NAD+, NMN & NR Explained: The Anti-Aging Peptide

n+ is great for anybody who's essentially trying to just feel their absolute best and trying to get more energy, trying to feel more clear-minded and clear-headed. Everything that our bodies do can be, to some degree, improved by the quality that it does it because of the presence of NAD. 'Cause like I said, this is the fuel source at every single cell. Taking NAD plus isn't extremely pleasant. There's a reality of taking that shot or taking that IV that makes taking it itself kind of a rough experience, and it hits you. And then I, you know, you kind of build up, just like anything else, a little tolerance, so you're like, "Sorry, I can handle this." But it took me like close to an hour and a half, and just how uncomfortable of an experience in IV Therapy. N is if you think about dosing, when you do an IV of NAD, you're doing 1,000 milligrams in one sitting. We use 1,000 migr vials, divide it up over a 30-day period. And if you do the math, it's like 33.3 Mig daily.

Welcome To The Man lab, where we combine science and health in the pursuit of making men great again. This is how Legends are [Music]. This is our Legends are born. Welcome back to the man lab. In this episode today, we're going to be covering NAD plus as well as its precursors NR and NMN in a little bit of detail too. So what we're going to be also looking in, looking into and examining for you guys is daily injections versus the traditional and better known uh IV drip for NAD. So just quickly, before we go into that, if you are new to the man lab and you are interested in peptides, testosterone, anything like that, T Clinic USA does offer 10% off to all man lab listeners, whether it's your first time, your 10th time listening, whatever it is. To make use of that, go to bitly clinics USA or TSA or TCL clinics usa.com, mention the man lab for 10% off. And um, that's as simple as it is. So I'm here right now with Jeff and Alex from T clinics, and uh, let's first dive into the first precursor of NAD, which is NR. Can you quickly just explain what that is, why people might want to take that, um, and why they might not?

So nicomide riboside has been shown to help the body produce more NAD, along with the other one which is NMN, which we'll talk about in a second. NR, uh, you know, there's a lot of debate, which you know showing which one helps produce more NAD in the body. Um, there's a lot of data showing that NR actually helps more for like metabolism or metabolic rate, uh, when it comes to exercise performance is better, um, whereas like if you want to look at the difference in the two, NMN, nicomide mononucleotide, I' say that 10 times fast. I don't know how you say it. Those up, I struggle with n. So that one actually, you know, has better like insulin sensitivity and like uh more like like neuroprotective or or you know neuro, not plid, neuro like like cognitive function. Um, I've taken both. Uh, I personally like NR, nicod toine ribos side. I do feel a difference in my metabolism with it. Um, but you know, those are supplements that it depends on the person. Everyone's response is going to be different. You know, a lot of times if I could choose to replace it or take it or inject it, I'm going to go that route. So so it's really necessary. Like your body has to be able to be producing NAD in the mitochondria for that to be useful. And if you're maybe at a certain age, maybe it's not beneficial digestive process. You know, there's so many factors that play into that. A lot of it comes down to cost too. You know, a lot of people choose the pathway of oral supplements. You know, they're a lot more affordable. Um, you know, anytime you're taking something like NAC comparably to glutathione, or in this case NMN or NRN comparably to NAD, you know, you're hoping that your body can take this precursor and convert it into the thing that the body understands. There's kind of these analogies I think we've used in previous podcast, where you wouldn't put the raw oil out of the earth into your gas tank. Like you know, you have to, you have to actually convert that oil into fuel that the fuel then, you know, your your engine understands how to drive with that gasoline, right? So yes, it is it's the beginning and in the end becomes gasoline. But in this, in this case, the body has to kind of convert you know that NMN into the thing that your body understands what to do with it, which is ultimately NAD plus, right? Um, and so so again, like these precursors, these two different variations, they're very similar. Um, it's it's the bioavailability and and as Jeff said, each one kind of has its highlight point. But ultimately, if you're going to choose one thing to choose off of this list of NAD products, obviously NAD itself is is is the ultimate boss in in this category, you know. So um, I know we as, as you guys are aware, we kind of are both a little bit more into let's just take it all, you know. [ __ ] I take NMN, RN and NAD. Um, you know, together or at times have done that. And and what's the, what's the reason someone would take the precursor that develops it as well as so NR or NMN in conjunction with also NAD plus as the external? I mean, you think of it, you still want your body to try to do it, do that process on its own. You're trying to assist that deficiency that happens over time as we age, whereas you're you're also going to supplement maybe the deficiency directly. So for me, I've I've always done both. Um, I I'd like to know that I'm getting the the true benefit. You see the benefit almost everyone I know who's tried NAD as far as injections or even IV can see a significant change pretty quick, whereas NR, NMN it just depends on the person and the response and how well their gut processes. There's also a reality of like how much NAD can you actually take or handle, you know? 'Cause one thing we'll chat about like taking NAD plus isn't extremely pleasant. Um, there's a reality of taking that shot or taking that IV that makes taking it itself kind of a rough experience. You get this gut feeling, you get this kind of weird leg feeling. It's very hard to describe. Like I mean, we we all take L and I and I try to describe it to people and I feel like I'm always missing the Mark. I tell people you get this shortness of breath and kind of this like weirdness in your legs, and it's like a mild anxiety but but not. It's like a tingle but then it's kind of in the gut and it's kind of it's just like something you know is there. Like I always, I always kind of say it's the reminder that it's like doing something. Almost to a point, if I took a shot and it wasn't there, I'd be like, "You getting jip?" But I think like going back to the question of why would you supplement with it, um, if you think about dosing, you know, when you do an IV of of NAD, you're doing a th000 milligrams in one sitting. And I know a lot of protocols, especially people who go through rehabs or post injury or post um covid for example, like they'll have protocols in which they'll do a th000 milligram bag for 7 days in a row for four hours though, because Tak four hours per one because the how difficult it is to absorb it. So you know, just give you reference point, we we use 1,000 milligram vials, divide it up over a 30-day period. And if you do the math, that's like 33.3 milligrams daily, yeah. So you know, if if there are protocols out there in which people are using 1,000 milligrams per day for a period of time, obviously we're not getting near that amount through the kind of micro doing strategy that this clinic and a lot of clinics choose to use. So adding NMN or adding NRN is is giving your body the ability to produce some own um some of it's own, so it can kind of supplement the difference. And I don't know, and this is probably something that we should look into at some point, is there a a maximum threshold of absorbability, and B, is there a point in which it becomes too much versus ex you know kind of experience too much of the side effect? There are definitely, um, like anything in life, there there are precautions that should come. Like most things that are good, there are potentially some some bad. Um, there's a few exceptions to this rule in the in the products that we give, and I think glutathione is in that category and BPC157 is probably in that category. But NAD plus, I don't know if we would ever be able to take enough of it to a point where it's like you've overdone it and you've now created a problem. Um, and so again, kind of giving the body the ability to produce its own has a little of a throttled reality, meaning the body is only going to produce so much, yeah. And then if you use those smaller doses in in in combination, um, you're definitely, what I think you're going to be getting is the optimal amount to get the benefits that we that we seek to to get out of this.

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Price-wise as well, um, if in terms of like cost for an IV bag, 'cause I see a lot of people pushing the IV um form of NAD, and as you mentioned, it's probably it's beneficial if you needed influx in it, like say if you're defici very sick, yeah, or something like that, or it's but it's it's unfair. Like let me be fair to the IV you know world. People say, "Oh yeah, but that bag is $1,000." It could be like, like I live, like we're here today in Miami. An NAD bag is $11,000 in someplace or La 500 in markets, depending on how many milligrams you get. But, in fairness to the IV place, you're also taking up two, three, 4 hours of their time. You're sitting in their office under the supervision of a medical practitioner who has to be, you know, a nurse practitioner, PA or somebody highly qualified. Those people make several, you know, $50, $100 an hour. So if you own an IV clinic and you're sitting somebody in a chair, you got to make enough money to justify that, whereas you know if we sell that bottle to somebody, of course we don't have all that, all that time invested; we just, "Here you go, you do it on your own." So so so in manpower and kind of taking up the seat component, yes, IVs are expensive. But there's also a reality of why that is, and that's part of the experience. Um, but yeah, I mean an IV can can can cost you. I mean I remember the one place you and I went up in South Carolina. I mean I think they were 700, 7 to 900 bucks for, on average they do 500 um 500 milligrams. Um, a lot of times that's fastest you you could run it, unless you're just a freaking nature, which is not common. Tried no. Like it's, you CH you choose how much goes an IV. You have this kind of like a throttle essentially that can can determine the the speed of the drip, and and it burns going in tell. So we went kind of funny story. It was 1, 2, 3, it was five of us, um maybe five or six of us. And the nurses came in, there was a few of them, and got everybody started. And you know, they got they're teaching us about different components of IV therapy, and I just wasn't paying attention, you know. I was like paying attention more to what was being taught versus what being told me by the nurse practitioner or the the nurse who's admin my IV. And they give you this little handle and it's like it chokes it off to speed it up or to slow it down, and and you can open it up. Mine was opened up, and it hits you. And if you feel when it hits you, there's still few seconds too late, like so if you're chok up like, "Oh [ __ ], I'm feeling it." So for the first couple minutes, I'm like curled up in a ball because it literally it it was like a punch in the gut. It was so uncomfortable. And then I, you know, you kind of build up, just like anything else, a little tolerance. So you're like, "All right, I can handle this." But it took me like close to an hour and a half, an hour 40 minutes, and I was the first or second one done. Um, and I think Jeff was the last. Was an hour and 40 minutes, and the longest was like 2 and a half hours. And this was a th000 MIG bag. So and solely not because you could have opened it up and got it in you theoretically in like minutes, but the UN the the discomfort and just how uncomfortable of an experience in IV Therapy, you know, NAD is like you just don't want to. Right? So so that's something that even in hindsight of us being this industry, I could get these things for free, I would not choose to do it, yeah. You know, well I had sounds like a similar thing. So I didn't tell you guys, but like I had the weirdest experience with NAD plus about a week ago. So H, I was sick and I feel felt like something was coming on, you know, a little bit of a snuffy nose, bit of a headache, and it was real rough. So I took my typical NAD shot, like I take 15 units, it's a little bit less than you guys recommend, but that's what what I I stick to. I put it in, and instantly it felt like the only way I can describe it is: you know when you turn a a light bulb on and you watch it in slow motion, the light bulb goes like "Spang" and then comes back? In my head felt like that, my body felt like that, and I felt like my body just exploded and came back in. I'm on the, I'm over the, you know, had had to hold myself down. And then I sat and like my whole world, it was the only time in my life I felt like we lived in a matrix, because I was like a light bulb shot on. My sickness pretty much disappeared, my headache disappeared after that, I wasn't tired. Your body's getting that super charge effect. It was it was literally like that feeling that I was a hit a vessel, and it went into the bloodstream really. It was weird. I had a client accidentally inject inject intramuscular, um, you know so versus Sub. So by the way, you're supposed to do a subcon continuous and these little tiny needles. And I know we're kind of jumping around here, but like subcon injections into belly fat on a daily basis is what we recommend for any MH. We have a lot of peptides, some are recommended intramuscular, some are recommended you know sub. So he mistakenly took his shot into the muscle, and now long story short, ended up on the bathroom with a split head because he hit his head on the sink and passed out and actually cracked his head open with a couple stitches because it hit him so quickly that he passed out from the impact of the NAD hitting him. So I don't know if it's hypoglycemia or there's some kind of a a choking out of oxygen, but it feels to me, because I've experienced what you've experienced, almost like that nitrous kind of whip it or like standing up fast feeling. That if feel kind of cool. In hindsight, I was like that was yeah. It's almost like you know when you when you just kind of stand up too quick, or if you taken any type of nitrous gas before, you know where you stand here it is, you know. Um, I don't know what it is about it, and you know I know there's some relationship of any to the nasin family and some of that flushing effect and stuff comes from it. But um, it cured my sickness. So like like my headache disappeared. It literally felt like my body flicked a switch and we all right, we're back. Yeah, I mean NAD, you know really what it is because we haven't really we haven't really talked about that is like it's the fuel that the trillions of cells that our bodies have in it that Powerhouse that of those cells called your mitochondria eats. So it's a basically the food that the cell or the Powerhouse of the cells that your body has in it consumes in order to do the jobs that they're intended to do. M, and so you're kind of like giving this high powered, high octane fuel to your body in like one hit, you know. And then and if you're deprived or sick or maybe tired or something went on, um maybe that quick surge of that it gives you these reactions that at times feels more severe than others. I've had days where you know I take my n shot and I feel little to nothing, and then at times I feel and I'm like, "Whoa, queasy." And sometimes it's delayed too, right? Like I'm sure you guys experienced that where you take a shot and you're kind of on the phone and you're walking around, all of a sudden you're like, "Here, here it come." And I'm sure I'm I'm sure people listening to this are probably like, "Oh, that doesn't sound like, like f that, I'm not taking it." It's one of those things where like I said, like even though I had that wild experience, it felt it actually kind of like solidified why I should be taking it. Because well, like an ice bath, like you do it, it sucks, but then afterward you're like, "Oh, I feel way better." Same thing. It was like this weird experience, but then after I just felt better.

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I mean, just let me clarify, like again, all the huge negative difficult ways to do this is based on the IV type of program. So if you're listening to this and you've done an IV and you had a really rough experience with it, why we do it the way we do it, which again just to reiterate, we give that same amount that's typically in one large amount of IV, which is 1,000 milligrams, and we split it up over 30 days injection period. One thing about NAD that people have to understand: if you're out there buying this from different places, they come in different quantities. So so compound pharmacies or people who produce it produce it in 500 milligrams and 750 milligrams and 1,000 milligram biles. So if you're taking it and you're not really paying attention to the dose, you could be getting half the amount that we that we think you should be getting. The other thing to take into consideration is duration of time. It's not a very stable product. So if you get it and it's already in a mixed state, meaning by the time it's delivered to your home it's already wet meaning it's already liquid, or if you're getting at lopiz which is a freeze-dried State and you're having to reconstitute it, the clock starts to tick on its life. You don't have a very long time to use it, and about 30 days is really the approximate time from the moment it's mixed before really it becomes almost garbage. It sort of breaks down a little bit. Yeah, and I've had clients that have bought this stuff and they're like, "Still using this bottle 3 months later." I'm like, "Bro, like you're just shooting well, I'm sure there's some percentage of it that's potentially still doing some, but I guarantee not near as much as they thought they were." So you really want to make sure if you're going to use this product that you know you're you're using it in a timely manner, or you buy it and maybe you know consider um when you're using it in relationship to your to your dose, um meaning don't buy it, mix it, go on a vacation for two weeks and then come back knowing you still have two, three weeks left. Really try to use the product in the time that that that's allotted you, you know.

Okay, and um so with with the NAD, what is like the, I know some people ask like what is the doses you guys typically recommend and what do you recommend your clients to take? So you got to remember, a lot of our clients are generally pretty healthy coming through the door. That's that's why I don't want to [ __ ] on the IVs, 'cause like you get people that have some severe issues. They were in the hospital for a couple months, they're coming off like covid or B sick for a long period of time, or even like Dr drug rehab, cancer, and the cells are depleted. It's a great way to kind of put power back to the cells, get the you know the the because it does help convert ATP to the mitochondria of the cells. But for someone who's generally healthy, that's why we prescrib to the micro doing protocol of 33 milligram. So we break 1,000 milligram bile up over the month. Um, we found, you know, I I know a lot of places out there actually only give 500 milligram vs. So we've always stuck with the thousands. 33 is about as much as you could to daily without not getting that queasy or that stomach nod or turn that happens from taking the dose. Um, it isn't miraculous unless maybe you need it. Like if you feel sick or you're a little depleted, you'll definitely see a pickup with a 33 Mig. But it over time it has this compiled effect by doing it daily in a micro do. So yeah, I mean I I've actually missed some doses before and doubled up, and you know that's obviously a little bit more rougher of a day to take twice the amount you're supposed to to catch up on your your kind of dosing schedule, 'cause again you're kind of running out of time to use your bottles. But um, anything more than that, you know it it it is a little more of a difficult injection process and a little bit more for the hardcore kind of NAD Enthusiast. So I think 33 milligrams is is very tolerable. It's enough to remind you that you're doing something, but not enough to deter you. Um, you know, n plus is great for anybody who's essentially trying to just feel their absolute best and trying to get more energy, trying to feel more clear-minded and clear-headed. Um, even to the point where your metabolism can take a little bit of a hindrance if if your NAD levels aren't as up to to par as they get they should be. The quality of your sleep at night, um the the quality of your hair, the quality of your skin, like really everything that our bodies do can be, to some degree, improved by the quality um that it does it because of the presence of NAD. Because like I said, this is the the fuel source at every single cell, the trillions of cells you have in your body, and a lot of them obviously have a a predetermined job, you know. You have you have cells in your eye that are designed to help you see, and cells in your brain does supposed to help you think or function or or do whatever. So every single cell has a task, and you're giving that cell the ability to do their job better and do his job longer and prevent it from dying and essentially creating the aging process. So NAD is just a wonderful drug. We offer it through our tea Clinic model. We offer it through our for our weight loss clinic. Um, I've been a big big big advocate for it. I've been doing it myself about 10 years. It's, I know you you're a big fan, Jeff. Um, I think it's the one thing that we all kind of collectively say is, you know, not performance-based but very lifestyle and kind of operational just to make you feel your best. And and you notice it after you've been on it for a long enough time when you start to not have it. And and that's another point, like I was, don't give up on it quickly. Like it's not something that after the first few weeks you're like, "Oh, I feel so much better and I have all this energy." That's not supposed to be that way. It's supposed to first off kind of pull you out of the deficient place that you were, and then get you to a point where it can kind of hold you where you where you where you're at. Um, and and what I mean by that, like if you're 50 years old or 60 years old, you know you've gone through a depletion State for the past decade or two decades or whatever, don't expect in one week or two weeks all of a sudden to feel some like Monumental everyday change. You may have a small kind of post injection benefit, but it will take some time for it to kind of correct those deficiencies and you start noticing and feeling it, and then all of a sudden it kind of collectively Builds on itself. And um, I've had I've had female clients who tell me especially going through menopause, it was a game changer for them to keep their head clear and get out of brain fog. We've had people who have had covid, and again like we're really like set off with like brain fog and and cognitive function memory issues, just feeling so much better. Um, people who have who have been sick and just kind of really really lethargic, can't snap out of it, start taking it, really kind of get their pet back. So it it just kind of hits on every single cylinder. And if you're into this Wellness thing, you know the one thing you should always kind of be thinking about, and you know if you think about red light therapy, hyper bear Chambers, cold plunging, sauna, it's it's always this concept of like creating more uh Health to the cells of your body. And what better idea of a product would there be than essentially creating that fuel source that those cells rely on? So that's true longevity. I mean, when you get down to the cellular level, you know when I was younger I used to look at the other things like how could I get more muscle or get lean. But ultimately, if you kind of start taking care of the cells of the body, whether it be you know getting rid of the free radicals with glutathione and then adding something like NAD, everything you're trying to accomplish happens better, happens easier. Um, and I was going to add to that, you were saying it's one of those things when you micro do, you don't notice it right away. Like I I believed in the science forever. Actually you started taking it before I did. Um, was on it for a long time. I'm probably going on8 years. Um, didn't put much weight to it. And there was a period of time where I for forgot to get my order in, didn't have it, didn't think anything of it. And I was like, I started feeling tired and I thought it was maybe because my it was my lyme disease or whatever kicking in. And I was like, man, I don't have NAD. And I finally showed up, started taking it. I'm like, feel a little bit better. By like a week, I was like, oh my God, I feel drastically better. I wonder if it was 'cause I wasn't taking it. So I kept it taking it for a month, purposely stopped taking it. And it was so textbook. And I'm like, all right, well I I definitely see the benefit. Just how much mental sharpness you have, energy through your day. Like I go morning tonight.

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You know, one of the interesting thing Jeff and I based on our careers is we get a lot of like anecdotal um kind of feedback because of you know kind of observations if you will. Like you know, we talk to a lot of clients, you know we give products to clients that our physicians approve these people for, and our our coaches get a chance to determine that that person's right fit for it. And some people are just like, "This has been the God sent, this has been the thing that they answer to all my prayers." And some people are very much like, "H, I don't really notice much," you know. And so there's no, this is going to be the thing for you. Um, you know, when we do blood work for example, I can tell like your testosterone levels are super low, you're going to have a remarkable experience from this. Your growth horm levels are extremely low, being on a peptid is going to save your life kind of thing. But NAD is one of those things that you know we don't know why you feel the way you feel, or if the ability to feel better is even there. And so like I said, I mean unless there's no blood test for or anything like that. I'm sure there are, like I remember going to the a4m a couple years ago, and they had this like spot test blood deal where you could tell if your NAD levels were low. And I was like, I should do this. I'm curiously how high I was. But there was like a line, I didn't want to deal with it. But um, 'cause I didn't really care, you know. It's like if I feel better from it, then yeah, then what's the threshold that I have enough? I mean, who's to say I have enough or not anyway, based on a running average. I don't I don't want to go to go by some kind of. But I'll tell you, over the years, I it's very rare that I've had somebody try NAD for you know usually a month maybe not so much 'cause it's a gradual pickup, but clients that have done it for a few months usually they notice when they come off of it or take a break from it or they switch the peptide, they're like, "Holy crap, like I need to get on any." Is there a time, sorry to cut you off, is there a time that is best to take an ad plus? I always to think earlier in the day, right? 'Cause I think an I I think about energy, yeah. Um, I will say I don't personally like the way I feel when I do it on empty stomach. It's like I tend to want to do it more in the middle of the day. I feel like it doesn't that negative reaction is is more avoidable, or the hypoglycemia feeling is something I don't kind of like feel as much. And that's no taking it with food, like if you know window not like CJ, it's not playing with your insulin levels and depend on like insulin response or anything like that. Like a really don't want people, I' say we cautious of: I if you have active cancer, you know, there's there's probably very little studies on whether NAD is supportive or against it. We we as a company would always just say like obviously anybody who has active cancer we're just not going to give them anything, because we just don't know the risk. That's just not the category we're in. Um, because because theoretically, I mean cancer is a bad cell, so you could be theoretically feeding it just the same as you could be you know feeding the good cells. But if you're looking at it from the kind of side of well, this could help potentially protect me, because like there's always a fight of good versus evil going on our body. IES of immune system cells that are fighting off the Bad cells. So if you're strengthening the immune cells, then you have the ability to kind of you know fight off the Bad cells to a point. So there's always this reality that um th those clientele unfortunately we're just um I just I don't think we know enough and and I think because of that, see a study on that a category of cre, yeah. You know, I always say the world we're in it's kind of like most people are shy against it as far as mainstream medicine. You know, doctors just don't want to mess with that se word, you know, for that very reason. And I think there's probably a reality in which it could be very very beneficial. And I think if I knock on would you know um ever get to that point where if I ever had to make that choice, you know something as a personal decision, you know I would I would want to evaluate for myself. But again, as as a clinic and and and working under the the licenses of the Physicians that we work with, it's just the one category that we don't support. We don't we don't touch. So that's the one person that say, "Hey, like unfortunately breastfeeding, pregnant." But the cost, you mentioned costs. I mean like you know we charge $250. We fight hard to get the cost down right for 1,000 milligram. I've seen places that do like 500 or 400, which is pretty crazy considering like an IV of the same amount in one day would be 700 to 1,000. Once again, you're usually about. For many years, this was looked at as like this Hollywood you know extreme anti-aging thing. It was like the the the more expensive it was, the more people felt it did. Um, you know, we want to make it affordable. I don't hours the money or the time to feel. And our business model is based on repetition and clients, you know. So if we make it so expensive to where it's not worth it for you, you're going to do one month and quit. We want you to start on it and be on it for months and years to come, and you tell your friends. Oh, that's that's how we as a business are successful and be able to do multiple things to support your health, not just be budgeted to one thing. Yeah, and and and as far as like um contraindications or like is it the right add-on to any other protocol you're on or is it a substitution? You know, I don't really know of something that you're currently on that I would say, "Well, this would substitute that," short of NMN or NRN, or short of going and getting NAD you know IVs all the time. Because if you're on peptides, if you're on glutathione, if you're on testosterone, if you're on you know a lot of other stuff that you know we guys that we offer, this is not a substitution but it's a great compliment. You know, and it definitely adds to the entire recipe that you know you're you're you're trying to take in to feel and look your best and live your best. So yeah, awesome questions. Yeah.

So guys, that's the episode. If you haven't subscribed already, make sure you do on whatever you're watching or listening to this podcast, the man laab. Also, just another reminder: if you are interested in na in NAD, um, hit up man lab, hit up tea clinics rather, at blyt clinics USA. The link is in the description of wherever you're seeing this, or t clinics usa.com, mention the man lab, 10% off your first purchase. And we'll see you next time. Peace. Oh [Music].