Transcription
Hey guys, it's Médicos, is perfection. Elsewhere, medicine makes perfect sense. Continuing our series of lectures about bleeding and coagulation disorders. In the previous video, I talked about inherited thrombocytopenia, and in the video before that, we talked about thrombus tinea. Today, I'll talk about GP1b versus GP2b3a. GP1b is here; GP2b3a is here. GP1b is responsible for platelet adhesion to the subendothelial cauldron. GP2b3a is responsible for platelet aggregation, which means they aggregate with another platelet; they hugged each other. What does GP stand for? Glycoprotein, because anything that's active in your body is a bloody protein. Have you ever met any active carbohydrate, let alone active fat? Never ever. With that being said, now let's get started. [Music]
GP1b vs GP2b3a. GP1b is also known as GP1b95; it's a complex GP1b95 complex. It's also known as CD42. CD is the cluster of differentiation, and as you know, your policemen can identify you by your ID; we can identify those cells through their CD. Okay, how about GP2b3a? It's also known as platelet integrin. It's also known as alpha2b beta3. It's also known as integrin alpha2b beta3. This is the new name; GP2b3a is the old name, but they both go location. GP1b, it's part of the glycoprotein coat of the platelet. Fine. GP2b3a, same thing, part of the glycoprotein coat of the platelet. GP1b, what's the function? Adhesion of the platelet to the von Willebrand factor on the subendothelial collagen, baby, above. GP2b3a, aggregation, platelet aggregation, platelet binding to fibrinogen and to the next GP2b3a receptor. They bind fibrinogen, then secondary hemostasis will convert this fibrinogen into strong vibrant fibers.
Disease involving GP1b: We have deficiency of GP1b in case of the Bernard Soulier disease (BSS), and these proteins are attacked by autoantibodies in case of immune thrombocytopenic purpura (ITP). GP2b3a: deficient in Glanzmann thrombasthenia and attacked by autoantibodies in ITP. But if I told you this patient has ITP and they have an autoantibody, and this autoantibody will attack either this one or this one, if you want to play odds, okay, the ITP autoantibody is commonly targeted GP2b3a and less commonly targeted GP1b. That's why this one is bold. Influence: GP1b is influenced by ADP; GP2b3a is not influenced by ADP. However, GP2b3a is influenced by ADP. I call it the whistleblower because it blows its whistle for other players to come and aggregate, and part of the dense granules, not the alpha granules, from ecology. There are no drugs that I know of that target the GP1b; however, there are many drugs that target the GP2b3a, such as Eptifibatide, Tirofiban, Abciximab, and vorapaxar. Collectively, they are known as GP2b3a inhibitors, which makes perfect sense.
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