Transcription
I'm David Tomman, author of NeuroTropicsExpert and this YouTube channel. In this video, you'll discover the neurotrophic benefits of piracetam. So, why should you want to listen to this video? About paracetamol circulation, improve creativity and verbal fluency, boost memory, learning, and recall, improve mood, and for the treatment of tardive dyskinesia. Sound good?
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Ampine, Neurotropics, in the racetam class of compounds, it was developed by a fellow famous Russian psychologist, Ivan Pavlov, by Dr. Cornelius G. Gug, who first synthesized piracetam at the Belgian-based pharmaceutical company UCB Pharma in 1964 as a cyclic derivative of GABA. Piracetam was first intended to be a calming type of drug for motion sickness. But, in spite of its connection with GABA, paracetamol, with this calming neurotransmitter, and it cannot directly affect GABA receptors. Instead, Dr. Gug discovered that piracetam was able to boost cognition even in healthy people. The company launched this new drug as Nootropil in Europe in the early 1970s. And the success of Nootropil soon allowed UCB Pharma to expand its operations, which led to many new pharmaceutical drugs. Dr. Gug coined the term "Nootropic" to describe this class of cognitive-optimizing compounds. Nootropic is derived from the Greek words for "mind" or "nous" and "towards" or "tropos."
Paracetamol is a prescription drug in Europe, in South America, and in countries around the world under various brand names. In the United States, paracetamol is an over-the-counter research compound and labeled as piracetam. Dozens of racetam derivatives have since been developed based on the original piracetam. All synthetic compounds, racetam, share a pyrrolidone nucleus. Paracetamol, AMPA, and NMDA receptors and improves the function of the neurotransmitter acetylcholine. People who use paracetamol are associated with learning and memory, and when paracetamol is supplemented, its effects are even more pronounced. Researchers have shown in hundreds of clinical studies that paracetamol improves learning and memory. Paracetamol improves blood flow, or blood flow in your brain. Blood delivers oxygen and glucose needed for cellular metabolism, and it helps carry away cellular waste, critical for a highly optimized brain.
So, if you're thinking about experimenting with any of the racetams, I recommend starting with piracetam because it works, it's safe, and it's cheaper than all the other nootropics in the racetam family. Piracetam boosts brain health and function in several ways, but two in particular stand out. First, piracetam modulates AMPA and NMDA receptors in the brain, and it improves the flow of acetylcholine and sensitivity and density of acetylcholine receptors. A German study connected with lab mice showed that piracetam mitigated deficits similar to that of a healthy brain. Deficits at the level of the NMDA receptors could, could be one of the mechanisms of action underlying age-related cognitive decline. And the research has concluded that paracetamol's plasticity is dependent on activation of NMDA receptors, and this neuroplasticity is at the heart of memory formation. Reviews of piracetam used by neurohackers frequently report the return of long-lost memories, further proof of the efficacy of using paracetamol.
Blood flow: several studies have shown how piracetam positively influences brain blood flow. Cerebral blood flow is critical for the highly optimized brain. Blood delivers oxygen and glucose needed for cellular metabolism, and it helps carry away cellular waste. Strokes can be caused by an interruption in cerebral blood flow, starving parts of the brain of oxygen and glucose. A double-blind, placebo-controlled study was done with 24 stroke patients. One group received 2400 milligrams of piracetam before the treatment. Both groups were comparable in performance during language tasks. The study found that piracetam improved recovery of various language functions, and this effect was attributed to the increased blood circulation to areas of the brain related to language. The placebo group showed very little improvement in the area of language. Piracetam helps increase blood flow in the brain; it improves oxygen levels; it enhances glucose use in brain cells; it maintains brain cell mitochondria and ATP synthesis.
Paracetamol of AMPA-sensitive glutamate receptors in neurons; it increases the density of specific binding sites for AMPA in neural synapses. Glutamate is a primary excitatory neurotransmitter in your brain. This glutamate activity, boosted by using piracetam, improves attention, memory, and learning. And one of the reasons why neurohackers consistently report that piracetam improves mental performance and memory is piracetam's uptake, which is the process that occurs in choline nerve endings, and it facilitates acetylcholine formation. Boosting acetylcholine with piracetam improves choline receptor density in the frontal cortex. This area of your brain is used for working memory and decision-making.
Adenine triphosphate energy is critical to your brain's survival. Brain cells must produce all of their own ATP from glucose and oxygen. This brain energy carbohydrate metabolism depends on cerebral blood flow and piracetam utilization and increases ATP synthesis in mitochondria. And piracetam has an anti-pain benefit. The anti-pain action is linked to piracetam's ability to reduce pain. Studies have shown that piracetam can cause pain. So you must add a good choline source when you're using it. Try using Alpha GPC or CDP choline with piracetam, and you give your brain the choline that it needs. Most neurohackers report a noticeable benefit from piracetam after about two weeks. Consider that piracetam changes your brain's chemistry, and this change is unlikely to occur immediately. Your brain needs some time to adjust to the new change in acetylcholine levels and how it uses it. Increasing cerebral blood flow takes a while to bring up levels of oxygen and nutrients and for your neuronal cells to respond. Your mileage may vary depending on your own neural chemical makeup.
Now, many suggest starting with an attack dose for the first three days: a 3,000 milligram attack dose of piracetam into your system right away, so it takes less time to build up before you start feeling the effects. And from there, step down to a maintenance dose and vary the quantity until you find your sweet spot. Once you begin to notice the effects of piracetam—anxiety reduction, heightened creativity, improved verbal fluency, and better memory—you will likely find that adding a good choline source, like CDP choline or Alpha GPC, to your piracetam stack helps. We have plenty of evidence that piracetam improves memory in animals and people who are suffering from many types of cognitive impairment.
Now, keep in mind that most of the scientific research available for nootropics is done for sick people trying to get well. The return on investment for research at institutions and universities comes from treating diseases and not from helping ordinary biohackers like us trying to get a competitive advantage at work or in school. Now, we can, however, extrapolate the findings from these studies and learn if and how something like piracetam works. In one study, researchers gave this healthy group of participants four 400-milligram capsules of piracetam during this experiment. But after 14 days, verbal learning had significantly increased. Researchers in Belgium, where piracetam originated and was developed by Dr. Gug, conducted an analysis of 19 double-blind, placebo-controlled studies done with patients suffering from dementia or cognitive impairment who took piracetam. The results of this meta-analysis demonstrated a significant difference between people who used piracetam and those who didn't. The end result of this analysis provided compelling evidence for the usefulness of piracetam. That you start with a higher dose.
A study in Germany with 78 elderly patients showed that there was a significant difference in cognition improvement while supplementing with piracetam, using 800 milligrams three times per day. Paracetamol condrieu outgrowth in neurons. Now, in this study, scientists investigated the effects of piracetam on neuronal outgrowth under normal conditions and under conditions initiating aging and damage done by reactive oxygen species and with cells representing early-stage Alzheimer's disease. The cells representing Alzheimer's conditions showed impaired contreal function under the baseline conditions. Paracetamol, piracetam, is able to repair mitochondria in those with mild Alzheimer's and return cell function back to normal.
Tardive dyskinesia is a serious and often disabling movement disorder, often caused by meds that are used to block dopamine receptors. There's not really any proven standard treatment yet for this disorder in mainstream medicine, but this is where nootropics come to the rescue once again. A study conducted at Bar-Ilan University's, Beer-Sheva Mental Health Center in Israel with 40 patients suffering with tardive dyskinesia, the study participants were randomly assigned either 4,800 milligrams per day of piracetam for four weeks. The study authors concluded at the end of the study that piracetam, three times a day, was effective for tardive dyskinesia. One benefit is key: you may find that a lower dose works well for you, or you may find your need to increase your dose even more. Dosing piracetam is a mystery.
Piracetam is generally safe. As with many of the racetams, piracetam can deplete the use of acetylcholine in your brain. Choline supplements like Alpha GPC or CDP choline can help you avoid this side effect. Many neurohackers find that stacking piracetam with a choline supplement boosts the effects on improved memory and cognition, and this is supported in several clinical studies. Paracetamol is available in tablet, capsule, and powder form. Tablets and capsules are usually 800 mg each. I recommend Cosmic Nootropics or Science.Bio, who both sell piracetam to be used in an academic laboratory research setting. They go on to state, "Nothing we sell is intended for, nor is it manufactured for diagnostic or therapeutic purposes in humans." But don't let that put you off trying piracetam or any of the other racetams for that matter, because the seller legally needs to use that verbiage so that they don't get in trouble with the drug police here in America.
In Europe, Asia, and South America, in other countries around the world, piracetam is a prescription drug and sold under many different brand names, including Nootropil. Now, see the transcript for this video on my website, NeuroTropicsExpert, to see the other brand names used to sell piracetam. If you want to see links to the studies I talked about, go to my website, NeuroTropicsExpert, and search for piracetam, or click on the link in the notes section below this video. Once you're at my website, NeuroTropicsExpert, you'll find a full transcript of this video, and you'll find dozens of articles on all the well-known nootropics. Over on NeuroTropicsExpert, if you haven't already, download your free copy of Secrets of the Optimized Brain. It's nearly 100 pages and it contains details on 92 of the most popular nootropics used today. And my four-time award-winning book, the second edition of Head First: The Complete Guide to Healing and Optimizing Your Brain with Nootropic Supplements is once again available. Yahoo! Head First, the second edition, is 962 pages and is available in hardcover, paperback, and for iPad or Kindle. You can get your copy at any major book seller, including Amazon, Barnes & Noble, B&N Press, Apple Books, Walmart, and others. You will find a link to these stores down below in the notes section of this video. And did I mention that Head First won four awards? You really need to get a copy if you haven't already. It's available worldwide.
And if you could use some personal help with choosing the right nootropics or figuring out how to deal with your own brain health issues, consider booking a personal consultation with me. You'll find a link to my calendar down below in the notes section below this video. And if you want to see more videos and all the best nootropics used today, subscribe to this channel before you leave. I'll be putting up new videos on nootropics and optimizing your brain every week. I'm David Tomman, author of NeuroTropicsExpert.