Transcription
Today I'm going to talk about another substance that's sold online. Another experimental chemical, not approved by the Food and Drug Administration, strictly experimental, almost very, very little, uh, human research. There is some research on it, though. There is some research.
This particular substance, unlike some of the previous, uh, substances I've talked about in my videos, is not a peptide. It's an actual, straight-on drug. Uh, what I'm talking about here is called tesopennine. Tesopennine, it's, it's like I said, it's a drug. It's not a peptide. Uh, it was originally developed, uh, to treat, believe it or not, Alzheimer's disease and mental disorders because what it is, it's a, it's what they call a triple monoamine reuptake inhibitor. In other words, it, it, it modulates three brain neurotransmitters in the brain: dopamine, dopamine, which, which influences motivation, focus, and reward pathways. Norepinephrine contributes to the resting energy expenditure, and serotonin promotes feelings of fullness or satiety and reduces cravings.
So, uh, they, again, tesopennine was originally developed because it works with these brain neurotransmitters. It was developed to treat brain diseases, but it failed in that respect. It was a complete flop, you know, treating, uh, brain diseases. It's kind of similar to aspartame, which was developed, uh, uh, originally, I'm sorry, Viagra, or sildenafil, which was developed as a blood pressure drug, failed as a blood pressure drug, but, but the people that were testing it found themselves getting erections, and, you know, the rest is history. Sometimes you have this serendipitous effect where a drug is developed for one purpose and it turns out to fail at the purpose it's being developed for, but it's good for other things, and that's where tesopennine's another example of that.
Uh, now, as far as from a bodybuilding standpoint, uh, it's, it's actually considered, I should say, it's considered a, a, uh, a, uh, uh, whatever you call it, um, a weight reduction or a fat loss drug. It's in some ways comparable to the GLP-1 agonists like semaglutide and tirzepatide, but it works differently. Uh, similar to tirzepatide and the GLP-1 agonists, it, it, it's very strong appetite suppression. So, let's say a bodybuilder is training for a contest or in a low-calorie diet, this stuff will control your appetite to the extent that it'll make it far easier to stay on the diet. Uh, and by reducing appetite, you also reduce caloric intake, and you'll also increase caloric expenditure, especially if you work out. It, it, it promotes tesopennine promotes significant fat loss, including the most dangerous type of fat, the deeply lying abdominal fat called visceral fat. Uh, there's some studies that suggest that tesopennine can help preserve lean muscle mass during a caloric deficit. Very important because one of the major dangers of extreme dieting is loss of muscle mass, and tesopennine, unlike the GLP-1 agonists where people tend to lose muscle, tesopennine tends to actually maintain muscle.
Uh, the, now, the increase in dopamine and norepinephrine and serotonin not only enhances leads to enhanced energy and motivation, but it also can, uh, can counteract mental fatigue and mental burnout.
Uh, now, the, uh, the potential side effects are increased heart rate, blood pressure. Possible, again, like norepinephrine, dopamine, you know, these can increase blood pressure. Uh, the, uh, it's somebody who already has high blood pressure or possibly cardiac or heart disease might want to avoid this thing, because again, it stimulates certain, uh, brain, uh, neurotransmitters involved in alertness. It can lead, it can also, uh, promote insomnia, sleep disturbances, dry mouth, uh, gastrointestinal issues, nausea, constipation, diarrhea, just like the GLP-1 agonists. Some people, because of the increase of dopamine and, and, uh, norepinephrine, they get anxiety and restlessness. Again, it's not FDA approved.
Uh, and, uh, what else can I tell you about this stuff? Again, it was, uh, originally developed to treat neurodegenerative diseases. And, uh, let me see if I could get some research on this. Uh, let me see. Okay, there was a trial. Okay, actually, there was a human study. Uh, the, uh, it was demonstrated in a, in a 24-week randomized double-blind placebo-controlled study. That's the gold standard of science studies. It was published in The Lancet, and, uh, and in this study, 203 obese individuals were divided into four groups: placebo, 0.25, 0.5 milligram, and 1 milligram of tesopennine daily. All participants followed a calorie-restricted diet where they reduced calories by 300 calories a day. The results at 24 weeks showed that, uh, the average body weight lost for the placebo was 2%. Those taking the 0.25 mg dose of tesopennine lost 6.7% body fat. Those taking the 0.5 milligram dose lost 11.3% body weight. And [snorts] the one, the people who, uh, who, uh, took 1 milligram of tesopennine lost 10.6% body weight, which is fairly comparable to the GLP-1 agonists like tirzepatide.
Uh, the, and interestingly enough, the 0.5 milligram group experienced the greatest overall fat loss with better tolerance and fewer side effects than the 1 milligram dose. So, what, what that means is, for, according to this study, the 0.5 milligram would be the ideal dose if you want to use tesopennine for weight loss. Now, the, the, uh, the other finding of the study, most of the weight loss came from visceral fat and abdominal adipose, other fat around the gut, which is very important because visceral fat is the by far the most dangerous fat. It's associated with insulin resistance, diabetes, and heart disease. The, the, uh, people taking the, uh, tesopennine maintained their lean mass. Like I said, the, you, the most popular weight loss drugs today, the GLP-1 agonists, semaglutide, you know, tirzepatide, and some of the other ones, you know, including, uh, liraglutide or something like the newer one that's not really available yet. It's only available on the internet. These things are known to cause muscle loss, especially if you don't work out and you don't increase your protein intake. 40% of the weight loss of drugs like tirzepatide is muscle, and that's not good. Tesopennine significantly improved waist circumference. In other words, the people using it showed smaller waists, and improved their lipid profiles like cholesterol, triglycerides, and their fasting glucose, which is helps prevent diabetes.
Uh, the, um, like, uh, one of the, some of the advantages of tesopennine, it provides appetite suppression. No stimulant jitters. There's no jitters, there's no racing heart, no cold sweats, no, none of the anxiety that can be caused by fat burner supplements that are rich in caffeine. Again, great advantage of tesopennine. Really a big advantage compared to other weight loss drugs is that it, uh, it preserves muscle. It preserves, spares muscle tissue. Almost all the fat loss with tesopennine, I'm sorry, almost all the weight loss with tesopennine, tesopennine is fat, not muscle. Again, because it increases dopamine and norepinephrine, these are the feel-good chemicals that elevate mood. So it makes it easier to go to the gym. You have more motivation, more focus, and more, more mental, uh, concentration.
Uh, so it also, um, let me see what else I can say. Well, as I, I talked about the dose range, you know, the, the, uh, usually three types of dosage: 0.25, 0.5, and 1.0. Uh, again, the 0.5 is probably the ideal dose because you get strong appetite suppression, and it's well, well balanced, less chance of side effects. You get better fat loss with a 1 milligram dose, but there's an increased risk of side effects like insomnia, dry mouth, and blood pressure spikes. The tesopennine, best to use tesopennine in a cycling fashion. 8 to 12 weeks is the best. Uh, some people who use it, they take intermittent, 5 days on, two days off to manage tolerance. Uh, usually you take it fasting in the morning to blunt appetite throughout the day and avoid sleep disruption. Tolerance can build up to the drug after 4 to 6 weeks at the higher dose, like 1 milligram. The more you take, the greater the chance of tolerance, which means it won't be working as well. So you, you might want to consider cycling off for four weeks or switching to another peptide, uh, to, to a peptide, uh, drug like some of the other ones I covered, uh, if it, uh, if, if you're noticing that the weight loss is not forthcoming.
Uh, again, though, people who have uncontrolled hypertension or cardiovascular disease should avoid tesopennine. If you're taking any kind of antidepressant, you should avoid tesopennine. If you have a history of severe anxiety, panic disorder, or cardiac rhythm disturbances, no tesopennine. Pregnant or breastfeeding women should avoid it because there isn't enough research to know the effects on pregnant women. So the best way to use it is to start out at 0.25 milligram and gradually increase the dose. You can go up to, again, 1 milligram. Don't take it with caffeine, yohimbine, or any other stimulants. It's not necessary. This has a natural stimulant effect without causing extreme stimulation. You want to keep, keep a close eye on your blood pressure, heart rate, and sleep quality. Uh, if, if, if side effects persist or worsen, you want to discontinue it.
So, let me see what else can I say. Uh, hey, I think I, that, let me, let me see. Unlike, uh, the GLP-1, tesopennine does not cause nausea or gastroparesis, which is a kind of frozen stomach effect, which is very serious. It does increase mental drive and energy, which can improve adherence to training and diet. Uh, no, very little cardiovascular stress other than possible blood pressure increase. Probably less than you would get if you took anabolic steroids. So, uh, let me see what else can I say.
Uh, it's classified as a research chemical. It's not approved for human consumption. Uh, it's usually sold online through people who sell peptides and research compounds. It's not on the DEA controlled substance list, but it falls into the gray area under FDA enforcement. It's not listed in the World Anti-Doping Agency as a, as a banned drug.
Uh, let me see what else. Um, now, if you want to, uh, consider buying tesopennine, you want to, like, you know, look for third-party lab testing to make sure it's, again, as I mentioned in previous videos, when you buy this stuff online, whether it's tesopennine or, or peptides, you never know what you're getting. You know, because these are not legitimate, uh, some pharmaceutical companies, they're, they're kind of, you know, just people that set up shop online, you don't know anything about them, you don't kind of quality control. So, you know, you want to request third-party lab testing. You want to have transparent ingredient sourcing. You know, check out the vendor reputation and, and possible customer reviews. And, uh, it is an oral drug, so that's good. So, you don't have to inject it. So, that, that's what's good about it.
And, uh, I think that really covers tesopennine. Pretty good stuff. I mean, uh, uh, again, it's my, you know, it's, it's again another drug that I admit I'd like to try, you know, especially when I'm trying to lose weight. But I mean, the fact is that there isn't a lot of the research I read to you is probably the only research I could find, human research. Uh, it does seem to have pretty good effects as far as weight loss. Uh, it's very comparable appetite suppression to the, uh, GLP-1 agonists like tirzepatide, which is very impressive because, um, it, it causes appetite suppression similar to these expensive drugs. And it also, uh, it also, uh, preserves muscle, which the other drugs don't do. That's the big advantage of tesopennine. So, you know, if you're considering to buy it, I already checked the prices. Seem to vary between, um, anywhere between $100 and up. Stuff is not cheap. It's, it's just expensive. Another expensive drug.
So, I think that's about it for tesopennine. If you want more information on nutrition, exercise science, anti-aging research, uh, uh, ergogenic aids, supplement science, which supplements work, which ones don't, uh, what else? Women's health and fitness, hormone therapy. All of these are covered in my Applied Metabolics publications. Comes out on the first of every month. No ads, strictly in-depth information covering everything related to nutrition, exercise, and general health and medicine. And of course, uh, anti-aging is a very important aspect, too. So, uh, subscribe today. It's at appliedmetabolics.com. When you subscribe, send me an email and I'll send you an invitation to join my private Applied Metabolics Facebook page, where each day I post brand new information on nutrition, exercise science, and medicine. I also have an email portal on my Applied Metabolics web page where current subscribers only can send me short questions about anything they read in Applied Metabolics or anything that they're curious about related to nutrition, exercise, and I will answer the question. However, I don't discuss anabolic steroids. I will not provide anabolic steroid cycles. Uh, frankly, I think those who do are quacks and they're engaging in very dangerous behavior because you never know who you're dealing with out there. I mean, you, you have kids like 12, 13 years old looking at these videos, and these schmucks are telling them to take doses of clen, trenbolone, and dangerous drugs that could kill these people. I think they're disgusting. I think that those videos should be banned because again, there's no screening. Anybody can watch those videos. It's very dangerous. I won't engage in that behavior. I think it's very unethical.
Now, on the other hand, I, I do discuss anabolic steroids and Applied Metabolics, but what I discuss is scientific studies related to anabolic steroids. I can, I also write case histories of bodybuilding athletes who took anabolic steroids and maybe they had some problems. I discuss why they had the problems, what they could have done to avoid the problems, and so on and so forth. So again, subscribe today, appliedmetabolics.com. Uh, if you, uh, please also consider, uh, subscribing to my video channel. This channel, I post a new video every Tuesday. Uh, there's, as you notice, there's no ads associated with this video. There's no 10% discount. Anytime you see a video where the guy's talking about giving you a 10% discount, uh, he's a shill. He or she is a shill. They're getting paid a lot of money by the companies that give out the discount to get you to buy their products. So you, you know, those guys can't be trusted. They're being paid a lot of money to push those products. I mean, my personal thing, and I'm not telling you to do this, is as soon as I see a video where the guy starts talking about 10% or starts showing pictures of supplements, I turn it right off. I'm not interested in watching advertisements. I, I don't care how good their information is. You know, if they can't give straight information like I do, I'm off. I turn them off. That's it. You know, that, that's your choice. I'm just telling you that, you know, you got to be very wary of these people. It's the internet, and YouTube in particular, has become extremely commercialized. This channel is one of the last of the non-commercialized channels on the entire internet. So, I mean, uh, please again, subscribe. It's free, and tell, and please by all means, tell others about my channel.
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