This video segment introduces a groundbreaking discovery by Dr. Nidhi Bhutani at Stanford Medicine concerning the regeneration of knee cartilage. The research identifies a protein, 15 PGDH, which increases with age and degrades the cartilage cushioning the knee bones. This degradation leads to pain and affects a significant portion of the adult population, with current treatments limited to knee replacement surgery. The scientists developed an injection containing a molecule that blocks 15 PGDH. When administered to old mice with worn-out knees, this injection successfully regrew thick and strong cartilage. Furthermore, the treatment prevented arthritis development in injured mice, a common issue for athletes. Remarkably, tests on human knee tissue from patients undergoing replacement surgery showed cartilage regrowth within a week. An oral pill form of this treatment is currently in clinical trials, offering the potential to eliminate the need for knee replacement surgeries.

Joseph Minkowitz

Scientists just regrew knee cartilage that disappeared from aging using a single injection that blocks an aging protein. Meet Dr. Nidhi Bhutani at Stanford Medicine.

She discovered a protein called 15 PGDH that doubles in your knees as you get older and destroys the cushion between your bones called cartilage. When cartilage disappears, your knees hurt and every step becomes painful. This affects one in five adults in America and costs $65 billion a year in medical bills. Right now, there is no drug that can fix it, only knee replacement surgery.

Here's what they did. They found a molecule that blocks 15 PGDH and injected it into old mice with worn-out knees. The cartilage grew back thick and strong like it was young again.

They tested it on injured mice with torn ligaments like basketball and soccer players get. The injection stopped arthritis from developing. Half of people who tear their ACL get arthritis within 15 years from that injury.

Here's where it gets insane. They tested it on human knee tissue from patients getting knee replacements. After 1 week, the cartilage started regrowing. An oral pill version is already in clinical trials and could eliminate knee replacements.

Follow me for the latest clinical trials and medical updates.

Knee surgery now optional??

Scientists just regrew knee cartilage
that disappeared from aging using a
single injection that blocks an aging
protein. Meet Dr. Nidhi Bhutani at
Stanford Medicine. She discovered a
protein called 15 PGDH that doubles in
your knees as you get older and destroys
the cushion between your bones called
cartilage. When cartilage disappears,
your knees hurt and every step becomes
painful. This affects one in five adults
in America and costs $65 billion a year
in medical bills. Right now, there is no
drug that can fix it, only knee
replacement surgery. Here's what they
did. They found a molecule that blocks
15 PGDH and injected it into old mice
with worn-out knees. The cartilage grew
back thick and strong like it was young
again. They tested it on injured mice
with torn ligaments like basketball and
soccer players get. The injection
stopped arthritis from developing. Half
of people who tear their ACL get
arthritis within 15 years from that
injury. Here's where it gets insane.
They tested it on human knee tissue from
patients getting knee replacements.
After 1 week, the cartilage started
regrowing. An oral pill version is
already in clinical trials and could
eliminate knee replacements. Follow me
for the latest clinical trials and
medical updates.

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Knee surgery now optional??

Transcription