Transcription
Hey everybody. I think I'm unmuted. I think you can probably hear me. And I think we're all getting pretty used to doing these Zoom GoToWebinar conferences. It's like the only way that we communicate now. It's so strange.
Anyways, I had a week off. I had a great time. Spent a lot of time with my son, who was in his final year at Washington University in St. Louis. And he just got a job a few, two, yesterday. Yesterday he got a job for when he graduates. He's going to be at UCSF's UCSF their cellular geometry department. He's a physicist and he's only 21, but he's getting a degree in physics and math, and he's got a job. I'm so excited. He's got his first real job. He's taking a year off before he goes to graduate school, and he's going to work at UCSF in Wallace Marshall's very famous cellular geometry program. And they measure organelles, cell size, organelle cell growth rates, all kinds of really cool stuff. So, very proud dad. I'm so excited that he has a job because I don't have to pay for anything anymore, you know? Oh my gosh, it's, it's a lot of money when these kids go to college. Everything was a lot of money. Now he's going to be on his own. It's pretty exciting. I'm just kidding. I don't mind paying for his stuff, but it's super great that he's gonna, he knows in his last year where he's gonna be and what.
So anyways, that's kind of been my latest. Now we're gonna get down here. For those of you that don't know me, this is me. I'm Dan Kalish. If you're new to this whole thing, um, I started the Kalish Institute, obviously not too creative with the naming structure here, but it's sort of an easy to say thing. I'm on the faculty for the Institute for Functional Medicine's, uh, practice implementation program. In fact, Christy Hughes and I basically created that program together over the last few years. I've done some research with Mayo Clinic. And right now, a lot of what we talk about in these classes is based on the work I'm doing with Dr. Richard Lord, kind of reintroducing everyone back to Richard and and the work that he's done to shape our industry. And, um, yeah, and I'm still in practice and still work with patients. If you guys really get into this detox thing, we have the Kalish Method 101 class, which has a deep dive on detoxification and also all the other aspects of what I teach in the mentorship. So it's an online class, obviously, you know, and you can kind of get into the nitty-gritty and learn more about, uh, not only detox, but GI brain connection, organic acids, neurotransmitters, thyroid, all that good stuff.
Okay, so, um, sort of a broad introduction to what I teach in the mentorship course. And then we're starting a new mentorship class come September. Those of you that have been on the fence for a while can sign up and join us before the year is out. And let us take a look at what we're going to talk about today. So I got a bunch of labs going to review labs. And this is going to be just like the regular classes that I teach when you're in the mentorship. And, um, I think a couple of, uh, sort of prefaces because we're talking about phase one and phase two. And this is a really important distinction. If those of you that are not aware of this, I'll just explain based on my teacher's experience. So my original teacher, Dr. Michael Leibowitz, my second teacher, Dr. Bill Timmons, both of them became quite ill themselves from aggressively pursuing detoxification programs too early in the healing process. So both of them, interestingly, had severe mercury toxicity. And both of them were made severely ill, mistakenly obviously, by natural health practitioners who were well-meaning but pushed their detox pathways before they were ready to be pushed. And so, you know, growing up in functional medicine, I had these two teachers and it was just really clear. This is not something you do because they had both had their lives ruined by aggressive detox too early in the process.
So when I set up my own sort of Kalish Method thing, even though we could all agree that detox is the most important issue of our time, right? Is to get our patients clear of chemicals and environmental toxins and heavy metals. It comes last in the sequence. Not because it's the least important, like when you read a typical textbook, like chapter 12, it's always the chapter that doesn't matter that much, right? It's like, I was going to throw this in at the end. But with detox being the last of the three body systems that I recommend be treated, it's because it's the most important. It's because it's the most risky. It's because you want to have excellent GI function first, so the person can clear toxins through the gut, gallbladder dump and bile, until that kind of stuff, right? And you want to have them on a pretty good track with brain function, adrenal function, thyroid function, mitochondrial function, make sure their ATP levels are really good before you initiate detox. So with really great mitochondrial function, which is up here, a neuroendocrine, and really great gut function, detoxification is smooth, and you will not make people sick, and people will appreciate that.
Okay, so we're also going to talk a little bit about, you know, how I divide these things up. Again, this is the third body system. You can see up here, um, I'll show you some other diagrams so it's a little more clear. This one here is helpful for a lot of people. So three body systems: neuroendocrine, consisting of adrenals, brain, mitochondrial energy, and sex hormones; GI is GI; and then detox is what we're talking about here. Detoxification, oxidation, and methylation. In my mind, these are all lumped together. They're kind of all so heavily interactive, right? If you're full of toxins, you're gonna have oxidative stress. If you can't methylate, you're gonna be full of toxins. You know, that's kind of just how the body works. And if this system is not working well, then you're going to have really serious ramifications and damage that occurs to the brain, to the neurotransmitters. People get depressed and anxious, and you're going to have really severe problems that happen because of all that oxidative stress damaging the mitochondria, which makes people tired and not that great at life, right? So that's kind of some of the bigger picture stuff.
So we never detox just right off the bat. We want to do this in a context. And why is it so important? Because everybody that we work with, everybody in the United States has got, I don't know, the last research I saw on this was anywhere from 122 to over 700 chemicals and heavy metals just mushing around circulating throughout the body. Some are water-soluble, we flush out sort of. Some are fat-soluble that we're going to talk about tonight. You don't flush out. There's 82,000 chemicals we've dumped into the environment, and you know, a couple hundred of them are in you. A couple hundred are not in me because I've done, you know, 56. I started doing pretty heavy-duty detoxing when I was 18. So yeah, I'm pretty, I'm not chemical-free, that would be arrogant to say that, but I'm low chemical. Um, in fact, the last time I was tested, this doctor looked at me like, all your tests look so good. Like, what's going on? I was like, well, I don't know. I've spent the last five years detoxing every day. I think it kind of worked, right? So it's something that you really got to keep at. And the body burden that we're talking about is from this total accumulation of chemicals, from the air, from the water. We're just all saturated with them, right? So we're kind of assuming you guys knew all that, and we're going to cut to the chase here and just look at the clinical application part.
Phase one, phase two. Phase one run by B vitamins. And let's not skip over B vitamins because we could just stop there at B vitamins and just do this whole three-week talk on B vitamins, okay? So B vitamins. Well, Dr. Lord asked me this the other day. He's like, this is his quiz question for me when we were doing this recording session. He's like, what's the single most important thing in the human body? Like, the single most important thing? You know, just name it. Oh, it's like, it was a trick question. I didn't know what to do. And he's like, B1. Diamond. If your B1 levels are gone, you're going to be dead before you hit the ground, right? If your B1 levels are gone, you can't make ATP. You wouldn't, you wouldn't even be able to take a step towards the door before you fell. Your leg would just coke along, right? So B vitamins are really important for ATP production, really important for detoxification. They're not like a peripheral thing. And in fact, I don't know, for 20, 30% of my patients, it's a high-dose B vitamin program that really turns them around. So we'll take it. We'll look at that in more detail in a moment, okay? And then you also have the antioxidants, you know, the Cs and Es of the world. And then under phase two, we have glycine, taurine, glutamine, cysteine, and N-acetylcysteine, right? These are all the sulfur-containing amino acids that run phase two.
And so what made Dr. Timmons so sick? What made Dr. Leibowitz so sick? Is that they, the practitioners treating them back in the '70s, cranked up phase one aggressively, and phase two wasn't working well. And these toxins, these toxins that are soluble, that are partially degraded, partially broken down in phase one, if they are not completely broken down in phase two and eliminated, can cause more damage in this intermediary phase than they did when they were just stored in this, you know, pre, in this, you know, pre-detox phase. And this, you know, when they weren't kind of activated in a sense. I got a diagram of that right here. So here we have an environmental toxin. Again, fat-soluble, water-soluble toxins, who cares? She says, get people hydrated, they're going to drink, you know, pee them out, right? We're not worried about water-soluble toxins. Eliminate the source of the toxin and then have them drink plenty of water for a few weeks. What we're worried about is lipid-soluble or fat-soluble toxins that are in the fat tissue. And phase one, again, it has this fancy term, cytochrome P450 enzymes, but basically we're talking about B vitamins, glutathione, and antioxidants. These then, these fat-soluble toxins are then broken down into this intermediary phase, these intermediary metabolites, reactive oxygen intermediates, and they can cause secondary tissue damage. They can make things worse.
All right, so if you, if you run phase one and phase two is kaput, then you're going to get this recycling and everything actually gets worse. That's what happened to Timmons. That's what happened to Leibowitz. So if you don't prepare the person and you run phase one aggressively, you're going to have a problem. Have you ever heard of somebody taking folate and crashing? Yes, you have. Have you ever heard of someone taking B12 and getting worse? Yeah, you have, right? This is why if their phase two is not adequately running, then these intermediaries, they call it pathological detoxification, right? These intermediaries make the situation worse. So what should happen is you run phase one, cytochrome P450 enzyme system does its thing, you get this intermediary, no big deal, because you have these conjugation pathways in phase two. They have these fancy names: sulfation, glucuronidation, acetylation, amino acid conjugation, methylation, etc., etc. So basically, these sulfur-containing amino acids then run phase two, and then boom, you've got something that's water-soluble that can come out in the vial, in the stool, or through the blood and the kidneys in the urine. It's excreted. You know, Tom Sold, uh, none of it wasn't Tom Sold. Oh, maybe it's Tom Sold. I think one of the IFM teachers said it this way. He said that, you know, the, um, phase one takes the toxin and kind of puts a handle on it, you know? And then phase two grabs that handle and tosses it out. That's a great little analogy he used a few years ago. Just kind of stuck in my head. So it's, you know, you don't want to just get the handle on, you want to toss it out. And so you have to have both faces working. And where people get the sickest, the most often, is if you accelerate phase one and phase two is not working. So again, that could be folate, B12, riboflavin, even a heavy-duty antioxidant could make the person sicker if their phase two isn't working.
So how do we get around this problem? We test, and we always treat phase two either first or along with phase one. Uh, yeah. Now, I should mention this one other thing, just because you may not think about this. Timmons taught me this years ago. Even if, let's say that the phase two test looks perfect, you're like, well, this person has the best phase two I've ever seen, but their phase one is all messed up. If you activate phase one and get it working harder, you better give them a little bit of phase two support because this system is gonna get cranked up. So no matter what, you always gotta anticipate the next thing that's going to go wrong, right? So if phase two tests fine, don't think that you can get away with just running phase one. Still give them a little token phase two support because you're gonna be forcing phase two to do a lot more work, and you wanna, you know, anticipate that a little bit ahead of time.
So again, let's look at what are these nutrients that we're talking about, and then we're going to look at some testing and we'll see where they appear on the tests. So, uh, niacin, riboflavin, right? Folate, B12, glutathione, vitamin A, vitamin C, vitamin E, copper, zinc, selenium, glycine, taurine, glutamine, N-acetylcysteine, cysteine, methionine. That's about it. Sulfur amino acids, B vitamins, and the classic antioxidants. So we're just going to do a little reality check here quickly, and I'll show you an example. I've got so many of these pulled up here. I'm going to show you a series of examples. But here's the first one. So just remember all that stuff we just talked about, and then you're thinking, hmm, it would be convenient if I could measure all those things. And then I'm going to say, well, yeah, actually you can pretty easily. It's all on the same panel, in fact. And now you can also, and perhaps shouldn't, if you're interested in it, also measure toxicants and measure heavy metals and measure all that kind of other stuff. I have nothing against that. However, you don't have to, because if you can see how the detox pathways are not working, then you can fix them. You don't really have to know what the actual toxins are.
So this is an Ion panel from Genova. And what did we just say for detox? Remember sulfur amino acids. Let me even group them together for you there. Sulfur amino acids. If methionine is low, you give methionine. If taurine is low, you give taurine. That's not too complicated. These are the phase two things, right? Sulfur amino acids. So you just scan through here and look at the sulfur amino acids and see which ones are low. In this case, it was taurine. And then you can also look at zinc and copper, right? Those are involved. We saw that a minute ago. So zinc is low, you'd want to give zinc for their detox. Here you can see the toxic elements. This person is high in arsenic. Here's the antioxidants that we were just looking at, vitamin E, vitamin A. Just saying how these are phase one nutrients. So you can measure those on the test. Gamma-tocopherol, alpha-tocopherol, that's a fancy name for vitamin E. I'm just going to kind of skip through here. We'll talk a little bit more about mitochondrial function in a minute. And then, oh, and here are the B vitamin markers. These are very important. You've got to, you've got to memorize these inside and out. You've got to know everything about these markers. So B complex vitamin markers, you can see them here. This one is high. That's one that's related to biotin. So if that's high, it means biotin is low. And then in terms of detox, we're thinking about xanthurenate as for B6, and then the methylation markers, methylmalonate, B12, and FIGLU or formiminoglutamate for folate. Okay, when this marker is high under FIGLU, that means the person is low in folate. So right off the bat, we know they have a methylation problem. They're not detoxing well. And then to cap it all off, there is this whole section called toxicants and detoxification. And now we're getting more into the nitty-gritty. Here's glucuronate, that's phase one and phase two. And these three markers here are all for glutathione: alpha-hydroxybutyrate, pyroglutamate, and sulfate glutathione markers. So just, you know, you can't really memorize this in a half an hour talk, but I just want you to be familiar with it. You can kind of see that, right? And then if we look here at the test again, I mean, sorry, at the liver detox pathways again, you can see we just, we just reviewed the B vitamin section, right? We just, I'm turning off my camera because the internet is not so great right now. The B vitamin section, we just saw. We saw the sulfur amino acid section. I pointed out, remember methionine, I showed you. We just saw methylation, right? Methylation, B12, and folate. We just saw that. You can measure vitamin A, vitamin E, copper, zinc. We saw all these nutrients. CoQ10. Okay, so these are all measured, and then you support what is needed specifically, with the caveat that if you're going to boost up phase one, make sure you give either a token amount of support for phase two, or if there's a major phase two problem, start with phase two first, get that working for a few weeks, and then get into phase one. That'll avoid most of those crashes that people like my teachers, Dr. Timmons and and Dr. Leibowitz, said.
Now, another thing that happens when we're toxic is that there's oxidative stress that damages mitochondria, and that means that the energy production levels suffer, and now you can't detoxify very well. Okay? So that is all kind of like a package deal in a really bad way. And let's look at a few more examples. Oh, and before I forget, yeah, you can do this Kalish Method 101 class. You guys should check that out. And we're starting a new mentorship class coming up soon. So now let's show you some more examples. Sample case studies. That should be it. Oh, no, no. Let's look at the classroom this morning. So this is this morning's class. You want to learn something? You want to see what the students went through this morning in my training program? Not making this stuff up. Like this was this morning, Tuesday, 9 a.m., 8/18/20. This is a 148 pages of labs that were sent in. Oh my gosh, we went through an hour and a half. We didn't even get through the whole thing. But let me, let me show you some examples. So what happens is you take the class, you listen to the videos in the, you know, mentorship program, then you submit labs, and then we just go over these every week until everyone understands everything. It's a really wonderful experience. This morning's class was particularly good. And not good because I'm like a really handsome and amazing person. It's good because there's really great students submitting really great cases, and then they're interacting with each other. I'm just like the host. I'm like the MC, you know? I mean, I chime in a lot, but it's really great to see people, the kind of the camaraderie that develops in the peer-to-peer teaching, peer-to-peer learning.
Okay, so let's see what this case was. This is from Aaron. And, uh, what's the main complaint? Wants to stay as healthy as possible, manage thyroid, tried Synthroid but didn't do well. So let's look and see. We're going to try to focus on the detox part, right? So remember we said B vitamins, this is phase one stuff. And right off the bat, you've got one marker here and one marker here that are high, and another one down here. So this is when this goes high, it means you need B12. When this goes high, it means you need B6. And when this goes high, it means you need B complex. So remember, without B vitamins, your next breath would be your last. These are not just like, oh, you know, some people need B vitamins kind of thing. This is like mission critical for energy production and mission critical for detoxification. And most of us have heard of methylation, that term, which revolves around B vitamins. So I just want to show you how these things interact. And one of the major jobs of B vitamins, in addition to, you know, running detox pathways, is to also help with metabolizing, uh, amino acids. So we're taking a really high-level view of methylation here. And methylation is an essential part of detoxification, right? We talked about methionine already. See methionine sitting right here, very important for methylation. And then we have your B12, which we're looking at now, right, on the lab, very important for methylation. And then we have folate, THF everywhere you see THF, tetrahydrofolate, super important for methylation or detoxification, right? Part of detoxification. And then to methylate, you need these amino acids: serine, glycine, histidine, tryptophan, and glutamate. Those five amino acids contribute to this single carbon pool, which then spins around and ends up being the centerpiece of methylation. So you need both amino acids and B vitamins to make this whole thing work. And this is one of the core problems that a lot of people that we work with have when they can't methylate.
All right, so B vitamins, super important, right? And what's the other thing with B vitamins? Everybody under doses B vitamins and they just don't work if you under dose them. So you have to figure out therapeutic dosages. They don't want to make people sick, but just, you know, 50 milligrams of B6 is not going to help anybody. It's just not enough. Now let's look at the detox markers here too. Well, this is a pleasant surprise. This person has all normal detox markers. Methylhippurate, a marker for xylene, normal. Orotate, a marker for ammonia toxicity, normal. Glucuronate, a phase one, phase two marker, normal. And then pyroglutamate and sulfate, both normal. Hydroxybutyrate's low, but it's hard to detect. So that one you kind of ignore when it's low like that. Doesn't, you know, it's not really sure what it means. But anyway, so this person is actually in good shape for detoxification. Or are they? This is a trick one. I didn't even plan this. This was the first lab that was submitted this morning. But you know, on the surface, you would think, oh, their detox section looks really great. I'm just going to relax and think that they don't have a problem with detox. And then you're like, no, no, no. That chaos guy, he seems a little crazy, but I don't know. He's working with Richard Lord. I think he knows what he's talking about. Richard Lord invented this test. Richard Lord spent 40 years looking at every one of these that was ever done. Richard Lord was the one that set up these machines. Richard talks to Dan every week. Maybe Dan knows something that I don't know. And then you would say, wait a minute. Benzoate is high. If benzoate is this high, and it's almost, well, it's more than two times the reference range. Benzoate is this high, and hippurate is not commensurately high. That's a glycine deficit. So this person has a major detox problem, specifically with glycine. Benzoate high, hippurate not as high. That's a glycine clearance problem. You clear benzoate into hippurate. You move it into hippurate in your liver. If you can't do that, benzoate builds up, hippurate doesn't. And that's a glycine problem. And now you're saying, well, glycine, what does glycine have to do within this? So we go back to our little image here and we realize, oh, wait a minute. The first one they list under, the first one they list under phase two is glycine. So this person has a phase two problem with glycine because their liver is not breaking down benzoate to hippurate. That's kind of a trick one. If you were in my class, you would have gotten that.
Okay, so anyways, let's go on to the next one. I'm really not making this stuff up. This is just what showed up in class this morning. So here's another patient from Aaron. And this patient's got anxiety, hot flashes, not sleeping. So let's look at the detox pathways. Go right to that B vitamin section first, okay? One is high. So it needs B complex. Alpha-keto-beta-methylvaleric acid. So B complex. Methylation looks pretty good. And then we see the rest of these. Hippurate is high. 2-methylhippurate, 2-methylhippurate is high. That's a xylene marker. So this person is toxic with xylene. Or as these markers look okay. Benzoate is undetected. Hippurate's a little high. All right, now you should write this down because you're not going to remember this. I swear you won't remember this. So write this down: If benzoate is high, the last one we saw, and hippurate is not as high, then that's a glycine problem, and they need phase two liver detox. If benzoate is normal or low, and hippurate is high, that is not a problem. That just means they have a lot of polyphenols. Means they're eating a lot of fruits and vegetables, okay? So you don't have to do anything about that. So it's just depending on the inverse, or you know, depending on that ratio, it can mean either they need a major liver detox or they're doing fine.
So let's see. Here's another case. Carolyn sent in this morning. Migraines, not a good thing. And then Carolyn's asking, I'm unsure of the issues with her GI tract. It says infection, but I don't see one. Where to start? Want to help her adrenals with migraines, but GI and adrenals, you know, it's confusing. You got all these labs, but you don't know, like, it's hard to know exactly where to start. Um, this person had a normal adrenal hormone production, which is great. So migraines weren't coming from that. But with the GI testing, dysbiosis and infection markers were high. So there's some GI work to do there. Remember, you want to do that first before you do some aggressive detox. So this is a GI case first, and then you can get to the detox as the next step. And then let's look at the detox markers here. Sorry, it's a little, a lot of labs here. Just, there we go. So remember B vitamins first. Oh, well, that's not too hard, is it? There's three B vitamin markers that are elevated. So this person needs phase one support with B vitamins. And then we can look at the detox markers, and they all look fine except, and look now, you know, we just saw this. Now you know, detox marker is suspiciously fine. Benzoate, however, is ridiculously high. Hippurate is not as high. This is a glycine problem. We got like two in a row. So this person needs glycine to run phase two. You can give them all the other phase two nutrients also. You don't have to just give them glycine alone. And by the way, to answer Jazz's question, how to increase serine levels if chronically low? You use glycine to increase serine. While we're on this subject here, um, let's see, uh, well, that's okay. I'll skip that. It's going to show you something else, but yeah, let me show you this one. Everyone here, we have time. Yeah, we're about half an hour into this. I'm trying to keep these really short. Um, so let's look here. Oh, no, I know the one I want to show you guys. Hang on a second. Let me pull it up. So phase one, phase two, which one you're going to treat? We'll look at a little more complicated lab here. Oh, also in the class, also, just so you know what happens. Um, Emily's saying, hey, can you make suggestions in relation to B vitamins causing nausea? Absolutely. We've been talking about that. Um, with super high lactate, what are the exact protocols you use? A couple, 300 milligrams of B1, 400 milligrams of B3. Who would have known that? Like, I don't know, you're just supposed to know that. So as we answer questions in class, um, people submit the adrenal labs a lot because they work a lot with the adrenals. So we kind of figured that out. As Jeff sent in a patient that has migraines, but I want to get to the end of this row of labs because there was a good one here that we did. We do a lot of GI testing too. We're kind of not talking about that today, but remember, you want to get the gut working before you do a lot of advanced detox. And here we go. So now we're thinking, okay, we're going to want to work on this person's detox, or just analyze, do they need detoxification support? When you're starting to get the hang of this a little bit, hopefully you're thinking, okay, well, let's think about what are the amino acids. Well, they group them together on the Ion panel under sulfur amino acids. And I'm flipping to the wrong page here, sorry. It's gotta be in here somewhere. I think I went too far. Sorry, let's go back this way. There we go. Sulfur amino acids. They even tell you glutathione related, in case you didn't know that. That's Dr. Lord's sense of humor. It's like, you know, you really should know that. But anyways, methionine, if it was low, you would give it. Homocysteine, cysteine. That's a whole other question here. Taurine, if that was low, you would give it. So you would give the sulfur amino acids to help with phase two. And similarly, you're going to see they also measure glycine, serine, etc. You basically replace whichever amino acids are low. If you can't figure it out, just give a combination formula that has them all. Okay, so you can get to the nitty-gritty of individual amino acids. And if it's too much for you to do that, just get some combination phase two detox product. All the supplement companies that we work with have really good phase two detox products. And somebody spent a year sitting down and planning that stuff out. You know, I go to these board meetings and lab company meetings and supplement company meetings all the time. And this, believe me, there is a room of like six people sitting around going, hmm, we need a phase two detox product. And then somebody went off and researched it for like, you know, six months and came back and said, here's what I think we should do. And then, you know, so these things are really well thought through. And I know most of the formulators. These are like really smart science people. So if you're working with Pure Encapsulations or Ortho Molecular or Designs for Health, you can just kind of trust that they're doing the right thing here. And then, okay, homocysteine is high. Well, that's a problem, isn't it? That's not really what we're talking about today, though. So we have to skip that. Sorry. It's worth mentioning, if you're going to get into detoxification, you should also know that selenium is an odd one. It's a mineral, but it's a very powerful detoxifier, especially protective of the brain against mercury and other heavy metals. So selenium, although it's a mineral like magnesium or copper, very important in detoxification, especially if you're working with glutathione and things like that. So selenium has a special importance.
So now we're thinking about phase one, CoQ10, vitamin E, hair, vitamin A, right? All normal in this patient. If these were low, then we would want to support with them. You can see the oxidative stress markers are a little low as well. And then let's come back around here, and I'll show you what a typical program would look like in one second. If you see three or four of these in a row, hopefully it'll start to sink in a little bit. So we're skipping through the rest of these markers here. Here we go. Wow, that doesn't look good, does it? But we're not talking about that right now, except to mention that if your, um, mitochondria are not working well, none of this is gonna work. So B vitamins, remember we're emphasizing them tonight. B complex, don't hold back. Give 50 milligrams. You know, give 100 or more of all the different Bs, you know, don't, don't be wimpy about it because you need more to move the needle here than the light dose. Methylation markers in this case are normal, so we're not worried about that. And then we can look at, uh, oh, here we go. Well, that's convenient, isn't it? So this particular one, alpha-hydroxybutyrate is high. When this one's high, it means they don't have enough glutathione. Okay, so we're going to want to work on glutathione with this person. The B vitamins, and then let's just scoot down and see. Benzoate and hippurate are relatively normal. So now, if we go back to where we started off here, but let's see where to go. Let me make this better for you guys so you can see it more clearly. Go back to the diagram where we started. Phase one and phase two. Now this should start to make some more sense. Phase one, B vitamins, don't pass that over. Give hefty amounts if needed. That'll get phase one working. Glutathione, we saw some markers for that. And then the antioxidants. You can measure all of these easily on the labs. Vitamin E, CoQ10, uh, vitamin A, all that. And then the phase two, remember sulfur amino acids, glycine, taurine, glutamine is one too. It's kind of weird, you wouldn't think of glutamine as being a gut one, but it's really important for your liver. Cysteine, more famously, usually people use N-acetylcysteine. These are the sulfur amino acids that run phase two. So if you just learn how to interpret the labs and then learn how to get on the aggressive side with supplements, and you can knock out all these liver detox problems, you can help a lot of people with a lot of different things. Sleep disorders, skin problems, weight gain. You can't lose weight if you're, if you really got a big problem with your detox pathways, right? You're not going to burn body fat very well. So just for weight loss programs alone, it's probably worth learning how to do this stuff.
Okay, and we'll summarize one more time so you can see how this all works. We looked at B vitamins, that would help with phase one. We looked at, uh, the antioxidants that help with these toxic intermediaries, right? CoQ10, vitamin A, vitamin E. We measure all these. I mentioned selenium is a special one. You get all that working, but not too aggressively, because you have to make sure phase two is engaged and working. If you crank up phase one and all this is dumped on phase two, and phase two isn't working well, then you're gonna go through this little bad arrow system here. They have. Let me show you. If you crank up phase one and phase two is shut down, okay? Then you're gonna have these reactive, reactive oxygen intermediaries causing secondary tissue damage and even more free radicals and messing things up even more. You don't want to do that. So to avoid that, you always start with phase two. Even if it looks like phase two is okay, give a little bit of phase two support along with phase one, and you'll have smooth detox programs. And you can get super specific, like we just said, that that one patient really needed glycine. Remember that earlier patient? Really needed taurine. It's going to make a big difference if you give the person that needs taurine, glycine. Is it going to help? I don't know. It would be like if a kid was having their birthday party and you gave them a present that they didn't really like, you know? They'd be like, oh, well, thanks for giving me, you know, that rice cooker. I really was looking forward to a video game because I'm 13 years old or something, right? I mean, like, is the body going to reject it? I'm not going to reject it, but it's like, uh, it's like it's going to fall flat. If their targeting levels are low and you give taurine, it's like, yahoo! It's like a 13-year-old getting like the best video game. It's like, yeah, that's just what we needed right now. Thank you. And then dose upwards, right? So how much? Three grams a day or more. How much glycine? Three grams a day or more. How much N-acetylcysteine? Three grams a day or more. What is more? Six grams. Do you do nine grams? Not that often, but three grams, four grams, six grams, somewhere in that range, okay? To really get these things to work. B vitamins, 15 milligrams? Nah, it's not gonna really do anything. 100? Now you're talking. Yeah, 200? Yeah, probably. 100 milligrams of B6, that's better than 50. 200 might be a little much, but you know, sometimes you're going to need to do that. How much niacin? 50, 100 milligrams at least, you know, if you really want to get these pathways working, you have to dose people therapeutically. A low dose of a product is just not really going to make a difference. You know, it's the same thing with CoQ10. 100 milligrams of CoQ10 never helped anybody. 200 at least. 400 if they can afford it. So get these into the therapeutic range, and you'll really see movement in people relatively quickly.
All right, so I'm going to end now in the sake of time here because we're hitting our limit. But hopefully you learned something. If you're really interested and you think this is cool stuff, take the Kalish Method 101 class. We're selling it for ridiculously cheap right now. It's an online course. It kind of lays out all the things I do in the mentorship in little bits, kind of like best of bits. And, um, we'll be sending out an email. If you can also just log right in, bit.ly/kalishmethod101. But we'll send out emails with links, um, if it's too hard for you to remember that little URL there. Okay, so I'm going to pause for a moment. I'm going to drink my lemon water and then I'll answer questions.
Okay, so a couple questions for a few minutes. We'll wrap it up. Uh, let me see. Do we need to have concern if the sulfate level is high in a patient with sulfur-containing supplements? Uh, so sulfate comes back high and the person is taking sulfur, that's what you would expect if you're giving them sulfur supplements. So I don't think that's necessarily bad, just means it's working. But at some point, you'd want to retest them when they've been off of the sulfur supplements for a couple weeks. So if the markers are high or low, is there a problem with antioxidant markers and B vitamins? Absolutely. High levels of, like, an antioxidant marker means that there's not enough antioxidants present. A low level of an antioxidant marker can mean something even worse. I will leave that to your imagination. Uh, let's see. How to increase serine levels? I talked about that for Jazz. You give glycine. How much? Three grams, six grams a day. Oh, if taurine is high, what does that mean? Well, it could mean they're eating too much protein or taking too much taurine, but that's pretty unusual. It's easy enough to figure out when an amino acid is high in the blood in a blood test, it generally means that it's circulating in the bloodstream and not being utilized. It's not getting into the cells. Okay, and this is a hard question, but what is the nutrient or the group of nutrients that metabolizes or breaks down amino acids? B vitamins. So high taurine is a lack of B vitamins. It's usually vitamin B6, but not always. I prefer the Ion panel over the NutraVal for a bunch of reasons. They both are run by Genova, and I think the Ion panels are, you can get a lot more data and information out of them. So I'm much more of an Ion panel fan. Molybdenum has a huge part to play in detox. Absolutely, that is true. If you're a patient, you can work with me over the phone. Just go to, this is for Floyd, go to Kalish. Let me show you my patient website. Oh, I have a, I have a little promo on that for Floyd here. Here, this is part of a different talk, but you can just, here's the challenge institute thing. You can schedule a call with our health coach, Jennifer. Just go to kshwellness.com and she'll get you started if you want to be a patient on the phone. Okay, I have patients all over the world. That's not a problem, Floyd. To support phase two, can you give liposomal glutathione? Yeah, you could, but you need to give the individual that. That is a good idea, okay? But you should also give the amino acids that are deficient. And if you're just doing the organics and you don't know, Shiresha, so then you do the broad spectrum. The again, look at the catalog of the supplement company you're working with and give the phase two product, and it'll have glycine and N-acetylcysteine and a bunch of taurine in it. You know, be like five or six amino acids. That's what you do. If you don't have the specific data of the more advanced testing, just give a combination product. It basically hits all the detox pathways simultaneously. Um, uh, Great Plains is a great company. I don't do their labs at all, but an old and good friend of mine named Kurt Wohler is one of their doctor educators. So if you like him, especially if you're doing autistic children, he's an expert in that area. Great Plains is a really good company to work with, and you can learn from Kurt Wohler. He's a wonderful teacher and doctor. All right, and let's see here. Um, there's one thing I wanted, one thought I wanted to end on. I forget what it was now. Let's see. Hang on a second. Oh, yeah. Okay, just quick review. All right, so we're gonna do it backwards because this is the order of importance. If you're doing, uh, if you have problems with phase two, you're gonna see it on these markers here. There's one phase two there. You're gonna see it here with benzoate being high. That was a glycine marker, remember that? Benzoate high, hippurate not high. We didn't talk about oxidative stress a lot, but we're gonna see typically also oxidative stress markers will be up. Okay. And then when you're doing to these actual treatments, to Shiresha's point, if you don't know exactly which pathway is blocked, use a combination product. It'll have typically glycine, taurine, maybe some glutamine and N-acetylcysteine in it. All the companies will have a phase two product that contains all these. So you don't have to get specific with the pathway. That is totally acceptable. Just dose up that phase two product to therapeutic levels. Similarly, most of the companies, not all, have a phase one product, and they don't have B vitamins and antioxidants and stuff like that in it. So you can kind of juggle those two, and you can do most of these programs in a simple way with two or three products, or you can go into depth and get into like, oh, I'm just going to give glycine kind of approach. So I'll wrap up on that idea. You can do in all. Oh, I was going to design a program. That's what I want to do. Sorry, I forgot. And we got to stop. See here. So I just want to show you what a typical program can end up looking like. So you get a visual on that. Let's say the person has all the problems because most of the time they have them all, right? It's not hard to imagine. I've set up thousands of these detox programs. I wouldn't say they're fun, but they really do help people. So let's say you would start always with phase two liver support product. If you want to keep it simple, make it a combo product. What's it going to have in it? Glycine, taurine, methionine. Again, there's like groups of scientists sitting around tables making this stuff up for you. So if you use Pure Encapsulations or Designs for Health or Ortho Molecular or Metagenics, it'll be a good product. Some super smart person, and I met and know all these people, they're the sweetest, most well-intentioned, super smart group you could imagine, and they're not going to design some crappy phase two product for you. But just use a good quality company. The ones that I use, Pure Encapsulations, Designs for Health, Metagenics, Ortho Molecular, all their products from those companies are good. And dose from pretty high, you know, maybe give three twice a day, something like that, whatever it may be. If you want to go old school, you could just do N-acetylcysteine. Then you would give antioxidants, some combination antioxidant formula. If you're not doing the individual testing, give a combo formula. And again, every company, don't have, it's going to have some vitamin E, it's going to have some C, it's going to have some A or beta-carotene, right? It's gonna have all that stuff in it. If you want to get specific, you can give specific stuff. Give a couple of those. Typically, if you're really doing detox in the real way, you need the B complex that I mentioned, and then you need some kind of a binding agent. And that could be fiber, apple pectin fiber, psyllium fiber, could be diatomaceous earth, something like that. It's going to bind things up and you'll grab toxins and pull them out. Okay, so phase two support, antioxidants, B complex, and some kind of binding agent. If you want to get fancier and you get into these reports, you could do glycine, let's say 500 milligrams, and you give like a ton of it, right? And then N-acetylcysteine, I just did one of these today, 900 milligrams, and you give a ton of it. And then, let's say a B complex with extra B6, if they have, remember we said high amino acids, then they need the extra B6. So you give a couple of those. And then you want some antioxidants. But let's say you're doing the advanced testing, you know, they need vitamin E, CoQ10, and vitamin A. So now you're dialing it in really specifically. You give those, and then a binding agent, right? Something to bind up the toxins as they're getting dumped out. And then the one special case to be on the lookout for is if the person is losing a lot of body fat. If they're on a weight loss program, they're going to be dumping out environmental toxins left and right. You want to make sure you do these kind of programs. Okay, so here's phase one, phase two. We start with, do it backwards. Here's phase one, right? And then a binding agent, and you're off and running with a customized detox program.
Okay, I'm going to wrap it up for now. Take care, everybody. Thanks for joining. We'll talk soon. You.