Transcription
All this is Dr. Mobin Sayad from Dr. bean.com. Welcome to one more show. And, uh, just let's very quickly look at this study. It actually shocked me, and the reason for the shock is my own ignorance. That I thought that people who are vaccinated and then they do not have any kind of persistent symptoms, I assumed, and I was wrong, that their immune system stays as it was before vaccination, other than that short-term response to the vaccine and developing the memory anti-memory cells to the vaccine, the B cells and the T cells, which would then be aware of the vaccine and when the actual virus comes in, they would then become activated and attack it. And maybe slight, uh, alteration in the, uh, immune training.
What shocked me was in this study from Germany. They showed that those who are messenger RNA vaccinated and then do not have any symptoms afterwards that persist, meaning they do not have post-vaccine syndrome, their immune system actually has recalibrated itself for long term. That was shocking for me. I did not expect this. And the immune system has recalibrated to reduce inflammatory molecules because maybe the vaccine is now producing more, and so the body's normal levels were reduced. The thrombotic markers, the one for clotting or thrombotic biomediators as well, that could cause clotting, these were reduced, which means that the vaccine may have actually a propensity, a persistent propensity for clotting even in the healthy individuals, and their immune system responds to reduce the other clotting mediators which are normally produced. And similarly, autonomic nervous system, the nervous system that is handling our heart rate and GI motility and sweating and, and pupil dilations, all that, all that autonomic nervous system controlling biomarkers or mediators were also changed to accommodate continuous vasoconstriction and, and, uh, heart rate increase. So these bio- these mediators were reduced in response to the vaccine to accommodate and reduce heart rate and cause vasodilation. So that was shocking. I always thought other than memory cells, there is no other effect on the body.
I know that I'm going to get a lot of comments from some of the folks who do not like vaccines to say, "How did you not know?" But I did not know that this kind of immune recalibration would occur in healthy individuals. I always thought that those who become vaccine injured and who have long COVID have a dysregulated immune system. So the other shock that I had in this study was that those who became vaccine injured or had the post-vaccine syndrome up to six months, this study goes up to six months, they actually had those calibrating biomarkers to be almost normal. They did not downregulate their immune system in response to vaccine changes. So their immune system failed to compensate for the changes brought in by the vaccine. What changes? Propensity for clotting, propensity for vasoconstriction causing hypertension and tachycardias, cardiovascular issues, and propensity for causing continuous inflammation. So when those who have the side effects, when they were not able to, their immune system was not able to respond to these increased propensities and downregulate itself, that's when they become sick.
That's a very interesting, uh, study. The question is, why do some people's immune system actually detect vaccine-induced propensities for thrombosis and cardiovascular issues and for inflammation and downregulate itself and correct itself? And why do in some people it doesn't happen, who end up getting vaccine side effects? And I'm not saying deliberately vaccine injury again and again because I just wrote a comment in which I said "vaccine injury" and the comment was blocked by saying YouTube thinks that you are spamming. So I'm just going to call it post-vaccine syndrome or, as the study called it, Post-Acute COVID Vaccine Syndrome. Everybody has a different name for this, okay?
So now let's look at this study together. This study also has, so other than these two shocks for me, the basic benefit of this study is it provides diagnostic criteria. It provides the biomarkers to be tested to identify post-vaccine syndrome in those patients who have autonomic nervous system issues. That is POTS-like syndrome, tachycardia, heart rate issues, palpitations, muscle fatigue, and brain fog. So if somebody has this set of symptoms, then the criteria is amazing that they have used. So let's look at it together.
Okay, my screen did not present correctly, so I'm going to try it again here. So first of all, this is Dr. bean.com. I would request you to go take a membership at Dr. bean.com and you can have access to a number of other courses as well. I think in here, the courses on the pain management, pain management, this course, and the Pharma Master is also very good. And then chronic inflammation or inflammation, these are amazing courses. Inflammation and Pain Management, these are must-haves. So anyways, that is about Dr. bean.com. And let's look at this study.
This is the study: "Chronic Fatigue and Disautonomia Following COVID-19 Vaccination is Distinguished from Normal Vaccination Response by Altered Blood Markers." This is the study as well. I'm going to just very quickly read some parts of it and then we'll go into further analysis. So they say, "We explored receptor autoantibodies for interleukin-6 or somatic correlates for post-acute COVID vaccine syndrome blood markers determined before and six months after." So this is their duration of the study, before the vaccination and six months after in healthy individuals. In those who were sick, who had the vaccination and had symptoms, they did not have their "before the vaccination" because they did not know that they will become sick. They only had their "after the vaccination." So that is a limitation of the study as well, because it may be that these individuals had some other immune abnormalities before.
"Blood markers determined before and six months after first-time SARS-CoV-2 vaccination of healthy controls (89, 71 female, mean and median age 39 and 49) were compared with corresponding values of vaccine-injured or PVS-affected persons (199, 159 females, mean median age 40 to 39). Why more females? Because autoimmune diseases usually affect women more than men, exhibiting chronic fatigue, disautonomia, palpitations, and dizziness. Three symptoms for five months after the last SARS-CoV-2 mRNA vaccination." They had a very strict criteria, inclusion criteria and exclusion criteria. So out of 1300 individuals who said that we are vaccine injured, they only chose 191. So that strict criteria can cause selection bias as well, but really we want to understand that those who are injured, what kind of biomarkers are in them, not due to SARS-CoV-2 infection or confounding diseases.
"Normal vaccination response encompassed decrease in 11 receptor antibodies." Normal response if you got a vaccine like I got mRNA and I am, I do not have any issues. So I got them whenever this, they started so many years later, at least I think I do not have any issues. So those individuals who had the vaccine and then were healthy afterwards, in them, that means in me, at least if you had measured my blood markers after six months, there were 11 antibodies that had reduced to accommodate for the changes that vaccine brought. And what kind of those things? Thrombosis propensity, inflammatory state propensity, and autonomic dysregulation propensity. So the body compensated to reduce its own system so that vaccine-generated effects are compensated or not overwhelming the person. Increase in two receptor antibodies and normal interleukin-6 in PVS. Serological vaccination response appeared significantly altered, allowing discrimination from normal post-vaccination state.
So number one, they are saying that we had significant changes in those who were injured compared to those who had the vaccine and not injured, that you could significantly separate them and say, "This may be a diagnostic panel." So that's a very important thing, and I'll show you that panel. And they say that important are Angiotensin Type 2, Angiotensin 2 Type 1 receptor antibodies were increased. Alpha 2B adrenergic receptor antibodies were reduced. That is, uh, autonomic nervous system. And interleukin-6 was increased. They actually saw interleukin-6 and 8 both increased.
Then they say something very interesting in the discussion of this manuscript. They say that many times these patients are dismissed by saying that you have a psychological issue. So they said, "Our study shows concrete somatic changes in the body, physiological changes in the body, physical changes. These are actually pathological, pathological changes in the body, but actual physical changes." So it is not a psychosomatic aspect, it is a somatic syndrome. Now, the autonomic dysregulation could actually cause psychological issues and anxiety as well. So that may be present as well, but it is not a psychosomatic effect. That is a very interesting comment that the authors made. I think they are aware that there are so many of the vaccine side effects patients, persistent side effect patients, who are dismissed as, you know, psychologically upset people.
So now let's go to my notes about this one. So these are gifts for humanity and they're continuing. And if you would like to support this work, um, there are links in the description for Buy Me a Coffee or or or PayPal or Patreon or Substack or Dr. bean.com. If you buy that, that is an amazing support and then you can get CMEs as well. So here, this is a study from, um, Germany. And interestingly, other than the various German hospitals and universities, do you see here? Cell Trend GmbH. Cell Trend has been the one that has been doing, um, offering the antibody panels for vaccine or long COVID patients. So Cell Trend is a participant in this study. Maybe they were offering the tests.
So this is the main finding. If you wanted to take away that, hey, I may have long COVID or have vaccine side effects, persistent side effects, you know the word I'm, I'm deliberately avoiding, and you wanted to see what are the things to do. This is the main panel. This panel had 90% sensitivity and specificity for diagnosing vaccine side effect patients. There is one important thing to consider, and that is this study did not differentiate or did not run further diagnostics to separate the post-vaccine syndrome from long COVID or from ME/CFS. Their panels, these two other diseases have similar panels. But you would see here that the, those individuals who were post-vaccine side effect patients, almost half of them never had COVID infection. And then the other half had the COVID infection as well. But the difference in the panel was negligible. So that means it is vaccine-induced and not infection-induced.
So here, first marker or antibody test was Angiotensin 1 receptor, Angiotensin 2, 1 receptor blocking antibodies or antibodies against AT1 receptor. These in the vaccine, um, syndrome patients, let me just call this PVS from now on, in the PVS patients, these were increased compared to healthy where these were reduced. So here is a delicate point I'm going to make. If you compare this to a person who is not vaccinated, then this level of AT1 receptor antibodies is equal to a normal, non-vaccinated healthy individual. So this may be the normal level. But when you compare it to a healthy who had the vaccine and is healthy afterwards, then it is increased because in the vaccinated, actually, this one is reduced. Similar thing here with the Alpha 2B adrenergic receptors. This is autonomic nervous system receptor. This antibodies against this receptor are reduced, while in the healthy, they are reduced as well. Interleukin-6 is increased, while in healthy, that is normal or reduced. Until you can, E is increased, and while in the healthy, normal or reduced. Very interesting panel.
And if, so this is that observation that I've been discussing, the one that shocked me first. Keep in mind that the study was from the vaccine up to six months. So it doesn't show us the data after. In healthy individuals, the healthy are those who were vaccinated and then stayed symptomless from vaccine effects, 25 to 50% reduction in antibodies against AT1 receptor, endothelin receptor, Mas receptor, Alpha 1 adrenergic receptor, Alpha 2 adrenergic receptor, Beta 1 adrenergic receptor, Beta 2 adrenergic receptor, muscarinic 1, muscarinic 2, muscarinic 3. Not muscarinic 4 and muscarinic 5 receptor. There was reduction in these antibodies. So think about it for a second. If somebody is not vaccinated, they have some levels of these antibodies present in their body. So why, you might ask, that why do they have these antibodies? Our immune system can regulate functions of various receptors by creating antibodies to stimulate them or creating antibodies to block them. So our body can actually work with the immune system to say, "Hey, this particular receptor is getting too much stimulated. So can you come in and produce some antibodies that can cover that receptor and make it inaccessible to its own stimulant so that it doesn't work?" Or our body can tell the immune system to produce some antibodies that would come in and stimulate some receptor. So we all, let's say we are all, before vaccine time, we all had some baseline levels of these antibodies. Once we get vaccinated, even after six months, there is a 25 to 50% reduction in these antibodies. Then there is another 15 to 20, 5% reduction in these antibodies, interleukin-1 receptor antibody, A2 receptor antibodies, Alpha 2B adrenergic receptor. And there was no change in these because they had measured them as well and they found no change. And that is, I mean, if you call six months to be persistent, then this downregulation or calibration of the immune system in a healthy individual after vaccination is an interesting change. It's a continuous change, downward regulation, protecting them from clotting, inflammation, and autoimmune disorders. If you do not downregulate them, then the patient becomes injured, which means that there is somehow vaccine contributing towards these effects as well. And if our body is already at a baseline, then when you overlap vaccine's effect, then the patients develop, uh, symptoms.
Now, for my pro-vaccine friends, I do not consider myself to be anti-vaccine or pro-vaccine. I consider myself to be a medical doctor who looks at the benefits, the side effects, and the management of all of these things. But for my pro-vaccine friends, this can also be thought of as when the vaccine is given and then a vast level of inflammation occurs, and spike protein-based vaccines would cause a lot of, you know, spike protein works on various kinds of receptors throughout the body. When that intense and widespread inflammation occurs, when the immune system tries to regulate itself afterwards, we know that all inflammations in healthy individuals are followed by a regulatory system that would then calm down the immune system. So when that regulatory system kicks in to calm down the immune system, to bring it back to normal levels, it actually prunes other immune system activities to kind of bring it back towards normal. So that may be the reason.
Anyways, now those who were vaccine side effect patients, persistent side effect patients, or PVS patients, they had antibodies relatively increased. So if you stand two people, one was healthy, got vaccinated, and stayed healthy, and the other one had the vaccine and did not stay healthy, if you compared their vac- their markers, the vaccine syndrome patient did not have a downregulation. Their immune system somehow did not decide to calibrate itself to compensate for the extra activity that vaccine did. So their antibodies remained closer to normal, but higher when compared to healthy individuals who were vaccinated, because the healthy individuals had their levels going down. Also, previous infection. So if somebody had infection with SARS-CoV-2 plus vaccination, their panel was not very different from those who were not infected but vaccinated. So infection did not play a role in these biomarker levels that we are discussing in this study.
Now, just very quickly, what are these antibodies generally? What were they doing? The ones that got downregulated or upregulated. So for example, AT1 and ETRA. So Angiotensin 2, 1 receptor and endothelin receptor. Their function is to help regulate the cardiac heart rate, and especially when we stand up after sitting down or lying down. So when these receptors are not working correctly, then the patient would develop POTS-like syndrome, standing up and developing palpitations and those, or even becoming dizzy and even falling. The muscarinic 2 receptor and muscarinic 3 receptors, these are the, uh, receptors of the autonomic nervous system as well. There is, they are concerned with heart rate and gut motility. So when they are not working correctly, then the heart rate, palpitations would occur, and the GI abnormality in movement, either more movement or less movement, would occur depending upon how the receptor is going stimulated or not. Then beta 2 adrenergic receptor, they are concerned with tachycardia and exercise intolerance. If they're not working correctly, so this is where the muscle fatigues occur. Mas receptor, Ms receptor is where actually Angiotensin 1 to 7 works. So remember we have renin-angiotensin system that makes Angiotensin 1, then Angiotensin 2. We have ACE2 that is a target of SARS-CoV-2, right? So ACE2 enzyme converts the Angiotensin 2 to Angiotensin 1 to 7. Angiotensin 2 itself is a vasoconstrictor. Angiotensin 1 to 7 is a vasodilator. Angiotensin 2 acts on a receptor called Mas receptor and causes vasodilation. In the case of when the person gets vaccine, what happens is that there is a vasoconstricting effect. So the Mas receptor gets blocked or there are antibodies generated against the Mas receptor which causes vasoconstriction, which can cause hypertension plus tachycardia plus the, uh, thrombosis. Although vasodilation should lead to less tachycardia, but because of all the remaining effects here, plus this is anti-inflammatory, it is kind of opposite to ACE2. So when there is a problem, when there is a dysregulation of Mas receptor, then the vascular dysfunction occurs, vasoconstriction occurs, which causes hypertension, plus it would cause clotting, plus immune dysregulation occurs. Inflammatory and anti-inflammatory system balance becomes reduced. Similarly, the interleukin-1 receptor is for immune signaling and inflammation resolution. So if this receptor is not working correctly, then inflammation resolution will not occur, and the person might end up with chronic inflammation. Similarly, Alpha 2B adrenergic receptor is a sympathetic modulator, and it is concerned with blood pressure and anxiety or or psychological, uh, well-being.
Now, expanded panel. If other than these four, you wanted to have some other panels as well, which they diagnosed in or worked within this study, then Mas receptor antibodies will be increased. Interleukin-1 receptor antibodies will be reduced. Beta 2 adrenergic receptor antibodies will be increased. And muscarinic 2 antibodies will be increased. This is in addition to the AT1R and the Alpha 2 adrenergic receptor, plus interleukin-6 and interleukin-8. Now, there may be, they say in their manuscript that you may still have to differentiate from long COVID and ME/CFS because this study did not look at these folks' blood samples to compare. And they do say that this kind of a comparison is needed afterwards.
So now, if you are a physician, if you are a clinician, and you want to diagnose a patient who has come to you with persistent symptoms five months after the vaccination of muscle pain, fatigue, uh, tachycardia, POTS-like symptom, dizziness, uh, brain fog, cognitive decline, then what you do is first of all, have your clinical assessment that there is persistence of symptoms. Number one, symptoms were new after the vaccine. And number two, they persisted more than five months. Then rule out any POTS, long COVID, or other similar diseases that can cause tachycardia or brain fog. Once you've ruled that out, then perform this panel. The core panel is these three, or sorry, four: Angiotensin 2, 1 receptor, Alpha 2B adrenergic receptor, IL-6, and IL-8. So here, AT1 receptor will be high, the antibodies against that. The antibodies against the Alpha 2 will be low. Interleukin-6 level will be persistently high. Interleukin-8 level will be persistently high. Interestingly, C-reactive protein levels stayed normal. That was also a shock for me because I always expect C-reactive protein levels to be high in chronic inflammation. But in these vaccine side effect patients, CRP levels were normal. And if you wanted to have an expanded panel, then optionally Mas receptor antibodies, this will be increased. Interleukin-1 receptor antibodies will be reduced. Muscarinic 2 receptor antibodies will be increased. Muscarinic 3 antibodies will be increased. If this panel comes back like this, then there is a high probability that this patient is vaccine is having persistent vaccine side effects. And if this panel does not come back to be this way, then at least according to this study, this patient may have some other problem.
Now, once again, immune recalibration in healthy individuals, vaccinated and staying healthy individuals, they were cardiovascular system-related antibodies that were reduced. There were autonomic nervous system-related antibodies that were reduced. There were vessel and clotting protection antibodies that were increased. While in the vaccinated and not healthy afterwards, this did not happen. Now, the result was these patients were experiencing POTS, postural orthostatic tachycardia syndrome, vascular instability, clotting, chronic inflammation, brain fog, fatigue, headache. And most important thing, this is not a psychosomatic effect, this is a somatic effect. So that is the discussion, the takeaway from here.
Other than the academic takeaway that, hey, we did not, I did not know that the vaccinated individual would have these immune system downregulating some of the antibodies to calibrate for the vaccine effects, but there is a diagnostic panel in here with either four markers or four plus another, I think four or six markers, which are very, very important. So my request to you is, number one, support this work if you like it. Secondly, share, share this work with your friends who may have these symptoms or who may have someone who has these symptoms. And finally, do add some comment there because YouTube algorithm likes the comments as well. So with that, please like, subscribe, and share. And I would see you next time. Have a great weekend.