Transcription
Eczema. Man, I actually got a lot of questions on eczema when I did that post yesterday on Instagram and and another version of it on Rumble. A little bit of a longer version. It's about a 5-minute video that breaks it down pretty straightforward. But eczema is no joke. Like it's not a skin problem, right? Let me look it. I'll go over how to solve it from A to Z. I'll give you all the answers and a bunch of things that I'm probably not allowed to say on social media or on whatever platform this is going to end up on because I can talk about every drug under the sun. No problem. But if I talk about an actual solution, for some reason that stuff gets censored, make it make sense.
But anyway, I'm still going to solve eczema for you. I'm just going to drink some coffee and then let's get to work because I want you guys to have the solutions. I like I said, I don't come out here to sell you anything. I got nothing to sell you. I've got zero to sell you. I don't care if you if you buy from Elite Biogenics or not. I don't care. I will tell you this. I've had people in my black card group get it tested independently. All a bunch of my products and the testing companies that they use said that most of the products out there are testing at 80% and mine tests at 99% plus purity, no endotoxins, nothing. So, I told you I do this because I actually give a crap. And I know for some people it's really difficult to believe because everybody out there for the most part is some pharma shill or some liar or trying to just make a buck. And I'm not doing this for the money. I'm doing this because I genuinely I'm here to help mankind serve humanity and mankind. And that's why God left me here. So, you decide what you want to do with that. But you want to buy from Elite Biogenics? Awesome. Thank you very much. If not, that's cool. If you want to join my black card, the membership, and you want to wire me $10,997 to the account that it's linked to here in Texas, Frost Bank is what I use. And you want to have a doctor that actually gives a crap, me, you get me for one year. It's not one-on-one. One-on-one is significantly more money, and rightfully so, because you're taking me away from my family. But if you want to have a membership in the black card for one year for one person, $10,997, you send an email to my personal executive assistant, Mia, who's a badass, at apply@unlockthecard.com. You get access to my live Q&A call every Monday at 5 Texas time. You get access to the protocol library and you get access to the VIP area where you can actually ask me questions, send me a live, send me your imaging, whatever it is, DEX, I don't care. Send it all to me. I'll take a look and I'll help you. My turnaround time is between 24 and 72 hours usually, unless it's a really complicated case. My job is to help you. So, you decide what you want to do with that. I'm not here to sell you on it. I'm here to give you information so you have the information and then you can actually do something with it.
But listen, how many of you guys know someone, maybe it's you, just scratching your skin like crazy until it bleeds? Bleeding. Not metaphorically, actual blood coming out. And here's what the dermatologist and I'm not here to roast dermatologists. They do that to themselves. But here's a cream. Use it forever. It's that's not medicine. That's not medicine. That's Oh, it makes me mad. That's management theater. And like I said, I'm not out here to roast dermatologists. They do a good enough job of that on their own because they're screwing things up. I'm out here because the smartest people, and actually the smartest, have been solving the wrong damn equation. They've been looking at the skin and asking what's wrong with the skin when they should be asking why is the skin communicating some kind of distress. It's too superficial. That's the issue with medicine is it's a first of all, it's a bunch of arrogant, ignorant medical students who have never seen a patient. They get 4.0 in school and have never seen a patient, which just makes you an idiot. It makes you arrogant. It's a bunch of doctors who've gotten lazy who use their phone to look things up and just send you to the right drug. It's the pharmaceutical companies that have demanded and indoctrinated everybody to believe that managed decline is normal. You're not supposed to get sick ever. And when you argue with me in my comments, I never read them, so I don't really care. When you argue with me in the comments, you are arguing to defend how getting sick is normal. your dog, your cat, your frigin lion fish, they never get sick. If your fish gets ick, real thing, it's not the fish, it's the environment. If your dog gets sick, it's going to be a problem of the three biological failures in a biological organism, a mammal. I solved this. Where's my Nobel Prize? Cuz I really I I honestly I deserve one for because I'm not doing this to make money. I'm doing this to help you guys.
But listen, here's the thing that your about your biology that medicine has completely forgot. Your skin isn't the frigin problem. Your skin is a messenger. It's literally got a it's got a megaphone and it's just yelling at you. And when you kill the messenger, you don't solve the message. You get a louder, much angrier version of that message elsewhere in your body. I'll show you how bad eczema gets systemically when it's not even on when you can't see it on your skin. Eczema isn't a skin condition. And it's a lie told by medicine because medicine specializes in skin. It's a systems failure. Three interconnected biological systems specifically for eczema. Immunity, metabolism, and cellular energy. Okay. It starts with disbiosis. Dispiosis causes leaky gut. Leaky gut causes endotoxmia. Endotoxmia causes immune dysregulation. Immune dysregulation causes barrier dysfunction. Barrier failure. To be honest, barrier failure causes, you ready? Here's lather, rinse, and repeat. More dispiosis. You've got this positive feedback loop that's destroying you. And there there are some children. This is what bugs me. There are some children out there. They're 10 years old and they're covered in eczema. And there's the parents. I don't blame the parents. Listen, if you're one of those parents and this is happening to you, I'm so empathetic for what you're going through and I'm so pissed off on your behalf because they keep giving your child cortisone. Are you out of your mind? Destroys human beings. I'm telling you right now it you need to I don't know just listen to this entire podcast and hopefully it helps you right but listen the barrier fails this is the problem with the barrier it fails in the skin eczema the lungs asthma the gut IBS the joints arthritis the brain anxiety and depression and metabolism diabetes metabolic syndrome all one disease different tissues that's it same disease look 31 million Americans right now 31 million that's a big ass number that's like the entire population of Canada just scratching themselves to oblivion where dermatologists tell them it's just genetics or it's just stress or it's just a skin problem. Topic: dermatitis. Got it? Except here's the thing. You might want to write this down because this is a premise about everything I'm going to go over. Eczema isn't a skin condition. It's a systemic disease that happens to have skin symptoms. And that single perspective shift is what separates people who get better from people who get worse.
This isn't complicated. And I realize some guy made a post. It's funny cuz I sent him a message and I go, "Hey, man. You want to?" He's the guy that says, he goes, "He puts up these posts dumbing down Dr. Trevor." And first of all, the ignorance around that statement is astronomical. But second of all, you're stealing my [ __ ] just to make yourself You're not coming up with anything. And you're not doing it because you care. You're doing it because it gets you traction because I get AI versions of me everywhere. And people are making reaction videos about me all over the place. But I'm right. What am I out here trying to do? This is what's funny to me. What am I I'm trying to coersse you to buy my stuff, coersse you to join my group. No, I don't care. I care that you have the information. The only reason people would ever get pissed off just follow the money. If it dips into their pocket, that's it. If it argues against their narrative and people are so fragile that they like punk man 471 in the comments starts arguing and making reaction videos and people lose their mind. Dude, you guys are in the fifth grade. Who cares? And if you go, you're talking about it. No, I'm telling you to stop doing it. I don't care. This is my show. I can do whatever I want here. This is my house. But listen, I'm trying to help you. So, anybody arguing about this, you should just ball up your fist, punch yourself right in the eye repeatedly until you black out. Because I'm actually the doctor that cares. I'm not trying to sell you something or make you take my magic lotion or my supplements that I happen to own. And I don't care. You want to buy from another peptide company, knock yourself out. I don't care. I care that you have the information. You know who else is doing this online? Nobody. I am the only doctor doing this. Because deep down inside, I'm the only real son of a [ __ ] out here because I care. Period.
Listen here. Let's go over the unsexy part of eczema. The biology, right? Eczema, it's not a skin condition. That's the lie. It's a barrier dysfunction disorder expressed through the skin. But originating in systemic, it's a systemic pathology. I need you to understand the actual mechanism because this is where most people lose the plot of this entire story. Your skin has a whole bunch of layers. Seven. It doesn't matter how many they are. We care about one of them. The stratum corneium, the outermost layer. This is the barrier. This is a layer. It's comprised of 15 to 20 layers of dead cornees. Basically, dead skin cells packed together with lipids, ceramides, cholesterol, free fatty acids. They're like like bricks. And the ceramides are the mortar, right? The bricks are the dead cells. The mortar is the lipids. By the way, I had to say this. I didn't finish my sentence about the guy dumbing down Dr. Trevor. I sent him a message. I go, "Hey, man. You ever think about just giving me credit for all of my videos that you keep stealing from me?" So he to be a smartass or she or it or AI, whatever the hell it is. Might be a he, she, it might be 37 genders that are making this thing. I really have no idea. There are only two, by the way, men and women. I don't care if you get mad. Go pound sand then. Don't listen to me. I got nothing for you other than a just a shot in the eye cuz grow up. So listen. So he went, "Let me give credit to you." And then he tagged me like 20 times because he was that's so childish, dude. Just if you're going to use my stuff, just give me credit. You didn't do the research. Do you have any idea how much time I spend on these podcasts putting them together on the information, the research, the actual stuff I do? Because I'm not trying to go against anybody. I'm trying to give you the answer. So listen, here's so just to come back, right? Mortar, lipids, right? The camides, the free fatty acids, all that stuff between the dead stills, the cornytes, right? So here's what's happening in eczema that nobody ever talks about. Lipid composition itself is completely dysfunctional. 2020 study in the journal of allergy and clinical immunology showed that eczema patients have a lipid barrier deficiency. Specifically, 40% reduction in ceramides. The there's a sphingicine and dihydrophing ratio, but it doesn't really matter what that is. Basically, what it means is that the mortar is broken. Okay? You have this big beautiful brick house and it's just got chinks in the armor. The mortar's all full of holes and people like it rains and it comes through your walls. It's like that old canvas tent, right? where your dad was like, "Don't you dare touch the out the tent wall when it's raining when you're in the tent." And of course, as a kid, you're like, and then it leaks, right? But this is a critical insight that changes everything. It's not a local problem. It's a systemic problem that's expressing locally. Wherever it is, your hair, your neck, it doesn't matter. That's something listen, ask yourself, would your entire endocrine system just down I'm itchy because apparently I have eczema. Your that would your endocrine system downregulate? Why? Ask. See, this is me. I'm the why guy. Why would your entire endocrine system downregulate ceramide production? Why? Why would it say, "Let's make the barrier worse?" It wouldn't. It just It wouldn't. God built your biology to be indestructible until he calls you home. Unless something upstream was telling it to, and that something is freaking inflammation. When your immune system is in this constant state of hyperactivation, when your macroofagages are chronically releasing cytoines, right? IL16, F alpha, IL7, all that. Your body starts making these tradeoffs because it has to. One of those trade-offs is stop making ceramides. We need amino acids and cholesterol for antibbody production and immune cell proliferation. Your body chose immunity over barrier integrity. That's not a skin problem. That's a systems prioritization problem. So the real mechanism is eczema is the skin level manifestation of immune dysregulation, metabolic dysfunction, and barrier compromise. It's a systemic inflammation wearing a skin suit. I'm trying to say this. Sometimes this stuff gets me so irritated because I think the answer to me seems so bloody obvious because once you understand biology, you just start putting into pieces. And this is a good example of when people go, I totally understand biology. No, you read the book, you got straight A's. You don't understand biology though. You don't. A 4.0 means nothing. If I got it, listen, my buddy Tom Delas, amazing jiu-jitsu fighter. And if I go, listen, I got 4.0 and let's say I I not I don't want to say this. Let's say he doesn't understand anything about how to articulate jiu-jitsu, right? But he's got like a good like a black belt with a whole bunch of stripes on it. He's very good and he's a good dude. But I go to school and I spend 10 years and I get a bachelor's, a masters, and a PhD in jiu-jitsu and I get a 4.0 all the way through and I come out and I get on the mat. You know what he's going to do? Kick my ass because he's got experience. It doesn't matter how what your I don't care about your stupid grades or where you went to school. I've seen over a million patients and I've dealt with a lot of problems that I see on repeat now. And you know what you start to see when you deal with a lot of patients? Patterns. Patterns emerge. And so what have I done? I've spent 30 years taking notes in journals about the patterns I see and going, "Wow, this is the same all the time. All the time." And then I start just solving the pattern and everybody starts to get better all the time. Listen, I got people with Parkinson's disease where it's faking gone. Gone in my group. It's not to brag. It's because if you understand biology, you solve the biological problem.
But here's where most doctors I said this and boy, people got mad yesterday where most doctors get fired, should be fired from medical school, and they should happen in real time. You suck at your job, you're out. Why would that not you? You go to Starbucks and somebody asks for a coffee and you keep giving people a sandwich and a freaking cookie and a power tool. Eventually, you're not going to work there cuz you suck at your job. So that's the same thing. If you suck at your job, you should either stop, get better. It's like the people that have been divorced seven times. you need to take a class cuz you're terrible at being married. So, here's the deal. They treat eczema, these docs treat eczema like it's a skin problem because they can see the skin, right? It's right in front of their face. It's itchy. It's pissed off. It's lacerated. It's red. It's swollen. And then it's exactly what I said yesterday, that confirmation bias. Woo! It runs deep. Huh? Listen, the skin is like one and a half to two square meters of your body surface area. Your gut lining is 30 to 40 square m. It is 20 times larger and comprised of the exact same type of barrier architecture that's failing in your skin. You need to look at how things are built. When you have a systemic inflammation strong enough to compromise your skin barrier, you don't have a localized inflammation. You have a systemic barrier dysfunction. Your gut lining is failing. Blood brain barrier is failing. Your respiratory epithelium is tanked. That's why and this is the pattern. Remember I talked about a pattern that nobody notices. People with eczema have coorbidities, not coincidences. There ain't no such thing as coincidence, sweetheart. None. Orbidities. 2015 metaanalysis, Journal of Allergy and Clinical Immunology looked at eczema and proved 40% increased risk in asthma, 50% increased allergic rhinitis, 45% increased food allergies, 30% increased risk of autoimmune thyroiditis. Those aren't separate diseases, you guys. That's one disease expressing in different tissues. It's what we call attopic the attopic triad. More accurately, systemic barrier dysfunction syndrome. There's names for these things and they just never tell you this. The skin is just the loudest thing that's screaming. Your liver compromised. I'll talk about it why in a minute. But your immune system permanent fight or flights, fight, flight or freeze all the time. Your nervous system completely disregulated. Your metabolism chaos. Eczema isn't a dermatological problem with systemic consequences. It's a systemic problem with dermatological expression. If you treat it locally, all you're doing is you're taking the disease. Listen, you're taking the disease and you're just moving it to quieter tissue, but you're not solving the problem. You're just shoving it somewhere else. So, some other expert specialist, like honestly, a medical doctor should be good at everything. I'm tired of people going, I'm a nephrologist, so you're just good at kidneys. You're good at one freaking thing. You're good at the heart. You're good at the renanotensin pathway, right? You're good at all that, but you're not good at biology. Are you out of your mind? You should be able to solve the problem. You can't solve the problem if you're only looking at part of it.
So look at let me go over asthma because this is really interesting to me physiologically your respiratory epithelium the lining of your lungs is a barrier just like your skin just like your gut it's comprised of tight junctions tight junction proteins right clotted occludin z1 the zula occludins one right so when you have a systemic inflam inflammation strong enough to comp to compromise the skin barrier you have a systemic inflammation strong enough to compromise the respiratory barrier connecting dots here's the mechanism tight. I'll prove it. Tight junction proteins are constantly being broken down and rebuilt. That's part of biology. That turnover rate is controlled by inflammatory cytoines. When you have elevated IL1, IL5, IL13, the TH2 inflammatory profile that characterizes eczema, those cytoines are literally instructing your respiratory epithelial cells to loosen their tight junctions. 2019 study in nature immunology showed that IL13 specifically downregulates claudin one expression in respiratory epithelial cells. So watch when claudin one drops tight junction opens. When the tight junction opens, here's what happens. Allergens, pathogens that would normally be excluded now penetrate the epithelium and hit the dendritic cells underneath. Those dendritic cells already primed by chronic immune activation from all the other barrier failures mount this insanely exaggerated response. They release more IL4, IL5. Your mass cells degranulate. Histamine floods your bronchial smooth muscle. Smooth muscle contracts. Your airway narrows. Asthma. It's not a lung problem. It's a barrier problem. The lung is just expressing the same systemic dysfunction that's showing up on your skin and in your gut. That's why people with eczema have asthma. Not sometimes, very frequently. All in my notes, man. Like, I've seen this so many times. The same immune profile causing barrier failure in the skin is causing barrier failure in the respiratory epithelium. But nobody is connecting the dots.
Look at the leaky gut. Okay, this is the root of the whole thing. Your gut lining, the intestinal epithelium is one cell thick. One. That's all that separates the bacteria, bacterial endotoxins and partially digested bits of food from your bloodstream. These cells are connected, you ready? You guessed it, tight junction proteins. And when they're tight, oh, they're tight. Lipopolyaccharides, the outer membrane of gram negative bacteria stays on the right side of the border, the right side of that barrier. When they're loose, those lipopolysaccharides cross into your blood. Leaky gut is real. Hey, I'm tired of people going, "That's just psychological." No, it's not. 2018 study in gastroenterology showed that increased intestinal permeability measured by zulin levels and the lactose to manitol ratio this is real stuff predates the onset of multiple autoimmune and allergic conditions by years it's not a consequence it's a precursor you guys here's how it connects to eczema I'll even show you dispiosis so it's a imbalanced microbiome increases zulin expression zulin is a protein that literally opens tight junctions when gram negative bacteria overgrow usually Because of eating like a muppet, high carbs, processed food diet that just feeds the hell out of these things. They produce more lipopolysaccharides, LPS, right? Stimulates zulin release. Zulin opens up the tight junctions. Once LPS crosses the barrier and enters the bloodstream and binds to those LPS receptors, TLR4 toll-like receptor 4 on your immune cells, this triggers what's called the first hit of systemic inflammation. 2016 study in nature microbiology showed that bacterial endotoxmia having LPS in your blood causes a per this is spooky man permanent shift in immune cell towards the TH2 inflammatory profile that TH2 profile is the immune signature you ready for this one asthma it's for asthma for eczema for allergies so your gut dispiosis is signaling your immune system the world is unsafe produced Ig am immunoglobulin E make mass cells get ready for war baby your immune Well, your immune system goes, "Huh? What? Listening. Got it." It says to your skin, "Tightighten up. Something's coming." But instead of tightening, ceramide production actually tanks. The barrier gets worse. Now you have this birectional pathology. Oh, this gets even better. This is a hot mess. Leaky gut causes endotoxmia causes the TH2 immune shift inflammatory causes the bail barrier failure in the skin. But the barrier failure in the skin means the loss of protective IL22 production which causes further dispiosis which causes because more things can get in more endotoxmia. It's this positive feedback loop. Leaky gut doesn't cause eczema. Both are expressions of the same upstream dysfunction. Leaky gut is just the first domino. Fix the gut and you break the damn cycle.
Look at here's where it gets incredibly it's like beautiful. The nervous system and the immune system are best friends or worst enemies. Depends on your situation. Look at stress, okay? Chronic physiological stress when increased. Sorry, my nose is itchy. When it Here's what happens. It increases cortisol acutely, but eventually disregulates the HPA axis, hypothalamic, pituitary, adrenal, right? When the HBA access disregulates, cortisol becomes incredibly unpredictable. It's all over the place. Sometimes it's elevated, sometimes it's collapsed, always chaotic. Cortisol is by its very nature imunosuppressive. It tells your immune system, "Hey man, calm down. Calm down, bro." When cortisol signaling becomes chaotic, your immune system loses its off signal and it stays on. There's more. Another mechanism that's even more powerful, neuropeptides. So nerve, it's not something you take. Nerve fibers in your skin release something called substance P and CGP, calcetonin gene related peptide, which we also see in fibromyalgia and rheumatoid arthritis, right? These neuropeptides directly stimulate mass cells. Mass cells release histamine, which causes itching. Itching causes stress. Stress increases more substance P release. Substance P increases mass cell activation. Oh, look at that. Another positive feedback loop. But you're not going to hear a dermatologist talk about this because they can't give you a cream. 2020 study in brain behavior and immunity showed that chronic stress increases substance P expression in skin nerve fibers. This is a huge freaking number. 40%. That's not subtle. That is a complete rewiring of the neuroimmune access. Oh, it goes even deeper. Hold on. I need more coffee. Look at this. Chronic stress promotes this shift in your autonomic nervous system. Your sympathetic nervous system, fight, flight or freeze, right, becomes hyperactive. The parasympathetic nerves, nervous system that rests and digest becomes hypoactive. It just goes for a snooze. The vagus nerve, your main parasympathetic nerve releases acetylcholine. Okay, just follow me on this. Choline is profoundly anti-inflammatory. It tells your immune system, who stand down. Stand down. Tells your gut to heal. tells your mass cells to stop degranulating so you can actually function. When your veagal tone is low and they prove this when you're chronically in sympathetic dominance, your entire anti-inflammatory system is offline. 2017 study in molecular psychiatry showed veagal tone directly predicted eczema severity. Low veagal tone worse eczema period. So here's the eczema neurology connection. Chronic stress and trauma disregulate your nervous system. I'll go line by line real quick. Your sympathetic nervous system becomes hyperactive releasing more norepinephrine. Norepinephrine pushes immune cells towards a TH1 TH2 mixed hyperactive response. Your parasympathetic nervous system tanks. It just collapses. Acetylcholine production, right? Veagal tone drops. Your mass cells go bananas. Histamine floods the skin. Watch. Here's what happens. Your skin itches. You scratch. You stress. And the cycle amplifies. And it never ends.
Look at the metabolic endocrine catastrophe. This is where silent killer in eczema cases. Eczema patients have dramatically elevated rates. I've seen this so many times. Dramatically elevated rates. Insulin resistance, type 2 diabetes, obesity, dysipidemia, metabolic syndrome. 2018 study in diabetes care found that eczema was associated with, excuse me, 23% increased risk of developing type 2 diabetes independent of the BMI. So, let me repeat that. Independent of your body weight, it's metabolic dysregulation, not just obesity. But here's why. Systemic inflammation directly impairs insulin signal. I've gone over this a ton of times. So, when you have chronic elevation of pro-inflammatory cytoines, these TNF, alpha, etc., right, these cytoines activate JNK and IK signaling pathways in your muscle, liver cells. These pathways phosphorolate IRS1 insulin receptor substrate one which blocks insulin signaling. When insulin signaling is blocked, glucose can't enter the cells efficiently. Your pancreas responds by producing more insulin. You develop hyperinsulinemia, elevated fasting insulin levels. 2021 study in nature immunology showed that hyperinsulinemia itself is pro-inflammatory. High insulin levels activate something called mTor signaling and promote TH1 and TH7 immune shift, increasing systemic inflammation. Even more, you've got another positive feedback. Watch. Systemic inflammation causes insulin resistance. Insulin resistance causes hyperinsulinemia. Hyperinsulinemia causes increased inflammation. It gets worse. Insulin resistance impairs mitochondrial function, too. So, now you don't even have the power to do anything. You can't fix anything. Here's a mechanism. Insulin normally activates PGC1 alpha which is the it's the control system of mitochondrial biogenesis making more power plants. When insulin is signaling is blocked PGC1 alpha doesn't get activated. It can't. So now your cells can't make new mitochondria. And what did I just say about ATP? Adenazine triphosphate gone. It it drops dramatically. When ATP production drops the sodium potassium ATPAS can't work properly. Your cells can't maintain their ion gradients. Intracellular calcium goes through the roof. When intracellular calcium rises uncontrollably, by the way, because it can't be managed, there's no ionic gradient. Nothing works. Cells become stressed and apoptoic. They self-destruct. That impaired mitochondrial function is probably the biggest driver of barrier dysfunction because what do you think tight junction proteins require to maintain? ATP. study in cell metabolism showed that mitochondrial dysfunction directly precedes before barrier function in epithelial cells. They don't have the gas in the tank to maintain the structure. So, eczema isn't about just immunity and barriers. It's about metabolic failure. People with eczema usually have low energy, brain fog, fatigue all over the place. Not because they're tired. Not not because they're tired, but because their cells literally can't produce enough adenazine triphosphate at all.
Look at the immune system. This is where everything converges and comes together. This is the real driver of this entire nightmare. The immune system, two main modes. That's it. TH1, TH2. I realized I talked about TH7E. Just follow me on this. Stay with me. TH1 is cell mediated immunity. It handles intracellular pathogens. So, intracellular bacteria, viruses. It produces IFN gamma. Okay. TH2 is humoral immunity. It handles extracellular pathogens and parasites. Okay. Produces IL5, IL13. produces Ig right imunogloabbulin E in the modern world with hygiene and antibiotics and lack of parasites your immune system doesn't see enough extracellular challenges so it manufactures them it becomes hyperactive to allergens and goes and comma cells right so it produces too much IL is 4 51 13 way too much you can see at lab work all day long in eczema the TH2 response completely disregulated specifically there is abnormal T- regulatory cell T-regs peacekeepers right function T-regs Excuse me. T-Rex are supposed to suppress immune activation. That's their job. 2019 study in nature immunology showed that eczema patients have reduced T-reg frequency, impaired IL10 production from T-regs, increased methylation, epigenetic suppression of T-reg genes, right, the FOX B3. But without, watch, here's the problem. Without adequate T-reg suppression, the TH2 response goes bananas. It runs like a forest fire, just totally wild. And there are a bunch of consequences. But here's the cascade mechanism that most people miss. Increased IG itself suppresses T-regs. So the signal signaling on dendritic cells inhibits IL27 production. I realize it's just a bunch of letters and numbers, but this is required for T-reg differentiation. So once you develop eczema and increased, the immune system perpetuates itself. The only way to break it, restore T-reg function. So how do you restore T-reg function? through metabolic signals and microbial signals, barrier restoration. I'll get to all this and I'll give you as best as I can. I'm like 31 minutes in.
So, look at your liver. Your liver is primarily I need you guys to understand why this is so systemic. Your liver is a your liver is your primary detox organ. Two main phases of def detoxification, right? It's got the phase one is cytochrome P450 enzymes oxidize, right? Foreign chemicals and phase two is conjugation enzymes, right? Glutathione as transfases, etc., and add water-soluble molecules to make things excreteable. When you have a systemic inflammation of any sort, both phases get severely impaired. TNF alpha and IL6 directly suppress phase one and phase 2 enzyme expression. So watch, this is important to understand. You might just go, it's just a bunch of liver stuff. Yeah, but the liver is keeping you alive. So 2018 study in hepatology showed that inflammatory cytoines reduce hippatic glutathione master antioxidant by 60%. So here's the problem. Without adequate glutathione, you can't effectively conjugate toxins. They accumulate. When toxins accumulate, they trigger more inflammation. More inflammation suppresses detoxification. Do you see how many feedback loops are we at right now? Five, six. But the mechanism gets even worse. Estrogen metabolism. Women have higher eczema rates than men, particularly postpuberty. Here's why. Estrogen is metabolized in the liver through phase one and phase two, right? When those pathways are impaired due to the inflammation and the estrogen or inflammation and all the problems I just talked about, here's what happens. estrogen recirculates. When estrogen levels get too high, they promote a TH2 immune response. So, watch. Here's what happens. And some of you guys might check all these boxes. Women with eczema usually have disregulated estrogen metabolism, elevated their circulating estrogen is through the roof. Worsened symptoms during high estrogen phase of the menstrual cycle and this perpetual TH2 immune state. So, additionally, microbiome in the gut that regulates estrogen reabsorption through the estrobolome. When disbiotic, the microbiota can't deconjugate estrogen in the colon. More estrogen gets reabsorbed. Circulating estrogen rises even more. What did I just say about high estrogen? It gets worse. 2020 study in microbiome showed that dispiosis and altered estrogen metabolism coexist in eczema. So, the liver isn't failing because of eczema. The liver is failing because of the same systemic inflammation driving eczema. But the liver failure perpetuates the entire friaking cascade.
I'll just give you the unified eczema mechanism to save a whole bunch of conversation so you guys don't have to listen to me drone on for an hour and a half. You have this insult, this challenge, whatever it is, the stress, infection, dietary change, dispiosis, bad decisions. This triggers systemic inflammation. Inflammation that you need to understand this inflammation causes insulin resistance. Insulin resistance impairs mitochondrial function. No ATP, right? Impaired mitochondrial function means that your epithelial cells can't produce ATP to maintain what? Tight junctions. Tight junctions fail. Barrier breaks down. Antigen transllocation occurs to get into your system. Immune system completely overreacts. This overreaction further increases systemic inflammation and now you're stuck in the loop. Welcome to horrific systemic problems that manifest as eczema. The skin expresses this as eczema. The lungs express it as asthma. The gut shows it as IBS. The joints express it as arthritis. It's the same disease, you guys. It's just different tissues.
Look at here. And here's look at the standard medical approach that fails catastrophically. Topical corticosteroids. So many of you guys are listening to this going, "Yeah, this is what my doctor gave me." They suppress TE- cell function or T- cell activation and inflammatory cytoine production. And so they work locally on the skin, but they're not solving the damn problem. You're suppressing the symptom while the disease get gets worse. Watch 2018 study in contact dermatitis found people using topical steroids they show initial improvement followed by these rebound flares that are so much worse than the original problem. This is called topical steroid addiction. There's another word for it. They even have it. When they have names for problems you guys might want to have flags go up. It's called red skin syndrome. But here's why. Your skin adapts to the damn steroid. Your immune cells become resistant. When you remove the steroid, they rebound with even more inflammatory activity because they're like, I'll show you you need stronger steroids. You become dependent. Yeah. See, this is you guys are starting to put this together. Here's the issue. The side effects. No such thing as side effects. The effects, but these are effects of topical cordic steroids. Skin atrophy. Your skin thins by about 30% with long-term use. You've got stretch marks from collagen breakdown, tail angasia, blood vessel rupture, perioral oral dermatitis. You got spreading of the condition. Your HPA access gets suppressed. body stops making cortisol all on its own. If you go, "It's only because of a cream." Wrong. Here's the bigger issue, though. You're immunosuppressing while your immune system is already disregulated. You're not restoring immune balance. You're actually making it worse. 2021 study in nature use immunology showed that prolonged corticosteroid use promotes a shift towards TH2 dominance. The exact problem that you started with. The treatment perpetuates the frigin disease. Don't tell me that this isn't planned.
Look at this. Topical calcin urine inhibitors. So tacrolamus. So they inhibit te- cell activation by blocking calcin urine by blocking calcin urine phosphotase which is required for te- cell proliferation. It the fails because of the same problem as a steroids local immunosuppression. No systemic restoration none. But it gets even here's where it gets real bad. This stuff has a blackbox warning. You know that I bet they never told you that though, right? This catastrophic blackbox warning for increased cancer risk, lymphoma and skin cancer. Wait a minute. So wait a minute. They're treating you with something for your skin that's going to give you skin cancer. How do you guys even sign up for this stuff? You should look at this stuff and give your doctor the finger if they offered this. I just I can't. Sometimes I really think you should be allowed just to punch your doctor because that's the stupidest thing you should. You're trusting these people. You if you trust me with your health, I will bleed to make sure you get the right answer or I won't give you an answer until I know it. That's what a good doctor does. Requires monitoring for organ toxicity. By the way, it suppresses it systemic immune function. And it's no better than steroids long term. 2018 meta analysis, the Cochran database showed that Tacrolamus was no more effective than steroids at a one one-year follow-up. Both failed at preventing recurrence completely, by the way, like catastrophically.
How about the biologic therapies? Dupillamap, this the newest, most expensive. They target immune pathways. Like you guys do understand that the purpose of most pharmaceuticals is to get in the way of things that your body's trying to do to solve the problem. And they're like, we're going to shut it down. But the body, your body just goes, I'll just put the problem somewhere else. Topillamav blocks IL4 receptor. Okay? So, it reduces the TH2 response. Here's the problem. It reduces the downstream effects of TH2 inflammation. You're blocking a symptom of immune disregulation. You're not fixing the dysregulation itself. You're not addressing the damn root cause. Dispiosis, leaky gut, metabolic dysfunction, mitochondrial failure. So, people improve initially. They actually do. I'm not going to I'm not going to blow sunshine up your body. They do. and then plateau and then most develop tolerance and then the disease adapts. 2022 study in jamba dermatology showed that 40% of dillamab users lose efficacy by year two. You want to hear some of these wicked effects? Look at this. It's about 40,000 bucks a year minimum increased conjunctivitis, eye inflammation, increased respiratory infections because you're modulating a pretty critical immune pathway. There's they have no idea what the long-term effects are, but they somebody's going to go, "What about peptides?" Dude, they've been around for decades. You are literally blocking a normal immune response, which means you're at a higher risk for infections that you wouldn't normally get. Here's the fundamental problem with all three of these, all three approaches. They treat eczema as if the disease is located on your skin. They don't address the systemic pathology. Disbiotic microbiota, the insulin resistance, the leaky gut, the mitochondrial dysfunction, the immune dysregulation, the neurological dysregulation. I could go on and on. You're doing cosmetic repairs on a building that's on freaking fire.
Look at look this is eczema is not this problem it's not permanent it's reversible the pathophysiology is modifiable that's why so here listen your skin barrier can regenerate completely caratinosytes or the basil layer divide every what two to four weeks the entire epidermis turns are over every two to four weeks here's the problem in order for them to regenerate properly you need adequate amino acids for protein synthesis you need adequate ATP for the tight junction maintenance right you need lipids for ceramide production you need reduced systemic inflammation to allow normal gene expression. 2020 study in the Journal of Investigative Dermatology showed, you ready for this? This is awesome. When you restore a normal lipid diet and reduce inflammation, ceramide production normalizes within 4 to 6 weeks and the barrier completely heals. Here's what else you need to restore immune balance. T-Rex can be restored. This is a key insight that most people miss. short- chain fatty acids butyrate, propionate, acetate that produced by healthy gut bacteria, they induce this expression that promotes T-reg, this gene expression that promotes T- rag differentiation. 2018 study in cells showed that butyrate producing bacteria essential for T-reg development. So when you restore healthy microbiota, you restore the short- chain fatty acid production. When you have adequate butyrate, your immune system resets, T-reg frequency increases, TH2 overreaction decreases. This isn't theory, by the way. This is completely measurable. 2019 study in nature microbiology showed that disbiotic individuals given a high fiber diet that promoted butyrate production showed 45% increase in T- rag frequency in 6 weeks, 60% reduction in IL6 levels, 40% reduction in eczema severity just by doing this one thing. How about this? Just restore the barrier function in the gut. You just think about doing that. Tight junction proteins can be rebuilt. The these cells are all turning over. When you reduce the inflammation and restore metabolic function, the proteins are rebuilt properly, not haphazardly. 2017 study and cell showed that llutamine, which fuels the intestinal epithelium, dietary resistant starch, which feeds butyrate producing bacteria, together restores barrier integrity and reduce intestinal permeability by up to 65% in 8 weeks%. And so all you guys heard was well up to it could be one. No, it's 50 to 65% just so you know. And the last thing is you just got to restore mitochondrial function. Mitochondrial biogenesis can be reactivated. PGC1 alpha responds to a lot of really easy stuff. Exercise, especially by the way, hit training, caloric restriction, intermittent fasting, cold exposure, restored insulin signaling. All of these solve the mitochondrial biogenesis problem. 2021 study in nature cell biology showed that when you restore insulin signaling through weight loss and dietary modification PGC1 alpha reactivates new mitochondria or produced ATP production goes through the roof which means increased ATP production means this the sodium potassium ATP is works properly tight junction proteins are maintained immune cells function properly inflammation resolves look here's the deal when you address these four mechanisms simultaneous ex eczema doesn't gradually improve It reverses. Okay. 2021 study I want to highlight here. I really do. Published in gut microbes by a team at UCLA followed 47 specific eczema patients with severe eczema who implemented this. You ready? You need to hear this. Eliminate elimination of disbiotic triggers. So processed foods, high omega6 oils, all that stuff. Seed oils, things like that. Gut barrier repair. So, llutamine, bone broth, resistant starch, microbiota restoration, fermented foods, dietary fiber. I'm just giving you examples. Metabolic restoration, intermittent fasting, strength training, hit training. After 12, listen to this is three months. People have gone through hell with this for a decade. 3 months, 89% achieved 90% improvement in eczema severity. 74% achieved complete resolution. Gone. Zero. Your skin looks perfect. Microbiota diversity increased 340%. Fasting insulin dropped 45%. All markers of systemic inflammation dropped by 80%. Not some of them, almost all of them. And here's the key takeaway. Those improvements weren't just skin level. Those are systemic, right? Asthma improved. Brain fog cleared. Energy increased. Anxiety took a hike. Why? Because you fixed the system, you guys. Your body wants to heal. It does. It wants to restore the barrier. It wants to suppress inflammatory pathways and activate healing. That's how it is. Human body has this incredibly absolutely absurd capacity for regeneration. You're closer to Wolverine than you think. Your skin cells turn over completely every 28 days. Strange. Every 28 days, huh? But we're on a 30 to 31day cycle in our world. You guys might want to look at that, too. But that's another conversation. Your gut lining turns over every 3 to 5 days. Your immune cell populations shift on a weekly basis. 2018 study in nature medicine showed that when you just do this, just remove the inflammatory stimulus. So, whatever it is, complete resolution of eczema of eczema lesions occurs four to six weeks. four to six weeks. Because here's why. When you remove once you remove the constant signaling that's just beating your immune system with instructions saying it's got to attack. And once you give your cells the resources that they need to heal through nutrition, peptides, and proper diet, your body's default state is recovery. Your body isn't trying to give you eczema. I don't know if you know that. It's responding to something. And people are going, "Let's just bury it."
Listen, I'll go right to I wasn't even going to do this, but I told you at the beginning I'll help you. So, I'll blow your mind on how to accelerate the process. Seven peptides for a kangaroo that work synergistically to address all aspects of the eczema issue. Okay, thymus and alpha 1. It amplifies T- I don't even need to get into it. Just it doesn't matter. Thyus and alpha 1. Let's see. SS31. And by the way, I really have to struggle with these because I'm not supposed to get I get censored. So thymus and alpha 1 for my kangaroo would be 1.5 milligrams three times a week. C would be 5 milligrams twice a week for my kangaroo. SS31 would be 5 milligs every day for my kangaroo. You're giving your mitochondria antioxidant protection so they can rebuild, by the way. That's how badass this is. BPC57 is should be standard for every kangaroo repair you've ever got. That's every single day. 500 micrograms. TB500 5 milligrams every 5 days. This it's this, by the way, that's like the blueprint for cellular healing. KPV, this is 300 micrograms every single day for the kangaroo. GHKCU 2 milligrams every single day. You're telling your skin, by the way, how to rebuild its own structural integrity. So here, watch, let me put this together just real quick because I actually I'm hungry. I want to go inside. Here's the synergy. Thyosin alpha 1 and KPB suppress your TH2 response. Okay. MC C, SS31, and GHKCU restore the mitochondrial function and the collagen production. BPC57, and TB500 accelerate epithelial barrier repair. So you put all seven together, and you're addressing the immune problem, the metabolic problem, the tissue damage problem all at the same time. And here's the best part. I didn't even talk about this because I have to be careful with this one. Alpha 7 nicotinic acetylcholine receptor agonism. Okay, you guys get this. I have to hold it up because people, this thing right here in my hand, this little square piece of sticky patch that I stick on me every day. 2003 Journal of Neuroinflammation showed that nicotine binds to alpha 7 nicotinic acetyloline receptors on immune cells and activates the cononergic anti-inflammatory pathway. It's called the veagal break on inflammation. So if hypothetically
This there was agon. This was agonized, right? If there was alpha 7 nicotinic acetylcholine receptor agonism, it's been shown in dozens and dozens of studies to reduce itch, improve eczema scores without any immunosuppression, by the way. Without any. How about this? 2007 study, Journal of Allergy and Clinical Immunology, showed that a patch, it reduced itch severity by 72%, improved skin integrity in eczema patients inside of four weeks. You are literally just activating an anti-inflammatory pathway that already exists in your body. That's it. Right?
Listen here. Let's go even further because I want to have some fun with this and I want to go inside. But I, I said I would give you this. So, I will. Carnivore diet. Eliminate every plant seed. Carnivore diet. Eliminate every plant toxin, seed oil, every refined carbohydrate, every plant lectin, all at the same time. You got a zero reason to mount an immune response against you carnivore because it's the highest micronutrient density possible with zero immune triggers. Period. 2022 Nutrients found that people on the carnivore diet had significantly lower lipopolysaccharide levels, LPS levels, right? Lower inflammatory markers and improved gut barrier integrity within four to six weeks. Sign me up. Sign me up.
Vitamin D, 10,000 IU every single day. I could go into the research. I just honestly, I just don't have the time right now. Zinc, 50 milligrams every single day. Omega-3, 4 milligrams every single day. EPA, DHA, right? Make sure you got the ratio right. 2016, by the way, meta-analysis, American Journal of Clinical Nutrition, 17 randomized control trials showed high-dose omega-3 supplementation reduced eczema severity by 42% on average. Yeah, I'm going to drink some coffee on that one because that's wild.
So, do you have to take a bunch of peptides? No. No, you don't. It's just faster. It accelerates the process. I think this is really important. Vitamins A, C, E. These are your cellular antioxidants. Eliminate alcohol and gluten forever. Alcohol increases intestinal permeability within 30 minutes of consumption. And it damages tight junction proteins, suppresses immune tolerance through effects on the IL-10 axis. 2014 study in American Journal of Gastroenterology showed that even moderate alcohol consumption, stop justifying drinking booze, okay? Alcohol consumption increased bacterial translocation and systemic inflammation. Gluten is a known trigger for zonulin release and susceptibility in susceptible individuals, but a lot of people are because of the system being completely demolished, right? The three biological failures makes you susceptible. Zonulin opens. I talked about this already. Tight junctions, your gut becomes insanely leaky. So, 2018 study in Nutrients showed that gluten elimination in eczema patients, excuse me, with celiac disease or gluten sensitivity reduced eczema severity, 73% in 3 months. Even in celiac individuals, gluten-specific lectins trigger immune response and increase permeability. It does the same thing.
So listen, here's how I would, if I was going to put this together. The first four weeks, I'd run carnivore. I'd eliminate all plant foods. Stop being vegan. Just stop it, okay? All seed oils out, all refined carbs. Begin vitamin D at 10,000 IU. Add zinc at 50 milligrams. Add omega-3 at 4 grams every day. Start the peptide protocol allegedly for your kangaroo, famine, alpha-1, MC, SS31, BPC157, TB500, KPV, and GH. And your barrier begins rebuilding. Your mitochondria begin healing. Your immune system actually starts to get retrained the way it's supposed to be. For the next, that's the first month. The second month, I would, the itch would probably be gone by 80-90% by then. Just stay on the protocol. You'll see all kinds. You might feel a temporary healing crisis. I have to say this because people go, "I tried it, it didn't work." No, you have more itch for three to five days while your immune system removes all the debris. This is a good thing, not a bad thing. It means healing is actually happening. Look at by the time you are 14 to 16 weeks, 20 weeks in, at the most of the stuff is gone. Just stay on the supplementation. It's not temporary. That's the thing. You guys are looking for something temporary. Just start reintroducing foods selectively. Not gluten and not alcohol, by the way. Just it's smarter. That's the whole point is you don't want to set this thing off. But four months in, it's completely resolved. You just maintain it. You've literally reset your immune system's tolerance.
Listen, here's why this works when everything else fails. Dermatology treats the symptom. They suppress inflammation locally without addressing why the inflammation started in the damn first place. This addresses the root. You restore mitochondrial function so your barrier can actually work. You suppress systemic inflammation so your immune system can actually regulate itself. You provide the necessary and specific nutrients your body requires to actually rebuild. You're not fighting your immune system. You're feeding it what it needs to come back online the way it's supposed to. 2019 study in Gut showed that people who eliminated inflammatory triggers and supplemented with anti-inflammatory nutrients and peptides had a 94% complete remission rate of eczema in less than 6 months. By the way, there's a control group compared to 12% in the standard care group that medical doctors are providing the care for. These aren't my numbers. This is published peer-reviewed science. This isn't me.
So, you guys need to look at this. Here's what I want you to understand. Eczema is not your fault. Okay? You gave it. It's your immune system is not broken. It's responding appropriately to the situation that this part is your fault that you put it in. You gave it a leaky gut and oxidative stress and broken mitochondria and you definitely gave it inflammatory foods. I've never accidentally eaten anything. Stop listening to muppet doctors who tell you to eat magic things that they get from the Himalayas that don't actually work. And your immune system responded appropriately by defending itself. But the beautiful and the absolutely wonderful beautiful truth is that you can reverse all of this. Your body wants to heal. You are a, you're a juggernaut. You're designed this way. Every cell in your body is designed to regenerate and to repair and to restore homeostasis. Your cells aren't designed to kill you. That's it. It makes me crazy. Stop the damage. Carnivore diet. No, no gluten, no alcohol. Provide the resources, nutrients, peptides, etc. Get the hell out of the way and let your body do what it was damn well designed to do.
Once you fix eczema, you don't just fix your skin, by the way. You fix your gut, immune system, metabolism, your nervous system, because eczema is not a skin disease. It's a systemic disease. When you fix systems, you fix everything downstream from them. Everything. That's not just treatment, right? This is a new lease on life. This is solving all the problems. You're welcome. Anyway, I hope you got something out of this. I got to go. Never miss.