Transcription
And said, "Okay, based on my genetic markers, right, what things um do I do need to take?" And then I also took my blood test results from my last blood test. It's all gets stored into a database. It's fed into AI. So, it's giving me actual real customized supplement advice.
Hi guys, I'm joined with John today and we're going to be talking all about peptides and combining it with AI and working out the best strategy associations with biomarkers, wearable trends and just uh seeing where the future takes us with these dashboards for like AI health coaching. So yeah, first of all, John, yeah, I wanted to discuss because we spoke like we I was in a webinar with him a few weeks ago and he's really giving a good overview of his open claw platform and he's got his own AI health coach and it's just seemed really useful. So yeah, could if you could just give a quick explanation please John on like everything you're doing and we can just go into uh the data.
>> Yeah. Yeah. So, I've been doing a lot of experiments, you know, self-experimentation like like a lot of people are doing with peptides since we don't have, you know, official guidance on this. You kind of have to figure this out on your own. So, um I'm I'm a software developer by trade. Um and so, uh I've been working with AI, so specifically a tool called OpenClaw, which is is basically kind of like a personal assistant. uh that it's it's almost like what what you wish Alexa was what you can communicate with on Telegram. Uh, you know, you can build things with it. And so what I've done is I've built some dashboards uh in order to sort of track my health data. I've been feeding my data into uh this agent uh this AI agent to have it not only like suggest what things that I should be taking uh based on my biomarkers but also to track uh and see okay over time you know I can grab all the data from my wearables from my Aura ring from my Garmin and I can sort of see trends and correlate them to different different things I'm taking you know it makes it so you know I think a lot of this stuff would be really difficult to track if you had to manually track it. But when it's kind of automatically happening, um that that's what I've been uh trying to do is basically have a health coach. Um and this this coach also tells me what to run. Uh, you know, it it tracks my runs. It it tracks my sleep data, all of that, and can tell me, okay, you need to run this many miles today. These are the supplements you need to take. Um, so I'm trying to kind of make it so that this AI can can really, you know, autoregulate all the all the things I'm trying to optimize health-wise and fitness wise.
>> Sure. Yeah. No, it makes a lot of sense. I mean, yeah, if if you got any examples on screen you could show because yeah, like I say, I'm doing the same kind of thing, but nowhere near as advanced. So I'm just using chat GPT just pumping in data and trying to get the um see what correlations there are like you know with you mentioned about gin in your ordering I'm doing with whoop and then just seeing like over 60 days 90 days just seeing those associations but it's very time consuming and then yeah, I mean a lot of clients of mine they might just pump in their supplement protocol into AI and say, you know, rationalize it a bit but the AI doesn't The the main thing is the AI is only as good as the information you give it. So if you just give it a supplement list, it's just going to look at all the generic information and tell you, well, take this out because of this and that and like, you know, whatever research. So this is where like really strategizing AI like you're doing, I think, you know, will pay dividends in the future.
>> Yeah. Yeah. Let me show you uh some of what I've I've built here. I think um so um so first of all kind of like what you were saying uh about AI giving you generic data. So I what what I have is I have kind of my supplement stack here and um I've used AI to generate a lot of this but I didn't just say what supplements should I take. What I did was I took my DNA data from 23 in me, the export of that, I fed that into this AI and said, "Okay, based on my genetic markers, right, what things um do I do need to take?" And then I also took my blood test results from my last blood test. It's all gets stored into a database. It's fed into AI. So, it's giving me actual real customized supplement advice. Uh that, you know, that that's a lot better than generic. So, one of the things that that I I do is I I've created um this is kind of just like an overview of the different um supplements, hormones.
>> Try to blow up a bit, please. Um just
>> Oh, yeah. Let me see if I can
>> I can only just make out some of it.
>> Yeah. Okay. See? Okay. There we go.
>> Yeah, that's good.
>> Okay. So, yeah. So, you can kind of see what what I've got set up. Like actually one of these ones is for pre-workout. Uh I need to take collagen peptides um and vitamin C because genetically uh I have a an issue with collagen synthesis. So this is one of the things I discovered. Um but you know some of these are peptides in here you know interactions with like right now um I'm recovering from about a year ago I had a complete quad tendon rupture. So I've been taking a BCP 157 TB500.
>> I remember you saying, "Yeah."
>> Yeah. And um um and so, you know, it's got all the all the things I'm taking in here. Um one thing I did too was if I click on one of these, so like why am I taking DIM? Well, um it's it's it's got the explanation for it. Estrogen management on TRT, right? Um it it kind of tracks all this stuff. So, it's like, okay, this is why I'm taking these particular supplements. Um, some of these are based off of u, you know, of genetic markers, right? This one uh is is off of a genetic marker. Um, I actually have this uh can't um convert uh beta carotene, so I need to take vitamin A. A lot of people don't need to, right? So, um, I think it's really really cool to have it um, you know, customized like that. Other things I've done here is um just looking at the training like I can see all my run data. This is all like being pulled from Garmin. Um, you know, the the trends over time. So I can chart all this data. Um even my my strength training. It's all chart you know and this is all just you know a custom app I built here that logs my workouts. Um I can just pull it up on my phone. So I'm able to you know track all that stuff. On the peptide side, um I actually track what I'm taking and then um I've been doing some experiments to try to improve my sleep. So I've got a list of different some of these are prescription um, you know, just different substances. Some of these are just uh, you know, standard supplements. But I'm I'm checking these things, trying different combinations, and then I'm having AI sort of analyze uh what what worked the best, right? So there's it tells me what I need to test and then I can go in here and I can say, "Okay, well, what gave me the best deep sleep?" Well, it's no surprise gabapentin is something that improves your deep sleep. Um Trazadone also, right, docipin but gabapentin is known for improving deep sleep. A lot of athletes use this, right? Um I can look at um Q Vivic seems to be the the king there. Gabenton also helps with that too, right? So um all all this data. So I'm trying to really get as much data as I can but make it as simple as possible so that at night all I have to do is just come in here check off the things. What have I taken? You know, I can look here and see.
>> Oh, nice. Okay. Yeah.
>> Yeah. This is exactly what I wanted to mention actually because say with Whoop, you've got like the journal, right? But the problem with the journal is it only tracks very generic things, maybe melatonin, magnesium, but you're not going to get any peptides or anything like that. So, it's not really customizable to that level.
>> And then the other drawback with Whoop is the only thing it will give you just recovery data, which recovery is interesting. I mean, that's a big, you know, covering a lot of things, recovery, but it's not going into the weeds. What's driving that recovery? Is it heart rate variability? Is it sleep? Is it you know what what kind you know increased whatever it might be. So that's the limitations of just using root journal I think.
>> Yeah. Yeah. And and it's like you know cuz I'm getting data from my uh my Garmin watch but also my Aura ring and then Apple Healthit right so I do an export of that from my phone and so so that gets like my scale data that has my body body fat percentage and all that health side and then there's kind of a hierarchy right. So, uh, the the best data for sleep and HRV is coming from the Aura Ring, right? That's more reliable than Garmin on a wrist. Um, you know, so, so there's kind of fallback. So, I combine all of that data. Uh, and then I can track the different things to see what's actually moving the needle and then I'll do experiments, right? So, it's like, you know, hey, what happens if I increase my GH dose or decrease it? uh what happens if I take MK677 or now, you know, whichever peptide some of these things are harder to track obviously like things like you know BCP 157 and TB500 is it really working is it really doing something it's kind of hard to tell because there's not really biomarkers that you can easily track to to to see that um but you know I mean if you have a really clean baseline and you only introduced one substance at a time and then you you did everything pretty much the same. Uh, you could probably get some some pretty good data.
>> Yeah, that's that's an interesting one you mentioned because I remember you saying you were doing the BBC and the TB500 for the injury and then um because you haven't really noticed it's not like massive amounts of healing from from that injury. Is that right?
>> Yeah, it's it's it's difficult with with those particular peptides. Um I think you know there there's not a lot of data for BCP 157 and TB500. um you know there's some rodent data there's some human trials on like I think with knee knee pain um for BCP 157 but it's hard to know if that's placebo so you know it's kind of one of those things where I'm like okay it it's not going to hurt but it could help it's just really hard to to know you know is this tendon healing naturally is it being accelerated by BCP 157 I guess if you had a nagging injury and you tried all kinds of things to get it to go away and then you start taking basic P157 TB500 and then it started to go away. That that would be pretty much the only way I could think of to really really
>> test it. But it's sort of one of those things where I'm like, "Okay, if it works." A lot of supplements I this is kind of my theory on it is it's probably not going to hurt, right? Um but it could help. I can't prove that it's going to help, so I might as well try it, you know? I might as well have it in there just in case.
>> Yeah. Yeah, I mean that's um something I'll show on my screen actually with I know we spoke before. I did briefly show it to you. This one is on over a longer period. I've got one with the clo the I don't know if you're familiar with the close stack. So that's just the same as the glow with KPV added.
>> Exactly. So this was like a longer cycle I think 22 days and then um so just even with recovery there was some like data with it improving recovery but it's hard to know as you're saying is it just a coincidence or not but then the interesting thing is when I look at the I think I got the clo one where this is over 10 days so very very intense and then
>> actually see more of an association there where the recovery score so just summing up of everything combined is like nearly 10 and a half% increase.
>> Yeah.
>> And then even though my actual strain was normally you know the you know the more strain you have that day the recovery score is down but interesting my I was pushing harder
>> but my recovery scores jumped up massively.
>> Yeah. So it makes you makes you wonder is it you know because it's so intense that cycle which is probably not the ideal if you're trying to repair like you know like an in quite a serious injury you do need time for these like pathways you know whatever it is ve signaling you know angioenesis formation of new blood vessels healing faster obviously these things they take do take time so but um yeah it's just interesting to see with a really intense like protocol with it it does seem to um yeah it's interesting my sleep was actually down a little bit but everything else like despite the sleep being down one and a half% all the other
>> markers um particularly that heart rate variability increase which I'll stop sharing now I wonder if there's oh yeah just quickly while I get the screen up because we talked about epalon the other day weren't we
>> so that's another one where I've seen some interesting stuff over that 20 days 2 and a half milligrams
>> and yeah some improvements there but then at the bottom I put like an honor mention to dip delta sleep inducing peptide because uh that's a longer course 5 weeks I started like two days in and so there's this is that's still ongoing even so I don't want to just say oh this is down to epalon you just have to you know take things like you know it's there's you know placebo effect as you just said but there's also like the noibo effect where like you don't believe something's working either so or like or if you're having side effects from something, but you're like, "Oh, well, that's just a coincidence, you know?" So, you you just have to really like be able to differentiate noise from actual real signals.
>> Yeah. Yeah. There's a lot of variables in here. I mean, I think with with the closed stack, too, it's like is the KPV reducing inflammation, which is making it so the BCP 157 and TB500 work better. Um, you know, I think there's there's some interactions. And then I think some of the other variables that uh that that you know we we sometimes don't consider is you know is a is a peptide degrading right like I mean how are you mixing the peptide how are you storing the peptide I think some peptides are more vulnerable than other ones right so um I think there there's some issue with with that as well um that you know that it's hard to take that into account right and then you know some of these things also um you know you got a lot of confounding variables you know based on what you know what are you doing what are your activities what what's your diet unless it's completely consistent over time but but what I'm really looking for I think that we can see too is like um major fluctuations or differences
>> right
>> so for example there's no question um when I take gabapentin uh when I go for sleep it definitely has a dramatic increase in deep sleep so I know that that is effective. I know that that works. Um, you know, some of the things you can feel too, right? I mean, if you've taken um what is it? Um I'm trying to think of the brome bromelene peptide. Um uh the one that it's the it's like it's a melatan 2, but it's the uh uh the other version of it.
>> What um what you talking about? PT141 or
>> yeah PT141. So I mean like for example if you ever take PT141 you know it's definitely doing something because you'll feel it
>> yesterday actually funny enough you know but I mean you'll feel the heat first like the flushing so obviously like something you know but u but but also the other the effects of it but u but it's interesting that but you know some some of them like I said like BCP 157 QB500 is harder to to know because it takes a longer time for those to have an effect Right.
>> Yeah. Yeah. Yeah. For sure. And then there's other peptides we were going to talk about was like MOT CI. I know you haven't tried it, but you have some interest in it. But I'm just I just started it a few days ago on the Monday and then um so far like I've seen an interesting correlation where I saw I last did it back in December and then despite
>> I know we're talking about horic variability in the past like um and then I know mine basically tanks during winter and then goes up during the summer and just very sensitive to cold but during December despite it getting colder during that month later in the month the hot variability was increasing and So, which is interesting with that mozzy and then now I've just started again. And then on the Monday I managed to get like a 91% recovery which is difficult for me with the root and then like the day before I matched it. And so like on the Monday I gone hard with the cardio. I never normally on a cardio day with the recovery scores I think it's like I don't know it's probably about 7% 5 to 7% reduction in recovery scores doing cardio that day. My three cardio days. But despite that on the Monday like that that Tuesday morning like I had a really really good recovery score.
>> Yeah.
>> So it's just interesting to see with a MOT C increasing heart variability through just improved heart contractility but also I think recovery just from that exercise itself like it takes less out of you. Your body just that recovery recovery rate just increases I think.
>> Yeah. Yeah. I'd like to try MSI. I haven't tried that. I had um I'd actually tried SLU PPP. Uh was it 322?
>> Yeah. And the only thing with that was when I took it, um, I'd gotten it, uh, I had to take a lot in order to get to the effective dosage because when I looked at the studies, um, it seemed like the dosages that you would get it for, you know, were way smaller than, uh, what it would have been in the actual rat studies. So it's it's hard to know, you know, it's like would it be it's effective perhaps, but are you going to take enough of it to actually see the the actual results of it? What was kind of your experience? Have you kind of
>> Yeah, I've tried various different doses like 500 micrograms, 1,000, and then um in the last few months I've been doing like around 3 milligrams.
>> Okay.
>> And yeah, 3 milligrams seems to be a nice zone for me, but then everyone's different. like um I've spoken to someone who did 3 milligrams and then although they noticed the benefits like a little bit of extra heat just feeling that little bit of just kind of increased metabolism energy but they also started getting headaches as well. So um yeah it's very like cuz that's the thing like when you're experimenting it's trying to do things in a measured way because if you're trying to improve like you know like people like Brian Johnson he's trying to extend how long he lives but it's being an experiment at the same time. So he's trying to measure like, you know, risk versus reward. So it's trying to get that balance because we all react to things differently.
>> Yeah. Yeah. It's hard to, you know, just interactions too, right? Like what's the the combination of things that that you're taking at the same time and then trying to track those things because I don't want to just go completely clean and then just, you know, I'm not trying to do a research experiment. So I don't want to just
>> Yeah. just pick one one substance and try that one substance in order to get um so I'm trying to isolate things but at the same time you do still have you know a stack that you're running at any given time. So, you know, is there there's a lot of confounding variables for sure, but
>> Yeah. Yeah. Exactly. I talk about a lot. It's just like, you know, during that period, you know, people would say like, well, what why not just try one thing and see if how much it works? But because if you're trying to improve at the fastest rate possible, you're trying to, you know, get synergy with other things. And so it's hard to truly isolate something. But when you do two, three things at the same time and you really see something improve. You know, you can't isolate it as well as you'd wish, but it's still showing at least something is working. And then sometimes you could drop out one of those three things and then next time and then see like if it's as good. But I mean, yeah, and that kind of gets me on to like biomarker tracking because I mean I personally I do it like every 3 months.
>> Yeah. Um I do like a big blood test every year and then I do like the epigenetics which is um
>> look at quite a big range of different things like vitamins, antioxidants, things like that and then uh but that basically so like being able to that that'll be interesting using AI at the same time with tracking the wearable data with the the biomarkers and then you know if you're running a model like saying one one substance you What is the effect of like mozzy whatever it might be like running running a model on both both things at the same time both the the wearable data over the last few months and then you if it's a blood test or epigenetics like trying to see those patterns and like it might there might be something that's you know if you're just looking at as you're saying just manually looking over things you know it could easily be missed but the you know AI could actually pick up some some kind of um variable that you didn't notice.
>> Exactly. Yeah. The the key is I think is having all of that data tracked and stored because then you can always go back and reanalyze that data. Right. So that's one of the things I try to do is I have my AI storing all this data into a database. So it's grabbing all of the stats on me every single day that are coming from my wearables and from my activities. And then if I want to go back in time, I can go back and ask it to research different things to look at, you know, what's what's happened over time, what's the snapshot over time. Um, which is helpful, right? Because I can ask it a lot of different questions about, oh, well, you know, when I did this, and I I just keep it updated. So if I change for example um you know I changed my GH dose up uh from from two units to three units and then to four units and and I just let it know okay I'm upping my GH dose or I'm I'm dropping retrotide or um and and then I've got those markers in there so that in that data when I look at it it can it can say oh hey actually what happened was this was um maybe this is actually because of your GH dose because looks like you had increased it here and this is why this data changed. Um but just having all of that data is really the key key thing is um you know is is to make sure that you're tracking it. I think that's the most important.
>> Yeah. No, for sure. And then I mean that got me thinking you mention about HGH like I've got an example I mentioned a few months ago where client of mine was a escalated they started doing at GH like two units and then their pace of aging score went up by six points. But then you'd think oh and that pace of aging takes into account like 19 different biomarkers and then one of them is telmir length. So like you'd assume that that that would probably be the one if you're increasing growth hormone telmirs probably would attrition would happen. And you're like going cellular turnover has increased but interesting their telomeirs over the I think it was 8 months like it uh they remain constant or a few few base pairs actually longer like few yeah like 10 20 base pairs longer um but there so it's actually something else in that pace of aging that went up so you know like BMI or hip hip to waist ratio I mean little other things can be affected HBA1C is taken into account that so the AI if it's reading a lot of this different data that's what I think in the future will be is just like the at the moment it's all very very fragmented you know like trying to pull things from different areas you to be able to use something like chat GPT you're going to really like it's going to be quite time consuming being able to just p pull that in at the same time and then try and get it to spot things um so that's where I think open claw I think would be a really useful tool
>> Yeah, absolutely. Yeah. Yeah. Cuz then because it's really hard. I mean, even, you know, uh what I used to do would I get my blood test, I'd look at the results, I would Google like the different biomarkers and try to figure out, okay, is this but now I can just take that entire blood test. I can put it all into AI and then it can analyze not only individual results but correlations to each other, right? Way better than than a doctor can do it. So, um, yeah. So, I think that's that that's an interesting, you know, ability that we have now. What have you found has been the most effective like in terms of peptides or supplements protocols?
>> Um yeah, I mean, it's with yeah it depends what area you're looking at but for the like I was mentioning about HBO1C and proving that then like I think like the mitochondrial peptides I was just talking about it the other day actually like I've been able to come off my uh so I'm on like diabetic medication for longevity and I've been able to half my dose of that. Um, so I'm really really big on the mitochondrial peptides just because like so both the one I mentioned MOT C but also SS31 so kind of repair that inner mitochondrial membrane the cardio liipium and so like because if you fix mitochondria so many downstream cascades happen you know cellular scinessence you know zombie cells they're driven by mitochondrial dysfunction so if you fix the mitochondria then like disease basically you really like kind of offset disease So, and yeah, so not just diabetic medication, I've half that. I've also my alpha lipoic acid.
>> I've managed to I've stopped that in the last few months. I'm doing that mainly for glucose metabolism, but also a little bit of detoxification and so I managed to drop that out in the last few months. What else? Um, bourberine again is just because I'm wearing the Yeah, it's on this on the glucose monitors as well. or like extra bit of data like I've realized that bourberine in the last week is no longer I don't need that even because the these peptides are just so helpful that well yeah same with the sloop as well I was on the SLU PP332 just
>> like just recently and switched to MOS but yeah they've all seemed to be really really effective
>> okay and when you said are is it metformin that that you're taking that you couldn't have
>> uh it's called impaglaflozen so it's like an SGLT2 inhibitor
>> oh Okay.
>> So, basically, funny enough, I did start Metformin um a month ago because uh I just wanted to run another experiment with it, like a mini experiment, just doing it one day a week cuz in the past it always uh by basically my cardio output drops off by around 5%. And that's doing it like say four days a week or something. not even on my cardio days, but because it has a long halflife, my cardio just without fail twice, you know, in the last few years, I've had to just come off it. So, I thought I'm going to give it another chance doing it one day a week and then see what happens. And then, um, yeah, so far my cardio hasn't dropped off or maybe like it's hard to say at this moment because it's only been a month, but maybe one to two% on that Monday. And but yeah the um you were saying about the the diabetic medication imple basically that's um metform has a drawback. there's so much data come out on it really affecting V2 max whereas um the SGLT2 inhibitors they don't affect mitochondria they're not a complex one inhibitor like metformin which a little bit of complex one inhibition you're giving a little bit of hormatic stress to mitochondria and then they in theory they come back stronger but when you overstress them then basically you get like energy collapse in those muscle cells and so you just get a lot of delayed onset muscle soreness and just bad recovery from exercise. So yeah, I think um I guess that and that's where it starts getting very complex the protocol because if I'm doing mitochondrial peptides, I'm doing one diabetic drug every day like half a dose of that and then metformin one day a week. It's very very complex and so the only way you can really deal with complexity is with AI with obviously a lot of diagnostics as well just to make sure you're not hurting yourself.
>> Exactly. Yeah. Yeah. Yeah. I was curious about that. Yeah. I had avoided the metformin because of the mitochondrial uh issues and I'm taking bourberine but um but yeah but that's that's interesting about that also the um uh statins also I had I was on like lowd dose statin uh receup statin but I actually knocked that out too because it seems like even at the lowest dose there's still mitochondrial issues with with the statin so I I dropped that from my protocol but um but yeah the cardio the cardio part is what I'm what I'm trying to figure out now cuz it it's actually weird because I don't know if it's due to my my injury but uh I used to run like 9 minute miles um which is I don't know what it is in kilometers but um you know pretty pretty fast pace like my marathon time was 3 hours and 45 minutes my my fastest but I'm running now I've been you know since I've been back running for the last four five months like 12 and a half minute mile pace. What would we be be basically like a five and a half to six hour marathon pace and heart rate is you know in the like 140 um at that pace and it's not improving very much. So I don't know like I've tried a lot of different things but I can't quite figure it out. The only thing I can come up with is that maybe it's due to the injury.
>> Sure. Yeah. Yeah. It's tough one. Yeah. like you say you drop the statins out and then yeah cuz that's the issue with you know like co-enzyme Q10 you know especially if you got genetic snips of a deficiency then it can like exacerbate that even more um yeah so like yeah that was one thing I was going to ask you was um yes so I guess the glucose management would be maybe something else in the future that um you know like AI health coach can really pick up. Oh yeah.
>> Yeah. At the moment like um you know exporting reports from it and stuff there's the one I use is not you can't really there's not much you can really export. So that could be something interesting in the future as well I think.
>> Yeah. I I actually did that. I actually got a a glucose monitor through the Aura Ring one that I think it they pair with what's the company? Um DEXA or something. I can't remember the name.
>> Dex.
>> Yeah. Okay. That's Yeah. And so I had one for for 30 days like they have those temporary ones and I tracked the data um with with AI and it did it did tell me uh it gave me some correlations between some of the things I was doing in when especially when I was doing my runs it could kind of correlate that data to see that okay what's happening is probably at the time I was taking uh rea uh as well and it was showing that on these runs what's happening is that you're getting uh you're running out of carbohydrates because you're you're all of a sudden um or or you're using more carbohydrates uh quicker because um you you're all a sudden you're um your blood sugar is dropping dramatically
>> and then you so it was like okay if you're taking reddishide on these when you're doing these runs you can't do these runs fasted uh you have to take in carbs because um it's dumping the uh the glucose from your liver faster and so you're you're losing that those glycogen stores quicker.
>> Yeah. No, it's interesting. Yeah. Know that's the real good payback with those glucose monitors, I think. Although they do get expensive.
>> Yeah.
>> Um so I guess like for the average person, I mean I I just running them like 50 50% on 50% off. But but even just doing them here and there just to see like if you're you know if you're pushing yourself into the ground like uh or you like I say running you know running keto too hard and then you know like doing doing these intense sessions like fasted and you can really like get your blood sugar crash it right down low.
>> Yeah.
>> And especially if you're pushing like mitochondrial agents diabetic drugs. I mean this is what I used to do and then I mean a couple of years ago I just looked like probably about 5 kilos less than what I am now. So I just looked like hollow in the face. My body fat was down really really low about 5% but I just looked like you know that term death face.
>> Yeah. Exactly. Yeah. Yeah. Have you have you experienced with any of the GLP like um upside or
>> No. No. Like I say, it just be I'm very fearful of like just losing losing muscle basically now. So, um
>> yeah, for me, I mean, I've got quite a big appetite. So, and I guess the the SGLT2 inhibitors basically what you're doing, you're peeing out a few hundred calories a day of glucose.
>> So, it is like it's helping kind of manage weight to a certain level. I do and I it means like I guess there there's some benefits of being on a GLP1 where you're just minimizing kind of gastric flow because you're not I have to eat quite a lot of food to kind of like maintain my weight like probably like 3,000 maybe more like calories a day. So
>> not that measure very often but so the
>> but then the drawback with that obviously if you're especially if you're a volume eater as well like quite low calorie food a lot of it then it means a lot a lot of eating basically. Yeah.
>> And then your gut, your gut is under more strain as well because if you got like quite a lot of volume of food going through even though you're peeing out a few hundred calories, then your gut
>> basically is more likely to get inflamed because you just, you know, you're never really getting a break from food. That's why some people do fasting.
>> Yeah. Yeah. Yeah. I did a lot of um my normal protocol for a long time was one meal a day, just fasting until dinner every day. But um but I did I was on trippetide tre reduide. Um I'm off it now because I was worried about the heart heart rate increase that was affecting my running but
>> oh yeah
>> it didn't seem like that's actually it because I I was trying to figure out all the variables. Is it dutasteride dutasteride takes uh six months to clear from your system? So I won't completely know for
>> I just quit dutasteride as well a few months ago.
>> Okay. Yeah. Yeah. It's like I didn't even realize it because I was trying to troubleshoot this running problem. And so I'm I'm asking AI. This is what also AI is great for. It's like, okay, here's all these biomarkers. Here's what's going on. Like what's happening? What is causing this issue? And um and then some studies came up on dutasteride showing that dutasteride actually uh decreased the carbohydrate utilization in muscles versus fat utilization. And so I was like, "Okay, well that's pretty interesting. That that could explain exactly the problem I'm seeing is because I can't hit zone two." Like my zone 2 is very very uh small. Like so, you know, normally um you you'd find your um your zone two where you're you're at a balance. You're not increasing lactate more than you can clear it. And um I for me like I I would run at 1 135 heart rate and I couldn't hold it. Instead it would just jump up to 140 145. So I'd have to slow down further and as soon as I slow down I would be in you know the 120s. And so it's like I could not get into zone 2. And you know my my guess was dutasteride was the cause. I can't prove it. It's I've been off of it for I think four or five weeks but it's still not enough to clear it from your system. So
>> Sure. Yeah. Yeah.
>> Yeah. And then that that you got me thinking about another one prop panel. I don't know if you know that like a beta blocker. And then I had the same issue where I was really struggling to, you know, well get even from zone two even into zone three and four like because it was just limiting my heart rate. Although it was keeping my resting heart rate down nice and low. Um heart rate variability was good on it. But then there's a massive like it's a you know double-edged sword because that I the cardio yeah I just couldn't get my heart rate into a certain zone like going even like hard and so like yeah by cutting that out it's yeah it's definitely increased but then the flip side then my you know resting heart rate is running a bit higher so then it's trying to like over time increase that fitness hopefully and then the resting heart rate will come down.
>> Yeah. Yeah. Yeah. It's uh it's a it feels like whack-a-ole sometimes. You change one thing. Well, I mean, because we're we're dealing with a very dynamic system, right? That's the other piece of it is it's like as you do something, something else may adapt. Um, you know, for example, even even like the the gabapentin for for sleep, that's great for deep sleep, but if you keep on taking it, you will build a tolerance and then so you have to cycle that. you have to um, you know, a lot of these things but we don't know for some of the peptides you know some people say cycle it some people don't say cycle it I think it's my I fall in the in the category of for most of the things cycling them just because we don't know what the long-term tolerance or effects are but you know can get the short term better
>> yeah no for sure I think with peptide you definitely start building up like a bit of a tolerance to it just your body's just kind of like building up like um not just well just antibodies in general but just it's just adaptation to it and so like uh say that's why like things like DIP people if they do respond to DIP they like they love it but then if they start like running multiple vials of it then they start noticing it's not like hitting the same anymore that sleep latency just like knocking them out like after 2 three hours but um another one is you melatonin obviously but Yeah, that again if you do that just continuously for months on end, you start noticing it's not doing the same thing. But on peptides, oxytocin is another interesting one. I do that in the evening and then for sure that gives me like a massive like amount of vaso dilation. I get a hot flush but then interesting even over a cycle of that like um a 10 milligram vial like by the end I've been on it for 65 days something like that 70 days something like that.
>> Yeah. So, and I'm noticing by the end you I've definitely built up a tolerance to it because like I'm the flush is very very subtle. I don't get the beginning of it you get even a migraine because a flush is that intense but towards the end it's like it's you don't get any kind of headaches or anything. It's just a very very subtle flush.
>> Yeah. Yeah. Yeah. I I also I take the oxytocin every once in a while, you know, for for sleep. And I did notice an improvement there. I haven't
>> Okay. What is that? Uh nasal spray. Is it or
>> uh injection?
>> Injection. Yeah, it's definitely more quite intense. The injection. Yeah.
>> Yeah. Yeah. I mean, it's Yeah. It's funny because my um you know, my injection schedule is is quite because I have morning and evening injection. So it's maybe it's like you know three or four things in the morning and then two or three things in the evening. Um, you know, a lot of people uh don't um I I think I think that's the other thing too is a lot of people don't follow through on the peptides because one they're not tracking the data and two they're not consistent um, you know, because that injection schedule is hard to do for for a lot of people. Yeah, I think you do get used to it if like once you've done it a few times, you get really and especially if like certain ones you can put in the same syringe depending what it is. But um the other thing as you say just the injections itself is just like it's quite intimidating but also I think the organization skills you know being able to cycle things. That's what I was going to ask you actually was
>> with um see with your open claw setup I mean you think you could have it like even for reminding you say if it knows what your kind of protocol is I'm doing epalon every 3 months you know the you've you've done your 20day cycle whatever it might be and then so another what two and a bit months later like you know you're due to start the next cycle again and then you you could have it managing the you know like your peptide cycles even supplements or a lot of things you know people buy on subscription but not everything so if it knows like you could really really integrate it really well I think if but obviously it's the it's the setup time I think is the thing that puts people off but once you do have these things in place I think like, you know, it does in the long time it just saves so much time and then
>> then like then it becomes a bit more like easier to manage basically. Yeah. Yeah. I have it set up for reminders for the things that I'm supposed to take and then for some of the cycles. Um that that's pretty pretty easy once you get it set up to to be able to do. Um and then one of the the cool things I do too is I'll have it it'll modify my supplements stack, but you know, every every month I have my big pill container and I, you know, fill them with all the supplements. But what I do is I I print out a sheet that it generates uh which is like a checklist of of all the supplements. And then as I fill the thing, I'll check off the box on
the thing. And then I'll check another box if I need to reorder if I don't have enough for the next. And then >> Yeah. Yeah. Yeah. Okay. >> Yeah. And then I'll just take a photo with my phone of the sheet and I'll say, "Order me whatever supplements I need to reorder um on Amazon." and it'll just automatically go and grab the stuff that um you know and then and then it keeps it updated so the next time I can just get another sheet.
So that that >> yeah that sounds really cool. Yeah. I mean because I was funny enough in a video which came out today I was just talking about exactly that. I used to fill like weekly supplement boxes but now I'm doing it as a four-week thing >> and then so that each week the four weeks needs has a number on it. So if I do there's something that runs out say on the third week then I know exactly what what day it runs out on and then so then I if I need to come back to it say if I have run out then I know exactly at the point it's run out but I haven't done what you're doing like I've got a supplement list but not I haven't done a print out but um yeah that would be amazing I mean yeah I don't know if you can give any more explanation on setting up an open claw and like an AI health coach and how maybe like in the future how integrated I think it could be cuz like I said at the moment It's just so fragmented all these things and I think really I think this could be a massive thing in the future.
>> Yeah. Yeah. I mean it's open it's not it's not super difficult to set up. You I have it running on a Mac mini uh in at my home network. You can set it up on a VPS server. You can use you know whatever VPS that you like. Hostinger is popular. um Digital Ocean, you know, the basically it's it's just a a virtual machine that's in in the cloud, right? Um and then um it it's really like a oneline install. I mean, you got to do it from terminal window or command prompt. Um so it does require a little bit of technical knowledge. Uh but if you go to the OpenClaw website, it it gives you the the link to drop in there the command. It's one command. And then going through the setup, you have to connect it to an LLM. So you either have to have um you an API key for let's say Open AI or Anthropic or one of the other models if you want. I mean, I would recommend using my my recommendation would be to use Open AI um and then use a chat GPT subscription. Um they have a $20, $100, $200, right? For $100 one, you probably get a pretty good amount of horsepower. So once you hook that up and go through that setup, um then you can you can set it up where you can talk to it on Telegram and that's what I recommend. There's other you can do Discord, WhatsApp, whatever, but Telegram is nice because you can actually divide your conversations into different topics and you can set up different agents, but but essentially what you'll have is you'll have a a personal agent that you can ask questions, tell it to do things. It has a memory. Um it can write code. Um you know, it can do anything on that machine. need to definitely make sure you secure the machine. Um, right.
>> Especially if you do VPS, especially if you're gonna have your private data on there. Um, so, you know, again, that's kind of beyond the scope of of this. But, um, but you can also ask OpenClaw, how do I, you know, um, secure this machine? But, um, but yeah, that that's that's kind of the the basic basics of it. Once you have that agent, then you can ask it to do things for you on that machine to create websites to um to grab your data from Garmin or a ring and it'll it'll kind of walk you through the steps of doing that. Um it's basically just like having your own AI assistant. But but that's something also um I I can help with too. um if if someone's interested, you know, that's one of the things I do is um is help set these up and um train on on on open claw setups because for non-technical people, it's it's a little bit of a a hurdle. Once you get it going, it's great. It's just a little intimidating, I think, for a lot of people getting it initially set up. Most people are using chat GPT um and just typing in there, which is okay, but you know, once you get something like this set up, it's way better um because you can do so much more stuff with it because it's personalized to you.
>> Yeah, for sure. I'll put a link in for your your website in the video description. And then yeah, I think like um as you say just it's just really utilizing these things and just that initial setup and once once you realize the power of it I think you know you won't go back but it's just that that initial hurdle getting over that because there is setup time involved but once once it's there it's like it's just a no-brainer.
>> Yeah. And it's kind of cool because like I mean we live in an age now with AI where well for example I just you know with with some of the apps I showed you. I have my own workout app, right? It's like I I created it myself where I track my workouts in there. Um you know I don't I don't have to use one in the app store. I like all the all the stuff that I'm using is all my own my own custom dashboard and stuff like that. So you know the average person can do all this stuff. You can make whatever fitness app that you want. Now track whatever data you want to track, see whatever you want. So you don't have to just use some dashboard that the the company gives you.
>> Yeah. Yeah. Yeah. For sure. Yeah. I know. It'll be um Yeah, I definitely want to start looking into stuff a bit more and really just utilizing this because not a lot of people Yeah. I can I go through like bar markers with people and triangulate as much as I can and say in a 2hour consultation but >> outside of that they're often on their own and trying to like navigate things I tell people oh like you know if you record when you start things when you finish them it's quite easy to note that down and then you can you know when you say if you got a whatever it might be Apple watch whoop you know you get like the monthly or say you you know you new month in you can just download the data then but it just takes that little bit of organization people again, yeah, just get quite quite confused with it all. So, I think having your own AI health coach, I think that's like customized to you that has a memory, not just giving you very generic advice like like for example, these things that do have, you know, like a Whoop has a health coach, but again, it's only got advice based on just on that Whoop data, it's very very limited.
>> Exactly. Yeah. Yeah.