, can a psychotherapist heal depression, anxiety without balancing the hormones first? Or can therapy be eternal if hormones are not balanced? So, if psychotherapy is working with what is called refractory depression, refractory anxiety disorder, which doesn't have, is because there's a hormone deficiency. So if you don't correct the hormone deficiency behind it, it doesn't, it's not helpful. You, you need to combine the best. And the best is psychotherapy, certainly. And certainly also in current or chronic psychological disorder, also hormone therapy. That's in my experience. There's also something that is a little different from psychotherapy that who even live in is spirituality. We are here for a reason. The fact that I'm lecturing has some good effects. But, but it's not only. I get this information from others. So basically, I'm just sharing information I received. I'm sharing you the gifts I've received. I'm not inventing everything. I'm just sharing. But, um, some people don't improve even with hormone therapy because they have part of their soul that is not there. They are like, you can recognize those people. They are there and not there. They are absent. You have the impression that part of them is not there. And that is what's called loss of soul. And, um, you can recover this by expressing emotions, by succeeding the spiritual experience. If you have a trauma, if you don't express the emotions that the trauma brings you, you stick with the trauma all the time. And you stick with the blocked emotions. They don't leave you. An emotion only leaves you when you accept it and express it in yourself. Doesn't have to be expressed outside. So if you accept, I accept in all my cells and all my molecules, in all right, etc. And I'm talking about also that spirituality in the model. And so any patient who blocks emotion will get sick about, uh, and it will give problems. And those who have anxiety disorders actually don't express enough anxiety on time. They don't accept anxiety. They're fighting against it. Don't fight against it. Use it as a force of transformation. But force that blocks your mind, that doesn't have to work all the time. And you transform. And after you are more sensitive, you can love more. So I would say psychotherapy, spiritual experience, successful run, and hormone treatments would be actually the three big things that make depression better. Otherwise, if you don't treat the hormone deficiency, and that was part of the question of Monica, you, the, the consequences of hormone disease remain. And there will be main depressive feelings or anxiety things that cannot be solved by psychotherapy. I have a question about why is it that PMDD patients can't stand progesterone after ovulation? So I suppose that it's not PMDD but PMS. Why do some premenstrual syndrome patients not tolerate progesterone after ovulation? Because they are too low in estrogen. So women who have ovaries that are weak and don't make enough estrogen and progesterone, they can have a premenstrual syndrome caused by lack of progesterone. When you get progesterone, progesterone decreases estrogen levels. The estradiol is more converted to the weaker estrone. And then they become estrogen deficient. Then from first irritable, they become then depressed, irritable because of progesterone, and depressed because of lack of estrogen. Have you had success in treating bipolar disorder using hormones? And so what did you use? Well, again, for bipolar disorder, you generally always need to give thyroid hormones. But also to treat adrenal hormones, the deficient adrenal hormones. And then growth hormone really takes psychosis away. Because bipolar disorder is sometimes considered psychosis. So it really takes cells with psychosis. And I would also give oxytocin. Now, the problem I have with patients with psychosis, uh, is that they refuse to take the treatment. Or they, they take it a while and it goes better, and then they let it down. They are rebelling for a medical treatment. So basically, they're, I have a hard time convincing, not the family, but the patient of taking the medication. So, um, I would say, uh, there has been success in the past, but not often. And not because the treatments don't work with hormones, but because, uh, basically refuse the treatment. But if you have a patient who accepts the treatment, you generally need to give thyroid hormones, hydrocortisone, and DHEA, plus growth hormone, and maybe oxytocin and melatonin. And then they are much better. My hands and feet are cold in winter. That's Jabber, who says that. Although I take thyroid around 60 micrograms a day in the morning before breakfast, my heartbeats are 90 times per minute. So I cannot increase thyroid. Can you know why they are cold? Is it because vitamin D? I don't think it's because vitamin D deficiency that the feet are cold. I think that Jabber actually, um, is not taking enough thyroid hormones. And it can tolerate it better by taking part in the morning and a little bit an additional part just before supper. But also because that Jabber has probably adrenal deficiency. And then you don't tolerate thyroid amounts. You go quickly into tachycardia. So maybe there's adrenal deficiency question that slows down a bit the conversion of T4 to T3. So there will be more heartbeats. Maybe helpful in this patient. Now, why are the extremities cold? Also, some patients have accumulated quick mercury. Mercury accumulates in the nerves. And, and, and so, so generally that can also give cool hands. By featuring, it might have to be chelation therapy in these patients. Also, what also warms the hand much more is growth hormone. So if you give growth hormone, that stimulates the thyroid function. And that it also gives warmer hands in feet and extremities, more blood flow. Here's another question. Can testosterone help with neuropathic pain? If so, how would you dose them? Well, but just test. And you give also trial of treatment. I suppose that the person who is anonymous is a man. Omar, is there a link between testosterone deficiency and neuropathic pain? Can testosterone help to protect nerves and reduce the pain? For neuropathic pain, um, it's usually also due to an inflammation. You, you need to have all complex vitamin B's, CoQ10 helps a lot. And, but testosterone can help against pain, but it's more muscular pain and, uh, ligament pain. If you have Achilles, vacuous tendon inflamed, it decreases that zone inflammation perfectly. And it will also decrease neuropathy. But there are other treatments that might have a better effect, like IGF-1, for example. And, and cortisol. Cortisol balanced with DHEA. DHEA increases the anti-inflammatory effects of cortisol. So you should give it together. And then also protects against any adverse effects of cortisol. Do any hormones help to stop alcoholism? Yes, oxytocin is known to decrease substance abuse, accused, including alcoholism, drug abuse, and things. So oxytocin is the number one. Progesterone also helps against alcoholism. And, um, also treating the adrenal deficiency you have with cortisol. So I give a half tablet or a full tablet of not the identical hormone in this case, synthetic hydrocortisone weighs longer, but like two to four milligrams of material with DHEA. And that helps a lot against our alcohol taking alcohol. So here's, uh, anonymous. My mom's 86, and she takes Euthyrox, L-thyroxine, despite from 75 micrograms to 100 micrograms, expecting 25 micrograms of zinc and Thorne Magnus, selenium. Thyroid shows severe hyperthyroidism. It's, it's not a thyroxine insufficient. She probably needs to take desiccated thyroid like Perfect Thyroid or Armour Thyroid. If you give Euthyrox and you want to do it with T4, you have to suppress the TSH to have efficacy against T3. T3 is 2 picograms, so it's quite low, at the low borderline low. And T4 is also is average. If you have anything besides neutral interest rate to fix low detriment, any benefit? They're further increasing antarctic. So again, if you only have Euthyrox, you have to have high normal T4 levels in blood to have an acceptable T3 level in the mid-range, which is good. So you really need to decrease TSH to undetectable levels generally to have efficacy, of course, without any heartbeats. Can amenorrhea, that's a lack of menstruation, cause anxiety, depression, or vice versa? Amenorrhea is linked to a lack of estrogens. You don't have any blood loss. And of course, in lack of estrogen, there will be a permanent, permanent, all day anxiety and more even more depression. So, um, now when you have depression for other reasons, like thyroid deficiency, then of course, you will have weak ovaries because of thyroid deficiencies that cause depression. But anyway, when there's amenorrhea, there's certainly ovarian failure. And you will release anxiety and depression by giving the female hormones, estrogens, and progesterone. Here's a question from France that I will translate into English. Can we, if I have, um, possibilities for neurological diseases like those with the Lary corpuscle? I don't really know what Lary corpuscle is, but if it's the same as Alzheimer's plaques that we have in the brain, or in the Parkinson plaques, growth hormone and IGF-1 are the best treatments against neurological diseases. So you need to have these tense injections of ancient growth hormone to have a reversal or a stop of the process. You can have all these hormone deficiencies. That's Mariana who guesses that you can have all these hormone deficiencies. But what I understand from Chinese medicine is that balance between Yin and Yang. And their hormone on all counterparts are there. For instance, optimal hormone ratios between all the hormones. There are optimal hormone ratios, not only between the hormones like estrogen, progesterone, but it's not like mathematics. You can check it by looking at the person. If one hormone is too high, the other too low, you can see that on the physical signs and symptoms. So you take it more with the patient on our on the patient's complaints and the patient's physical signs. Those balances between estrogen and progesterone, thyroid hormone and cortisol. And I, in my hormone handbook, I explain the balances that have to be respected. In the beginning of the hormone handbook, that is really the basic guide and practical dynamic hormone therapy. So Yin Yang, you find it also in hormone medicine. How is the hormone handbook? The endocrine book and other essences of different from testosterone book? Testosterone book has much more, much more like 15 times more information on whatever is related to testosterone and sex hormones than the hormone handbook. So if you want to know everything on testosterone and really enrich yourself, testosterone book by far. The book. I don't think you have another book on testosterone that has so much useful and practical information and updated with the latest references. When you dose estrogen and progesterone opposition in a postpartum depression woman, you want to continue breastfeeding, registered baby. So in my wife, after one month after delivery, I provided her female hormones during breastfeeding. And she each time breastfed during two years. She during two years after in a postpartum, she took female hormones while breastfeeding. Was no harm to children. Two pumps of estrogen, which is, um, like two and a half, I think it's 1.5 milligrams of estradiol transdermal in the morning and the evening from first day to 25th day of the month. Also 100 milligrams of progesterone. And there was no harm and breast was okay for breastfeeding. And it's better to do so because some women in the postpartum because of their breastfeeding have osteoporosis. And then because of the low female hormone levels. And you don't get that, of course. And the reason I gave to my wife was also because she was, she was the director of a firm. She had a full-time job. And, and, and she had to direct her firm. So give her the energy to do so. And then I will ask, let's say, maybe, um, some more questions, but not too much more. How can you tell the difference between low cortisol and cortisol excess? Well, you have that information in the hormone handbook. But basically, low cortisol is for example, low energy, a hollow face, inflammation all over, um, and, and they're weak. In cortisol excess, the patient is more euphoric, too agitated, too much energy, is swollen in the face. So there are many, many differences. But those are basic ones. Uh, uh, you're rather thin with low cortisol and rather thick and fatty and swollen with too much cortisol. I seem to have both hypothyroid and hypothyroid. The hypothyroid symptoms when I start a low dose of this kidney feel much better, but also have hyperthyroid symptoms. Do you have any suggestions? Well, this patient called Alex, or this person has, um, low cortisol. And when you have low cortisol, you have a too quick conversion of the weak T4 to the potent T3. And so in stress conditions, there will be increase of low cortisol. And there will be hyperthyroid symptoms in stress conditions. But in other conditions where there's no stress, the patient will be hypothyroid because there's none of that. So these patients should spread the dose of thyroid, once, two times bigger dose in the morning, smaller dose for your supper. And take hydrocortisone and maybe other adrenal hormones like DHEA and maybe aldosterone. And that will normalize the situation. And that's the question in French. I'll translate in English. How can we diagnose the pollen source in 10 years? And I, this, and I'm taking antidepressant treatment with a placodrome. I have a lot of anxiety. This patient called Marisha, or this person should go and get hormone therapy. It will be much better than those drugs. And then the bipolar disorder will go. There's a lack of thyroid hormones. There's a lack of certainly because of the very strong anxiety of lack of, um, great alone, and, and other other hormones that come down inside. But that has to be individually checked. There's a question, I think it's from a person of Russia or Ukraine. Will be very interesting to listen about the role of hormones in orthopedic pathology? Yes, hormones are very potent to reverse osteoporosis, to repair knee points, to reduce arthritis in osteoarthritis. So yes, it's very interesting. But it's another topic, too much information to talk about now. So I will continue with some questions, but then we'll finish. What is the risk to administer too much progesterone in men? How can you evaluate if progesterone can help a?

A man who does sports and is, uh, affected by anxiety. Well, typically a man who is affected by, exactly because like progesterone has those tense shoulders in the evening. So if it takes possession in the evening, it won't impair his, uh, professional performance, and he can take 100 milligrams if there's a lot of anxiety in the evening. However, progesterone can also block testosterone. So you should not take possession before having sexual intercourse because it can increase erections. So you take it off the intercourse when you go to sleep, and then it's okay for a man and generally without any problem. Can use a precision. Men increase the estradiol? No, it decreases estradiol. It can stimulate conversion of estrogen to a strong. And then let's say two more questions. Um, is hormone-dependent breast cancer treated by an aromatase inhibitor susceptible to get a prescription of DHEA testosterone to compensate for the lack of estrogen, per system by this medication? So this difficult question, I cannot answer like this, easy. It depends on the person's. But basically, studies have shown that after breast cancer, if you provide female and male hormones, so estrogen, progesterone, and testosterone, you have a decrease in mortality. That's very important. And you have a decrease in recurrence by between 30 and 70. Especially in hormone-dependent cancer, there's a decrease when they take estrogens of 70% of, uh, the recurrence of breast cancer. It's rather good to give hormones, but still, it has to be evaluated and per person.

What are the hormones that help the memory at menopause? Well, of course, estrogens. There's eight times more Alzheimer's disease in one Italian study. Women who were never took estrogens compared to women who were actually taking estrogens. So hurry on to the estrogen. There are many other hormones. They improve their stress. There's thyroid hormones. There's prone lung. So it's better you could check this with a physician. And she rose here or carrying here. For men who have gynecomastia, will take the start which can arrange taste to estrogen, would progesterone cream applied topically help meningially for gynecomastia? That's a real milk glands in the rest of men. They have too much estradiol. They can put progesterone, but they mostly have to put dehydroepiandrosterone on the breast, and that helps to decrease the situation and to take enamel taste in bitter to decrease the estrogen. So they have also to stop the coffee and alcohol that increases estrogens in the blood. Okay.

Um, I think I will stop here because, um, we're out of time. Maybe just one question. What do you think causes stinging eyebrows? When, um, do tiny eyebrows come back when you give thyroid therapy? So thinning eyebrows is a typical sign here at the, the outer third of the eyebrow, lack of, lack of thyroid hormones. When you provide thyroid hormones, in nature, they don't seem to come back unless you provide at the same time grow tomorrow. So growth month of stardom makes your eyebrows, uh, terrific. I think, uh, inner eyebrow, the lack of inner eyebrow, that's due to lack of testosterone. There you need to create testosterone. Okay.

Um, so voila, this is it. There's maybe one question because it looks like an emergency here. I have a severe burnout with periods of anxiety and so so forth. We cannot start DHEA alone to help me with my issues. At which those the problem of burnout is mostly a deficiency in cortisol. If you can decrease cortisol, you better take cortisol with the DHEA to get out of the burnout. That's the minimum to do. But, uh, the YouTube could lower the secretion of cortisol and aggravate the burnout. So it's not necessary. You can try, but it could aggravate the cases. And if you have sociophobia and anxiety, you need other hormones increasing sight like oxytocin and other. So go to a physician, get a good treatment, and that's my advice. Thank you for being there. You. I must thank you. You were 1800 to subscribe. Um, there were many questions, and I think a lot of interest, and I really thank you for being there. It's heartwarming to have you. Bye bye. Thank you.