Transcription
PP 405 versus GT20 029 video. Let's just break down what exactly happens.
So this isn't working at the level of the dermal pillar cell where uh things like GT 200029 and Brazuler are. It's actually working on the mitochondrial pyuvate carrier of the stem cells in the bulge. So the stems the bulge is where the stem cells are typically housed. And what happens is PP 405 binds to the mitochondrial pyuvate carrier MPC and it interacts with it in such a way that it shifts cellular metabolism. So stem cells then become active again which means that dormant hair follicles reenter the hair growth cycle. So they can activate dormant hair follicles and that's really encouraging and it does this independent of DHT. So it doesn't change hormones, does not mitigate DHT interaction with those binding sites one iota.
So if you compare that to GT, we'll call it GT for short because my tongue is getting tied. What happens with GT? As we just answered in that first question, is GT comes along at the level of the dermal propeller cell where you've got these DHT molecules binding to the antigen receptor. And as we just said through this ubiquitin process protac technology you've got the situation in which that little androgen receptor gets flagged by the liase. The proteosone comes along and degrades the androgen receptor and so you have less androgen receptors available to bind DHT.
So they are very distinct. PP 405 has no interaction whatsoever with the DHT and binding sites and receptor binding sites. GT does. So they work independently very different uh different mechanisms of action. So I hope that summarizes that question for you.