Vegan Declaration of Independence from Western Diseases

From New York to California, from the east to western shores, we have always reached beyond what the world has seen. Seen before. We have walked through fire together. We have dared what few conceived. Built a nation from a vision where our rights are guaranteed. And every step that brought us here, every sacrifice and scar lives inside the hope we carry in the beating of our hearts. We are America, land of the brave and free. A million different voices still sing in harmony. Join together through the years. By the ties that make us one, we breathe the air of freedom alive in everyone. There's a calling deep within us. A purpose we understand. Every generation rising knows the future's in their hands. Not by fear, not by hatred, but by courage, faith, and grace. We are stronger when united. One people, one embrace. And everyone that built this land. Every prayer through darkest nights made a home worth loving. Forged a beacon that burns bright. We are America, land of the brave and free. A million different voices still sing in harmony. Join together through the years by the ties that make us one. We breathe the air of freedom alive in everyone. Raise the flag higher. Let every heart believe. This is the land of promise. This is the land of dreams. And no matter where we came from, no matter who we are, we stand beneath one heaven. Steered by the stripes and stars. We are America, home of liberty, guardians of the promise for all humanity. And if the world grows darker, starlight. We are America and America is free.

Hey guys, welcome. Welcome. We're starting. I want to say that that song is written by my wife Sabrina. She wrote that, so I thought I'd play it for today. It's very apt. And uh, let me uh play here with something. How can I do that? That's what I want to do because I'm going to talk before you, Peter. Folks, uh, welcome to our vegan declaration of independence from Western Diseases. Today, we're doing something fun for the 4th of July, but also something serious. We're declaring independence from the idea that heart disease, high blood pressure, type two diabetes, obesity, and other diet and lifestyle driven illnesses are just normal aging. Uh, they're not destiny, they're not inevitable, and we don't have to quietly accept them. And to lead the charge, we have Dr. Peter Rogers with us today, a physician and an amazing mind, decades of experience, and a truly staggering command of the research. Peter doesn't just give opinions. He digs into the papers, the mechanisms, the history, and the evidence. And we're going to start with Peter's own declaration, his case for why it's time to break free from the toxic food environment and the habits that are making people sick. Then we're going to move on to something that's potentially, I think, very useful, and that's landmark papers supporting a vegan diet. Because you know how it goes. You tell someone you eat this way and they say, you know, is it, is it really healthy or, you know, where's the evidence? Well, today Peter is going to arm you with actual studies, actual references, actual citations that you can use the next time someone challenges you. So, grab a pen, take notes, and get ready. Today, we declare independence not just from bad government or bad ideas, but from diseases those bad ideas helped to create. And I, I just have to say, doesn't the reflection pool, doesn't it look pretty good today? I don't know what all that was about. But anyhow, let me uh get us started here into the twoot. I'm playing with it. And actually, even before we start, I saw a comment. Let me see if I can find it here that I want to just show and comment on. Someone came in and made this comment. I was vegan for 12 years when I had a heart attack at 45. 100% blocked coronary artery. 95% blocked widowmaker, uh, bypass. I quit the vegan diet then and there because it failed to prevent it. Yikes. That's terrible if that's true. When someone says, you know, I was vegan for 12 years and I still had a widowmaker. Well, that's heartbreaking, but it's also not enough information to tell us whether the diet failed. Vegan only tells us what someone doesn't eat. It doesn't tell us what they were eating. And this is exactly why I've been making these recent videos. A lot of people hear the term the vegan diet prevents heart disease. So, they become vegan. They assume they're protected. But vegan is an ethical label. It's not a therapeutic diet. And I think we've done people a disservice by talking as if there's one vegan diet. There isn't. There's as much variation among vegans and vegan diets as there are among omnivorous diets. And, um, so if you learned about veganism from a documentary or you heard someone talking about it, you know, nobody might have explained that the diets with the strongest evidence for reversing or arresting coronary artery disease, they weren't just vegan. They were very low in fat, centered around whole plant foods, people who follow McDougall, Esselstyn, people who then lose a lot of weight. So it's a different diet than Beyond Burgers or olive oil or vegan cheese or coconut products having handfuls of nuts and all that, you know. So that's what we, we all have to wonder what kind of vegan diet was somebody eating because if it's Esselstyn's diet, we know how that does. Anyhow, that's I'm repeating myself. People just deserve to know the difference between a general plant-based diet that may lower risk and the specific dietary patterns that have a lot of published evidence for what they do for coronary artery disease. Okay, so let me just close this and Peter, you ready to go? Yep. >> Well, let me, let me do this. Let me put your talk up there. Welcome. And I'm going to uh remove myself from the talk here. Take it away. >> Yeah. Okay. Well, you know, to the USA, happy 250th birthday, 1776 to 2026. Okay. And here is uh GW at Valley Forge saying his prayer. Here is Thomas Jefferson writing the Declaration of Independence being proofread by Ben Franklin and John Adams. And here is the young Thomas Jefferson. I just want you to hear a couple quotes he said because he is not as well understood as he should be. He should be studied in all the schools. The guy was a genius. Read in multiple languages. He was also by modern standards a religious fanatic. They try to pretend he wasn't religious. He was. But here's just a quote. Moderation is the mask of failure. That's like something Dr. McDougall says. You don't half-ass things. Okay. The mass of mankind is not born with saddles on their back. Our liberty depends on freedom of the press. There is a natural aristocracy among men. The grounds of this are virtue and talents. So as far as health is concerned, the low-fat vegans are aristocrats. And when I say low-fat vegan, I mean fat like 10% in calories or less. If you are like a Taho Huma and can run 100 miles in two days and you're running all the time, you don't have a car, you can eat up to about 15% of your calories from fat. But for most people who don't exercise as much as they could in the Western world, it's good to keep your total fat below 10%. McDougall diet was about 7% of calories from fat. Esselstyn says always less than 10%. Uh, the Walter Kempner diet was only 3% of calories from fat. You know, my version of it's about four or five% of calories from fat. Jeff says something similar. So low-fat, we're the low-fat fanatics. We are not the high-fat phonies. This is not the Mediterranean diet. That's a bunch of nonsense. Okay? And this is not the ethical cultural vegans. I hope the family farms keep having chickens and eggs and stuff available as a backup food supply. We might need it someday. Okay. Um, let's see, what else did he say? Cultivators of the earth are the most valuable citizens. They are the most vigorous. They are tied to the country and wedded to its liberty and their interest by the most lasting bands. Leave all the afternoon for exercise and recreation which are as necessary as reading. I would rather say more necessary because health is worth more than learning. Walking is the best possible exercise. Habituate yourself to walk very far. Give about two hours every day to exercise. A strong body makes the mind strong. That is all very true. You have neurogenesis, angiogenesis, production of new neurons, production of new vessels, capillaries on the surface of your brain from exercise. We're made to move. And you know, the morning's good time to do your intellectual work. Afternoon, late afternoon's good time to do your physical work. You have less pain sensitivity. You're physically strong. It's late in the afternoon. And the evening's time to eat, spend, spend time with your your wife or your husband or whatever. Okay. So, oh, one last thing. Here's a book about Thomas Jefferson by David Barton. You get the real story about Thomas Jefferson. He was far more religious, far more scholarly uh than is widely recognized. Okay? He was giving everybody a copy of the Bible, doing all kinds of things you'd be amazed at. And here is our Declaration of Independence for the the low-fat vegan community, the low-fat fanatics, Spartan vegans, etc. And the USA Declaration of Independence was signed on July 4th, 1776. Ours will be signed today, July 4th, 2026. Some of these faces in the audience, you might recognize him. There's uh Mr. Jeff Nelson. There is Caldwell. There's Nathan Pritikin. Mike the Vegan's in there. Doug Lyle Campbell, Chef AJ, Neal Barnard, yours truly, and a few others you might know. There's Dr. McDougall, there's Alan Goldhamer, etc. And there's others who should be in there. I didn't have time to get them all in the picture. And I'm showing you that this is conventional medicine. Here is Dante and Virgil before the gates of hell from Dante's Inferno. This painting is by William Blake. And the sign on above the gates of hell, which are also the sign above conventional western hospitals as far as treatment of the chronic diseases is concerned. Abandon hope all ye who enter. The cure rate for obesity, diabetes, hypertension, coronary artery disease, autoimmune disease, and conventional medicine. It's zero 0%. Okay, it's so bad it's not even funny. What's done is to match the ill to the pill and send a bill. And so the patient is turned into a chump, like a cow, a cash cow for the system to get milked every day while they take their medicines which never cure them. The cure rate for low-fat vegans is about 100% for coronary artery disease. To catch type 2 diabetes and hypertension early. It's about 100%. So it's not like a close competition, 2 to 1, 5 to 4, it's 100 to zero. Now, if some people might not understand this, so I'll say it again, 100 to zero. So that's why all this paleo keto carnivore is nonsense. All this high-fat phony uh Mediterranean diet with nuts and seeds, omega-3s, omega-6 oils, nuts and seeds three times a day, you know, like the Harvard specialist recommends. It's nonsense. Okay? Just so you know, Walter Kempner was 3% of calories from fat. They're giving you 40% of calories from fat. As Nathan Pritikin said, fat is bad. As Dr. McDougall said, the biggest toxin in the Western diet is fat. The fat you eat is the fat you wear. And fat sticks red cells together, makes your blood thick, increased blood viscosity, causes hypertension, increased dietary fat causes diabetes, causes obesity. They both contribute to causing atherosclerosis. So there you are, fat, sick, and stupid by 55 years of age typically if you go down that path as most people do. Hosea from the Bible says, "My people perish from a lack of knowledge." Ruth Heidrich, the great uh triathlete and marathon runner, survivor of breast cancer for over 40 years. She said the most common disease is ignorance and so we are saving the declaration of independence, the declaration of independence for freedom and the declaration of independence for health, you know, freedom from the chronic western diseases. So here is the American Declaration of Independence. The opening line of course is one in the course of human events about separation from England. We hold these truths to be self-evident that all men are created equal that they are endowed by their creator with certain unalienable rights. That among these are life, liberty, and the pursuit of happiness. So here is the vegan declaration of independence. We hold these truths to be self-evident that the low-fat, low-sodium, whole food, organic only, 100% vegan diet with no oil, no caffeine, no alcohol, caffeine, or artificial sweeteners. Persons who follow this diet will never get most of the chronic western diseases. They also have a dramatically reduced incidence of cancer and a dramatically almost completely reduced incidence of autoimmune disease. But there's still some other causes of autoimmune disease and cancer. We declare independence from these diseases and we demand lower insurance premiums. Why should we have to subsidize all those fat, sick, sad diet, standard American diet eaters and the paleo keto dummies and the high-fat phonies? No taxation without representation. No taxation without representation. Most of the western diseases are diseases of excess, excess animal protein that also causes increased cholesterol. Sort of the body mobilizes for an anabolic cell replication phase, cell growth phase and it also accelerates cancer. It activates mTor, mammalian target of rapamycin. You can also call it mechanistic target of rapamycin, which is a nutrient sensing pathway which senses when all the building blocks are available to replicate the cell. When you're 20 years old trying to put on some muscles, you know, impress the babes at the beach, you want mTor activated. Okay? But when you're after 30 and you don't want cancer and these other problems, you don't want to be activating mTor. All right? Excess saturated fat can also activate mTor. It causes insulin resistance, diabetes, obesity, coronary artery disease, myocardial infarction, heart attack, impotence, atrial fibrillation, and eventually congestive heart failure. Excessive sodium causes hypertension, cerebral atherosclerosis like in the Japanese in the 1960s, eventually leading to stroke, brain hypoxia, tissue hypoxia, cancer. Activates platelets too. It's prothrombotic. It also causes a little bit of immune dysfunction. Can cause exercise-induced asthma as well. Excess chloride causes low-grade metabolic acidosis because it displaces bicarbonate in the blood, the pH buffer. Okay, so it increases the risk of cancer a little bit in that sense. And it also, you know, it's damaging. The chlorine in the tap water is damaging to your gut flora. So, it predisposes to leaky gut. Excess oils. You know, you don't want to eat any of these uh, these processed oils. Omega-6 oils, they undergo lipid peroxidation. Uh, one of their metabolic, uh, toxic metabolic byproducts is hydroxyenol, which causes brain damage, causes pancreatic beta cell damage, predisposing to diabetes. You look at all these people from India, okay? And you see all these people from India and they're skinny and they go, "I'm a vegetarian." You go, "Oh, yeah, really." And then you say to yourself, "Well, why is it that so many of them have diabetes and coronary artery disease?" Because the omega-6 oils. Because they ate too much fried food, a lot of them. And so that's why all this nonsense, you know, coming out of uh Viva and other places, omega-6 oils are okay. Omega-6 oils are okay. I would beg to differ. I think the literature strongly says exactly the opposite. Okay. Um, they also cause cell death, um, brain damage, and that's especially been researched by Tetsumori Yamashima, MD, PhD from Japan. He was the guy in Japan asked to figure out how come so many more Japanese people are becoming demented compared to the past. And he figured it out. It's from the omega-6 oils that had increased in their diet. Excessive iron. There's a lot of iron in red meat, for example, but there's also a lot of iron in processed foods that are fortified with iron. Uh, for example, when I was a young guy, I wanted to be strong, a wrestler, and I used to eat, I used to on purpose eat Raisin Bran cereal because it had extra iron loaded, probably, you know, mechanically shaved off a piece of iron. I didn't know. And so my ferritin was normal, close to about 300. You know, that's still totally normal, but ideally, you want your serum ferritin down around, you know, 30 to 80 or so. So, I just will donate a little blood here and there. Like when I go for a blood draw, I have him pull off a couple extra tubes and discard them. So, I'm gradually working it down. Mine was 110 last time I went over there. Okay? Because you don't want to get free iron. The typical western male is iron overloaded by his u his mid-20s. Typical female, you know, about 5 to 10 years after she's post-menopausal. Because when you have free iron in the blood, iron is like a fire. Eugene Weinberg said this. He's an iron researcher. He said iron is like fire. You want it in your stove for cooking. You want it in your fireplace to heat your house. But you don't want it free because it'll burn stuff up. So when you have free iron in the blood, it has a, it's a transitional metal with a variable valence, meaning it can redox cycle between Fe2+, Fe3+. And in so doing, it's given off an electron that can then activate something called the Fenton reaction. You can remember Fe for Ferris, Fe for like means rust, red in in Latin and Fe for Fenton reaction, which is generating reactive oxygen species, free radicals that will then initiate a lipid peroxidation and damage to adjacent structures. So you don't want to be iron overloaded. Um, it also causes distortion of the shape of the fibrinogen, the clotting protein in the blood, and you get amyloid clots. So it's very prothrombotic, bad, bad. Okay. And also these excess oils, all these things, chloride, oils, tap water, fluoride, tap water, aluminum, they all predispose to leaky gut. And when you got leaky gut, the bacterial endotoxins LPS and LTA, they get into the blood. And they also cause an amyloid transformation of the fibrinogen clotting protein. So an amyloid transformation means to go from an alpha helix like a slinky cylindrical shape to being flat. That's called beta pleated sheet in terms of biochemistry, secondary protein structure. The problem is the beta pleated sheets all stick together like a deck of playing cards and so they have an increased molecular weight of a single molecule. When the molecular weight of an individual molecule goes up in the blood in the plasma, it'll precipitate, which means the clot. So that's how you form amyloid clots or sometimes also called fibrinolytic clots. Okay. Douglas Kell and Therese Pretorius are the two big PhDs that figured that out. He's from England. She's from South Africa. They both deserve a Nobel Prize, but nobody will ever hear of them because there's no money in it. Um, GMO corn, non-organic stuff. High fructose corn syrup that increases your serum uric acid. It's also sprayed with atrazine, which is a powerful estrogenic, turns a male frog into female frogs. It also is a mitochondrial inhibitor, inhibits complex 3 of the inner mitochondrial membrane for electron transport. Bad, bad, bad. It's often contaminated, the high fructose corn syrup with mercury, which is a major neurotoxin. Okay. What else? The GMO soy, the glyphosate. It's a neurotoxin. It's toxic to the liver, predisposes to fatty liver. It's toxic to the gut, predisposes to leaky gut. It's often processed, the soy, the non-organic soy with hexane. That's why I always laugh when people say soy is a health food. Yeah, right. Estrogenic, off the charts, high in fat, great. Goitrogenic, toxic to your gonads, both male and female, brilliant. More, you know, high-fat phony nonsense. Okay. And then these are just some preservatives. Okay. But I, you know, I could go on and on, but there's excess alcohol. We have excess stress, sleep deprivation, caffeine. Uh, tap water. You got to filter your tap water. Reverse osmosis is usually best. Distillation is okay, but you also got to pay attention to osmolality issues. And then all these things are bad. Alcohol, tobacco, MJ, vaping, it's all for chumps. Minimize estrogenic chemicals. Be simple. Simplify your life. I don't use laundry detergent or any of those like anti-wrinkle things. I don't have any problems with that stuff. I don't use dishwasher detergent. If you don't fry anything, you don't need dishwasher detergent. Uh, excess EMF, excess vulgar ignorance. Society sort of makes people stupid. So, I mean, here's what it basically comes down to. If you want to use your brain, you kind of live like Adam and Eve, but keep your indoor heating and plumbing. Don't do stuff your ancestors wouldn't do, and you have the benefits of modern sanitation and and heat. And then you eat the low-fat, vegan, whole food, organic only diet, and you're unlikely to get any of the chronic western diseases. This is called God's way. Okay. Uh, Dr. Day had promoted that idea and, uh, you'll be dead probably, you know, you know, we can't guarantee you when you die, but you'll probably make it on average into your late 80s, maybe in your 90s. You go down the path of the typical chump eating all this uh stuff we talked about, meat, oil, processed food. Um, you go to the conventional doc, it's going to be drug, drug, drug. The drugs don't work. Then they're going to recommend surgery. Chop, chop, chop. Bye-bye money. Premature sickness, disability, and death. Very painful. Seldom works. Okay, here's abdominal pressure syndrome. Basically, the key thing to know is dietary fiber as shown by Dennis Burkitt. In the colon, it pulls water into the stool and makes it soft so that when you defecate, it should come out real soft like a cow patty or very soft Tootsie Rolls or really should be like a swirly, you know, like an ice cream swirly. That's what your your defecation should be like. And it's a reflex contraction. So, normally the bulky wet stool, it stretches the rectum down here. And then you come home and as soon as you get home, your butt knows you're home. This is one of the dangers of dressing in layers for the winter because as soon as you walk in that door, your butt knows you're home, but it doesn't understand dressing in layers. So, you got to get off all those layers real fast and make a run for the the porcelain god, uh, so you don't mess up the carpet. But anyways, that's what uh defecation should be like. If you don't eat enough fiber, then you got a bunch of goat pellet, hard little turds down here, like hard Tootsie Rolls. And because they don't stretch the side of the rectum, when you start to defecate, they don't come out all at once without effort. So, you tighten up your stomach muscle. That's called Valsalva maneuver. Tightening up the stomach muscle to get a little pushing pressure to pop out the stool to pinch a loaf. Well, the back pressure from the Valsalva maneuver is transmitted to the sigmoid colon and it causes out-pouching of the wall of the colon. That's called diverticulosis. If one of them pops, that's called diverticulitis. You spill stool over the abdomen. Fat. The mesenteric fat causes intense inflammation. I've drained hundreds of abscesses for that reason. There's like about one patient gets admitted every week to a conventional medical hospital for that problem. Okay. Then there's back pressure on the stomach and the stomach keeps pushing up into the chest and eventually part of it pops into the chest. That's called a hiatal hernia because it pops through the diaphragmatic hiatus and it causes loosening of the lower esophageal sphincter. And so gastric acid starts rinsing up into the chest into the lower esophagus and it becomes inflamed, esophagitis, and then it becomes scarred, esophageal fibrosis. The fibrosis causes tissue ischemia. The ischemia, lack of oxygen delivery to the adjacent tissues can cause cancer. So that's hot disease, inflammation, cold disease, fibrosis, subsequent tissue ischemia, possible cancer. So you'll often inflame something and then down the road it can become cancerous. So you don't want that. All the high-fat diet will precipitate with gallstones. 95% of gallstones are cholesterol-related. So these high-fat diets causing high blood cholesterol will lead to high cholesterol in the bile and eventually gallstones. Gallstones are ubiquitous. I see them all day long every day. Um, the stool being dry can form little rocks in the right side of the abdomen. They can obstruct the connection between the appendix and the cecum of the colon. The appendix hangs off like a little pinky finger. And when this, you know, lith means stone. So appendicolith means stone in the appendix. You can also call it fecalith, a stone of feces. The mucus-secreting glands in the more distal appendix continue to secrete mucus, but it can't get past the stone. So eventually it pops. So high-fat eaters, low in fiber, they get a lot more appendicitis. Okay. Back pressure is transmitted down to the veins of the leg, you get varicose veins. Down to the veins of the scrotum, you get varicocele. And that's why constipation can cause infertility in a man. Okay. You get back pressure on the veins of the rectum, you get rectal hemorrhoids. More bleeding at the stool. Little back pressure on your hernia weakness spots, increased incidence. Inguinal hernia, increased incidence as well. Periumbilical hernia around your belly button. Oops. I got to get back to the right picture. Here we go. And then that's that thing is called the, um, that thing is called what I just showed you was Dennis Burkitt's abdominal pressure syndrome. What I'm showing you now is what I call, I made this term up myself, the Western Abdomen Syndrome. Okay? Basically, because I always see the same thing. The vast majority of patients have a fatty liver. The way we can tell on a CT scan is the liver is more, uh, less dense than is the spleen. Normally, it should be more dense. Okay. Then the pancreas fills up with fat. And what's going on here? When you get fatty liver, that's basically diabetes of the liver. You can call it metabolic syndrome. But what it means is when there's fat throughout the liver, abnormal increased amount. The liver becomes unable to accurately sense the blood glucose level. And so it keeps inappropriately pushing glucose out into the blood. You know, breaking down glycogen, running gluconeogenesis, and the person becomes persistently hypoglycemic even while fasting. And then eventually the fat overload accumulates in the pancreas and it destroys the pancreatic beta cells. The pancreatic beta cells are the ones that make insulin. So once they're destroyed, the patient's screwed. They're going to be insulin dependent for life. So really, if somebody has type 2 diabetes, the intelligent thing to do is try to reverse it as fast as possible, which is actually very easy to do. You eat a low-fat diet. Okay, that's what you do. That's what Kempner did. And I'm going to show you that's what Roy Taylor did. And he cured all his type 2 diabetics. Okay. Kevin would cure all his type 2 diabetics. You hear McDougall lecture on all type 2 can easily be cured, uh, before you become insulin dependent by destroying the pancreas. Okay. You always see the coronary artery calcifications. Now here's the other thing you see. You also see extensive atherosclerosis calcifications of the abdominal aorta. You'll very often see small AAAs, abdominal aorta aneurysms. You'll see atherosclerosis going into the kidneys. High meat diets cause a markedly increased incidence of kidney stones because the acidotic protein in the meat, and meat has a different amino acid composition than plant foods. It has a lot more methionine, for example. Methionine, uh, has a sulfur group and it's sort of cysteine and part of it is metabolized as sulfuric acid. So when it's excreted by the kidney, the kidney co-secretes the, uh, the acid, you know, the hydrogen proton with calcium. So you get calciuria, increased calcium in the urine, and over time that'll start to precipitate and eventually it can form a stone. It'll also block up kidney tubules. So it predisposes you to a gradual onset of kidney failure. Okay. And the atherosclerosis causing poor perfusion of the kidney, lack of blood flow will also predispose you to kidney failure. There are tons and tons of Americans that are in mild kidney failure and they're just, you know, progressively gradually getting worse because they don't know anything about what we're talking about here today. Okay, what else? The poor blood supply. Here's the renal artery, but the, the abdominal aorta gives off a branch at the mid-height of the lumbar vertebrae as well. It's called the lumbar artery. And when it gets narrowed, um, by atherosclerosis or even occluded, it drops the blood supply to the spine. So, people get degenerative disc disease. Here's an example of asymmetric disc space narrowing. It's more narrow on, this is the right side. Here's the left side. The way you know what side is which is whenever you look at a CT scan, an MRI, an ultrasound, an X-ray, always imagine the patient's feet are pushed towards you. Okay? So, this is my right foot. So, this would be my right side. This is my left foot. This would be my left side. But looking at this patient, this would be the patient's right side and the left side because imagine their feet were coming towards you like that. Okay? So, what I'm saying, and I'm the one who figured it out, by the way, this is a Peter Rogers MD theory of spinal degeneration. Okay? Both ischemic and biochemical. I figured all this out. I've written three books on the subject. I'm the number one expert in the whole world on it. And so when you have a lack of blood supply to one side of the spine, not the other, you get more severe disc space narrowing on that side that leads to degenerative scoliosis. And this is all part of Western Abdomen Syndrome. I see this every day. I've seen many, many thousands and thousands and thousands of cases of this because it's ubiquitous. Most of the patients have it. Typical patient has most of what I just showed you before. Or they don't necessarily have appendicitis or active diverticulitis, but they've got all the other manifestations, the diverticulosis, the gallstones, the fatty liver, the kidney calcifications or frank stones. Okay? And then here's what it's doing to the spine in more detail. Basically, it destroys the disc by ischemia, lack of blood flow, and then the disc gets abnormal motion, segmental instability. The spine has a lot of proprioceptors. Its job is to protect the spinal cord and the nerve roots. Okay? Okay. So when it senses abnormal motion, segmental instability, a segment is the VB above and the VB below with the intervening disc. It lays down bone. Like Ralph Waldo Emerson had said in like around 1850. The hedgehog is only one trick, but it's the best trick. Okay? Plays dead. The other animals leave it alone. In the spine, the spine will fuse that segment. So bone grows in from above and bone grows in from below and it fuses that segment. And when it fuses that segment, then you won't get abnormal motion anymore. But let's say we fuse this segment first, then you'll have abnormal stress on the disc above, the disc below, and the process just propagates itself all the way from the sacrum, which means the pelvis, up to your skull. I see this all day long every day. And I can also tell you the textbooks are all stupid. Like here is ossification of the posterior longitudinal ligament where the disc meets with the posterior longitudinal ligament of the spine. I routinely see a calcified, ossified all over the place every day. If you read the old textbooks from the 1990s, they'll go, OPL is a rare condition, more common than persons of Asian descent. Oh, BS. I see it all day long every day. And it's all related. The spine doesn't care how it fuses. It just wants to stop the abnormal motion. It'll fuse across the posterior disc. It'll fuse right in between the vertebral body, straight through the disc. It'll fuse in front with vertebral bridging osteophytes called DISH, diffuse idiopathic skeletal hyperostosis, also called Forestier's disease. Okay. It'll fuse in the back and the spinous processes. That's called Baastrup's disease. And it'll march its way all the way up and down the spine. And I confirmed it in multiple ways, but we're not, you know, spine is not our main topic for today. Okay. Here's leaky gut. So, what I'm trying to say is all of these diseases are so routine with people who eat high-fat Western diseases, Western diets, that we consider this normal aging. Everything I just showed you, gallstones, that's normal. I, that would I wouldn't call anybody for gallstones. I would just, I, I wouldn't, I would just put it in the body of the book. Uh, gallbladder contains gallstones, but there was no evidence of acute cholecystitis. Next, if there's a kidney stone, I'll mention it. Nobody really cares until it gets over a centimeter or if it's obstructive, but these things are ubiquitous. Now, here's leaky gut. Normally, the dietary fiber, remember, fiber is your friend. Uh, I think Jeff, Jeff has a slogan, fiber is health and pharma is death, or fiber is life, pharma is death. Fiber going to the good bacteria with a smiley face converts it into short-chain fatty acids. In particular, butyrate. Butyrate's a four-carbon fatty acid, carboxylic acid. But it's like same thing as a butyric acid taken up by the enterocytes. They convert into TJs, tight junctions. So the tight junctions are like, imagine, um, my hands are the, are the, are the enterocyte, the gut lining cell, and the yellow right here, I should, I should use red because my tight junction in my picture is red. So here be a red highlighter. That's the tight junction. And it blocks anything bad from the gut getting across the gut lining and getting into your body. Okay. The gut lining, the gut lumen, what's inside the tube of your gut. That's the outside world, and you don't want bad stuff like bacteria. The purple things are the bacteria. Purple people eaters. The LPS is the bacterial toxin, endotoxin. It's called LPS from gram-negative bacteria, is called lipopolysaccharide. Gram-positive bacteria make a similar toxin called LTA, lipoteichoic acid. And they're very toxic to your body. When the immune system binds to them, it creates a big response and that will cause inflammation in your gut. That's what all this leaky gut's about. And that's what, you know, irritable bowel syndrome, Crohn's disease, ulcerative colitis. And also after it does its job over here, there's extra butyrate left over and it passes into the blood. It travels up to the brain and it makes your blood-brain barrier, uh, have tight junctions as well. So this butyrate is of extremely high value to your gut and to your brain. It also is important for your retinal barrier and your gonad barrier. Okay? So you want to get your fiber. You really need it. All right? And if you, when you have leaky gut, what that means is you're going to be short on butyrate and you're going to have leaky blood-brain barrier and then you're going to be getting in bacterial endotoxins. They're going to get in your blood and they're going to contact the outer surface of your brain and then your brain's immune system, like your microglia. They're going to be activated. They're going to go, "Incoming bacterial invasion, possible meningitis, clear the area, release toxic chemicals to kill bacteria," and they're going to try to kill it because when they bind it with their pattern recognition receptors, as far as they're concerned, meningitis is beginning, you know, bacterial infection of the brain, and they got to stop it. So they release these toxic chemicals, a bunch of reactive oxygen species, and they'll destroy brain cells in the vicinity. So you're, you're, you're causing real tiny amounts of brain damage every day when you're allowing yourself to have ongoing leaky gut. You also, it's also the mechanism for, um, for big chunks of protein being able to get across. Normally only one, two, or three amino acids, you know, monopeptide, dipeptide, tripeptide, that's all they can get across. But when you've got a leaky gut, no tight junction, big chunks of protein can get across and that can cause autoimmune disease. It's the main mechanism of autoimmune disease. And then we, I alluded to it earlier, that these bacterial endotoxins, free iron, if that's available in the blood, shouldn't be, but if it is, they distort the shape of fibrinogen from alpha helix, cylindrical like a slinky shape to flat beta pleated sheets. They form a big molecule, precipitates, that's a clot. And then you got these little clots floating all over your body, plugging up arteries in your brain, increasing your risk of neurologic symptoms, plugging up arteries in your heart, increasing the risk of atrial fibrillation, etc. Okay, here's the two they figured out. He's a PhD from England, Douglas Kell. Therese Pretorius. She's from South Africa, and they did genius work on figuring all that stuff out about amyloid clotting related to LPS and LTA. I just want to show you this one lady here, Jacqueline du Pré. She was like the best cello player in the world, you know, back in like the 1970s. And, um, she got multiple sclerosis and her husband was Daniel Barenboim and another, you know, great magnificent musician. They're both world-famous, world-class musicians. But the point that I'm trying to make is even if you're rich and famous, conventional medicine can't help you. You can't buy a cure. Okay? Whereas, you know, Royce Swank, friends with Dr. McDougall, MD, PhD from Harvard originally in in Canada, and then he went to Oregon. He had 95% of his MS patients with no significant increase in symptoms after 32 years. She was dead within 10 years. Disaster. Okay. And you know, and what did he do? We recommend minimizing saturated fat, avoiding animal foods. Oh, this is just showing you the iron takes off. You know, when you're growing up to about 20 years of age, your body can handle the iron. But if you keep eating a high iron diet, men are iron overloaded in their 20s. Women when they go post-menopausal, and then I was telling you about the ferrous redox cycle, Fe2+, Fe3+, you can initiate the Fenton reaction and then you get all these reactive oxygen species and all kinds of tissue damage. Here's a brain. Here's the internal carotid artery going up like a thumb goes up into the brain. Middle cerebral artery. There's an anterior cerebral artery here in the middle, but I can't, I don't want to draw because it's too crowded. But here's the middle cerebral artery goes out over the brain, over the side, over the convexities, and then it drops penetrating arteries. There's ascending arteries called the lenticular striates. Okay, there's three levels of brain tissue. There's basal ganglia at the bottom of the brain. There's corona radiata that is at the level of the lateral ventricles. And then up above that, centrum semiovale, and right here is the money area where I put the skull and crossbones. Every day I see hundreds of strokes in this location. And most of them are due to hypoperfusion. Okay. And there's a lot of reasons for that. One of them is overtreated hypertension. Why do people have a blood pressure to get blood to the top of their brain? Okay. Normal blood is like kind of like water. Okay. When you eat high-fat diets, the blood becomes thick and now you're pumping like a milkshake to the top of your brain. All right. Pressure has to go up. If you eat a lot of sodium, that's a vasodilator, narrows the artery diameter. Now you're pumping thick blood through a narrow system. Pressure goes up more. So then they give you a hypertensive medication and they set some arbitrary goal like keep your systolic below 130. Well, guess what? Maybe the reason your blood pressure was 170, 180 before was that's what it takes to get adequate perfusion in your brain. So you got to be careful about dropping that pressure too fast because you can underperuse this little segment here and you end up with little tiny strokes there. They are often relatively mild symptoms, if any. Okay. And they're so common strokes in this area, we consider them normal aging. I kind of laugh because I'll, I'll describe a radiology report of a brain MRI. Moderate amount of periventricular flare hyperintensity is most likely due to small vessel atherosclerotic ischemic disease. Okay, next case. And then I'll look at the internal medicine doctors and they'll go, "Oh, it's just normal aging. Normal aging. It's normal to have strokes in the Western world." So here's what a normal brain really looks like. Small ventricles. The brain's up tight around the skull. And these spots are all clear. There's a little bit of minimal hyperintensity brightness due to the corticospinal tracts in this location. Here's what a typical westerner's brain looks like. Like this would be like a typical 75-year-old. All these white spots are strokes. Pop, pop, pop. And over time you'll have like say a stroke here, a stroke here, a stroke here. And they'll become coalescent. They'll all merge together because you have ongoing loss of brain tissue, loss of the penumbra. Penumbra is like a Greek word for twilight. And what it means is there's a little bit of tissue around each individual stroke which has a compromised blood-brain barrier. And if you keep having leaky gut, for example, or hypotension, you'll just gradually knock off all those cells and these little strokes will get bigger and they merge into a coalescent blob that looks like a cloud up in the sky. These are all strokes, destruction of brain tissue. And this would be like an older person who might still be able to move their limbs, but they, they're, they're just slower. Their speech is slower. Their interval to response to a question is slower. Their thinking is slower. Their movement is slower. They're becoming more and more fragile, debilitated, and cognitively impaired. This is typical. I see this all day long every day. Okay, here's the other thing I see. This is a typical brain. Let's say a 75-year-old in the Western world. Um, remember how I talked about the brain should be up tight against the skull. This is a CT scan. This is not that previous one was an MRI. So here is the skull and here is the brain tissue up close to the parenchyma in the back where it's gravity dependent. But notice there's all this cerebrospinal fluid CSF up anterior and the brain has fallen away from the skull. So this would be moderate, uh, to severe atrophy. And what I'm trying to say is this is what I see all day long every day. I primarily see atrophy. Yeah, I see tons of those strokes I just alluded to, the deep white matter strokes, but I see shrunken brain and it's diffuse atrophy. It's not Alzheimer's. Alzheimer's is BS. Okay. The so-called familial Alzheimer's, genetic Alzheimer's, that's a real thing. Okay, but sporadic Alzheimer's is the most exaggerated crock of BS known to mankind. Okay, we're not going to get into this. This talk's not about that, but I'm like a world expert on dementia. I'm actually the best one in the world with regard to figuring out what causes dementia. And I can assure you the de, the Alzheimer's research foundations, many of them have exaggerated the frequency of Alzheimer's because they get more money. If they can say it's the most common cause of dementia, they get more money. But we're not going to get into Alzheimer's. That's not the point of the talk. What I'm trying to tell you is I don't see focal parietal temporal atrophy. I see diffuse atrophy all day long every day. And that fits for apoptosis due to hypoperfusion and excitotoxicity. And supply and demand problems. Peter Rogers, MD, supply and demand theory. Okay. All right. Here's just one example. And this is typical. All of the epidemiology is the same. It's always the same. People ate their old-fashioned whole food diet, predominantly plant-based, 85 to 95% plant-based, and they were skinny with none of the chronic western diseases and with a lot of energy. And then they move to a western area, or they become westernized, and they become fat, sick, and stupid like all the other westerners. So here's two populations. This is the USA Mexican border in northern Mexico. You got the Tarahumara people, like fleet of foot, that means, and they got, they live in a Sierra Madre mountain. Sierra means like a saw, like the edge of a saw on the mountain range, Copper Canyon area. They don't have cars. They eat local greens, lots of corn and beans. They do eat a little bit of chia seeds, but if you're running 100 miles in two days, their their total fat when it was studied was about 13%. You can go up to about 13%, as I said, but if you're a westerner and you're, you know, you're working in a cubicle all day, you can't eat that much fat. You shouldn't, especially as you get older. All right. The Pima population was combined with them, but the Pima after the Mexican-American War in 1848 got pulled into Arizona and then now they eat the SAD diet. And it shows, man. So, here's what they used to look like. Here's an old photo of the Pima. They look like Tarahumara. This looks like a college wrestling team, okay? They're fit. Now, here's what the Pima look like. Or fat, tons of diabetes, hypertension. They get diabetes-related leg amputations, BKA, below-knee amputation, sigmoid colon resection for diverticulitis, appendicitis, gallstones, gallbladder taken out, CABG, coronary artery bypass graft, open heart surgery. Here's a Tarahumara running 100 miles in two days. Nathan Pritikin was so impressed by them that he patterned his diet after the Tarahumara. Okay. And what I'm trying to say is it's always like that. Rice-eating Asians, you know, 90% of their calories from rice, the rest from, uh, fruits, vegetables, and, you know, tiny bits of meat, like less than 5% typically. They go to Hawaii, get westernized, they start getting fatter and sicker. They go to California, get more westernized, get fatter.

and sicker. Those are the migration studies. It's always like that all over the world. You're going to see that's the pattern. Okay. All right.

And here's another little interesting thing. Okay. Of course, T. Colon Campbell wrote this magnificent book, The China Study. His biggest emphasis was on protein, how animal protein in particular having a different amino acid composition. In particular, in this case, it has more lucine, which is an activator of mTor and that promotes cell growth and that's thought to accelerate the rate of growth of cancer. But here's an interesting thing in a paper by T. Colon Campbell. Okay. Uh this is from the American Journal of Cardiology in 1998. He talked about two patterns of diseases. Group A is typical of a developing country, third world countries. Okay. Group B is more typical of a western country. So western country diseases we are all familiar with these. Colon cancer, lung cancer, breast cancer, diabetes, coronary artery, atheroscerosis and uh stomach cancer, liver cancer. Okay, so he's mostly focused on the cancer, but we also know that's hypertension, obesity, autoimmune disease. And now the third world countries, the diseases they get is mostly infections. Okay. Uh so what I'm trying to say is in the western world because we have indoor heating and plumbing, we don't get that many infections and we got antibiotics. So basically if you don't if you eat the low-fat vegan diet, you avoid all the common chronic western diseases. And because we have indoor heating and plumbing and we got antibiotics, you can avoid most diseases. You should be healthy. Okay? I'm 63. I'm still going strong. Okay? I'm not afraid of these diseases. The only thing I'm afraid of is I might piss somebody off and they'll and they and they'll kill me. But as LONG AS I DON'T DO THAT, I think I'm probably going to get a long time. Okay.

Now, here's Adam and Eve in the Garden of Eden by um Peter Paul Rubin and Yan Bgal 1615. Isn't that beautiful? So, try to live like them. Simplify your life. Try to eat and do things that they could have done to the extent that's possible. I know there's some things that are minimally processed that are still good you won't completely avoid. Like, uh I think oatmeal is a good food, organic oatmeal. Okay. And then here is Big George crossing the Delaware to go after the Hessians Christmas Eve rag. God bless America. And uh I hope you found that helpful. >> Terrific, Peter. Now that's the uh the Constitution, right? The the the vegan constitution talk. You've got a second talk. >> That was my Yeah, that was my declaration. My vegan declaration of independence. I do I do have another talk if you want to see it. >> Yeah, I'd say let's let's do it. Why not? >> Okay. All right. Let me let me open it up. >> Okay. Is it in? >> Yeah, I got the talk already. It's ready to go. Okay. >> Okay. Let me pull myself out and see if it appear. >> All right. It should say daily stepcom at the top. You see it? >> It's there. >> Go for it. >> Okay.

So, this is this is a new talk. Now, this is landmark papers in the vegan diet. And this is to help vegans. When they run into one of these aggressive paleo keto carnivores, they have nothing to support the paleo keto carnivore diet. So, what they do is they start throwing insults at you. You're crazy. you're stupid. I ate meat and I became so much stronger and my diabetes got better and everything went away. Yeah, right. Okay. And it's also true there's something called the Hawthorne effect, meaning that whenever somebody's part of an experiment or starts a new diet, they have increased awareness and they're paying attention to every little detail and they got more self-control and restraint. So, people can initially improve on any diet for the first six months or so, but long term you keep eating paleo, keto, carnivore, highfat phony, that fat's going to catch up with you. Anyways, so one paper was just to show that the more people walk, especially if they get 10,000 or more steps per day, they have a significant drop in the likelihood of becoming depressed. And as Thomas Jefferson has said, it's like the one of the best exercise. I've done a whole bunch of study of geniuses. It's very routine that geniuses walk a lot. Thomas Jefferson would walk for hours. Charles Dickens would walk for hours. Nitzki was a jerk. I don't like Nitzki, but he was a genius in his own way. Okay? And there's lots of other ones. Beethoven would walk for hours. Gera would walk and walk and walk. It's a very common thing. And I like to walk on a treadmill and read because I can titrate the dose to how well I want to sleep. If I walk, you know, five, six, seven, eight miles, man, I sleep like a baby. It's great. Okay. Uh so that's article about that.

Now we'll talk about hypertension. So here's the paper. Blood pressure in the African native. It's bearing upon the ideology of hyperpia, hypertension and atheroscerosis. This paper is by CP Donison is written uh in 1929 in the Lancet Journal. And what I'm going to tell you is when a paper like this comes out, I notice over the years it gets harder and harder to find on the internet. Go in the head, search it yourself, and you will see they won't let you watch it. No matter where you go, they'll almost never let you get this paper. You used to be able to get the whole paper just five years ago and then now maybe they heard me lecturing about it. are hiding this paper because they don't want people to know because it makes it so obvious. This was done in Kenya with adult black men, okay? Where they ate a primarily plant-based diet. They had 1,800 adult black men admitted to the hospital, checked their blood pressure. How many were hypertensive, do you think? In the USA, I would predict about 80%. Okay. At this time, not a single case of hypertension was encountered. None. Zero. Zero. None. I I don't know if you realize how amazing that was. I discussed this with a bunch of health care workers in the American conventional system. They couldn't believe it until they saw it because all they see all day long, blacks have hypertension off the charts. Okay? None. Zero. When they eat a plant-based diet, all that stuff about genetics, it's all BS. Salt sensitivity, the African climate, it's all BS. if they eat plant-based diet, they don't get hypertension. Okay? They also, I don't have that the the sheet, but if you if you read the thing, you'll see for the average 60- year old man, they compared the Kenyans versus the Europeans. And the Europeans were eating more of a westernized type diet. The average blood pressure in a 60-year-old man from Kenya at that time was 105 over 67. Same as a baby, okay? Like a like a teenager. Okay. Perfect. All right. whereas the the westerner had average blood pressure 140 over 90. So I'm trying to show you those are amazing numbers.

Okay, now we're talking about diabetes. Okay, here's the guy. This is the big genius of diabetes. Michael Brownley. He had type 1 diabetes. He was told when he's a young guy that he's probably going to be dead in his early 30s. And he's like, I don't like that. He decided to devote his life to studying diabetes. And this guy wrote this paper here. He won the Banting Award in 2004 for being the best diabetes researcher in the entire world. Uh this guy is is is like beyond genius. He's a genius amongst geniuses. This guy Michael Brownley, he devoted his whole life to studying diabetes. He figured out every last little freaking detail of diabetes. It's so awesome. When I read this paper, I started crying. It was like this is the cyine chapel of diabetes paper. It's like the cysteine chapel ceiling of research papers in general. This is one of the most beautiful papers you will ever read in your life. I have u doctor friends and they all tell me they think it's the greatest medical paper they've ever read in their life. They said you should if you only take one paper. Let's say you have a physician and you want to convert them to not being an idiot and being completely ignorant about nutrition and toxicology. He said give them this paper. print out this paper before they hide it completely behind a payw wall or or make it unaccessible on the internet and give them this paper. Anybody with a brain in their head will read this paper and they'll they'll want to become a vegan. Okay, it's that extraordinary. So, highfat diets and you can also have some cells that can't control the uptake of glucose into them like an endothelial cell. That's a little more complex, but the bottom line is it's highfat diets are the number one cause of insulin resistance. And what happens is they get into the cell too quickly. I'll explain why, but the fat gets into the cell too quickly, overwhelms the cell, gets into the mitochondria, and it sends up too many NADH electron carriers. And that means that the electron transport proton pumps which pump hydrogen protons into the intermembrane space. This is the inner mitochondrial membrane. Up here would be the outer mitochondrial membrane. They drive this gradient up too high. This gradient is the highest gradient in the human body. Let's say it's around 150 uh mills, negative 150 millolts. When it gets too high though, they can't pump protons against that proton pressure. It'll start to back up and go in reverse. And then electrons will be dropped down into the mitochondrial matrix, the center of the mitochondria, and then they're going to form reactive oxygen species, meaning free radicals. A free radical is something that has an unpaired electron in its outer orbital. Now, the mitochondria normally can handle them when they occur in small amounts. They got something called SOD, superoxide dismutates. But when they happen too frequently, it starts becoming overwhelmed by them and they start destroying mitochondrial tissue and causing this whole uh chain reaction of problems. And one of the reasons why this paper is so magnificent is you'll probably see this and you'll have some dispute with the paper. You say, "Well, what about this?" And Brown will go, "We checked that. What about this? We checked that. What about this? We checked that. What about this? We checked that." He goes through about 30 different things. any little thing you could say to challenge what he's saying. We checked it. We checked it. We checked it. We checked it. We checked it. It It's a It's a remarkable paper. It's extraordinary is how great this paper is.

Okay. Now, here's a few other thoughts related to all this. Actually, um I'm mixing in here a little bit of coronary artery disease stuff, but here's a paper, the incident of myocardial infuction. Um and again, this was a comparison in Uganda where they did autopsies. They did autopsies in 1,427 adults in Uganda. Okay. In black and black adults, there was zero fatal myioardial inffections. So, not a single person and 1,427 uh black adults in Uganda died from a heart attack. In the USA, that'd be like 35%. This is these are incredible numbers. These are unheard of numbers. Western doctors would not believe these papers. They would go, "Let me see that. Let me see that." They would be freaked out by it. Okay, you didn't have heart attacks in the USA until the 1900s either. You know, almost never. Okay, here's another paper. You know, Africans and Asians and Uganda. So, the Africans tended to be poor. The Asians tended to be rich ones that came in for some type of industrial thing. So the the point being is there the Africans were eating low-fat diets, low-fat plant-based diets. Whereas the Asian population at that time was eating highfat diets. So they would have um you know they're eating the ghee and the yogurt and oils and fried food, they would have coronary arter disease. But the native population eating the low-fat plant-based diets, you know, plantain, sweet potatoes, banana leaves, yams, maize, millet, they would not have it. Okay.

And now here's uh one of the researchers for diabetes, another Banting Award winner. This is Roy Taylor. He's a physician from England. He wrote this book here, Life Without Diabetes: How to Understand and Reverse Type 2 Diabetes. Here's his paper, Banting Lecture from 2012, How to Reverse Type 2 Diabetes. He calls them twin cycles, meaning that when you crank up the amount of fat in the liver, you get diabetes. When you crank up the amount of fat in the pancreas, your diabetes gets worse, eventually becomes irreversible. But actually, it starts in the muscle, the accumulation of fat. Anyways, what he did to prove he was right is he just used an MRI to measure the percentage of fat in the liver. And then he put people on low calorie diets. He was using a controlled experimental setting, and he just minimized total calories. He was actually using these shakes he would make. And um as soon as he got the people to lose about 30 pounds of weight, all of his type 2 diabetics who had diabetes four years or less, they're all cured, every one of them. And he noticed that the liver would drop from being 36% fat down to 2% fat. Because like I said, when you get a fatty liver, that's diabetes of the liver. The liver no longer is able to accurately sense the blood glucose level, and it keeps on releasing glucose into the blood. The main job of the liver, the number one thing the liver does is maintain adequate glucose in the blood for your brain because your brain wants glucose. Your brain always wants glucose. In an emergency, it can burn ketones, but it does not want ketones. It wants glucose. So, the liver's job is just keep making sure the brain is happy. You happy, boss? Yeah, I'm happy. You happy, boss? Yeah, I'm happy. Make sure you got adequate glucose in the blood for the brain. That is the job of the liver number one. It does a whole bunch of other things. It detoxifies a bunch of things. It's actually the immune system for small molecules. In order to have an immune response like antibodies and all that stuff, you have to have at least 16 amino acids or more on the size of a peptide. Okay? Peptides like less than 50 amino acids. Proteins, you know, bigger than that, a polyeptide. Anyway, so the point I'm making, so the liver does that, it makes the bile. It does a few other things too. It's a metabolic workhorse of the body. But the important thing to know is the metab the fat in the liver is the most metabolically active fat in the body. It's the first fat to go away when you lose weight. Okay? The visceral fat and your subcutaneous fat, that's not as important as the liver fat. Okay? The subcutaneous fat is the least important. So, but this is wonderful news. All you got to do is lose the weight and you lose a fatty liver and your diabetes is cured. Okay? And then if you look at, you know, low-fat vegans, a billion out of a billion rice eaters are skinny back when they used to eat around 85 90% of their calories and rice and then a little bit of fruits and veggies and a tiny bit of animal foods. The Asians are all skinny. You won't see a fat one. Okay. So, anyways, this is big stuff. Diabetes type two. The reason this is big stuff. Now, a lot of you in the vegan community, you think I'm think, "Oh, you already knew that." Oh, yeah. That's great because in the vegan community knows a lot more than the regular world. But if you talk to MDs, you can talk to guys. I got friends who are first in their class who were AOAs, top percent of the 10% of their class. They don't know this stuff. They've never heard it before. They've memorized the conventional books forwards and backwards. None of this is in there. None of the pioneers of nutrition and health, Kempner, McDougall, Campbell, Ornish, Pritikin, none of them, Swank, Sloop, all the great names. Hoggins, not a single one of them are in the conventional books. Burkett's only mentioned for Burket lymphoma, not for anything else.

Okay, here's another genius. This is a guy from Yale, Gerald Shelman, MDPhD, and him his group was using magnetic resonance spectroscopy over at Yale. Roy Taylor actually visited them for a while. And what they found was the earliest number one earliest finding of insulin resistance was the accumulation of fat in the skeletal muscle. So here it is. Mechanism of free fatty acid induced insulin resistance in humans. There it is. I mean, let's say that again. fat causes insulin resistance because all these paleo keto idiots don't aren't aware of that. Trust me. Not only this guy won the Banting Award in 2018 as the best diabetes researcher in the world. You can watch his talk on the internet. You can find it. Just type his name in Gerald Shelman lecture on diabetes. I think I might even have a slide that'll show you where it is on my next slide or something. And so here it is. Free fatty acids induce insulin resistance in humans by the initial inhibition of glucose transport phosphorilation which is then followed by a 50% reduction in muscle glycogen synthesis and in glucose oxidation. So what he's saying is when you take fat into your skeletal muscle cells you shut down glycolysis which means burning glucose and you also shut down building muscle glycogen storage up because you're not allowing glucose to come into the cell. There's another reason for that. I'm going to show you the reason for that in a moment. But I just want you to know this is not a matter for discussion. It's been shown fat causes diabetes. That's an important point because people don't know this. Conventional doctors don't know this. You can show them this paper. You can show them this talk that I'm sharing with you today. This is a key point. This is fundamental. And as Dr. McDougall said, if the poor patient doesn't know fat is what causes diabetes, how do they know what to do in terms of changing their diet? They don't.

Okay, here's actually a slide from one of his lectures. You can find it at University of Miami Department of Medicine Grand Rounds done on April 5th, 2023. And this slide here is showing the connection between insulin resistance, meaning diabetes with many of the other chronic western diseases, atheroscerosis. And aththeroscerosis is a blood clot. Okay, having diabetes is prothrombotic. We don't have time to go into the mechanism, but it is. Okay, same patient has NAFLD non-alcoholic fatty liver disease which progresses to nash non-alcoholic stato hepatitis meaning fatty liver plus inflammation impaired glucose tolerance duh that's just like early diabetes okay like pre-diabetes all right fail the oral glucose tolerance test the other thing too you can tell your paleo keto idiots that you talk to that they're going to go oh well my diabetes under control yeah right give them give them an oral glucose tolerance test and they're going to fail it because they have insulin resistance and what they don't understand is they're building up atheroscerosis. They're damaging their body. They're causing tissue eskeemia. Uh what else is associated with hypertension, obesity associated cancers. There's a lot of cancers obesity associated like let's say breast cancer. The fat has more aromatase enzyme converting testosterones androgens into estrogens increasing your risk of breast cancer. They have increased risk of cognitive decline. I wouldn't put the word Alzheimer's in there because like I said, the word Alzheimer's is a bit of a joke to people who actually know what's going on. uh lower HDL, higher LDLs, polycystic ovary, you know, PCOS. Tons and tons of infertile females have that. I have friends that work at fertility clinics and they tell me almost all the patients have PCOS, polycystic ovarian syndrome. That's like when a woman, she's fat and it looks like she has a beard and she doesn't want to have a beard. Hyperasemia, you know, high uric acid in the blood predisposing to gout. High uric acid in the blood is also prothrombotic. Okay. It's also a vasal constrictor. It inhibits endothelial nitric oxide synthes and that causes insulin resistance because then the insulin then the uh glucose can't get into the muscle because the capillaries are clamped down. Um it's pro-inflammatory decreased fibbrinolytic activity which just means it's it's it's prothrombotic. Okay, predisposes to clotting and then high blood triglycerides. So they all go together. All this badness goes together.

Okay, now I'm going to show you something really cool. This is this is an AO. You know what an AO is? It means academic orgasm. And I figured it out. I'm like, well, how could fat do it? Why does fat do it? So, I started trying to figure out how does fat enter the way you solve complex problems is you start asking small questions. How does the fat get into the skeletal muscle? And here's the answer. I found it. I found the paper. The guy who did the research work, his name is James A. Hamilton. And what he found was that a fatty acid will come up to the plasma membrane of the skeletal muscle cell. It'll then interact with it. And if it's negatively charged, you know, it's not going to combine with it because you're sort of non-polar once you get into the lipid tail part of the blayer, but it'll get protetonated. It'll lose its charge and then it'll intercolate itself into the outer leaflet of the plasma membrane. Then it under goes what is called the flip-flop maneuver. And that's its name, flip-flop maneuver. And it flips from the outer leaflet of the plasma membrane to the inner leaflet of the plasma membrane. Okay. And um part of the net result is it also carries a proton into the into the cytoplasm. Okay. And when it carries a proton into the cytoplasm that will inhibit glycolysis. So it causes insulin resistance. Okay. Now there are fatty acid transporters like CD36s but you don't need them. They very rapidly will just flip-flop maneuver into the cytoplasm. And it's constitutive, meaning that the more fat you eat, the more fat that's in your skeletal muscle. There's nothing you could do about it. No medical surgical bulattoy is going to change that. So here's one of his papers. There he is. Ja Hamilton fatty acid flip-flop and phospholipid billayers is extremely fast. Extremely fast. Oleic acid fatty acid the um you know C18 it is an omega 9 meaning it's a MUFA. It's a monounsaturated fatty acid. This is olive oil. Okay, the main ingredient in olive oil, it just zooms right into the cell. Another reason why olive oil is for chumps. All that stuff about olive oil being good for you, it's not true. It's nonsense. Okay, I just want you to know this so you can unchump yourself.

Here's a journal Europe PMC. When fatty acid move unidirectionally across phospholipid billayers, the rapid movement of the unionized component, meaning the proteinated component, results in transport of protons. So you acidify the cytoplasm which inhibits glycolysis the glucose burning pathway and you shut down glucose entry you get insulin resistance. So besides damaging inner mitochondrian electron transport and oxidative phosphorilation as a mechanism of insulin resistance as Michael Brownley had shown you're also having a secondary mechanism of insulin resistance because you're causing acidification of the uh the cytoplasm. So you're going to block glycolysis. Glycolysis happens in the cytoplasm. KB cycle happens in the mitochondrial matrix. Electron transport and oxidative phosphorilation happens in the inner mitochondri memory. So basically you're screwing your cell. Okay. It happened with the MUFAS in this experiment. They just tested the olive oil and then they also tested saffat different versions of saffat medium chain um 12 carbon 16 carbon and 18 carbon you know palmetic acid steric acid. Okay. All of them were bad. Here's just another paper. Changes in internal pH caused by the movement of fatty acids. Okay, James Hamilton again, same thing. I was just telling you that you're getting the um and the pH change inhibits glycolysis. Okay. All right. Let's see here. Phosphorrukinise, that's the main regulatory enzyme in glycolysis, is very sensitive to pH changes. And a decrease in pH, meaning acidification of acid, will potentiate inhibition of the enzyme. There you go. This is insulin resistance. The extreme elevation of plasma fatty acid and diabetes could contribute to glucose intolerance. Meaning insulin resistance. There it is.

Coronary artery disease. Okay. Cowwell Essison's landmark paper, Journal of Family Practice 2014. I think it was July. Uh plant-based nutrition achieved coronary artery disease arrest. He stopped it and reversed it. Okay. 198 consecutive patient volunteers. Um 89% stuck with the diet. One thing I'm going to tell you is you hear these extraordinary levels of compliance following the diet in Essen study. That's because intelligent people scared they're going to die went out to Esen and asked them to help. Okay. So he's got a very high they're scared they're going to die. A lot of them were not re able to be revascularized through stances or open heart surgery. I say that because if you talk to the regular person, if you talk to the average Joe six-pack and they just get diagnosed with, you know, one of these chronic western disease, you tell them, "You should eat lowfat vegan diet." They go, "Are you crazy? I would rather die than stop eating me. I'm going fishing this weekend." That's the kind of stuff I hear. Oh, no. It ain't diet, doc. It's genetic. Everybody in my family is overweight, diabetic, hypertensive, coronary artery disease. And I go, "Yeah, that's because you all eat the same diet, genius." So, the average patient, I would say 95% do not want this diet stuff. As a matter of fact, very often when I talk to patients, they roll their eyes at me like I'm stupid or I'm crazy or I'm acting weird and they think all this diet stuff is BS. And you know, my friends tell me, they go, for a regular person who hasn't studied in much detail, they said it's impossible to tell what a good diet is because we see all these so-called experts on the internet on YouTube that seem credible. you know, they got the degrees, they've got the look, and they say the exact opposite. So, how are we supposed to know what the truth is? And I say, you look at epidemiology. A billion out of a billion rice eaters is skinny. When Roy Swank went to China in 1960, they couldn't find a single patient with multiple scerosis. Okay? I think the first case of MS, I have the paper somewhere. It wasn't even reported in in a black African like until like 1979. Rheumatoid arthritis was not reported in a person of African descent until 1957. In the USA, they got tons of autoimmune disease, tons of it. Okay? There was no hypertension in these countries in Africa. None. But then there's tons of it in the USA. The only difference is the diet. Okay? And it's always like that with the migration studies, the epidemiology like that. Like Dr. McDougall had said, all long-term large healthy populations ate a starch-based diet. Okay, there's your answer. That's why I think McDougall is the greatest doctor who ever lived because he told you that's what you have to do. You don't have to read all the papers. You don't have to know anything. Eat 90% of your calories from starch, 5% from fruits, 5% from vegetables, and you prevent all this stuff. Take it or leave it. You don't want to take it, fine. Go have your pills. Go have them chop you up. There's a ton of the doctors that want to practice will love to chop you up.

Okay, Prevent and reverse heart disease book by callin. Here's a few quotes by Dr. Eelston. Nitric oxide is the most powerful vasoddilator in the body. It is the life jacket of your arteries. The number one goal of good arterial function is to maintain adequate amounts of nitric oxide. As we get older, our arteries produce less nitric oxide. But the body has another way to produce nitric oxide from plants. Eat green veggies six times a day to keep your arteries bathed in nitric oxide. So he recommends people are chewing on veggies, grazing like a cow all day long. And what happens is there's plant nitrates. They're NO3. And then uh the back of the tongue is bacteria that convert them to NO2. They go in the stomach. Stomach acid converts it to NO nitric oxide and that goes into your blood and vasoddal dilates you all over the place. You also get release of nitric oxide precursors from your subcutaneous tissues when you go out in the sun. You know how as soon as you go out in the sun you get this good feeling. It improves mitochondrial function but it's you know big things you get the systemic vasodilation release um nitric oxide precursor. So sunshine really helps you a lot. But that's also why you don't want to brush your teeth with a fluoride toothpaste or use a fluoride mouthwash because it kills the bacteria in the back of your tongue. Excuse me. And you lose that first conversion step from the nitrate to the nitrite from NO3 to NO2. So you don't want that and that can make you hypertensive.

Here's another paper. This is like in the animal studies comparing dietary monounsaturated saffat and polyunsaturated fat. And what they found is the MUFAS cause just as much aththeroscerosis as sat fat. This is relevant because a lot of people try to say athoscerosis is good fat, good oil, but sat fat's bad. Well, the MUFAS, the olive oil caused just as much aththeroscerosis as a sat fat. Okay, PUFA wasn't quite as bad. But here's another study. David Blankenhorn, he's a famous aththeroscerosis researcher. Dr. McDougall was friends with him. And when he did his research study, he found that the the PUFAs caused just as much aoscerosis as the uh sat fats. Okay. Each quartile of increased consumption of total fat and polyunsaturated fat was associated with a significant increase in risk of lesion. Okay. Increased intakes of lauric acid, oleic acid, and linoleic acid significantly increased risks. So you you couldn't protect yourself with the um PUFAS, polyunsaturated fatty acids. The omega-6 oils were not protective. Okay? And I don't have any papers in this particular talk today about omega-3s, but omega-3s are bogus, too. Elevated intakes of omega-3 are associated with increased risk of atrial fibrillation, increased risk of immune suppression, increased risk of prostate cancer. Okay? I would not go down that path. Increased risk of immune suppression. And you know, I wouldn't want my immune suppress my immune system suppressed for fighting infections, for fighting cancer. It's your immune system that gets cancer out of your body.

Here's a red blood cell, negative charge on the outer surface. That's called a zeta potential. All right? And it's formed by a couple things. It's by the glycosaminoglycans, the heperin sulfates, the cholesterol sulfates, and at the very ends scalic acids. Okay? But the bottom line, negative charge in all your red blood cells. Guess what? There's a negative charge in all your white blood cells. Guess what? There's a negative charge in your endothelium, your arterial lining cells. Everything's negative charged. Why? Because that's how God designed it. It's all negative charge. So, nothing sticks together. In the movies, people die from bleeding. You know, bang bang, blood on the carpet, death. Okay, it's very sad drama. Okay, in real life, people die from clotting. You plug up an artery in the heart, heart attack, dead. You plug up an artery in the brain, stroke, eventually dead. You plug up arteries to your tissue, it becomes es chemic, lacking in oxygen and it's predisposed to increased risk of cancer. You plug up arteries in your eyes, you're going blind. You plug up arteries to your hearing apparatus, you go deaf. You plug up arteries to Johnson, Johnson, they'll work no more. You plug up arteries in the heart, you can get a heart attack, but you also plug up arteries in the heart, small little clots all over the place, like those amla clots I was talking about, atrial fibrillation, gradual destruction of cardiac muscle. Cardiac muscle when it's eskeemic and infared in little tiny pits it gets replaced by fibrosis pushes you into congestive heart failure. Tons of patients have atrial fibrillation and congestive heart failure. Super common. And the the AIB in particular predisposes to stroke. All these things go together. Anyways, if you get a molecule that's positively charged of adequate size, it can overcome the zeta potential and stick two red blood cells together. In an acute infection, you got elevated IgM type antibodies. That's the big one. Okay. looks like a jack. You know, you throw the little jack thing, you know, when you're playing with marbles that will stick the red blood cells together and that's why you get a lot more clotting in acute infection. LDL cholesterol sticks these uh red cells together. Elevated blood triglycerides will lead to these molecules sticking together. Elevated kyomicrons will cause them to stick together. Elevated uric acid has a bit of a uh prothrombotic increasing viscosity effect. A lot of this work here I'm showing you with LDL cholesterol was done by Gregory Sloop MD. He's like the pioneer of a thrombosis theory. He's a friend of mine. Um when LDL cholesterol goes up, uh blood viscosity goes up too. Meaning the blood becomes thicker because all these red cells are stuck together and it's more predisposed to clotting and blood pressure has to go up as well.

So here is something you want to know. Typical capillary diameter is five microns. Five microns in diameter. Typical red blood cells about seven microns in diameter. So even under normal optimal conditions the red blood cell has to fold back on itself a little as it passes through a capillary. Okay. If you have a bridging molecule like these things we were just talking about elevated LDL cholesterol kyomicrons from fat or um triglyceride fat in the blood elevated uric acid. It'll stick red cells together and now it's like instead of pushing an individual red cell through a capillary you're like pushing a submarine sandwich through there. Blood pressure has to go up. Ruo is the French word for stack of coins. It's also more commonly called blood sludge. The blood will become opaque. Normally, if you put it in a test tube and it sediments out, the red cells down here, the white cells right here, the buffy coat, and then the plasma up above, you can see through the plasma. But when you got all this fat, you won't see through it anymore. It becomes opaque. In the movie Game Changers about vegan diet for athletes, there there was a picture of this when they drew the blood from some athletes. Okay. Normal blood flow is laminer. So it's fastest in the center with the red blood cells and then you got the white blood cells right next to it and then further outside a parabolic velocity profile. Further out you're going to have the plasma adjacent to the endothelial cells. So it's fastest in the center. That's normal laminar flow. That's what it's supposed to be like. Um oh here was I just again showing you here's a normal looking brain. Small ventricles. Uh these are normal cortical spinal tracts but the brain tissue is free of strokes. And here is like a typical 75 year old in the western world eats a sad diet. All these little white spots are strokes. All right. And we talked before um middle cerebral artery comes up. Well, here's the internal cority comes up. MCA middle cerebral artery goes on along the convexity and a lot of people are underperusing their deep white matter where all those strokes were because they've overtreated their hypertension or because they've got incranial aththeroscerosis blocking these arteries. So that's a real common spot to get the strokes. You need a Goldilocks balance. You don't want the pressure too high. You don't want it too low. And guess what? God's a lot smarter than a doctor. So, do what mother nature and God want you to do. Eat your primarily plant-based, low-fat diet, and you keep these arteries open for your whole life. I see lots of old people um who've got good-looking brains. Okay? Don't get me wrong, most of them don't, but there are some who do manage to escape somehow unscathed. Um here's a atro brain. Kind of talked about that earlier. Here's what a stroke looks like. Here's a clot. This this black thing right here is a clot. This is the middle cerebral artery. Um core means core infarct. All of the brain in this spot is completely dead. Okay. The brain tissue over here is a schemic meaning it's lacking in oxygen, but it's not dead. It's a penumbra. Penumbra is a Greek word for twilight, meaning that you know it's like Schroinger's cat. It could be alive, it could be dead. If blood flow to this segment could be reestablished, this part could live. it could return to normal function. It's probably dysfunctional initially because it's es chemic, meaning it has less oxygen but not not severely deprived enough to kill it. So anyways, the what you want to have if somebody had a stroke even, they still got to be very careful in the rehab to try to preserve the penumbra and not have it go. And all those little tiny strokes have a little tiny penumbra around them that they could either save or lose. So it's always worthwhile to try to do things right to keep whatever brain tissue you can. Here's another picture of it. uh core infark dead brain surrounding penumbra salvageable brain and it's salvageable by optimizing one's health habits and that's what you want to do okay so here's Dr. McDougall with Roy Swank in one of the papers by Roy Swank uh role of hypoxy and lesion formation and location. Okay. Um this is from Roy Swank's paper showing the red cells uh stuck together after a highfat meal clumping together. There's a video at Dr. McDougall's YouTube channel, Dr. McDougall Health and Medical Center. It's only 50 seconds long where after the highfat meal, you see the red cells sticking together. Here's a paper by Swank. That other one was related to it, but it wasn't Swank. I thought it was, it wasn't. Here it is with kyomicrons. Kyomicrons are the initial transport system for fat, right? When you eat it and it's absorbed into your blood. And so as the kyomicrons go up, you get more blood sludge effect. Okay? And the positive signs are when it's most adhesive, most sticky. When the when when the kyomicrons are highest in the blood, fat causes thick blood and that can injure the bloodb brain barrier. That was their point was they felt that not only does it cause blood sludge but the blood sludge induces hypoxia and the net effect is it damages the bloodb brain barrier. Part of the problem is a highfat diet tends to be a diet low in fiber which is going to lead to leaky gut and to leaky bloodb brain barrier. Here's a paper showing that triglycerides cause increased ru formation meaning they cause increased blood sludge as well. The rate of ru formation was increased with the increase of triglyceride concentration. The enhanced red blood cell aggregation reduced oxygen released from the red blood cells flowing in the micro vessels. In conclusion, high triglyceride level um changes the behavior of red blood cells in the microirculation, increases flow resistance, and it also prevents uniform tissue oxygenation. So, it's bad. That's an important point because not everybody knows that. Triglycerides do it too. So you're screwed with kyomicrons initial fat transport. You're screwed with triglycerides and you're screwed with um LDL cholesterol, whole blood viscosity with metabolic syndrome and type two diabetics independent association with post-reglyceridemia. So diabetes metabolic syndrome increased triglycerides are associated with you know blood sludge. Postre post breakfast triglycerides was an independent determiner of increased whole blood viscosity.

Okay, here was some paper about bloodb brain barrier failure as a core mechanism in cerebral small vessel disease and dementia. This is just a paper alluding to what I mentioned earlier that when you have a core infar or one of those little white spots in that brain I showed you earlier the flare hyperintensity is parventricular and the deep white matter um it all has a penumbra and you lose that penumbra you're going to get worse. We provide conclusive invivo evidence that normal appearing white matter in the presence of white matter hyperintensities strokes is not normal at any age but it is increasingly abnormal and has an increasing white matter hyperintensity burden by proximity to it. So what they're saying is every little stroke is an ongoing battle for survival of the adjacent cells because they're compromised. And so what I'm trying to say is a lot of people don't understand. They'll tell you, "Oh, well, I've been doing this for 50 years, drinking all this coffee, eating all these highfat foods." And what I'm saying is the older you get, the more fragile you get. As Dr. Estles had mentioned earlier, you're going to make less nitric oxide. You're going to have more accumulated likely aoscerosis into cranial. And if you don't change your habits and you keep doing all this stuff, uh, you're going to make your brain cells eskeemic and you're going to start losing them to apoptosis. I don't know if I got a picture of the apoptoic mechanism in this talk. I think I might have one coming up.

Here's a paper serum lipids and conjunctal circulation after fat ingestion in men exhibiting type A behavior. So this was done by a couple opthalmologists Meer Friedman and Ray Rosman and Dr. McDougall was friends with them and they also tested it with vegetable oils. It was not just sat fat and all of them the the vegetable oils caused even worse blood sludging than did the sat fat. They they put an 80 magnification 80fold magnification over the eyes and they could see the capillaries oluding in real time. So here's a paper from the journal of circulation 1964 volume 29 uh page 874. Okay. And this one right here. Yep. That's June 1964. There's their paper. So what I'm trying to say is you can't win with that. There there's no way to win like like Nathan Pritikin. The guy was a genius and you know he was he was really rich too and he had a lot of time to sit around reading. He said no matter how you look at it fat is bad. That is the real conclusion when you actually study it. Here's a paper by Gregory Sloop the pioneer of athrombosis theory and he said the effect of low density lipoprotein on blood viscosity correlates with the association with the risk of aththeroscerosis in humans. And he was a pathologist so he would look at it under a microscope. And like I said, when I was a young guy, I was an imaging guided surgeon, interventional radiologist, Harvard trained, you know, big Brighamin Women's Hospital with the emphasis on cardiology. I rotated through interventional cardiology with all these world famous cardiologists doing stances, cardiac cath, etc. Okay. And I thought we are the big dogs in the athoscerosis world and the vascular surgeons and the cardiothoracic surgeons, heart surgeons. But what I later understood once I started to really study it was the big dogs in the athoscerosis world are the pathologists. The vascular surgeons and interventional radiologists, interventional cardiologists, they're just plumbers. If they see a blockage, a narrowing, they try to stent it open or surgically bypass it. They don't really look at it under a microscope. I've looked at, you know, many, many, many thousands of CT andrograms, MR andrograms, catheter andrograms. But what I'm trying to say is Gregory Sloop guy like William C. Roberts they look under a microscope they go ethos gross is a blood clot and actually they knew that back in the mid 1800s I think it was roatansky and verjou it's a blood clot and I went back and I looked at all these ct and you can't tell atheroscerosis apart from a blood clot because it's the same thing okay when the blood comes up in hypertens normally blood comes up in a laminar profile it hits the median divider a soft tissue uh between the external corateed so the external cor is like my fingers there's a bunch of branches on it goes to the face internal corate is like my thumb going up to the brain. So common corateed artery CCA common corateed artery goes up to the brain. The I'm sorry goes up in the in the neck. The internal corate is like my thumb goes up up into the middle of the brain. The external corateed that goes around the face and the scalp and stuff. All right. When it hits the median divider or soft tissue, it bounces off of there and you're going to get turbulent flow which just means chaotic flow. And you're going to get retrograde flow. Retrograde flow is also called eddyurren, slow flow. When you have an excessive amount of retrograde ediurrens because your pressure is too high. So hypertension caused an excessive an excessive force of the blood hitting the median divider and you get excessive turbulent flow and excessive retrograde ediurrens. It will confuse the arterial lining cells in this location endothelial cells and they will then shed their anti-thrombotic glycalix with its zeta potential. It's negative charge and deep beneath that will be prothrombotic adhesive molecules things like vcam vascular cell adhesion molecule and you'll get red blood cells sticking to that you'll start forming a clot. Now the person can remain in steady state for like a decade but they'll start eventually losing that battle and this will get bigger and then little tiny pieces break off and embleize to the brain. So a clot moving through a blood vessel to another distal location to become lodged in a small artery that's called an embolism and they'll emilize to the brain and cause small strokes. You don't want this.

Okay, here's the endothelial cells. They're spindle-shaped. Their lung axis is aligned in the direction of flow and they have these psyia like feelers that can sense the direction of blood flow. So when there's too much retrograde ediurrens they freak out and they release their glycoalics.

Their anti-thrombotic zeta potential glyicoalix sugar coating. They, they've got a whole bunch of disaccharide glycosamoglycans attached to core proteins. I don't want to get too technical here, but the bottom line is they got lots of negatively charged molecules on their cell surface that generate a zeta potential and it repels anything from sticking to it under normal conditions. But hypertension destroys that, and that's why hypertension is, along with high cholesterol, the two biggest risk factors for stroke and the two biggest risk factors for heart attack.

Okay. Diabetes also damages the endothelium. So it's very prothramotic as well, and it, it causes, uh, leads to occlusion of arteries, especially small vessels. Okay. The endothelial cell releases nitric oxide. Nitric oxide is a gas. So as a gas, it'll diffuse into the lumen of the artery. It inhibits the platelets from clotting. That's good. It diffuses into the wall of the artery, goes into the smooth muscle cells and causes them to relax so they don't constrict, and the arterial diameter will increase. So it's a vasodilator and it's also anti-clotting, meaning anti-thrombotic.

Here's what it looks like. A normal capillary, red blood cells floating through. The green stuff are the vascular smooth muscle cells in the brain. They're called parasites. The yellow stuff is the capillary basement membrane. Okay. The blue circles are the oxygen traveling from the red blood cell through the capillary to the axon, the brain cell, the neuron. Okay.

Now, here it is in a diseased artery. When you got diabetes, you get this thickened capillary basement membrane. Harder for the oxygen to get through it. You get this thickened muscular wall with hyperplasia of the muscles, more of them. Okay? And you'll often have fibroic tissue laid down within here, collagen. So less oxygen gets to the brain cell. So you're already half screwed from the baseline atherosclerosis. Then you superimpose on that a high-fat meal. You drop the oxygen delivering another 20%. Well, this brain cell might not get enough oxygen. If the brain cell doesn't get enough oxygen, it can't maintain its ionic gradients. It can't maintain, I don't want to get too complicated. I'll just mention it to you so you've heard of it. We don't have time to go in it now, but you have something called phosphotidal serarine. It's a type of phospholipid in the phospholipid bilayer of the plasma membrane. And normally it should be kept on the inner leaflet, but it requires ATP to keep it in the inner leaflet. If you don't have it, adequate amounts of ATP, it'll flip into the outer leaflet and the immune system can recognize that and it's a signal, an "eat me" signal that the neuron is deficient in energy and the immune cells, the microglia, they'll come in there and they'll eat the brain cell. The reason they do that is if the brain cell continues to drop its energy, it'll burst open because it can't maintain its osmotic gradients in which case it would release all its inner contents causing intense local inflammation and you don't want that because that would destroy a lot more brain cells. So the immune system, microglia phagocytes, they're basically the macrophages of the brain. They'll come in and they'll eat the neuron. So that's why low energy means the neuron is screwed. Okay. And, and my whole theory, the Peter Rogers MD supply and demand theory of neurodegeneration is based on that. Okay. We're not going to go into my theory today. That's not the point of this talk. But that's what causes brain damage. Okay. And that's why I always laugh at all these jokers saying, "Oh, for to prevent dementia, take some omega-3s." Yeah. Right. You need to address the supply and demand issues. Okay. And I've talked about it before. I've gone through all the work of, you know, Jack Delator. I've gone through all the work on excitotoxicity. I've gone through all my work on the mitochondria and putting it all together. How the EMF opens up voltage-gated calcium channels, etc. Anyways, this is just more of that same stuff about penumbra.

Okay, here's, here's something good. I'm glad I had this slide in here. When you get leaky gut, you'll get bacteria and bacterial endotoxins, especially the endotoxins getting across the gut wall. So, that's postprandial. Prandial means meal. So, postprandial means after eating, endotoxemia. LPS and LTA are called endotoxins. Bacterial endotoxins. Well, guess what? When you got leaky gut because you have a deficiency of butyrate, you will get leaky blood-brain barrier. Meaning that these bacterial endotoxins will get access to the outer surface of the brain. And once they enter the outer surface of the brain, you have immune surveillance cells which will bind to them. They've got PRRs. They're called pattern recognition receptors. And once they bind to LPS, lipopolysaccharide from gram-negative bacteria, LTA, lipoteichoic acid from gram-positive bacteria. The microglia is programmed. It's, it's the macrophage of the brain, the immune system protector cell. It's the guard cell of the brain. It goes, "Incoming bacterial invasion, meningitis. Clear the area." And it's going to release all these toxic respiratory burst chemicals. Okay? And they're just going to kill everything in the vicinity because they're trying to kill what they sense as a bacterial invasion so the brain doesn't get bacterial meningitis which will kill the patient. So all the neurons in this area, they're going to be sacrificed, destroyed. So what I'm saying is when you give yourself, when somebody's got leaky gut, you're also getting brain damage. Okay?

Okay, now you can make some new neurons every day through neurogenesis, but you don't want to make a habit of this. You know, 30, 40 years of this and you're stupid. Okay. I can tell you my internal medicine friends tell me and my own experience is pretty much the same. The average western patient after 60 years of age is cognitively impaired. They maybe can, you know, find their way, uh, to the drugstore, but they're no longer capable of a sophisticated, intelligent conversation. They are mentally slow. Okay. Okay. You know, basically most people after 50 years of age are fat, sick, and stupid. Okay. And you don't want to end up that way. And what I'm telling you is you don't want leaky gut. Leaky gut's a big deal. And I'm also going to tell you, once you understand this stuff, you become capable of understanding a lot of other things. You know, it has been said that when a man grasps a new concept, it's like having a new sense. We see with our eyes, we hear with our ears. Well, guess what? We think with concepts. So here's the concept for you. You now know that when you got leaky gut, you got leaky blood-brain barrier. You now know that bacterial toxins not only get through your gut into your blood causing clotting with problems all over the body, they also cause brain damage. Now it becomes very easy because people tell you all these Crohn's patients, also ulcerative colitis patients, they're all kind of crazy. Well, maybe it's because their brain has got a lot of inflammation. Okay? Get it?

All right, these are just some papers about. I'm not, we don't have time to get into all this stuff, but the gist of it is is just along the lines of what I was telling you earlier that you need the fiber so you make the butyrate so you make tight junctions not only for your gut but for your brain. This is just some supporting papers that show that.

Okay, a little on protein. I'm not going to talk about it too much. Uh, I could go on forever obviously. Um, Pritikin, you know, uh, shows this paper in his book. People fed 2.5% of calories from protein did very well and, um, Kempner was feeding people like around three and a half, four percent of calories from protein and, um, they were maintaining their serum albumens, meaning they were not protein deficient because everybody's afraid of protein deficiency, but I never see it. Okay. And then somebody might give you one case report from somewhere. All day long, most of the patients a doctor will see in the western world, middle age, they're going to have, uh, uh, all these diseases, obesity, hypertension. Not necessarily obesity because some of them are so poor they're practically starving, but their arteries are still plugged up. They're going to be hypertensive, diabetic with atherosclerosis all over the place. And this is something I, I talked a little bit earlier in my Declaration of Vegan Independence talk, but basically you got the chronic western diseases, obesity, hypertension, diabetes, coronary artery disease, hiatal hernia, gastroesophageal reflux disease, arteries plugged up everywhere, hearing loss, vision loss, atrial fibrillation, congestive heart failure, diverticulosis, constipation, etc. You can prevent those or cure those by going low-fat vegan. And then all the third world diseases, you know, developing countries, uh, most of that stuff is primarily infections. And we prevent that by having indoor heating and plumbing and indoor sanitation and we don't have so much overcrowding. So there it is. And don't be too promiscuous. Lots of infections from, uh, excessive promiscuity. Watch out for that. Can ruin your life.

So what I'm basically saying is you don't have to be sick. In the western world, everybody considers it normal to be fat, sick, and stupid by the time you're 55, 60 years of age. It doesn't have to be that way. I'm 63. I'm still going strong. Knock on wood. You know, as long as I don't piss somebody off and they kill me, I think I'm going to be gone for a long while, probably. I hope so. And so, what I'm saying is, thank God for this. I was fat in my 30s. I was a Star McDougall, actually. You can look me up on Dr. McDougall, Star McDougall. He helped me lose my last, you know, 20 or so pounds, maybe 30 pounds before that because I got real fat in my 30s 'cause I was overworked. I was a total workaholic. Um, I had a baby at home and I wasn't sleeping. I was drinking seven cups of coffee a day and then I turned that all around. That was like many, many years ago. Um, so what I'm trying to tell you, it's not inevitable. You're not inevitably screwed. And anything you do, you want to go down this path because it improves blood flow. It improves immune function. Everything in your body works better when you have good blood flow, good immune function, and you're not inhibiting your mitochondria. Anyways, that's what I got. I hope you found that helpful.

Be >> beautiful, Peter. Thank you so much. I think that's going to do it for today. And I really, I love those quotes from Thomas Jefferson about moderation and walking. I never heard those before. Those were some great quotes in your, uh, vegan declaration of independence from Western Diseases talk. And I, the second talk is great on these landmark papers that support a vegan diet. They, they've been around for a while, a lot of them, but people don't necessarily understand how powerful, how significant they are in supporting what you're and I am, you know, promoting here. I hope everybody leaves not just inspired but equipped with evidence that you can share, studies that you can cite, and, uh, the confidence to make informed decisions for yourself and for your family. If you enjoyed today's discussion, please give the video a thumbs up, subscribe. If you're new, share it with someone who's ready to take back control of their health. And happy 4th of July, everybody. Have a wonderful Independence Day. Peter. You too. Stay healthy and we'll see you next time. Thanks a lot.